Factors that influence the stability of the FDG

Introduction – The absence of a cyclotron for production of 2-[18F]Fluor-2- -deoxy-D-glucose (18F-FDG) is now a reality for most of the centers where Positron Emission Tomography (TEP) exams are held in. It is therefore important to ensure the quality of this radiopharmaceutical from the moment of i...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Ana Graça [verfasserIn] Román Sánchez Sánchez [verfasserIn] Luda Grada Bernardo [verfasserIn] Juan Rayo Madrid [verfasserIn] Filipa Lucena [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch ; Portugiesisch

Erschienen:	2015

Schlagwörter:	18F-FDG, pureza radioquímica, autoradiólise, percentagem de 18F

Übergeordnetes Werk:	In: Saúde & Tecnologia - Escola Superior de Tecnologia da Saúde de Lisboa, 2013, (2015), 5, Seite 35-38
Übergeordnetes Werk:	year:2015 ; number:5 ; pages:35-38

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.25758/s&t.v0i5.354

Katalog-ID:	DOAJ060571373

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spelling	10.25758/s&t.v0i5.354 doi (DE-627)DOAJ060571373 (DE-599)DOAJ35c6a281846a4d6abf2825fb852dc644 DE-627 ger DE-627 rakwb eng por Ana Graça verfasserin aut Factors that influence the stability of the FDG 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction – The absence of a cyclotron for production of 2-[18F]Fluor-2- -deoxy-D-glucose (18F-FDG) is now a reality for most of the centers where Positron Emission Tomography (TEP) exams are held in. It is therefore important to ensure the quality of this radiopharmaceutical from the moment of its synthesis till the administration to the patient. The purpose of this study is to show the influence of the parameters temperature, pH, radioactive concentration (CR) and time in radiochemical purity. Methodology – We analyzed the pH and the radiochemical purity [by thin layer chromatography (TLC)] of six samples of 18F-FDG with different CR and at different times and temperatures. Results – There was an increase in the percentage of 18F with time. Nevertheless, results show that samples’ dilution decreases the degradation of 18F-FDG. However, comparing only the diluted samples (185 and 740 MBq / ml), there is a positive relationship between CR and the percentage of 18F-. There was also an increase in percentage of 18F at higher temperatures. Conclusion – We advise to dilute the solution and the period of time for storage the 18F-FDG should not be so long. The samples must have a stable temperature and pH. 18F-FDG, pureza radioquímica, autoradiólise, percentagem de 18F Medicine R Román Sánchez Sánchez verfasserin aut Luda Grada Bernardo verfasserin aut Juan Rayo Madrid verfasserin aut Filipa Lucena verfasserin aut In Saúde & Tecnologia Escola Superior de Tecnologia da Saúde de Lisboa, 2013 (2015), 5, Seite 35-38 (DE-627)634381873 (DE-600)2570972-0 21834342 nnns year:2015 number:5 pages:35-38 https://doi.org/10.25758/s&t.v0i5.354 kostenfrei https://doaj.org/article/35c6a281846a4d6abf2825fb852dc644 kostenfrei https://web.estesl.ipl.pt/ojs/index.php/ST/article/view/354 kostenfrei https://doaj.org/toc/1646-9704 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2015 5 35-38
allfields_unstemmed	10.25758/s&t.v0i5.354 doi (DE-627)DOAJ060571373 (DE-599)DOAJ35c6a281846a4d6abf2825fb852dc644 DE-627 ger DE-627 rakwb eng por Ana Graça verfasserin aut Factors that influence the stability of the FDG 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction – The absence of a cyclotron for production of 2-[18F]Fluor-2- -deoxy-D-glucose (18F-FDG) is now a reality for most of the centers where Positron Emission Tomography (TEP) exams are held in. It is therefore important to ensure the quality of this radiopharmaceutical from the moment of its synthesis till the administration to the patient. The purpose of this study is to show the influence of the parameters temperature, pH, radioactive concentration (CR) and time in radiochemical purity. Methodology – We analyzed the pH and the radiochemical purity [by thin layer chromatography (TLC)] of six samples of 18F-FDG with different CR and at different times and temperatures. Results – There was an increase in the percentage of 18F with time. Nevertheless, results show that samples’ dilution decreases the degradation of 18F-FDG. However, comparing only the diluted samples (185 and 740 MBq / ml), there is a positive relationship between CR and the percentage of 18F-. There was also an increase in percentage of 18F at higher temperatures. Conclusion – We advise to dilute the solution and the period of time for storage the 18F-FDG should not be so long. The samples must have a stable temperature and pH. 18F-FDG, pureza radioquímica, autoradiólise, percentagem de 18F Medicine R Román Sánchez Sánchez verfasserin aut Luda Grada Bernardo verfasserin aut Juan Rayo Madrid verfasserin aut Filipa Lucena verfasserin aut In Saúde & Tecnologia Escola Superior de Tecnologia da Saúde de Lisboa, 2013 (2015), 5, Seite 35-38 (DE-627)634381873 (DE-600)2570972-0 21834342 nnns year:2015 number:5 pages:35-38 https://doi.org/10.25758/s&t.v0i5.354 kostenfrei https://doaj.org/article/35c6a281846a4d6abf2825fb852dc644 kostenfrei https://web.estesl.ipl.pt/ojs/index.php/ST/article/view/354 kostenfrei https://doaj.org/toc/1646-9704 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2015 5 35-38
allfieldsGer	10.25758/s&t.v0i5.354 doi (DE-627)DOAJ060571373 (DE-599)DOAJ35c6a281846a4d6abf2825fb852dc644 DE-627 ger DE-627 rakwb eng por Ana Graça verfasserin aut Factors that influence the stability of the FDG 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction – The absence of a cyclotron for production of 2-[18F]Fluor-2- -deoxy-D-glucose (18F-FDG) is now a reality for most of the centers where Positron Emission Tomography (TEP) exams are held in. It is therefore important to ensure the quality of this radiopharmaceutical from the moment of its synthesis till the administration to the patient. The purpose of this study is to show the influence of the parameters temperature, pH, radioactive concentration (CR) and time in radiochemical purity. Methodology – We analyzed the pH and the radiochemical purity [by thin layer chromatography (TLC)] of six samples of 18F-FDG with different CR and at different times and temperatures. Results – There was an increase in the percentage of 18F with time. Nevertheless, results show that samples’ dilution decreases the degradation of 18F-FDG. However, comparing only the diluted samples (185 and 740 MBq / ml), there is a positive relationship between CR and the percentage of 18F-. There was also an increase in percentage of 18F at higher temperatures. Conclusion – We advise to dilute the solution and the period of time for storage the 18F-FDG should not be so long. The samples must have a stable temperature and pH. 18F-FDG, pureza radioquímica, autoradiólise, percentagem de 18F Medicine R Román Sánchez Sánchez verfasserin aut Luda Grada Bernardo verfasserin aut Juan Rayo Madrid verfasserin aut Filipa Lucena verfasserin aut In Saúde & Tecnologia Escola Superior de Tecnologia da Saúde de Lisboa, 2013 (2015), 5, Seite 35-38 (DE-627)634381873 (DE-600)2570972-0 21834342 nnns year:2015 number:5 pages:35-38 https://doi.org/10.25758/s&t.v0i5.354 kostenfrei https://doaj.org/article/35c6a281846a4d6abf2825fb852dc644 kostenfrei https://web.estesl.ipl.pt/ojs/index.php/ST/article/view/354 kostenfrei https://doaj.org/toc/1646-9704 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2015 5 35-38
allfieldsSound	10.25758/s&t.v0i5.354 doi (DE-627)DOAJ060571373 (DE-599)DOAJ35c6a281846a4d6abf2825fb852dc644 DE-627 ger DE-627 rakwb eng por Ana Graça verfasserin aut Factors that influence the stability of the FDG 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction – The absence of a cyclotron for production of 2-[18F]Fluor-2- -deoxy-D-glucose (18F-FDG) is now a reality for most of the centers where Positron Emission Tomography (TEP) exams are held in. It is therefore important to ensure the quality of this radiopharmaceutical from the moment of its synthesis till the administration to the patient. The purpose of this study is to show the influence of the parameters temperature, pH, radioactive concentration (CR) and time in radiochemical purity. Methodology – We analyzed the pH and the radiochemical purity [by thin layer chromatography (TLC)] of six samples of 18F-FDG with different CR and at different times and temperatures. Results – There was an increase in the percentage of 18F with time. Nevertheless, results show that samples’ dilution decreases the degradation of 18F-FDG. However, comparing only the diluted samples (185 and 740 MBq / ml), there is a positive relationship between CR and the percentage of 18F-. There was also an increase in percentage of 18F at higher temperatures. Conclusion – We advise to dilute the solution and the period of time for storage the 18F-FDG should not be so long. The samples must have a stable temperature and pH. 18F-FDG, pureza radioquímica, autoradiólise, percentagem de 18F Medicine R Román Sánchez Sánchez verfasserin aut Luda Grada Bernardo verfasserin aut Juan Rayo Madrid verfasserin aut Filipa Lucena verfasserin aut In Saúde & Tecnologia Escola Superior de Tecnologia da Saúde de Lisboa, 2013 (2015), 5, Seite 35-38 (DE-627)634381873 (DE-600)2570972-0 21834342 nnns year:2015 number:5 pages:35-38 https://doi.org/10.25758/s&t.v0i5.354 kostenfrei https://doaj.org/article/35c6a281846a4d6abf2825fb852dc644 kostenfrei https://web.estesl.ipl.pt/ojs/index.php/ST/article/view/354 kostenfrei https://doaj.org/toc/1646-9704 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2015 5 35-38
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It is therefore important to ensure the quality of this radiopharmaceutical from the moment of its synthesis till the administration to the patient. The purpose of this study is to show the influence of the parameters temperature, pH, radioactive concentration (CR) and time in radiochemical purity. Methodology – We analyzed the pH and the radiochemical purity [by thin layer chromatography (TLC)] of six samples of 18F-FDG with different CR and at different times and temperatures. Results – There was an increase in the percentage of 18F with time. Nevertheless, results show that samples’ dilution decreases the degradation of 18F-FDG. However, comparing only the diluted samples (185 and 740 MBq / ml), there is a positive relationship between CR and the percentage of 18F-. There was also an increase in percentage of 18F at higher temperatures. Conclusion – We advise to dilute the solution and the period of time for storage the 18F-FDG should not be so long. 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author	Ana Graça
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topic_title	Factors that influence the stability of the FDG 18F-FDG, pureza radioquímica, autoradiólise, percentagem de 18F
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title	Factors that influence the stability of the FDG
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title_full	Factors that influence the stability of the FDG
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author_browse	Ana Graça Román Sánchez Sánchez Luda Grada Bernardo Juan Rayo Madrid Filipa Lucena
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title_sort	factors that influence the stability of the fdg
title_auth	Factors that influence the stability of the FDG
abstract	Introduction – The absence of a cyclotron for production of 2-[18F]Fluor-2- -deoxy-D-glucose (18F-FDG) is now a reality for most of the centers where Positron Emission Tomography (TEP) exams are held in. It is therefore important to ensure the quality of this radiopharmaceutical from the moment of its synthesis till the administration to the patient. The purpose of this study is to show the influence of the parameters temperature, pH, radioactive concentration (CR) and time in radiochemical purity. Methodology – We analyzed the pH and the radiochemical purity [by thin layer chromatography (TLC)] of six samples of 18F-FDG with different CR and at different times and temperatures. Results – There was an increase in the percentage of 18F with time. Nevertheless, results show that samples’ dilution decreases the degradation of 18F-FDG. However, comparing only the diluted samples (185 and 740 MBq / ml), there is a positive relationship between CR and the percentage of 18F-. There was also an increase in percentage of 18F at higher temperatures. Conclusion – We advise to dilute the solution and the period of time for storage the 18F-FDG should not be so long. The samples must have a stable temperature and pH.
abstractGer	Introduction – The absence of a cyclotron for production of 2-[18F]Fluor-2- -deoxy-D-glucose (18F-FDG) is now a reality for most of the centers where Positron Emission Tomography (TEP) exams are held in. It is therefore important to ensure the quality of this radiopharmaceutical from the moment of its synthesis till the administration to the patient. The purpose of this study is to show the influence of the parameters temperature, pH, radioactive concentration (CR) and time in radiochemical purity. Methodology – We analyzed the pH and the radiochemical purity [by thin layer chromatography (TLC)] of six samples of 18F-FDG with different CR and at different times and temperatures. Results – There was an increase in the percentage of 18F with time. Nevertheless, results show that samples’ dilution decreases the degradation of 18F-FDG. However, comparing only the diluted samples (185 and 740 MBq / ml), there is a positive relationship between CR and the percentage of 18F-. There was also an increase in percentage of 18F at higher temperatures. Conclusion – We advise to dilute the solution and the period of time for storage the 18F-FDG should not be so long. The samples must have a stable temperature and pH.
abstract_unstemmed	Introduction – The absence of a cyclotron for production of 2-[18F]Fluor-2- -deoxy-D-glucose (18F-FDG) is now a reality for most of the centers where Positron Emission Tomography (TEP) exams are held in. It is therefore important to ensure the quality of this radiopharmaceutical from the moment of its synthesis till the administration to the patient. The purpose of this study is to show the influence of the parameters temperature, pH, radioactive concentration (CR) and time in radiochemical purity. Methodology – We analyzed the pH and the radiochemical purity [by thin layer chromatography (TLC)] of six samples of 18F-FDG with different CR and at different times and temperatures. Results – There was an increase in the percentage of 18F with time. Nevertheless, results show that samples’ dilution decreases the degradation of 18F-FDG. However, comparing only the diluted samples (185 and 740 MBq / ml), there is a positive relationship between CR and the percentage of 18F-. There was also an increase in percentage of 18F at higher temperatures. Conclusion – We advise to dilute the solution and the period of time for storage the 18F-FDG should not be so long. The samples must have a stable temperature and pH.
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title_short	Factors that influence the stability of the FDG
url	https://doi.org/10.25758/s&t.v0i5.354 https://doaj.org/article/35c6a281846a4d6abf2825fb852dc644 https://web.estesl.ipl.pt/ojs/index.php/ST/article/view/354 https://doaj.org/toc/1646-9704
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