Variability in Annual Fasting Glucose and the Risk of Peripheral Artery Disease in Patients with Diabetes Mellitus

Yu-Shan Chang,1,2 Liang-Yi Lee,3 I-Te Lee1,2,4 1Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung City, Taiwan; 2School of Medicine, Chung Shan Medical University, Taichung City, Taiwan; 3Mingdao High School, Taichung City, Taiwan; 4School of Medicine, National Yang Ming Chiao Tung University, Taipei, TaiwanCorrespondence: I-Te LeeDivision of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, 1650, Section 4, Taiwan Boulevard, Taichung City, 40705, TaiwanEmail itleevghtc.gov.twPurpose: High glucose concentrations and swings are associated with endothelial dysfunction. We examined the effects of variability in fasting plasma glucose on peripheral artery disease (PAD) in patients with diabetes mellitus (DM).Patients and Methods: In this screening study for the risk factors of PAD, we retrospectively collected data on the ankle-brachial index (ABI) and the percentage of mean arterial pressure (%MAP) at the ankle between August 01, 2016 and July 31, 2017. We defined low ABI ≤ 0.90, high %MAP ≥ 45%, or both as high-risk PAD and others as low-risk PAD. We compared the standard deviation (SD) of the first fasting plasma glucose data available each year after January 01, 2007.Results: In 2577 patients, a higher SD of annual fasting glucose was observed in those with an ABI ≤ 0.90 than in patients with an ABI < 0.90 (2.6 ± 2.1 vs 2.2 ± 2.3, P = 0.009), and in patients with %MAP ≥ 45% than in those with %MAP < 45% (2.4 ± 2.1 vs 2.2 ± 2.3, P = 0.034). A high-risk PAD was significantly associated with the SD (P = 0.032) but not with the mean (P = 0.338) of annual fasting glucose. The former was an independent risk factor for high-risk PAD (odds ratio = 1.424; 95% CI = 1.118‒1.814; P = 0.004).Conclusion: Variability but not mean of annual fasting plasma glucose was significantly associated with a high risk of PAD in patients with DM.Keywords: ankle-brachial index, arterial stiffness, lower extremity arterial disease, percentage of the mean arterial pressure, standard deviation Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Chang YS [verfasserIn] Lee LY [verfasserIn] Lee IT [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	ankle-brachial index arterial stiffness lower extremity arterial disease percentage of the mean arterial pressure standard deviation

Übergeordnetes Werk:	In: Diabetes, Metabolic Syndrome and Obesity - Dove Medical Press, 2009, (2021), Seite 4109-4119
Übergeordnetes Werk:	year:2021 ; pages:4109-4119

Links:	Link aufrufen Link aufrufen Journal toc

Katalog-ID:	DOAJ060577207

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520			\|a Yu-Shan Chang,1,2 Liang-Yi Lee,3 I-Te Lee1,2,4 1Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung City, Taiwan; 2School of Medicine, Chung Shan Medical University, Taichung City, Taiwan; 3Mingdao High School, Taichung City, Taiwan; 4School of Medicine, National Yang Ming Chiao Tung University, Taipei, TaiwanCorrespondence: I-Te LeeDivision of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, 1650, Section 4, Taiwan Boulevard, Taichung City, 40705, TaiwanEmail itleevghtc.gov.twPurpose: High glucose concentrations and swings are associated with endothelial dysfunction. We examined the effects of variability in fasting plasma glucose on peripheral artery disease (PAD) in patients with diabetes mellitus (DM).Patients and Methods: In this screening study for the risk factors of PAD, we retrospectively collected data on the ankle-brachial index (ABI) and the percentage of mean arterial pressure (%MAP) at the ankle between August 01, 2016 and July 31, 2017. We defined low ABI ≤ 0.90, high %MAP ≥ 45%, or both as high-risk PAD and others as low-risk PAD. We compared the standard deviation (SD) of the first fasting plasma glucose data available each year after January 01, 2007.Results: In 2577 patients, a higher SD of annual fasting glucose was observed in those with an ABI ≤ 0.90 than in patients with an ABI < 0.90 (2.6 ± 2.1 vs 2.2 ± 2.3, P = 0.009), and in patients with %MAP ≥ 45% than in those with %MAP < 45% (2.4 ± 2.1 vs 2.2 ± 2.3, P = 0.034). A high-risk PAD was significantly associated with the SD (P = 0.032) but not with the mean (P = 0.338) of annual fasting glucose. The former was an independent risk factor for high-risk PAD (odds ratio = 1.424; 95% CI = 1.118‒1.814; P = 0.004).Conclusion: Variability but not mean of annual fasting plasma glucose was significantly associated with a high risk of PAD in patients with DM.Keywords: ankle-brachial index, arterial stiffness, lower extremity arterial disease, percentage of the mean arterial pressure, standard deviation
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allfields	(DE-627)DOAJ060577207 (DE-599)DOAJ4700818779674987bb5676c63ac43ff8 DE-627 ger DE-627 rakwb eng RC581-951 Chang YS verfasserin aut Variability in Annual Fasting Glucose and the Risk of Peripheral Artery Disease in Patients with Diabetes Mellitus 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Yu-Shan Chang,1,2 Liang-Yi Lee,3 I-Te Lee1,2,4 1Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung City, Taiwan; 2School of Medicine, Chung Shan Medical University, Taichung City, Taiwan; 3Mingdao High School, Taichung City, Taiwan; 4School of Medicine, National Yang Ming Chiao Tung University, Taipei, TaiwanCorrespondence: I-Te LeeDivision of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, 1650, Section 4, Taiwan Boulevard, Taichung City, 40705, TaiwanEmail itleevghtc.gov.twPurpose: High glucose concentrations and swings are associated with endothelial dysfunction. We examined the effects of variability in fasting plasma glucose on peripheral artery disease (PAD) in patients with diabetes mellitus (DM).Patients and Methods: In this screening study for the risk factors of PAD, we retrospectively collected data on the ankle-brachial index (ABI) and the percentage of mean arterial pressure (%MAP) at the ankle between August 01, 2016 and July 31, 2017. We defined low ABI ≤ 0.90, high %MAP ≥ 45%, or both as high-risk PAD and others as low-risk PAD. We compared the standard deviation (SD) of the first fasting plasma glucose data available each year after January 01, 2007.Results: In 2577 patients, a higher SD of annual fasting glucose was observed in those with an ABI ≤ 0.90 than in patients with an ABI < 0.90 (2.6 ± 2.1 vs 2.2 ± 2.3, P = 0.009), and in patients with %MAP ≥ 45% than in those with %MAP < 45% (2.4 ± 2.1 vs 2.2 ± 2.3, P = 0.034). A high-risk PAD was significantly associated with the SD (P = 0.032) but not with the mean (P = 0.338) of annual fasting glucose. The former was an independent risk factor for high-risk PAD (odds ratio = 1.424; 95% CI = 1.118‒1.814; P = 0.004).Conclusion: Variability but not mean of annual fasting plasma glucose was significantly associated with a high risk of PAD in patients with DM.Keywords: ankle-brachial index, arterial stiffness, lower extremity arterial disease, percentage of the mean arterial pressure, standard deviation ankle-brachial index arterial stiffness lower extremity arterial disease percentage of the mean arterial pressure standard deviation Specialties of internal medicine Lee LY verfasserin aut Lee IT verfasserin aut In Diabetes, Metabolic Syndrome and Obesity Dove Medical Press, 2009 (2021), Seite 4109-4119 (DE-627)60030597X (DE-600)2494854-8 11787007 nnns year:2021 pages:4109-4119 https://doaj.org/article/4700818779674987bb5676c63ac43ff8 kostenfrei https://www.dovepress.com/variability-in-annual-fasting-glucose-and-the-risk-of-peripheral-arter-peer-reviewed-fulltext-article-DMSO kostenfrei https://doaj.org/toc/1178-7007 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2021 4109-4119
spelling	(DE-627)DOAJ060577207 (DE-599)DOAJ4700818779674987bb5676c63ac43ff8 DE-627 ger DE-627 rakwb eng RC581-951 Chang YS verfasserin aut Variability in Annual Fasting Glucose and the Risk of Peripheral Artery Disease in Patients with Diabetes Mellitus 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Yu-Shan Chang,1,2 Liang-Yi Lee,3 I-Te Lee1,2,4 1Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung City, Taiwan; 2School of Medicine, Chung Shan Medical University, Taichung City, Taiwan; 3Mingdao High School, Taichung City, Taiwan; 4School of Medicine, National Yang Ming Chiao Tung University, Taipei, TaiwanCorrespondence: I-Te LeeDivision of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, 1650, Section 4, Taiwan Boulevard, Taichung City, 40705, TaiwanEmail itleevghtc.gov.twPurpose: High glucose concentrations and swings are associated with endothelial dysfunction. We examined the effects of variability in fasting plasma glucose on peripheral artery disease (PAD) in patients with diabetes mellitus (DM).Patients and Methods: In this screening study for the risk factors of PAD, we retrospectively collected data on the ankle-brachial index (ABI) and the percentage of mean arterial pressure (%MAP) at the ankle between August 01, 2016 and July 31, 2017. We defined low ABI ≤ 0.90, high %MAP ≥ 45%, or both as high-risk PAD and others as low-risk PAD. We compared the standard deviation (SD) of the first fasting plasma glucose data available each year after January 01, 2007.Results: In 2577 patients, a higher SD of annual fasting glucose was observed in those with an ABI ≤ 0.90 than in patients with an ABI < 0.90 (2.6 ± 2.1 vs 2.2 ± 2.3, P = 0.009), and in patients with %MAP ≥ 45% than in those with %MAP < 45% (2.4 ± 2.1 vs 2.2 ± 2.3, P = 0.034). A high-risk PAD was significantly associated with the SD (P = 0.032) but not with the mean (P = 0.338) of annual fasting glucose. The former was an independent risk factor for high-risk PAD (odds ratio = 1.424; 95% CI = 1.118‒1.814; P = 0.004).Conclusion: Variability but not mean of annual fasting plasma glucose was significantly associated with a high risk of PAD in patients with DM.Keywords: ankle-brachial index, arterial stiffness, lower extremity arterial disease, percentage of the mean arterial pressure, standard deviation ankle-brachial index arterial stiffness lower extremity arterial disease percentage of the mean arterial pressure standard deviation Specialties of internal medicine Lee LY verfasserin aut Lee IT verfasserin aut In Diabetes, Metabolic Syndrome and Obesity Dove Medical Press, 2009 (2021), Seite 4109-4119 (DE-627)60030597X (DE-600)2494854-8 11787007 nnns year:2021 pages:4109-4119 https://doaj.org/article/4700818779674987bb5676c63ac43ff8 kostenfrei https://www.dovepress.com/variability-in-annual-fasting-glucose-and-the-risk-of-peripheral-arter-peer-reviewed-fulltext-article-DMSO kostenfrei https://doaj.org/toc/1178-7007 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2021 4109-4119
allfields_unstemmed	(DE-627)DOAJ060577207 (DE-599)DOAJ4700818779674987bb5676c63ac43ff8 DE-627 ger DE-627 rakwb eng RC581-951 Chang YS verfasserin aut Variability in Annual Fasting Glucose and the Risk of Peripheral Artery Disease in Patients with Diabetes Mellitus 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Yu-Shan Chang,1,2 Liang-Yi Lee,3 I-Te Lee1,2,4 1Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung City, Taiwan; 2School of Medicine, Chung Shan Medical University, Taichung City, Taiwan; 3Mingdao High School, Taichung City, Taiwan; 4School of Medicine, National Yang Ming Chiao Tung University, Taipei, TaiwanCorrespondence: I-Te LeeDivision of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, 1650, Section 4, Taiwan Boulevard, Taichung City, 40705, TaiwanEmail itleevghtc.gov.twPurpose: High glucose concentrations and swings are associated with endothelial dysfunction. We examined the effects of variability in fasting plasma glucose on peripheral artery disease (PAD) in patients with diabetes mellitus (DM).Patients and Methods: In this screening study for the risk factors of PAD, we retrospectively collected data on the ankle-brachial index (ABI) and the percentage of mean arterial pressure (%MAP) at the ankle between August 01, 2016 and July 31, 2017. We defined low ABI ≤ 0.90, high %MAP ≥ 45%, or both as high-risk PAD and others as low-risk PAD. We compared the standard deviation (SD) of the first fasting plasma glucose data available each year after January 01, 2007.Results: In 2577 patients, a higher SD of annual fasting glucose was observed in those with an ABI ≤ 0.90 than in patients with an ABI < 0.90 (2.6 ± 2.1 vs 2.2 ± 2.3, P = 0.009), and in patients with %MAP ≥ 45% than in those with %MAP < 45% (2.4 ± 2.1 vs 2.2 ± 2.3, P = 0.034). A high-risk PAD was significantly associated with the SD (P = 0.032) but not with the mean (P = 0.338) of annual fasting glucose. The former was an independent risk factor for high-risk PAD (odds ratio = 1.424; 95% CI = 1.118‒1.814; P = 0.004).Conclusion: Variability but not mean of annual fasting plasma glucose was significantly associated with a high risk of PAD in patients with DM.Keywords: ankle-brachial index, arterial stiffness, lower extremity arterial disease, percentage of the mean arterial pressure, standard deviation ankle-brachial index arterial stiffness lower extremity arterial disease percentage of the mean arterial pressure standard deviation Specialties of internal medicine Lee LY verfasserin aut Lee IT verfasserin aut In Diabetes, Metabolic Syndrome and Obesity Dove Medical Press, 2009 (2021), Seite 4109-4119 (DE-627)60030597X (DE-600)2494854-8 11787007 nnns year:2021 pages:4109-4119 https://doaj.org/article/4700818779674987bb5676c63ac43ff8 kostenfrei https://www.dovepress.com/variability-in-annual-fasting-glucose-and-the-risk-of-peripheral-arter-peer-reviewed-fulltext-article-DMSO kostenfrei https://doaj.org/toc/1178-7007 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2021 4109-4119
allfieldsGer	(DE-627)DOAJ060577207 (DE-599)DOAJ4700818779674987bb5676c63ac43ff8 DE-627 ger DE-627 rakwb eng RC581-951 Chang YS verfasserin aut Variability in Annual Fasting Glucose and the Risk of Peripheral Artery Disease in Patients with Diabetes Mellitus 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Yu-Shan Chang,1,2 Liang-Yi Lee,3 I-Te Lee1,2,4 1Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung City, Taiwan; 2School of Medicine, Chung Shan Medical University, Taichung City, Taiwan; 3Mingdao High School, Taichung City, Taiwan; 4School of Medicine, National Yang Ming Chiao Tung University, Taipei, TaiwanCorrespondence: I-Te LeeDivision of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, 1650, Section 4, Taiwan Boulevard, Taichung City, 40705, TaiwanEmail itleevghtc.gov.twPurpose: High glucose concentrations and swings are associated with endothelial dysfunction. We examined the effects of variability in fasting plasma glucose on peripheral artery disease (PAD) in patients with diabetes mellitus (DM).Patients and Methods: In this screening study for the risk factors of PAD, we retrospectively collected data on the ankle-brachial index (ABI) and the percentage of mean arterial pressure (%MAP) at the ankle between August 01, 2016 and July 31, 2017. We defined low ABI ≤ 0.90, high %MAP ≥ 45%, or both as high-risk PAD and others as low-risk PAD. We compared the standard deviation (SD) of the first fasting plasma glucose data available each year after January 01, 2007.Results: In 2577 patients, a higher SD of annual fasting glucose was observed in those with an ABI ≤ 0.90 than in patients with an ABI < 0.90 (2.6 ± 2.1 vs 2.2 ± 2.3, P = 0.009), and in patients with %MAP ≥ 45% than in those with %MAP < 45% (2.4 ± 2.1 vs 2.2 ± 2.3, P = 0.034). A high-risk PAD was significantly associated with the SD (P = 0.032) but not with the mean (P = 0.338) of annual fasting glucose. The former was an independent risk factor for high-risk PAD (odds ratio = 1.424; 95% CI = 1.118‒1.814; P = 0.004).Conclusion: Variability but not mean of annual fasting plasma glucose was significantly associated with a high risk of PAD in patients with DM.Keywords: ankle-brachial index, arterial stiffness, lower extremity arterial disease, percentage of the mean arterial pressure, standard deviation ankle-brachial index arterial stiffness lower extremity arterial disease percentage of the mean arterial pressure standard deviation Specialties of internal medicine Lee LY verfasserin aut Lee IT verfasserin aut In Diabetes, Metabolic Syndrome and Obesity Dove Medical Press, 2009 (2021), Seite 4109-4119 (DE-627)60030597X (DE-600)2494854-8 11787007 nnns year:2021 pages:4109-4119 https://doaj.org/article/4700818779674987bb5676c63ac43ff8 kostenfrei https://www.dovepress.com/variability-in-annual-fasting-glucose-and-the-risk-of-peripheral-arter-peer-reviewed-fulltext-article-DMSO kostenfrei https://doaj.org/toc/1178-7007 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2021 4109-4119
allfieldsSound	(DE-627)DOAJ060577207 (DE-599)DOAJ4700818779674987bb5676c63ac43ff8 DE-627 ger DE-627 rakwb eng RC581-951 Chang YS verfasserin aut Variability in Annual Fasting Glucose and the Risk of Peripheral Artery Disease in Patients with Diabetes Mellitus 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Yu-Shan Chang,1,2 Liang-Yi Lee,3 I-Te Lee1,2,4 1Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung City, Taiwan; 2School of Medicine, Chung Shan Medical University, Taichung City, Taiwan; 3Mingdao High School, Taichung City, Taiwan; 4School of Medicine, National Yang Ming Chiao Tung University, Taipei, TaiwanCorrespondence: I-Te LeeDivision of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, 1650, Section 4, Taiwan Boulevard, Taichung City, 40705, TaiwanEmail itleevghtc.gov.twPurpose: High glucose concentrations and swings are associated with endothelial dysfunction. We examined the effects of variability in fasting plasma glucose on peripheral artery disease (PAD) in patients with diabetes mellitus (DM).Patients and Methods: In this screening study for the risk factors of PAD, we retrospectively collected data on the ankle-brachial index (ABI) and the percentage of mean arterial pressure (%MAP) at the ankle between August 01, 2016 and July 31, 2017. We defined low ABI ≤ 0.90, high %MAP ≥ 45%, or both as high-risk PAD and others as low-risk PAD. We compared the standard deviation (SD) of the first fasting plasma glucose data available each year after January 01, 2007.Results: In 2577 patients, a higher SD of annual fasting glucose was observed in those with an ABI ≤ 0.90 than in patients with an ABI < 0.90 (2.6 ± 2.1 vs 2.2 ± 2.3, P = 0.009), and in patients with %MAP ≥ 45% than in those with %MAP < 45% (2.4 ± 2.1 vs 2.2 ± 2.3, P = 0.034). A high-risk PAD was significantly associated with the SD (P = 0.032) but not with the mean (P = 0.338) of annual fasting glucose. The former was an independent risk factor for high-risk PAD (odds ratio = 1.424; 95% CI = 1.118‒1.814; P = 0.004).Conclusion: Variability but not mean of annual fasting plasma glucose was significantly associated with a high risk of PAD in patients with DM.Keywords: ankle-brachial index, arterial stiffness, lower extremity arterial disease, percentage of the mean arterial pressure, standard deviation ankle-brachial index arterial stiffness lower extremity arterial disease percentage of the mean arterial pressure standard deviation Specialties of internal medicine Lee LY verfasserin aut Lee IT verfasserin aut In Diabetes, Metabolic Syndrome and Obesity Dove Medical Press, 2009 (2021), Seite 4109-4119 (DE-627)60030597X (DE-600)2494854-8 11787007 nnns year:2021 pages:4109-4119 https://doaj.org/article/4700818779674987bb5676c63ac43ff8 kostenfrei https://www.dovepress.com/variability-in-annual-fasting-glucose-and-the-risk-of-peripheral-arter-peer-reviewed-fulltext-article-DMSO kostenfrei https://doaj.org/toc/1178-7007 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2021 4109-4119
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We examined the effects of variability in fasting plasma glucose on peripheral artery disease (PAD) in patients with diabetes mellitus (DM).Patients and Methods: In this screening study for the risk factors of PAD, we retrospectively collected data on the ankle-brachial index (ABI) and the percentage of mean arterial pressure (%MAP) at the ankle between August 01, 2016 and July 31, 2017. We defined low ABI ≤ 0.90, high %MAP ≥ 45%, or both as high-risk PAD and others as low-risk PAD. We compared the standard deviation (SD) of the first fasting plasma glucose data available each year after January 01, 2007.Results: In 2577 patients, a higher SD of annual fasting glucose was observed in those with an ABI ≤ 0.90 than in patients with an ABI < 0.90 (2.6 ± 2.1 vs 2.2 ± 2.3, P = 0.009), and in patients with %MAP ≥ 45% than in those with %MAP < 45% (2.4 ± 2.1 vs 2.2 ± 2.3, P = 0.034). 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spellingShingle	Chang YS misc RC581-951 misc ankle-brachial index misc arterial stiffness misc lower extremity arterial disease misc percentage of the mean arterial pressure misc standard deviation misc Specialties of internal medicine Variability in Annual Fasting Glucose and the Risk of Peripheral Artery Disease in Patients with Diabetes Mellitus
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topic_title	RC581-951 Variability in Annual Fasting Glucose and the Risk of Peripheral Artery Disease in Patients with Diabetes Mellitus ankle-brachial index arterial stiffness lower extremity arterial disease percentage of the mean arterial pressure standard deviation
topic	misc RC581-951 misc ankle-brachial index misc arterial stiffness misc lower extremity arterial disease misc percentage of the mean arterial pressure misc standard deviation misc Specialties of internal medicine
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title	Variability in Annual Fasting Glucose and the Risk of Peripheral Artery Disease in Patients with Diabetes Mellitus
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title_full	Variability in Annual Fasting Glucose and the Risk of Peripheral Artery Disease in Patients with Diabetes Mellitus
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title_sort	variability in annual fasting glucose and the risk of peripheral artery disease in patients with diabetes mellitus
callnumber	RC581-951
title_auth	Variability in Annual Fasting Glucose and the Risk of Peripheral Artery Disease in Patients with Diabetes Mellitus
abstract	Yu-Shan Chang,1,2 Liang-Yi Lee,3 I-Te Lee1,2,4 1Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung City, Taiwan; 2School of Medicine, Chung Shan Medical University, Taichung City, Taiwan; 3Mingdao High School, Taichung City, Taiwan; 4School of Medicine, National Yang Ming Chiao Tung University, Taipei, TaiwanCorrespondence: I-Te LeeDivision of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, 1650, Section 4, Taiwan Boulevard, Taichung City, 40705, TaiwanEmail itleevghtc.gov.twPurpose: High glucose concentrations and swings are associated with endothelial dysfunction. We examined the effects of variability in fasting plasma glucose on peripheral artery disease (PAD) in patients with diabetes mellitus (DM).Patients and Methods: In this screening study for the risk factors of PAD, we retrospectively collected data on the ankle-brachial index (ABI) and the percentage of mean arterial pressure (%MAP) at the ankle between August 01, 2016 and July 31, 2017. We defined low ABI ≤ 0.90, high %MAP ≥ 45%, or both as high-risk PAD and others as low-risk PAD. We compared the standard deviation (SD) of the first fasting plasma glucose data available each year after January 01, 2007.Results: In 2577 patients, a higher SD of annual fasting glucose was observed in those with an ABI ≤ 0.90 than in patients with an ABI < 0.90 (2.6 ± 2.1 vs 2.2 ± 2.3, P = 0.009), and in patients with %MAP ≥ 45% than in those with %MAP < 45% (2.4 ± 2.1 vs 2.2 ± 2.3, P = 0.034). A high-risk PAD was significantly associated with the SD (P = 0.032) but not with the mean (P = 0.338) of annual fasting glucose. The former was an independent risk factor for high-risk PAD (odds ratio = 1.424; 95% CI = 1.118‒1.814; P = 0.004).Conclusion: Variability but not mean of annual fasting plasma glucose was significantly associated with a high risk of PAD in patients with DM.Keywords: ankle-brachial index, arterial stiffness, lower extremity arterial disease, percentage of the mean arterial pressure, standard deviation
abstractGer	Yu-Shan Chang,1,2 Liang-Yi Lee,3 I-Te Lee1,2,4 1Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung City, Taiwan; 2School of Medicine, Chung Shan Medical University, Taichung City, Taiwan; 3Mingdao High School, Taichung City, Taiwan; 4School of Medicine, National Yang Ming Chiao Tung University, Taipei, TaiwanCorrespondence: I-Te LeeDivision of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, 1650, Section 4, Taiwan Boulevard, Taichung City, 40705, TaiwanEmail itleevghtc.gov.twPurpose: High glucose concentrations and swings are associated with endothelial dysfunction. We examined the effects of variability in fasting plasma glucose on peripheral artery disease (PAD) in patients with diabetes mellitus (DM).Patients and Methods: In this screening study for the risk factors of PAD, we retrospectively collected data on the ankle-brachial index (ABI) and the percentage of mean arterial pressure (%MAP) at the ankle between August 01, 2016 and July 31, 2017. We defined low ABI ≤ 0.90, high %MAP ≥ 45%, or both as high-risk PAD and others as low-risk PAD. We compared the standard deviation (SD) of the first fasting plasma glucose data available each year after January 01, 2007.Results: In 2577 patients, a higher SD of annual fasting glucose was observed in those with an ABI ≤ 0.90 than in patients with an ABI < 0.90 (2.6 ± 2.1 vs 2.2 ± 2.3, P = 0.009), and in patients with %MAP ≥ 45% than in those with %MAP < 45% (2.4 ± 2.1 vs 2.2 ± 2.3, P = 0.034). A high-risk PAD was significantly associated with the SD (P = 0.032) but not with the mean (P = 0.338) of annual fasting glucose. The former was an independent risk factor for high-risk PAD (odds ratio = 1.424; 95% CI = 1.118‒1.814; P = 0.004).Conclusion: Variability but not mean of annual fasting plasma glucose was significantly associated with a high risk of PAD in patients with DM.Keywords: ankle-brachial index, arterial stiffness, lower extremity arterial disease, percentage of the mean arterial pressure, standard deviation
abstract_unstemmed	Yu-Shan Chang,1,2 Liang-Yi Lee,3 I-Te Lee1,2,4 1Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung City, Taiwan; 2School of Medicine, Chung Shan Medical University, Taichung City, Taiwan; 3Mingdao High School, Taichung City, Taiwan; 4School of Medicine, National Yang Ming Chiao Tung University, Taipei, TaiwanCorrespondence: I-Te LeeDivision of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, 1650, Section 4, Taiwan Boulevard, Taichung City, 40705, TaiwanEmail itleevghtc.gov.twPurpose: High glucose concentrations and swings are associated with endothelial dysfunction. We examined the effects of variability in fasting plasma glucose on peripheral artery disease (PAD) in patients with diabetes mellitus (DM).Patients and Methods: In this screening study for the risk factors of PAD, we retrospectively collected data on the ankle-brachial index (ABI) and the percentage of mean arterial pressure (%MAP) at the ankle between August 01, 2016 and July 31, 2017. We defined low ABI ≤ 0.90, high %MAP ≥ 45%, or both as high-risk PAD and others as low-risk PAD. We compared the standard deviation (SD) of the first fasting plasma glucose data available each year after January 01, 2007.Results: In 2577 patients, a higher SD of annual fasting glucose was observed in those with an ABI ≤ 0.90 than in patients with an ABI < 0.90 (2.6 ± 2.1 vs 2.2 ± 2.3, P = 0.009), and in patients with %MAP ≥ 45% than in those with %MAP < 45% (2.4 ± 2.1 vs 2.2 ± 2.3, P = 0.034). A high-risk PAD was significantly associated with the SD (P = 0.032) but not with the mean (P = 0.338) of annual fasting glucose. The former was an independent risk factor for high-risk PAD (odds ratio = 1.424; 95% CI = 1.118‒1.814; P = 0.004).Conclusion: Variability but not mean of annual fasting plasma glucose was significantly associated with a high risk of PAD in patients with DM.Keywords: ankle-brachial index, arterial stiffness, lower extremity arterial disease, percentage of the mean arterial pressure, standard deviation
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title_short	Variability in Annual Fasting Glucose and the Risk of Peripheral Artery Disease in Patients with Diabetes Mellitus
url	https://doaj.org/article/4700818779674987bb5676c63ac43ff8 https://www.dovepress.com/variability-in-annual-fasting-glucose-and-the-risk-of-peripheral-arter-peer-reviewed-fulltext-article-DMSO https://doaj.org/toc/1178-7007
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