A CRISPR/Cas9 genetically engineered organoid biobank reveals essential host factors for coronaviruses

Rapid identification of host genes essential for virus replication may expedite the generation of therapeutic interventions. Here the authors generate mutant clonal intestinal organoids for 19 host genes previously implicated in coronavirus biology and identify the cell surface protease TMPRSS2 as a...
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Autor*in:	Joep Beumer [verfasserIn] Maarten H. Geurts [verfasserIn] Mart M. Lamers [verfasserIn] Jens Puschhof [verfasserIn] Jingshu Zhang [verfasserIn] Jelte van der Vaart [verfasserIn] Anna Z. Mykytyn [verfasserIn] Tim I. Breugem [verfasserIn] Samra Riesebosch [verfasserIn] Debby Schipper [verfasserIn] Petra B. van den Doel [verfasserIn] Wim de Lau [verfasserIn] Cayetano Pleguezuelos-Manzano [verfasserIn] Georg Busslinger [verfasserIn] Bart L. Haagmans [verfasserIn] Hans Clevers [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Übergeordnetes Werk:	In: Nature Communications - Nature Portfolio, 2016, 12(2021), 1, Seite 12
Übergeordnetes Werk:	volume:12 ; year:2021 ; number:1 ; pages:12

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1038/s41467-021-25729-7

Katalog-ID:	DOAJ060596228

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Indexfelder

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allfields	10.1038/s41467-021-25729-7 doi (DE-627)DOAJ060596228 (DE-599)DOAJ1db487b66712463886d067b96ac47dba DE-627 ger DE-627 rakwb eng Joep Beumer verfasserin aut A CRISPR/Cas9 genetically engineered organoid biobank reveals essential host factors for coronaviruses 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Rapid identification of host genes essential for virus replication may expedite the generation of therapeutic interventions. Here the authors generate mutant clonal intestinal organoids for 19 host genes previously implicated in coronavirus biology and identify the cell surface protease TMPRSS2 as a potential therapeutic target. Science Q Maarten H. Geurts verfasserin aut Mart M. Lamers verfasserin aut Jens Puschhof verfasserin aut Jingshu Zhang verfasserin aut Jelte van der Vaart verfasserin aut Anna Z. Mykytyn verfasserin aut Tim I. Breugem verfasserin aut Samra Riesebosch verfasserin aut Debby Schipper verfasserin aut Petra B. van den Doel verfasserin aut Wim de Lau verfasserin aut Cayetano Pleguezuelos-Manzano verfasserin aut Georg Busslinger verfasserin aut Bart L. Haagmans verfasserin aut Hans Clevers verfasserin aut In Nature Communications Nature Portfolio, 2016 12(2021), 1, Seite 12 (DE-627)626457688 (DE-600)2553671-0 20411723 nnns volume:12 year:2021 number:1 pages:12 https://doi.org/10.1038/s41467-021-25729-7 kostenfrei https://doaj.org/article/1db487b66712463886d067b96ac47dba kostenfrei https://doi.org/10.1038/s41467-021-25729-7 kostenfrei https://doaj.org/toc/2041-1723 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_211 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2110 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2021 1 12
spelling	10.1038/s41467-021-25729-7 doi (DE-627)DOAJ060596228 (DE-599)DOAJ1db487b66712463886d067b96ac47dba DE-627 ger DE-627 rakwb eng Joep Beumer verfasserin aut A CRISPR/Cas9 genetically engineered organoid biobank reveals essential host factors for coronaviruses 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Rapid identification of host genes essential for virus replication may expedite the generation of therapeutic interventions. Here the authors generate mutant clonal intestinal organoids for 19 host genes previously implicated in coronavirus biology and identify the cell surface protease TMPRSS2 as a potential therapeutic target. Science Q Maarten H. Geurts verfasserin aut Mart M. Lamers verfasserin aut Jens Puschhof verfasserin aut Jingshu Zhang verfasserin aut Jelte van der Vaart verfasserin aut Anna Z. Mykytyn verfasserin aut Tim I. Breugem verfasserin aut Samra Riesebosch verfasserin aut Debby Schipper verfasserin aut Petra B. van den Doel verfasserin aut Wim de Lau verfasserin aut Cayetano Pleguezuelos-Manzano verfasserin aut Georg Busslinger verfasserin aut Bart L. Haagmans verfasserin aut Hans Clevers verfasserin aut In Nature Communications Nature Portfolio, 2016 12(2021), 1, Seite 12 (DE-627)626457688 (DE-600)2553671-0 20411723 nnns volume:12 year:2021 number:1 pages:12 https://doi.org/10.1038/s41467-021-25729-7 kostenfrei https://doaj.org/article/1db487b66712463886d067b96ac47dba kostenfrei https://doi.org/10.1038/s41467-021-25729-7 kostenfrei https://doaj.org/toc/2041-1723 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_211 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2110 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2021 1 12
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allfieldsGer	10.1038/s41467-021-25729-7 doi (DE-627)DOAJ060596228 (DE-599)DOAJ1db487b66712463886d067b96ac47dba DE-627 ger DE-627 rakwb eng Joep Beumer verfasserin aut A CRISPR/Cas9 genetically engineered organoid biobank reveals essential host factors for coronaviruses 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Rapid identification of host genes essential for virus replication may expedite the generation of therapeutic interventions. Here the authors generate mutant clonal intestinal organoids for 19 host genes previously implicated in coronavirus biology and identify the cell surface protease TMPRSS2 as a potential therapeutic target. Science Q Maarten H. Geurts verfasserin aut Mart M. Lamers verfasserin aut Jens Puschhof verfasserin aut Jingshu Zhang verfasserin aut Jelte van der Vaart verfasserin aut Anna Z. Mykytyn verfasserin aut Tim I. Breugem verfasserin aut Samra Riesebosch verfasserin aut Debby Schipper verfasserin aut Petra B. van den Doel verfasserin aut Wim de Lau verfasserin aut Cayetano Pleguezuelos-Manzano verfasserin aut Georg Busslinger verfasserin aut Bart L. Haagmans verfasserin aut Hans Clevers verfasserin aut In Nature Communications Nature Portfolio, 2016 12(2021), 1, Seite 12 (DE-627)626457688 (DE-600)2553671-0 20411723 nnns volume:12 year:2021 number:1 pages:12 https://doi.org/10.1038/s41467-021-25729-7 kostenfrei https://doaj.org/article/1db487b66712463886d067b96ac47dba kostenfrei https://doi.org/10.1038/s41467-021-25729-7 kostenfrei https://doaj.org/toc/2041-1723 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_211 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2110 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2021 1 12
allfieldsSound	10.1038/s41467-021-25729-7 doi (DE-627)DOAJ060596228 (DE-599)DOAJ1db487b66712463886d067b96ac47dba DE-627 ger DE-627 rakwb eng Joep Beumer verfasserin aut A CRISPR/Cas9 genetically engineered organoid biobank reveals essential host factors for coronaviruses 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Rapid identification of host genes essential for virus replication may expedite the generation of therapeutic interventions. Here the authors generate mutant clonal intestinal organoids for 19 host genes previously implicated in coronavirus biology and identify the cell surface protease TMPRSS2 as a potential therapeutic target. Science Q Maarten H. Geurts verfasserin aut Mart M. Lamers verfasserin aut Jens Puschhof verfasserin aut Jingshu Zhang verfasserin aut Jelte van der Vaart verfasserin aut Anna Z. Mykytyn verfasserin aut Tim I. Breugem verfasserin aut Samra Riesebosch verfasserin aut Debby Schipper verfasserin aut Petra B. van den Doel verfasserin aut Wim de Lau verfasserin aut Cayetano Pleguezuelos-Manzano verfasserin aut Georg Busslinger verfasserin aut Bart L. Haagmans verfasserin aut Hans Clevers verfasserin aut In Nature Communications Nature Portfolio, 2016 12(2021), 1, Seite 12 (DE-627)626457688 (DE-600)2553671-0 20411723 nnns volume:12 year:2021 number:1 pages:12 https://doi.org/10.1038/s41467-021-25729-7 kostenfrei https://doaj.org/article/1db487b66712463886d067b96ac47dba kostenfrei https://doi.org/10.1038/s41467-021-25729-7 kostenfrei https://doaj.org/toc/2041-1723 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_211 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2110 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2021 1 12
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author	Joep Beumer
spellingShingle	Joep Beumer misc Science misc Q A CRISPR/Cas9 genetically engineered organoid biobank reveals essential host factors for coronaviruses
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topic_title	A CRISPR/Cas9 genetically engineered organoid biobank reveals essential host factors for coronaviruses
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title	A CRISPR/Cas9 genetically engineered organoid biobank reveals essential host factors for coronaviruses
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title_full	A CRISPR/Cas9 genetically engineered organoid biobank reveals essential host factors for coronaviruses
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author_browse	Joep Beumer Maarten H. Geurts Mart M. Lamers Jens Puschhof Jingshu Zhang Jelte van der Vaart Anna Z. Mykytyn Tim I. Breugem Samra Riesebosch Debby Schipper Petra B. van den Doel Wim de Lau Cayetano Pleguezuelos-Manzano Georg Busslinger Bart L. Haagmans Hans Clevers
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title_sort	crispr/cas9 genetically engineered organoid biobank reveals essential host factors for coronaviruses
title_auth	A CRISPR/Cas9 genetically engineered organoid biobank reveals essential host factors for coronaviruses
abstract	Rapid identification of host genes essential for virus replication may expedite the generation of therapeutic interventions. Here the authors generate mutant clonal intestinal organoids for 19 host genes previously implicated in coronavirus biology and identify the cell surface protease TMPRSS2 as a potential therapeutic target.
abstractGer	Rapid identification of host genes essential for virus replication may expedite the generation of therapeutic interventions. Here the authors generate mutant clonal intestinal organoids for 19 host genes previously implicated in coronavirus biology and identify the cell surface protease TMPRSS2 as a potential therapeutic target.
abstract_unstemmed	Rapid identification of host genes essential for virus replication may expedite the generation of therapeutic interventions. Here the authors generate mutant clonal intestinal organoids for 19 host genes previously implicated in coronavirus biology and identify the cell surface protease TMPRSS2 as a potential therapeutic target.
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title_short	A CRISPR/Cas9 genetically engineered organoid biobank reveals essential host factors for coronaviruses
url	https://doi.org/10.1038/s41467-021-25729-7 https://doaj.org/article/1db487b66712463886d067b96ac47dba https://doaj.org/toc/2041-1723
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author2	Maarten H. Geurts Mart M. Lamers Jens Puschhof Jingshu Zhang Jelte van der Vaart Anna Z. Mykytyn Tim I. Breugem Samra Riesebosch Debby Schipper Petra B. van den Doel Wim de Lau Cayetano Pleguezuelos-Manzano Georg Busslinger Bart L. Haagmans Hans Clevers
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up_date	2024-07-03T15:55:33.624Z
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