Diverse polyketides from the marine endophytic Alternaria sp. LV52: Structure determination and cytotoxic activities

We report the isolation and characterization of five polyketides [alternariol (1), alternariol-9-methyl ether (2), altertoxin I (3), altertoxin II (4) and tenuazonic acid (5)] from the marine endophytic Alternaria sp. LV52 derived from Cystoseira tamariscifolia, collected from the Red Sea at Nabq-Ba...
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Autor*in:	Manar M. Mahmoud [verfasserIn] Ahmed S. Abdel-Razek [verfasserIn] Hesham S.M. Soliman [verfasserIn] Larissa V. Ponomareva [verfasserIn] Jon S. Thorson [verfasserIn] Khaled A. Shaaban [verfasserIn] Mohamed Shaaban [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	Polyketides Marine endophyte Alternaria sp. Taxonomy Cytotoxicity

Übergeordnetes Werk:	In: Biotechnology Reports - Elsevier, 2015, 33(2022), Seite e00628-
Übergeordnetes Werk:	volume:33 ; year:2022 ; pages:e00628-

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1016/j.btre.2021.e00628

Katalog-ID:	DOAJ060626844

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245	1	0	\|a Diverse polyketides from the marine endophytic Alternaria sp. LV52: Structure determination and cytotoxic activities
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520			\|a We report the isolation and characterization of five polyketides [alternariol (1), alternariol-9-methyl ether (2), altertoxin I (3), altertoxin II (4) and tenuazonic acid (5)] from the marine endophytic Alternaria sp. LV52 derived from Cystoseira tamariscifolia, collected from the Red Sea at Nabq-Bay, Egypt. The chemical structures of compounds 1–5 were identified by extensive 1D, 2D NMR, and HR mass measurements. Isolation and phenotypic and genotypic characterization of the producing fungus is reported. The antimicrobial activity of the produced extract and derived compounds was examined against a panel of test organisms. In addition, an in vitro cytotoxic activity of 1–5 was performed against diverse cancer cell lines: HEPG2, HELA, A549 and PC3, revealing that compounds 2 and 4 are potentially cytotoxic against A549 and PC3 with EC50 of 0.73 µg/ml (2.69 µM) and 0.17 µg/ml (0.64 µM) for 2, and 0.40 µg/ml (1.15 µM) and 0.12 µg/ml (0.33 µM) for 4, respectively.
650		4	\|a Polyketides
650		4	\|a Marine endophyte
650		4	\|a Alternaria sp.
650		4	\|a Taxonomy
650		4	\|a Cytotoxicity
653		0	\|a Biotechnology
700	0		\|a Ahmed S. Abdel-Razek \|e verfasserin \|4 aut
700	0		\|a Hesham S.M. Soliman \|e verfasserin \|4 aut
700	0		\|a Larissa V. Ponomareva \|e verfasserin \|4 aut
700	0		\|a Jon S. Thorson \|e verfasserin \|4 aut
700	0		\|a Khaled A. Shaaban \|e verfasserin \|4 aut
700	0		\|a Mohamed Shaaban \|e verfasserin \|4 aut
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publishDate	2022
allfields	10.1016/j.btre.2021.e00628 doi (DE-627)DOAJ060626844 (DE-599)DOAJ16b2073081d048f1a1fdf5d636055949 DE-627 ger DE-627 rakwb eng TP248.13-248.65 Manar M. Mahmoud verfasserin aut Diverse polyketides from the marine endophytic Alternaria sp. LV52: Structure determination and cytotoxic activities 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier We report the isolation and characterization of five polyketides [alternariol (1), alternariol-9-methyl ether (2), altertoxin I (3), altertoxin II (4) and tenuazonic acid (5)] from the marine endophytic Alternaria sp. LV52 derived from Cystoseira tamariscifolia, collected from the Red Sea at Nabq-Bay, Egypt. The chemical structures of compounds 1–5 were identified by extensive 1D, 2D NMR, and HR mass measurements. Isolation and phenotypic and genotypic characterization of the producing fungus is reported. The antimicrobial activity of the produced extract and derived compounds was examined against a panel of test organisms. In addition, an in vitro cytotoxic activity of 1–5 was performed against diverse cancer cell lines: HEPG2, HELA, A549 and PC3, revealing that compounds 2 and 4 are potentially cytotoxic against A549 and PC3 with EC50 of 0.73 µg/ml (2.69 µM) and 0.17 µg/ml (0.64 µM) for 2, and 0.40 µg/ml (1.15 µM) and 0.12 µg/ml (0.33 µM) for 4, respectively. Polyketides Marine endophyte Alternaria sp. Taxonomy Cytotoxicity Biotechnology Ahmed S. Abdel-Razek verfasserin aut Hesham S.M. Soliman verfasserin aut Larissa V. Ponomareva verfasserin aut Jon S. Thorson verfasserin aut Khaled A. Shaaban verfasserin aut Mohamed Shaaban verfasserin aut In Biotechnology Reports Elsevier, 2015 33(2022), Seite e00628- (DE-627)810530678 (DE-600)2801018-8 2215017X nnns volume:33 year:2022 pages:e00628- https://doi.org/10.1016/j.btre.2021.e00628 kostenfrei https://doaj.org/article/16b2073081d048f1a1fdf5d636055949 kostenfrei http://www.sciencedirect.com/science/article/pii/S2215017X21000448 kostenfrei https://doaj.org/toc/2215-017X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 33 2022 e00628-
spelling	10.1016/j.btre.2021.e00628 doi (DE-627)DOAJ060626844 (DE-599)DOAJ16b2073081d048f1a1fdf5d636055949 DE-627 ger DE-627 rakwb eng TP248.13-248.65 Manar M. Mahmoud verfasserin aut Diverse polyketides from the marine endophytic Alternaria sp. LV52: Structure determination and cytotoxic activities 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier We report the isolation and characterization of five polyketides [alternariol (1), alternariol-9-methyl ether (2), altertoxin I (3), altertoxin II (4) and tenuazonic acid (5)] from the marine endophytic Alternaria sp. LV52 derived from Cystoseira tamariscifolia, collected from the Red Sea at Nabq-Bay, Egypt. The chemical structures of compounds 1–5 were identified by extensive 1D, 2D NMR, and HR mass measurements. Isolation and phenotypic and genotypic characterization of the producing fungus is reported. The antimicrobial activity of the produced extract and derived compounds was examined against a panel of test organisms. In addition, an in vitro cytotoxic activity of 1–5 was performed against diverse cancer cell lines: HEPG2, HELA, A549 and PC3, revealing that compounds 2 and 4 are potentially cytotoxic against A549 and PC3 with EC50 of 0.73 µg/ml (2.69 µM) and 0.17 µg/ml (0.64 µM) for 2, and 0.40 µg/ml (1.15 µM) and 0.12 µg/ml (0.33 µM) for 4, respectively. Polyketides Marine endophyte Alternaria sp. Taxonomy Cytotoxicity Biotechnology Ahmed S. Abdel-Razek verfasserin aut Hesham S.M. Soliman verfasserin aut Larissa V. Ponomareva verfasserin aut Jon S. Thorson verfasserin aut Khaled A. Shaaban verfasserin aut Mohamed Shaaban verfasserin aut In Biotechnology Reports Elsevier, 2015 33(2022), Seite e00628- (DE-627)810530678 (DE-600)2801018-8 2215017X nnns volume:33 year:2022 pages:e00628- https://doi.org/10.1016/j.btre.2021.e00628 kostenfrei https://doaj.org/article/16b2073081d048f1a1fdf5d636055949 kostenfrei http://www.sciencedirect.com/science/article/pii/S2215017X21000448 kostenfrei https://doaj.org/toc/2215-017X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 33 2022 e00628-
allfields_unstemmed	10.1016/j.btre.2021.e00628 doi (DE-627)DOAJ060626844 (DE-599)DOAJ16b2073081d048f1a1fdf5d636055949 DE-627 ger DE-627 rakwb eng TP248.13-248.65 Manar M. Mahmoud verfasserin aut Diverse polyketides from the marine endophytic Alternaria sp. LV52: Structure determination and cytotoxic activities 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier We report the isolation and characterization of five polyketides [alternariol (1), alternariol-9-methyl ether (2), altertoxin I (3), altertoxin II (4) and tenuazonic acid (5)] from the marine endophytic Alternaria sp. LV52 derived from Cystoseira tamariscifolia, collected from the Red Sea at Nabq-Bay, Egypt. The chemical structures of compounds 1–5 were identified by extensive 1D, 2D NMR, and HR mass measurements. Isolation and phenotypic and genotypic characterization of the producing fungus is reported. The antimicrobial activity of the produced extract and derived compounds was examined against a panel of test organisms. In addition, an in vitro cytotoxic activity of 1–5 was performed against diverse cancer cell lines: HEPG2, HELA, A549 and PC3, revealing that compounds 2 and 4 are potentially cytotoxic against A549 and PC3 with EC50 of 0.73 µg/ml (2.69 µM) and 0.17 µg/ml (0.64 µM) for 2, and 0.40 µg/ml (1.15 µM) and 0.12 µg/ml (0.33 µM) for 4, respectively. Polyketides Marine endophyte Alternaria sp. Taxonomy Cytotoxicity Biotechnology Ahmed S. Abdel-Razek verfasserin aut Hesham S.M. Soliman verfasserin aut Larissa V. Ponomareva verfasserin aut Jon S. Thorson verfasserin aut Khaled A. Shaaban verfasserin aut Mohamed Shaaban verfasserin aut In Biotechnology Reports Elsevier, 2015 33(2022), Seite e00628- (DE-627)810530678 (DE-600)2801018-8 2215017X nnns volume:33 year:2022 pages:e00628- https://doi.org/10.1016/j.btre.2021.e00628 kostenfrei https://doaj.org/article/16b2073081d048f1a1fdf5d636055949 kostenfrei http://www.sciencedirect.com/science/article/pii/S2215017X21000448 kostenfrei https://doaj.org/toc/2215-017X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 33 2022 e00628-
allfieldsGer	10.1016/j.btre.2021.e00628 doi (DE-627)DOAJ060626844 (DE-599)DOAJ16b2073081d048f1a1fdf5d636055949 DE-627 ger DE-627 rakwb eng TP248.13-248.65 Manar M. Mahmoud verfasserin aut Diverse polyketides from the marine endophytic Alternaria sp. LV52: Structure determination and cytotoxic activities 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier We report the isolation and characterization of five polyketides [alternariol (1), alternariol-9-methyl ether (2), altertoxin I (3), altertoxin II (4) and tenuazonic acid (5)] from the marine endophytic Alternaria sp. LV52 derived from Cystoseira tamariscifolia, collected from the Red Sea at Nabq-Bay, Egypt. The chemical structures of compounds 1–5 were identified by extensive 1D, 2D NMR, and HR mass measurements. Isolation and phenotypic and genotypic characterization of the producing fungus is reported. The antimicrobial activity of the produced extract and derived compounds was examined against a panel of test organisms. In addition, an in vitro cytotoxic activity of 1–5 was performed against diverse cancer cell lines: HEPG2, HELA, A549 and PC3, revealing that compounds 2 and 4 are potentially cytotoxic against A549 and PC3 with EC50 of 0.73 µg/ml (2.69 µM) and 0.17 µg/ml (0.64 µM) for 2, and 0.40 µg/ml (1.15 µM) and 0.12 µg/ml (0.33 µM) for 4, respectively. Polyketides Marine endophyte Alternaria sp. Taxonomy Cytotoxicity Biotechnology Ahmed S. Abdel-Razek verfasserin aut Hesham S.M. Soliman verfasserin aut Larissa V. Ponomareva verfasserin aut Jon S. Thorson verfasserin aut Khaled A. Shaaban verfasserin aut Mohamed Shaaban verfasserin aut In Biotechnology Reports Elsevier, 2015 33(2022), Seite e00628- (DE-627)810530678 (DE-600)2801018-8 2215017X nnns volume:33 year:2022 pages:e00628- https://doi.org/10.1016/j.btre.2021.e00628 kostenfrei https://doaj.org/article/16b2073081d048f1a1fdf5d636055949 kostenfrei http://www.sciencedirect.com/science/article/pii/S2215017X21000448 kostenfrei https://doaj.org/toc/2215-017X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 33 2022 e00628-
allfieldsSound	10.1016/j.btre.2021.e00628 doi (DE-627)DOAJ060626844 (DE-599)DOAJ16b2073081d048f1a1fdf5d636055949 DE-627 ger DE-627 rakwb eng TP248.13-248.65 Manar M. Mahmoud verfasserin aut Diverse polyketides from the marine endophytic Alternaria sp. LV52: Structure determination and cytotoxic activities 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier We report the isolation and characterization of five polyketides [alternariol (1), alternariol-9-methyl ether (2), altertoxin I (3), altertoxin II (4) and tenuazonic acid (5)] from the marine endophytic Alternaria sp. LV52 derived from Cystoseira tamariscifolia, collected from the Red Sea at Nabq-Bay, Egypt. The chemical structures of compounds 1–5 were identified by extensive 1D, 2D NMR, and HR mass measurements. Isolation and phenotypic and genotypic characterization of the producing fungus is reported. The antimicrobial activity of the produced extract and derived compounds was examined against a panel of test organisms. In addition, an in vitro cytotoxic activity of 1–5 was performed against diverse cancer cell lines: HEPG2, HELA, A549 and PC3, revealing that compounds 2 and 4 are potentially cytotoxic against A549 and PC3 with EC50 of 0.73 µg/ml (2.69 µM) and 0.17 µg/ml (0.64 µM) for 2, and 0.40 µg/ml (1.15 µM) and 0.12 µg/ml (0.33 µM) for 4, respectively. Polyketides Marine endophyte Alternaria sp. Taxonomy Cytotoxicity Biotechnology Ahmed S. Abdel-Razek verfasserin aut Hesham S.M. Soliman verfasserin aut Larissa V. Ponomareva verfasserin aut Jon S. Thorson verfasserin aut Khaled A. Shaaban verfasserin aut Mohamed Shaaban verfasserin aut In Biotechnology Reports Elsevier, 2015 33(2022), Seite e00628- (DE-627)810530678 (DE-600)2801018-8 2215017X nnns volume:33 year:2022 pages:e00628- https://doi.org/10.1016/j.btre.2021.e00628 kostenfrei https://doaj.org/article/16b2073081d048f1a1fdf5d636055949 kostenfrei http://www.sciencedirect.com/science/article/pii/S2215017X21000448 kostenfrei https://doaj.org/toc/2215-017X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 33 2022 e00628-
language	English
source	In Biotechnology Reports 33(2022), Seite e00628- volume:33 year:2022 pages:e00628-
sourceStr	In Biotechnology Reports 33(2022), Seite e00628- volume:33 year:2022 pages:e00628-
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Polyketides Marine endophyte Alternaria sp. Taxonomy Cytotoxicity Biotechnology
isfreeaccess_bool	true
container_title	Biotechnology Reports
authorswithroles_txt_mv	Manar M. Mahmoud @@aut@@ Ahmed S. Abdel-Razek @@aut@@ Hesham S.M. Soliman @@aut@@ Larissa V. Ponomareva @@aut@@ Jon S. Thorson @@aut@@ Khaled A. Shaaban @@aut@@ Mohamed Shaaban @@aut@@
publishDateDaySort_date	2022-01-01T00:00:00Z
hierarchy_top_id	810530678
id	DOAJ060626844
language_de	englisch
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callnumber-first	T - Technology
author	Manar M. Mahmoud
spellingShingle	Manar M. Mahmoud misc TP248.13-248.65 misc Polyketides misc Marine endophyte misc Alternaria sp. misc Taxonomy misc Cytotoxicity misc Biotechnology Diverse polyketides from the marine endophytic Alternaria sp. LV52: Structure determination and cytotoxic activities
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topic_title	TP248.13-248.65 Diverse polyketides from the marine endophytic Alternaria sp. LV52: Structure determination and cytotoxic activities Polyketides Marine endophyte Alternaria sp Taxonomy Cytotoxicity
topic	misc TP248.13-248.65 misc Polyketides misc Marine endophyte misc Alternaria sp. misc Taxonomy misc Cytotoxicity misc Biotechnology
topic_unstemmed	misc TP248.13-248.65 misc Polyketides misc Marine endophyte misc Alternaria sp. misc Taxonomy misc Cytotoxicity misc Biotechnology
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title	Diverse polyketides from the marine endophytic Alternaria sp. LV52: Structure determination and cytotoxic activities
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title_full	Diverse polyketides from the marine endophytic Alternaria sp. LV52: Structure determination and cytotoxic activities
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author_browse	Manar M. Mahmoud Ahmed S. Abdel-Razek Hesham S.M. Soliman Larissa V. Ponomareva Jon S. Thorson Khaled A. Shaaban Mohamed Shaaban
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title_sort	diverse polyketides from the marine endophytic alternaria sp. lv52: structure determination and cytotoxic activities
callnumber	TP248.13-248.65
title_auth	Diverse polyketides from the marine endophytic Alternaria sp. LV52: Structure determination and cytotoxic activities
abstract	We report the isolation and characterization of five polyketides [alternariol (1), alternariol-9-methyl ether (2), altertoxin I (3), altertoxin II (4) and tenuazonic acid (5)] from the marine endophytic Alternaria sp. LV52 derived from Cystoseira tamariscifolia, collected from the Red Sea at Nabq-Bay, Egypt. The chemical structures of compounds 1–5 were identified by extensive 1D, 2D NMR, and HR mass measurements. Isolation and phenotypic and genotypic characterization of the producing fungus is reported. The antimicrobial activity of the produced extract and derived compounds was examined against a panel of test organisms. In addition, an in vitro cytotoxic activity of 1–5 was performed against diverse cancer cell lines: HEPG2, HELA, A549 and PC3, revealing that compounds 2 and 4 are potentially cytotoxic against A549 and PC3 with EC50 of 0.73 µg/ml (2.69 µM) and 0.17 µg/ml (0.64 µM) for 2, and 0.40 µg/ml (1.15 µM) and 0.12 µg/ml (0.33 µM) for 4, respectively.
abstractGer	We report the isolation and characterization of five polyketides [alternariol (1), alternariol-9-methyl ether (2), altertoxin I (3), altertoxin II (4) and tenuazonic acid (5)] from the marine endophytic Alternaria sp. LV52 derived from Cystoseira tamariscifolia, collected from the Red Sea at Nabq-Bay, Egypt. The chemical structures of compounds 1–5 were identified by extensive 1D, 2D NMR, and HR mass measurements. Isolation and phenotypic and genotypic characterization of the producing fungus is reported. The antimicrobial activity of the produced extract and derived compounds was examined against a panel of test organisms. In addition, an in vitro cytotoxic activity of 1–5 was performed against diverse cancer cell lines: HEPG2, HELA, A549 and PC3, revealing that compounds 2 and 4 are potentially cytotoxic against A549 and PC3 with EC50 of 0.73 µg/ml (2.69 µM) and 0.17 µg/ml (0.64 µM) for 2, and 0.40 µg/ml (1.15 µM) and 0.12 µg/ml (0.33 µM) for 4, respectively.
abstract_unstemmed	We report the isolation and characterization of five polyketides [alternariol (1), alternariol-9-methyl ether (2), altertoxin I (3), altertoxin II (4) and tenuazonic acid (5)] from the marine endophytic Alternaria sp. LV52 derived from Cystoseira tamariscifolia, collected from the Red Sea at Nabq-Bay, Egypt. The chemical structures of compounds 1–5 were identified by extensive 1D, 2D NMR, and HR mass measurements. Isolation and phenotypic and genotypic characterization of the producing fungus is reported. The antimicrobial activity of the produced extract and derived compounds was examined against a panel of test organisms. In addition, an in vitro cytotoxic activity of 1–5 was performed against diverse cancer cell lines: HEPG2, HELA, A549 and PC3, revealing that compounds 2 and 4 are potentially cytotoxic against A549 and PC3 with EC50 of 0.73 µg/ml (2.69 µM) and 0.17 µg/ml (0.64 µM) for 2, and 0.40 µg/ml (1.15 µM) and 0.12 µg/ml (0.33 µM) for 4, respectively.
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title_short	Diverse polyketides from the marine endophytic Alternaria sp. LV52: Structure determination and cytotoxic activities
url	https://doi.org/10.1016/j.btre.2021.e00628 https://doaj.org/article/16b2073081d048f1a1fdf5d636055949 http://www.sciencedirect.com/science/article/pii/S2215017X21000448 https://doaj.org/toc/2215-017X
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author2	Ahmed S. Abdel-Razek Hesham S.M. Soliman Larissa V. Ponomareva Jon S. Thorson Khaled A. Shaaban Mohamed Shaaban
author2Str	Ahmed S. Abdel-Razek Hesham S.M. Soliman Larissa V. Ponomareva Jon S. Thorson Khaled A. Shaaban Mohamed Shaaban
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LV52 derived from Cystoseira tamariscifolia, collected from the Red Sea at Nabq-Bay, Egypt. The chemical structures of compounds 1–5 were identified by extensive 1D, 2D NMR, and HR mass measurements. Isolation and phenotypic and genotypic characterization of the producing fungus is reported. The antimicrobial activity of the produced extract and derived compounds was examined against a panel of test organisms. 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Abdel-Razek</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Hesham S.M. Soliman</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Larissa V. Ponomareva</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Jon S. Thorson</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Khaled A. 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Diverse polyketides from the marine endophytic Alternaria sp. LV52: Structure determination and cytotoxic activities

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