Grafting of 18β-Glycyrrhetinic Acid and Sialic Acid onto Chitosan to Produce a New Amphipathic Chitosan Derivative: Synthesis, Characterization, and Cytotoxicity

Chitosan is the only cationic polysaccharide found in nature. It has broad application prospects in biomaterials, but its application is limited due to its poor solubility in water. A novel chitosan derivative was synthesized by amidation of chitosan with 18β-glycyrrhetinic acid and sialic acid. The...
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Autor*in:	Wei-Yan Quan [verfasserIn] Song-Zhi Kong [verfasserIn] Si-Dong Li [verfasserIn] Hua-Zhong Liu [verfasserIn] Qian-Qian Ouyang [verfasserIn] Yong-Mei Huang [verfasserIn] Hui Luo [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	chitosan chitosan derivatives 18β-glycyrrhetinic acid sialic acid cytotoxicity

Übergeordnetes Werk:	In: Molecules - MDPI AG, 2003, 26(2021), 2, p 452
Übergeordnetes Werk:	volume:26 ; year:2021 ; number:2, p 452

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/molecules26020452

Katalog-ID:	DOAJ060852631

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520			\|a Chitosan is the only cationic polysaccharide found in nature. It has broad application prospects in biomaterials, but its application is limited due to its poor solubility in water. A novel chitosan derivative was synthesized by amidation of chitosan with 18β-glycyrrhetinic acid and sialic acid. The chitosan derivatives were characterized by Fourier transform infrared spectroscopy, thermogravimetric analysis, and measurement of the zeta potential. We also investigated the solubility, cytotoxicity, and blood compatibility of chitosan derivatives. 18β-glycyrrhetinic acid and sialic acid could be grafted onto chitosan molecular chains. The thermal stability of the synthesized chitosan derivatives was decreased and the surface was positively charged in water and phosphate-buffered saline. After chitosan had been modified by 18 β-glycyrrhetinic acid and sialic acid, the solubility of chitosan was improved greatly in water and phosphate-buffered saline, and percent hemolysis was <5%. Novel amphiphilic chitosan derivatives could be suitable polymers for biomedical purposes.
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allfieldsGer	10.3390/molecules26020452 doi (DE-627)DOAJ060852631 (DE-599)DOAJf08094342ed64daf820efc72123535fe DE-627 ger DE-627 rakwb eng QD241-441 Wei-Yan Quan verfasserin aut Grafting of 18β-Glycyrrhetinic Acid and Sialic Acid onto Chitosan to Produce a New Amphipathic Chitosan Derivative: Synthesis, Characterization, and Cytotoxicity 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Chitosan is the only cationic polysaccharide found in nature. It has broad application prospects in biomaterials, but its application is limited due to its poor solubility in water. A novel chitosan derivative was synthesized by amidation of chitosan with 18β-glycyrrhetinic acid and sialic acid. The chitosan derivatives were characterized by Fourier transform infrared spectroscopy, thermogravimetric analysis, and measurement of the zeta potential. We also investigated the solubility, cytotoxicity, and blood compatibility of chitosan derivatives. 18β-glycyrrhetinic acid and sialic acid could be grafted onto chitosan molecular chains. The thermal stability of the synthesized chitosan derivatives was decreased and the surface was positively charged in water and phosphate-buffered saline. After chitosan had been modified by 18 β-glycyrrhetinic acid and sialic acid, the solubility of chitosan was improved greatly in water and phosphate-buffered saline, and percent hemolysis was <5%. Novel amphiphilic chitosan derivatives could be suitable polymers for biomedical purposes. chitosan chitosan derivatives 18β-glycyrrhetinic acid sialic acid cytotoxicity Organic chemistry Song-Zhi Kong verfasserin aut Si-Dong Li verfasserin aut Hua-Zhong Liu verfasserin aut Qian-Qian Ouyang verfasserin aut Yong-Mei Huang verfasserin aut Hui Luo verfasserin aut In Molecules MDPI AG, 2003 26(2021), 2, p 452 (DE-627)311313132 (DE-600)2008644-1 14203049 nnns volume:26 year:2021 number:2, p 452 https://doi.org/10.3390/molecules26020452 kostenfrei https://doaj.org/article/f08094342ed64daf820efc72123535fe kostenfrei https://www.mdpi.com/1420-3049/26/2/452 kostenfrei https://doaj.org/toc/1420-3049 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 26 2021 2, p 452
allfieldsSound	10.3390/molecules26020452 doi (DE-627)DOAJ060852631 (DE-599)DOAJf08094342ed64daf820efc72123535fe DE-627 ger DE-627 rakwb eng QD241-441 Wei-Yan Quan verfasserin aut Grafting of 18β-Glycyrrhetinic Acid and Sialic Acid onto Chitosan to Produce a New Amphipathic Chitosan Derivative: Synthesis, Characterization, and Cytotoxicity 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Chitosan is the only cationic polysaccharide found in nature. It has broad application prospects in biomaterials, but its application is limited due to its poor solubility in water. A novel chitosan derivative was synthesized by amidation of chitosan with 18β-glycyrrhetinic acid and sialic acid. The chitosan derivatives were characterized by Fourier transform infrared spectroscopy, thermogravimetric analysis, and measurement of the zeta potential. We also investigated the solubility, cytotoxicity, and blood compatibility of chitosan derivatives. 18β-glycyrrhetinic acid and sialic acid could be grafted onto chitosan molecular chains. The thermal stability of the synthesized chitosan derivatives was decreased and the surface was positively charged in water and phosphate-buffered saline. After chitosan had been modified by 18 β-glycyrrhetinic acid and sialic acid, the solubility of chitosan was improved greatly in water and phosphate-buffered saline, and percent hemolysis was <5%. Novel amphiphilic chitosan derivatives could be suitable polymers for biomedical purposes. chitosan chitosan derivatives 18β-glycyrrhetinic acid sialic acid cytotoxicity Organic chemistry Song-Zhi Kong verfasserin aut Si-Dong Li verfasserin aut Hua-Zhong Liu verfasserin aut Qian-Qian Ouyang verfasserin aut Yong-Mei Huang verfasserin aut Hui Luo verfasserin aut In Molecules MDPI AG, 2003 26(2021), 2, p 452 (DE-627)311313132 (DE-600)2008644-1 14203049 nnns volume:26 year:2021 number:2, p 452 https://doi.org/10.3390/molecules26020452 kostenfrei https://doaj.org/article/f08094342ed64daf820efc72123535fe kostenfrei https://www.mdpi.com/1420-3049/26/2/452 kostenfrei https://doaj.org/toc/1420-3049 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 26 2021 2, p 452
language	English
source	In Molecules 26(2021), 2, p 452 volume:26 year:2021 number:2, p 452
sourceStr	In Molecules 26(2021), 2, p 452 volume:26 year:2021 number:2, p 452
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topic_facet	chitosan chitosan derivatives 18β-glycyrrhetinic acid sialic acid cytotoxicity Organic chemistry
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container_title	Molecules
authorswithroles_txt_mv	Wei-Yan Quan @@aut@@ Song-Zhi Kong @@aut@@ Si-Dong Li @@aut@@ Hua-Zhong Liu @@aut@@ Qian-Qian Ouyang @@aut@@ Yong-Mei Huang @@aut@@ Hui Luo @@aut@@
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callnumber-first	Q - Science
author	Wei-Yan Quan
spellingShingle	Wei-Yan Quan misc QD241-441 misc chitosan misc chitosan derivatives misc 18β-glycyrrhetinic acid misc sialic acid misc cytotoxicity misc Organic chemistry Grafting of 18β-Glycyrrhetinic Acid and Sialic Acid onto Chitosan to Produce a New Amphipathic Chitosan Derivative: Synthesis, Characterization, and Cytotoxicity
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topic_title	QD241-441 Grafting of 18β-Glycyrrhetinic Acid and Sialic Acid onto Chitosan to Produce a New Amphipathic Chitosan Derivative: Synthesis, Characterization, and Cytotoxicity chitosan chitosan derivatives 18β-glycyrrhetinic acid sialic acid cytotoxicity
topic	misc QD241-441 misc chitosan misc chitosan derivatives misc 18β-glycyrrhetinic acid misc sialic acid misc cytotoxicity misc Organic chemistry
topic_unstemmed	misc QD241-441 misc chitosan misc chitosan derivatives misc 18β-glycyrrhetinic acid misc sialic acid misc cytotoxicity misc Organic chemistry
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title	Grafting of 18β-Glycyrrhetinic Acid and Sialic Acid onto Chitosan to Produce a New Amphipathic Chitosan Derivative: Synthesis, Characterization, and Cytotoxicity
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title_full	Grafting of 18β-Glycyrrhetinic Acid and Sialic Acid onto Chitosan to Produce a New Amphipathic Chitosan Derivative: Synthesis, Characterization, and Cytotoxicity
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title_sort	grafting of 18β-glycyrrhetinic acid and sialic acid onto chitosan to produce a new amphipathic chitosan derivative: synthesis, characterization, and cytotoxicity
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title_auth	Grafting of 18β-Glycyrrhetinic Acid and Sialic Acid onto Chitosan to Produce a New Amphipathic Chitosan Derivative: Synthesis, Characterization, and Cytotoxicity
abstract	Chitosan is the only cationic polysaccharide found in nature. It has broad application prospects in biomaterials, but its application is limited due to its poor solubility in water. A novel chitosan derivative was synthesized by amidation of chitosan with 18β-glycyrrhetinic acid and sialic acid. The chitosan derivatives were characterized by Fourier transform infrared spectroscopy, thermogravimetric analysis, and measurement of the zeta potential. We also investigated the solubility, cytotoxicity, and blood compatibility of chitosan derivatives. 18β-glycyrrhetinic acid and sialic acid could be grafted onto chitosan molecular chains. The thermal stability of the synthesized chitosan derivatives was decreased and the surface was positively charged in water and phosphate-buffered saline. After chitosan had been modified by 18 β-glycyrrhetinic acid and sialic acid, the solubility of chitosan was improved greatly in water and phosphate-buffered saline, and percent hemolysis was <5%. Novel amphiphilic chitosan derivatives could be suitable polymers for biomedical purposes.
abstractGer	Chitosan is the only cationic polysaccharide found in nature. It has broad application prospects in biomaterials, but its application is limited due to its poor solubility in water. A novel chitosan derivative was synthesized by amidation of chitosan with 18β-glycyrrhetinic acid and sialic acid. The chitosan derivatives were characterized by Fourier transform infrared spectroscopy, thermogravimetric analysis, and measurement of the zeta potential. We also investigated the solubility, cytotoxicity, and blood compatibility of chitosan derivatives. 18β-glycyrrhetinic acid and sialic acid could be grafted onto chitosan molecular chains. The thermal stability of the synthesized chitosan derivatives was decreased and the surface was positively charged in water and phosphate-buffered saline. After chitosan had been modified by 18 β-glycyrrhetinic acid and sialic acid, the solubility of chitosan was improved greatly in water and phosphate-buffered saline, and percent hemolysis was <5%. Novel amphiphilic chitosan derivatives could be suitable polymers for biomedical purposes.
abstract_unstemmed	Chitosan is the only cationic polysaccharide found in nature. It has broad application prospects in biomaterials, but its application is limited due to its poor solubility in water. A novel chitosan derivative was synthesized by amidation of chitosan with 18β-glycyrrhetinic acid and sialic acid. The chitosan derivatives were characterized by Fourier transform infrared spectroscopy, thermogravimetric analysis, and measurement of the zeta potential. We also investigated the solubility, cytotoxicity, and blood compatibility of chitosan derivatives. 18β-glycyrrhetinic acid and sialic acid could be grafted onto chitosan molecular chains. The thermal stability of the synthesized chitosan derivatives was decreased and the surface was positively charged in water and phosphate-buffered saline. After chitosan had been modified by 18 β-glycyrrhetinic acid and sialic acid, the solubility of chitosan was improved greatly in water and phosphate-buffered saline, and percent hemolysis was <5%. Novel amphiphilic chitosan derivatives could be suitable polymers for biomedical purposes.
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container_issue	2, p 452
title_short	Grafting of 18β-Glycyrrhetinic Acid and Sialic Acid onto Chitosan to Produce a New Amphipathic Chitosan Derivative: Synthesis, Characterization, and Cytotoxicity
url	https://doi.org/10.3390/molecules26020452 https://doaj.org/article/f08094342ed64daf820efc72123535fe https://www.mdpi.com/1420-3049/26/2/452 https://doaj.org/toc/1420-3049
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up_date	2024-07-03T17:24:20.086Z
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Grafting of 18β-Glycyrrhetinic Acid and Sialic Acid onto Chitosan to Produce a New Amphipathic Chitosan Derivative: Synthesis, Characterization, and Cytotoxicity

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