Quantification of brain oxygen extraction and metabolism with [15O]-gas PET: A technical review in the era of PET/MRI

Oxygen extraction fraction (OEF) and the cerebral metabolic rate of oxygen (CMRO2) are key cerebral physiological parameters to identify at-risk cerebrovascular patients and understand brain health and function. PET imaging with [15O]-oxygen tracers, either through continuous or bolus inhalation, pr...
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Autor*in:	Audrey P. Fan [verfasserIn] Hongyu An [verfasserIn] Farshad Moradi [verfasserIn] Jarrett Rosenberg [verfasserIn] Yosuke Ishii [verfasserIn] Tadashi Nariai [verfasserIn] Hidehiko Okazawa [verfasserIn] Greg Zaharchuk [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	Oxygen extraction fraction Cerebral metabolic rate of oxygen Positron emission tomography [15O]-oxygen

Übergeordnetes Werk:	In: NeuroImage - Elsevier, 2020, 220(2020), Seite 117136-
Übergeordnetes Werk:	volume:220 ; year:2020 ; pages:117136-

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1016/j.neuroimage.2020.117136

Katalog-ID:	DOAJ060874422

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allfieldsGer	10.1016/j.neuroimage.2020.117136 doi (DE-627)DOAJ060874422 (DE-599)DOAJ609a34ae86bd41ac9136440bfb1fc087 DE-627 ger DE-627 rakwb eng RC321-571 Audrey P. Fan verfasserin aut Quantification of brain oxygen extraction and metabolism with [15O]-gas PET: A technical review in the era of PET/MRI 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Oxygen extraction fraction (OEF) and the cerebral metabolic rate of oxygen (CMRO2) are key cerebral physiological parameters to identify at-risk cerebrovascular patients and understand brain health and function. PET imaging with [15O]-oxygen tracers, either through continuous or bolus inhalation, provides non-invasive assessment of OEF and CMRO2. Numerous tracer delivery, PET acquisition, and kinetic modeling approaches have been adopted to map brain oxygenation. The purpose of this technical review is to critically evaluate different methods for [15O]-gas PET and its impact on the accuracy and reproducibility of OEF and CMRO2 measurements. We perform a meta-analysis of brain oxygenation PET studies in healthy volunteers and compare between continuous and bolus inhalation techniques. We also describe OEF metrics that have been used to detect hemodynamic impairment in cerebrovascular disease. For these patients, advanced techniques to accelerate the PET scans and potential synthesis with MRI to avoid arterial blood sampling would facilitate broader use of [15O]-oxygen PET for brain physiological assessment. Oxygen extraction fraction Cerebral metabolic rate of oxygen Positron emission tomography [15O]-oxygen Neurosciences. Biological psychiatry. Neuropsychiatry Hongyu An verfasserin aut Farshad Moradi verfasserin aut Jarrett Rosenberg verfasserin aut Yosuke Ishii verfasserin aut Tadashi Nariai verfasserin aut Hidehiko Okazawa verfasserin aut Greg Zaharchuk verfasserin aut In NeuroImage Elsevier, 2020 220(2020), Seite 117136- (DE-627)268125503 (DE-600)1471418-8 10959572 nnns volume:220 year:2020 pages:117136- https://doi.org/10.1016/j.neuroimage.2020.117136 kostenfrei https://doaj.org/article/609a34ae86bd41ac9136440bfb1fc087 kostenfrei http://www.sciencedirect.com/science/article/pii/S1053811920306224 kostenfrei https://doaj.org/toc/1095-9572 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2025 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 220 2020 117136-
allfieldsSound	10.1016/j.neuroimage.2020.117136 doi (DE-627)DOAJ060874422 (DE-599)DOAJ609a34ae86bd41ac9136440bfb1fc087 DE-627 ger DE-627 rakwb eng RC321-571 Audrey P. Fan verfasserin aut Quantification of brain oxygen extraction and metabolism with [15O]-gas PET: A technical review in the era of PET/MRI 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Oxygen extraction fraction (OEF) and the cerebral metabolic rate of oxygen (CMRO2) are key cerebral physiological parameters to identify at-risk cerebrovascular patients and understand brain health and function. PET imaging with [15O]-oxygen tracers, either through continuous or bolus inhalation, provides non-invasive assessment of OEF and CMRO2. Numerous tracer delivery, PET acquisition, and kinetic modeling approaches have been adopted to map brain oxygenation. The purpose of this technical review is to critically evaluate different methods for [15O]-gas PET and its impact on the accuracy and reproducibility of OEF and CMRO2 measurements. We perform a meta-analysis of brain oxygenation PET studies in healthy volunteers and compare between continuous and bolus inhalation techniques. We also describe OEF metrics that have been used to detect hemodynamic impairment in cerebrovascular disease. For these patients, advanced techniques to accelerate the PET scans and potential synthesis with MRI to avoid arterial blood sampling would facilitate broader use of [15O]-oxygen PET for brain physiological assessment. Oxygen extraction fraction Cerebral metabolic rate of oxygen Positron emission tomography [15O]-oxygen Neurosciences. Biological psychiatry. Neuropsychiatry Hongyu An verfasserin aut Farshad Moradi verfasserin aut Jarrett Rosenberg verfasserin aut Yosuke Ishii verfasserin aut Tadashi Nariai verfasserin aut Hidehiko Okazawa verfasserin aut Greg Zaharchuk verfasserin aut In NeuroImage Elsevier, 2020 220(2020), Seite 117136- (DE-627)268125503 (DE-600)1471418-8 10959572 nnns volume:220 year:2020 pages:117136- https://doi.org/10.1016/j.neuroimage.2020.117136 kostenfrei https://doaj.org/article/609a34ae86bd41ac9136440bfb1fc087 kostenfrei http://www.sciencedirect.com/science/article/pii/S1053811920306224 kostenfrei https://doaj.org/toc/1095-9572 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2025 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 220 2020 117136-
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callnumber-first	R - Medicine
author	Audrey P. Fan
spellingShingle	Audrey P. Fan misc RC321-571 misc Oxygen extraction fraction misc Cerebral metabolic rate of oxygen misc Positron emission tomography misc [15O]-oxygen misc Neurosciences. Biological psychiatry. Neuropsychiatry Quantification of brain oxygen extraction and metabolism with [15O]-gas PET: A technical review in the era of PET/MRI
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topic_title	RC321-571 Quantification of brain oxygen extraction and metabolism with [15O]-gas PET: A technical review in the era of PET/MRI Oxygen extraction fraction Cerebral metabolic rate of oxygen Positron emission tomography [15O]-oxygen
topic	misc RC321-571 misc Oxygen extraction fraction misc Cerebral metabolic rate of oxygen misc Positron emission tomography misc [15O]-oxygen misc Neurosciences. Biological psychiatry. Neuropsychiatry
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title	Quantification of brain oxygen extraction and metabolism with [15O]-gas PET: A technical review in the era of PET/MRI
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title_full	Quantification of brain oxygen extraction and metabolism with [15O]-gas PET: A technical review in the era of PET/MRI
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title_sort	quantification of brain oxygen extraction and metabolism with [15o]-gas pet: a technical review in the era of pet/mri
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title_auth	Quantification of brain oxygen extraction and metabolism with [15O]-gas PET: A technical review in the era of PET/MRI
abstract	Oxygen extraction fraction (OEF) and the cerebral metabolic rate of oxygen (CMRO2) are key cerebral physiological parameters to identify at-risk cerebrovascular patients and understand brain health and function. PET imaging with [15O]-oxygen tracers, either through continuous or bolus inhalation, provides non-invasive assessment of OEF and CMRO2. Numerous tracer delivery, PET acquisition, and kinetic modeling approaches have been adopted to map brain oxygenation. The purpose of this technical review is to critically evaluate different methods for [15O]-gas PET and its impact on the accuracy and reproducibility of OEF and CMRO2 measurements. We perform a meta-analysis of brain oxygenation PET studies in healthy volunteers and compare between continuous and bolus inhalation techniques. We also describe OEF metrics that have been used to detect hemodynamic impairment in cerebrovascular disease. For these patients, advanced techniques to accelerate the PET scans and potential synthesis with MRI to avoid arterial blood sampling would facilitate broader use of [15O]-oxygen PET for brain physiological assessment.
abstractGer	Oxygen extraction fraction (OEF) and the cerebral metabolic rate of oxygen (CMRO2) are key cerebral physiological parameters to identify at-risk cerebrovascular patients and understand brain health and function. PET imaging with [15O]-oxygen tracers, either through continuous or bolus inhalation, provides non-invasive assessment of OEF and CMRO2. Numerous tracer delivery, PET acquisition, and kinetic modeling approaches have been adopted to map brain oxygenation. The purpose of this technical review is to critically evaluate different methods for [15O]-gas PET and its impact on the accuracy and reproducibility of OEF and CMRO2 measurements. We perform a meta-analysis of brain oxygenation PET studies in healthy volunteers and compare between continuous and bolus inhalation techniques. We also describe OEF metrics that have been used to detect hemodynamic impairment in cerebrovascular disease. For these patients, advanced techniques to accelerate the PET scans and potential synthesis with MRI to avoid arterial blood sampling would facilitate broader use of [15O]-oxygen PET for brain physiological assessment.
abstract_unstemmed	Oxygen extraction fraction (OEF) and the cerebral metabolic rate of oxygen (CMRO2) are key cerebral physiological parameters to identify at-risk cerebrovascular patients and understand brain health and function. PET imaging with [15O]-oxygen tracers, either through continuous or bolus inhalation, provides non-invasive assessment of OEF and CMRO2. Numerous tracer delivery, PET acquisition, and kinetic modeling approaches have been adopted to map brain oxygenation. The purpose of this technical review is to critically evaluate different methods for [15O]-gas PET and its impact on the accuracy and reproducibility of OEF and CMRO2 measurements. We perform a meta-analysis of brain oxygenation PET studies in healthy volunteers and compare between continuous and bolus inhalation techniques. We also describe OEF metrics that have been used to detect hemodynamic impairment in cerebrovascular disease. For these patients, advanced techniques to accelerate the PET scans and potential synthesis with MRI to avoid arterial blood sampling would facilitate broader use of [15O]-oxygen PET for brain physiological assessment.
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title_short	Quantification of brain oxygen extraction and metabolism with [15O]-gas PET: A technical review in the era of PET/MRI
url	https://doi.org/10.1016/j.neuroimage.2020.117136 https://doaj.org/article/609a34ae86bd41ac9136440bfb1fc087 http://www.sciencedirect.com/science/article/pii/S1053811920306224 https://doaj.org/toc/1095-9572
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For these patients, advanced techniques to accelerate the PET scans and potential synthesis with MRI to avoid arterial blood sampling would facilitate broader use of [15O]-oxygen PET for brain physiological assessment.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Oxygen extraction fraction</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Cerebral metabolic rate of oxygen</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Positron emission tomography</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">[15O]-oxygen</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Neurosciences. Biological psychiatry. 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Quantification of brain oxygen extraction and metabolism with [15O]-gas PET: A technical review in the era of PET/MRI

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