A Prospective Multicenter Cohort Surveillance Study of Invasive Aspergillosis in Patients with Hematologic Malignancies in Greece: Impact of the Revised EORTC/MSGERC 2020 Criteria

Data concerning the incidence of invasive aspergillosis (IA) in high-risk patients in Greece are scarce, while the impact of the revised 2020 EORTC/MSGERC consensus criteria definitions on the reported incidence rate of IA remains unknown. A total of 93 adult hematology patients were screened for IA...
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Gespeichert in:

Autor*in:	Maria Siopi [verfasserIn] Stamatis Karakatsanis [verfasserIn] Christoforos Roumpakis [verfasserIn] Konstantinos Korantanis [verfasserIn] Helen Sambatakou [verfasserIn] Nikolaos V. Sipsas [verfasserIn] Panagiotis Tsirigotis [verfasserIn] Maria Pagoni [verfasserIn] Joseph Meletiadis [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	invasive aspergillosis hematology patients diagnosis Greece 2020 EORTC/MSGERC criteria

Übergeordnetes Werk:	In: Journal of Fungi - MDPI AG, 2015, 7(2021), 1, p 27
Übergeordnetes Werk:	volume:7 ; year:2021 ; number:1, p 27

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/jof7010027

Katalog-ID:	DOAJ060939095

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allfieldsSound	10.3390/jof7010027 doi (DE-627)DOAJ060939095 (DE-599)DOAJ186678765c244fffb7c3510840245baa DE-627 ger DE-627 rakwb eng QH301-705.5 Maria Siopi verfasserin aut A Prospective Multicenter Cohort Surveillance Study of Invasive Aspergillosis in Patients with Hematologic Malignancies in Greece: Impact of the Revised EORTC/MSGERC 2020 Criteria 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Data concerning the incidence of invasive aspergillosis (IA) in high-risk patients in Greece are scarce, while the impact of the revised 2020 EORTC/MSGERC consensus criteria definitions on the reported incidence rate of IA remains unknown. A total of 93 adult hematology patients were screened for IA for six months in four tertiary care Greek hospitals. Serial serum specimens (<i<n</i< = 240) the sample was considered negative by PCR were collected twice-weekly and tested for galactomannan (GM) and <i<Aspergillus</i< DNA (PCR) detection. IA was defined according to both the 2008 EORTC/MSG and the 2020 EORTC/MSGERC consensus criteria. Based on the 2008 EORTC/MSG criteria, the incidence rates of probable and possible IA was 9/93 (10%) and 24/93 (26%), respectively, while no proven IA was documented. Acute myeloid leukemia was the most (67%) common underlying disease with most (82%) patients being on antifungal prophylaxis/treatment. Based on the new 2020 EORTC/MSGERC criteria, 2/9 (22%) of probable and 1/24 (4%) of possible cases should be reclassified as possible and probable, respectively. The episodes of probable IA were reduced by 33% when GM alone and 11% when GM + PCR were used as mycological criterion. The incidence rate of IA in hematology patients was 10%. Application of the 2020 EORTC/MSGERC updated criteria results in a reduction in the classification of probable IA particularly when PCR is not available. invasive aspergillosis hematology patients diagnosis Greece 2020 EORTC/MSGERC criteria Biology (General) Stamatis Karakatsanis verfasserin aut Christoforos Roumpakis verfasserin aut Konstantinos Korantanis verfasserin aut Helen Sambatakou verfasserin aut Nikolaos V. Sipsas verfasserin aut Panagiotis Tsirigotis verfasserin aut Maria Pagoni verfasserin aut Joseph Meletiadis verfasserin aut In Journal of Fungi MDPI AG, 2015 7(2021), 1, p 27 (DE-627)796588538 (DE-600)2784229-0 2309608X nnns volume:7 year:2021 number:1, p 27 https://doi.org/10.3390/jof7010027 kostenfrei https://doaj.org/article/186678765c244fffb7c3510840245baa kostenfrei https://www.mdpi.com/2309-608X/7/1/27 kostenfrei https://doaj.org/toc/2309-608X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2021 1, p 27
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author	Maria Siopi
spellingShingle	Maria Siopi misc QH301-705.5 misc invasive aspergillosis misc hematology patients misc diagnosis misc Greece misc 2020 EORTC/MSGERC criteria misc Biology (General) A Prospective Multicenter Cohort Surveillance Study of Invasive Aspergillosis in Patients with Hematologic Malignancies in Greece: Impact of the Revised EORTC/MSGERC 2020 Criteria
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topic_title	QH301-705.5 A Prospective Multicenter Cohort Surveillance Study of Invasive Aspergillosis in Patients with Hematologic Malignancies in Greece: Impact of the Revised EORTC/MSGERC 2020 Criteria invasive aspergillosis hematology patients diagnosis Greece 2020 EORTC/MSGERC criteria
topic	misc QH301-705.5 misc invasive aspergillosis misc hematology patients misc diagnosis misc Greece misc 2020 EORTC/MSGERC criteria misc Biology (General)
topic_unstemmed	misc QH301-705.5 misc invasive aspergillosis misc hematology patients misc diagnosis misc Greece misc 2020 EORTC/MSGERC criteria misc Biology (General)
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title	A Prospective Multicenter Cohort Surveillance Study of Invasive Aspergillosis in Patients with Hematologic Malignancies in Greece: Impact of the Revised EORTC/MSGERC 2020 Criteria
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title_full	A Prospective Multicenter Cohort Surveillance Study of Invasive Aspergillosis in Patients with Hematologic Malignancies in Greece: Impact of the Revised EORTC/MSGERC 2020 Criteria
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author_browse	Maria Siopi Stamatis Karakatsanis Christoforos Roumpakis Konstantinos Korantanis Helen Sambatakou Nikolaos V. Sipsas Panagiotis Tsirigotis Maria Pagoni Joseph Meletiadis
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title_sort	prospective multicenter cohort surveillance study of invasive aspergillosis in patients with hematologic malignancies in greece: impact of the revised eortc/msgerc 2020 criteria
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title_auth	A Prospective Multicenter Cohort Surveillance Study of Invasive Aspergillosis in Patients with Hematologic Malignancies in Greece: Impact of the Revised EORTC/MSGERC 2020 Criteria
abstract	Data concerning the incidence of invasive aspergillosis (IA) in high-risk patients in Greece are scarce, while the impact of the revised 2020 EORTC/MSGERC consensus criteria definitions on the reported incidence rate of IA remains unknown. A total of 93 adult hematology patients were screened for IA for six months in four tertiary care Greek hospitals. Serial serum specimens (<i<n</i< = 240) the sample was considered negative by PCR were collected twice-weekly and tested for galactomannan (GM) and <i<Aspergillus</i< DNA (PCR) detection. IA was defined according to both the 2008 EORTC/MSG and the 2020 EORTC/MSGERC consensus criteria. Based on the 2008 EORTC/MSG criteria, the incidence rates of probable and possible IA was 9/93 (10%) and 24/93 (26%), respectively, while no proven IA was documented. Acute myeloid leukemia was the most (67%) common underlying disease with most (82%) patients being on antifungal prophylaxis/treatment. Based on the new 2020 EORTC/MSGERC criteria, 2/9 (22%) of probable and 1/24 (4%) of possible cases should be reclassified as possible and probable, respectively. The episodes of probable IA were reduced by 33% when GM alone and 11% when GM + PCR were used as mycological criterion. The incidence rate of IA in hematology patients was 10%. Application of the 2020 EORTC/MSGERC updated criteria results in a reduction in the classification of probable IA particularly when PCR is not available.
abstractGer	Data concerning the incidence of invasive aspergillosis (IA) in high-risk patients in Greece are scarce, while the impact of the revised 2020 EORTC/MSGERC consensus criteria definitions on the reported incidence rate of IA remains unknown. A total of 93 adult hematology patients were screened for IA for six months in four tertiary care Greek hospitals. Serial serum specimens (<i<n</i< = 240) the sample was considered negative by PCR were collected twice-weekly and tested for galactomannan (GM) and <i<Aspergillus</i< DNA (PCR) detection. IA was defined according to both the 2008 EORTC/MSG and the 2020 EORTC/MSGERC consensus criteria. Based on the 2008 EORTC/MSG criteria, the incidence rates of probable and possible IA was 9/93 (10%) and 24/93 (26%), respectively, while no proven IA was documented. Acute myeloid leukemia was the most (67%) common underlying disease with most (82%) patients being on antifungal prophylaxis/treatment. Based on the new 2020 EORTC/MSGERC criteria, 2/9 (22%) of probable and 1/24 (4%) of possible cases should be reclassified as possible and probable, respectively. The episodes of probable IA were reduced by 33% when GM alone and 11% when GM + PCR were used as mycological criterion. The incidence rate of IA in hematology patients was 10%. Application of the 2020 EORTC/MSGERC updated criteria results in a reduction in the classification of probable IA particularly when PCR is not available.
abstract_unstemmed	Data concerning the incidence of invasive aspergillosis (IA) in high-risk patients in Greece are scarce, while the impact of the revised 2020 EORTC/MSGERC consensus criteria definitions on the reported incidence rate of IA remains unknown. A total of 93 adult hematology patients were screened for IA for six months in four tertiary care Greek hospitals. Serial serum specimens (<i<n</i< = 240) the sample was considered negative by PCR were collected twice-weekly and tested for galactomannan (GM) and <i<Aspergillus</i< DNA (PCR) detection. IA was defined according to both the 2008 EORTC/MSG and the 2020 EORTC/MSGERC consensus criteria. Based on the 2008 EORTC/MSG criteria, the incidence rates of probable and possible IA was 9/93 (10%) and 24/93 (26%), respectively, while no proven IA was documented. Acute myeloid leukemia was the most (67%) common underlying disease with most (82%) patients being on antifungal prophylaxis/treatment. Based on the new 2020 EORTC/MSGERC criteria, 2/9 (22%) of probable and 1/24 (4%) of possible cases should be reclassified as possible and probable, respectively. The episodes of probable IA were reduced by 33% when GM alone and 11% when GM + PCR were used as mycological criterion. The incidence rate of IA in hematology patients was 10%. Application of the 2020 EORTC/MSGERC updated criteria results in a reduction in the classification of probable IA particularly when PCR is not available.
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title_short	A Prospective Multicenter Cohort Surveillance Study of Invasive Aspergillosis in Patients with Hematologic Malignancies in Greece: Impact of the Revised EORTC/MSGERC 2020 Criteria
url	https://doi.org/10.3390/jof7010027 https://doaj.org/article/186678765c244fffb7c3510840245baa https://www.mdpi.com/2309-608X/7/1/27 https://doaj.org/toc/2309-608X
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up_date	2024-07-03T17:53:49.171Z
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A total of 93 adult hematology patients were screened for IA for six months in four tertiary care Greek hospitals. Serial serum specimens (<i<n</i< = 240) the sample was considered negative by PCR were collected twice-weekly and tested for galactomannan (GM) and <i<Aspergillus</i< DNA (PCR) detection. IA was defined according to both the 2008 EORTC/MSG and the 2020 EORTC/MSGERC consensus criteria. Based on the 2008 EORTC/MSG criteria, the incidence rates of probable and possible IA was 9/93 (10%) and 24/93 (26%), respectively, while no proven IA was documented. Acute myeloid leukemia was the most (67%) common underlying disease with most (82%) patients being on antifungal prophylaxis/treatment. Based on the new 2020 EORTC/MSGERC criteria, 2/9 (22%) of probable and 1/24 (4%) of possible cases should be reclassified as possible and probable, respectively. The episodes of probable IA were reduced by 33% when GM alone and 11% when GM + PCR were used as mycological criterion. 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A Prospective Multicenter Cohort Surveillance Study of Invasive Aspergillosis in Patients with Hematologic Malignancies in Greece: Impact of the Revised EORTC/MSGERC 2020 Criteria

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