The roles of GTPase-activating proteins in regulated cell death and tumor immunity

Abstract GTPase-activating protein (GAP) is a negative regulator of GTPase protein that is thought to promote the conversion of the active GTPase-GTP form to the GTPase-GDP form. Based on its ability to regulate GTPase proteins and other domains, GAPs are directly or indirectly involved in various c...
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Autor*in:	Hua He [verfasserIn] Jingjing Huang [verfasserIn] Sufang Wu [verfasserIn] Shiyao Jiang [verfasserIn] Lu Liang [verfasserIn] Yueying Liu [verfasserIn] Wenbing Liu [verfasserIn] Li Xie [verfasserIn] Yongguang Tao [verfasserIn] Yiqun Jiang [verfasserIn] Li Cong [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	GTPase-activating proteins Regulated cell death Tumor immunity

Übergeordnetes Werk:	In: Journal of Hematology & Oncology - BMC, 2008, 14(2021), 1, Seite 15
Übergeordnetes Werk:	volume:14 ; year:2021 ; number:1 ; pages:15

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1186/s13045-021-01184-1

Katalog-ID:	DOAJ060994894

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520			\|a Abstract GTPase-activating protein (GAP) is a negative regulator of GTPase protein that is thought to promote the conversion of the active GTPase-GTP form to the GTPase-GDP form. Based on its ability to regulate GTPase proteins and other domains, GAPs are directly or indirectly involved in various cell requirement processes. We reviewed the existing evidence of GAPs regulating regulated cell death (RCD), mainly apoptosis and autophagy, as well as some novel RCDs, with particular attention to their association in diseases, especially cancer. We also considered that GAPs could affect tumor immunity and attempted to link GAPs, RCD and tumor immunity. A deeper understanding of the GAPs for regulating these processes could lead to the discovery of new therapeutic targets to avoid pathologic cell loss or to mediate cancer cell death.
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allfields	10.1186/s13045-021-01184-1 doi (DE-627)DOAJ060994894 (DE-599)DOAJ235bed04680348b0bf68711b622cbe01 DE-627 ger DE-627 rakwb eng RC633-647.5 RC254-282 Hua He verfasserin aut The roles of GTPase-activating proteins in regulated cell death and tumor immunity 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract GTPase-activating protein (GAP) is a negative regulator of GTPase protein that is thought to promote the conversion of the active GTPase-GTP form to the GTPase-GDP form. Based on its ability to regulate GTPase proteins and other domains, GAPs are directly or indirectly involved in various cell requirement processes. We reviewed the existing evidence of GAPs regulating regulated cell death (RCD), mainly apoptosis and autophagy, as well as some novel RCDs, with particular attention to their association in diseases, especially cancer. We also considered that GAPs could affect tumor immunity and attempted to link GAPs, RCD and tumor immunity. A deeper understanding of the GAPs for regulating these processes could lead to the discovery of new therapeutic targets to avoid pathologic cell loss or to mediate cancer cell death. GTPase-activating proteins Regulated cell death Tumor immunity Diseases of the blood and blood-forming organs Neoplasms. Tumors. Oncology. Including cancer and carcinogens Jingjing Huang verfasserin aut Sufang Wu verfasserin aut Shiyao Jiang verfasserin aut Lu Liang verfasserin aut Yueying Liu verfasserin aut Wenbing Liu verfasserin aut Li Xie verfasserin aut Yongguang Tao verfasserin aut Yiqun Jiang verfasserin aut Li Cong verfasserin aut In Journal of Hematology & Oncology BMC, 2008 14(2021), 1, Seite 15 (DE-627)568914813 (DE-600)2429631-4 17568722 nnns volume:14 year:2021 number:1 pages:15 https://doi.org/10.1186/s13045-021-01184-1 kostenfrei https://doaj.org/article/235bed04680348b0bf68711b622cbe01 kostenfrei https://doi.org/10.1186/s13045-021-01184-1 kostenfrei https://doaj.org/toc/1756-8722 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2021 1 15
spelling	10.1186/s13045-021-01184-1 doi (DE-627)DOAJ060994894 (DE-599)DOAJ235bed04680348b0bf68711b622cbe01 DE-627 ger DE-627 rakwb eng RC633-647.5 RC254-282 Hua He verfasserin aut The roles of GTPase-activating proteins in regulated cell death and tumor immunity 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract GTPase-activating protein (GAP) is a negative regulator of GTPase protein that is thought to promote the conversion of the active GTPase-GTP form to the GTPase-GDP form. Based on its ability to regulate GTPase proteins and other domains, GAPs are directly or indirectly involved in various cell requirement processes. We reviewed the existing evidence of GAPs regulating regulated cell death (RCD), mainly apoptosis and autophagy, as well as some novel RCDs, with particular attention to their association in diseases, especially cancer. We also considered that GAPs could affect tumor immunity and attempted to link GAPs, RCD and tumor immunity. A deeper understanding of the GAPs for regulating these processes could lead to the discovery of new therapeutic targets to avoid pathologic cell loss or to mediate cancer cell death. GTPase-activating proteins Regulated cell death Tumor immunity Diseases of the blood and blood-forming organs Neoplasms. Tumors. Oncology. Including cancer and carcinogens Jingjing Huang verfasserin aut Sufang Wu verfasserin aut Shiyao Jiang verfasserin aut Lu Liang verfasserin aut Yueying Liu verfasserin aut Wenbing Liu verfasserin aut Li Xie verfasserin aut Yongguang Tao verfasserin aut Yiqun Jiang verfasserin aut Li Cong verfasserin aut In Journal of Hematology & Oncology BMC, 2008 14(2021), 1, Seite 15 (DE-627)568914813 (DE-600)2429631-4 17568722 nnns volume:14 year:2021 number:1 pages:15 https://doi.org/10.1186/s13045-021-01184-1 kostenfrei https://doaj.org/article/235bed04680348b0bf68711b622cbe01 kostenfrei https://doi.org/10.1186/s13045-021-01184-1 kostenfrei https://doaj.org/toc/1756-8722 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2021 1 15
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allfieldsSound	10.1186/s13045-021-01184-1 doi (DE-627)DOAJ060994894 (DE-599)DOAJ235bed04680348b0bf68711b622cbe01 DE-627 ger DE-627 rakwb eng RC633-647.5 RC254-282 Hua He verfasserin aut The roles of GTPase-activating proteins in regulated cell death and tumor immunity 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract GTPase-activating protein (GAP) is a negative regulator of GTPase protein that is thought to promote the conversion of the active GTPase-GTP form to the GTPase-GDP form. Based on its ability to regulate GTPase proteins and other domains, GAPs are directly or indirectly involved in various cell requirement processes. We reviewed the existing evidence of GAPs regulating regulated cell death (RCD), mainly apoptosis and autophagy, as well as some novel RCDs, with particular attention to their association in diseases, especially cancer. We also considered that GAPs could affect tumor immunity and attempted to link GAPs, RCD and tumor immunity. A deeper understanding of the GAPs for regulating these processes could lead to the discovery of new therapeutic targets to avoid pathologic cell loss or to mediate cancer cell death. GTPase-activating proteins Regulated cell death Tumor immunity Diseases of the blood and blood-forming organs Neoplasms. Tumors. Oncology. Including cancer and carcinogens Jingjing Huang verfasserin aut Sufang Wu verfasserin aut Shiyao Jiang verfasserin aut Lu Liang verfasserin aut Yueying Liu verfasserin aut Wenbing Liu verfasserin aut Li Xie verfasserin aut Yongguang Tao verfasserin aut Yiqun Jiang verfasserin aut Li Cong verfasserin aut In Journal of Hematology & Oncology BMC, 2008 14(2021), 1, Seite 15 (DE-627)568914813 (DE-600)2429631-4 17568722 nnns volume:14 year:2021 number:1 pages:15 https://doi.org/10.1186/s13045-021-01184-1 kostenfrei https://doaj.org/article/235bed04680348b0bf68711b622cbe01 kostenfrei https://doi.org/10.1186/s13045-021-01184-1 kostenfrei https://doaj.org/toc/1756-8722 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2021 1 15
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source	In Journal of Hematology & Oncology 14(2021), 1, Seite 15 volume:14 year:2021 number:1 pages:15
sourceStr	In Journal of Hematology & Oncology 14(2021), 1, Seite 15 volume:14 year:2021 number:1 pages:15
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topic_facet	GTPase-activating proteins Regulated cell death Tumor immunity Diseases of the blood and blood-forming organs Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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authorswithroles_txt_mv	Hua He @@aut@@ Jingjing Huang @@aut@@ Sufang Wu @@aut@@ Shiyao Jiang @@aut@@ Lu Liang @@aut@@ Yueying Liu @@aut@@ Wenbing Liu @@aut@@ Li Xie @@aut@@ Yongguang Tao @@aut@@ Yiqun Jiang @@aut@@ Li Cong @@aut@@
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callnumber-first	R - Medicine
author	Hua He
spellingShingle	Hua He misc RC633-647.5 misc RC254-282 misc GTPase-activating proteins misc Regulated cell death misc Tumor immunity misc Diseases of the blood and blood-forming organs misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens The roles of GTPase-activating proteins in regulated cell death and tumor immunity
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topic_title	RC633-647.5 RC254-282 The roles of GTPase-activating proteins in regulated cell death and tumor immunity GTPase-activating proteins Regulated cell death Tumor immunity
topic	misc RC633-647.5 misc RC254-282 misc GTPase-activating proteins misc Regulated cell death misc Tumor immunity misc Diseases of the blood and blood-forming organs misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_unstemmed	misc RC633-647.5 misc RC254-282 misc GTPase-activating proteins misc Regulated cell death misc Tumor immunity misc Diseases of the blood and blood-forming organs misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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title	The roles of GTPase-activating proteins in regulated cell death and tumor immunity
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title_full	The roles of GTPase-activating proteins in regulated cell death and tumor immunity
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title_auth	The roles of GTPase-activating proteins in regulated cell death and tumor immunity
abstract	Abstract GTPase-activating protein (GAP) is a negative regulator of GTPase protein that is thought to promote the conversion of the active GTPase-GTP form to the GTPase-GDP form. Based on its ability to regulate GTPase proteins and other domains, GAPs are directly or indirectly involved in various cell requirement processes. We reviewed the existing evidence of GAPs regulating regulated cell death (RCD), mainly apoptosis and autophagy, as well as some novel RCDs, with particular attention to their association in diseases, especially cancer. We also considered that GAPs could affect tumor immunity and attempted to link GAPs, RCD and tumor immunity. A deeper understanding of the GAPs for regulating these processes could lead to the discovery of new therapeutic targets to avoid pathologic cell loss or to mediate cancer cell death.
abstractGer	Abstract GTPase-activating protein (GAP) is a negative regulator of GTPase protein that is thought to promote the conversion of the active GTPase-GTP form to the GTPase-GDP form. Based on its ability to regulate GTPase proteins and other domains, GAPs are directly or indirectly involved in various cell requirement processes. We reviewed the existing evidence of GAPs regulating regulated cell death (RCD), mainly apoptosis and autophagy, as well as some novel RCDs, with particular attention to their association in diseases, especially cancer. We also considered that GAPs could affect tumor immunity and attempted to link GAPs, RCD and tumor immunity. A deeper understanding of the GAPs for regulating these processes could lead to the discovery of new therapeutic targets to avoid pathologic cell loss or to mediate cancer cell death.
abstract_unstemmed	Abstract GTPase-activating protein (GAP) is a negative regulator of GTPase protein that is thought to promote the conversion of the active GTPase-GTP form to the GTPase-GDP form. Based on its ability to regulate GTPase proteins and other domains, GAPs are directly or indirectly involved in various cell requirement processes. We reviewed the existing evidence of GAPs regulating regulated cell death (RCD), mainly apoptosis and autophagy, as well as some novel RCDs, with particular attention to their association in diseases, especially cancer. We also considered that GAPs could affect tumor immunity and attempted to link GAPs, RCD and tumor immunity. A deeper understanding of the GAPs for regulating these processes could lead to the discovery of new therapeutic targets to avoid pathologic cell loss or to mediate cancer cell death.
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title_short	The roles of GTPase-activating proteins in regulated cell death and tumor immunity
url	https://doi.org/10.1186/s13045-021-01184-1 https://doaj.org/article/235bed04680348b0bf68711b622cbe01 https://doaj.org/toc/1756-8722
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up_date	2024-07-03T18:14:00.588Z
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The roles of GTPase-activating proteins in regulated cell death and tumor immunity

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