Stand-alone Emollient Treatment Reduces Flares After Discontinuation of Topical Steroid Treatment in Atopic Dermatitis: A Double-blind, Randomized, Vehicle-controlled, Left-right Comparison Study

Prevention of the flares is a main goal in the long-term treatment of atopic dermatitis (AD). Therefore we investigated the efficacy of a water-in-oil emollient, containing licochalcone A, omega-6-fatty acids, ceramide 3 and glycerol, for prevention of the flares in adults with mild to moderately se...
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Gespeichert in:

Autor*in:	Irena Angelova-Fischer [verfasserIn] Frank Rippke [verfasserIn] Daniel Richter [verfasserIn] Alexander Filbry [verfasserIn] Craig Arrowitz [verfasserIn] Teresa Weber [verfasserIn] Tobias W. Fischer [verfasserIn] Detlef Zillikens [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2018

Schlagwörter:	atopicdermatitis maintenancetreatment emollients skinbarrier licochalconeA omega-6fattyacids

Übergeordnetes Werk:	In: Acta Dermato-Venereologica - Medical Journals Sweden, 2011, 98(2018), 5, Seite 517-523
Übergeordnetes Werk:	volume:98 ; year:2018 ; number:5 ; pages:517-523

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.2340/00015555-2882

Katalog-ID:	DOAJ061072761

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allfields	10.2340/00015555-2882 doi (DE-627)DOAJ061072761 (DE-599)DOAJ96ca1b1a951e42d3816e884654276cf2 DE-627 ger DE-627 rakwb eng RL1-803 Irena Angelova-Fischer verfasserin aut Stand-alone Emollient Treatment Reduces Flares After Discontinuation of Topical Steroid Treatment in Atopic Dermatitis: A Double-blind, Randomized, Vehicle-controlled, Left-right Comparison Study 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Prevention of the flares is a main goal in the long-term treatment of atopic dermatitis (AD). Therefore we investigated the efficacy of a water-in-oil emollient, containing licochalcone A, omega-6-fatty acids, ceramide 3 and glycerol, for prevention of the flares in adults with mild to moderately severe AD, treated with topical steroids, that led to clearing of the inflammatory lesions and had been discontinued prior to inclusion. The study was a 12-week, double-blind, randomized, vehicle-controlled, left-right comparison test with the number of relapses, defined as re-occurrence of erythema for at least 3 consecutive days, considered the primary outcome. Compared with the vehicle, the active formulation significantly reduced the number of relapses and maintained the barrier homeostasis of the respective arm. To the best of knowledge, this is the first study to show prevention of the AD flares by the use of stand-alone emollient treatment, based on comparison with the corresponding vehicle while excluding concomitant/rescue medications. atopicdermatitis maintenancetreatment emollients skinbarrier licochalconeA omega-6fattyacids Dermatology Frank Rippke verfasserin aut Daniel Richter verfasserin aut Alexander Filbry verfasserin aut Craig Arrowitz verfasserin aut Teresa Weber verfasserin aut Tobias W. Fischer verfasserin aut Detlef Zillikens verfasserin aut In Acta Dermato-Venereologica Medical Journals Sweden, 2011 98(2018), 5, Seite 517-523 (DE-627)302725431 (DE-600)1492617-9 16512057 nnns volume:98 year:2018 number:5 pages:517-523 https://doi.org/10.2340/00015555-2882 kostenfrei https://doaj.org/article/96ca1b1a951e42d3816e884654276cf2 kostenfrei https://www.medicaljournals.se/acta/content/html/10.2340/00015555-2882 kostenfrei https://doaj.org/toc/0001-5555 Journal toc kostenfrei https://doaj.org/toc/1651-2057 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 98 2018 5 517-523
spelling	10.2340/00015555-2882 doi (DE-627)DOAJ061072761 (DE-599)DOAJ96ca1b1a951e42d3816e884654276cf2 DE-627 ger DE-627 rakwb eng RL1-803 Irena Angelova-Fischer verfasserin aut Stand-alone Emollient Treatment Reduces Flares After Discontinuation of Topical Steroid Treatment in Atopic Dermatitis: A Double-blind, Randomized, Vehicle-controlled, Left-right Comparison Study 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Prevention of the flares is a main goal in the long-term treatment of atopic dermatitis (AD). Therefore we investigated the efficacy of a water-in-oil emollient, containing licochalcone A, omega-6-fatty acids, ceramide 3 and glycerol, for prevention of the flares in adults with mild to moderately severe AD, treated with topical steroids, that led to clearing of the inflammatory lesions and had been discontinued prior to inclusion. The study was a 12-week, double-blind, randomized, vehicle-controlled, left-right comparison test with the number of relapses, defined as re-occurrence of erythema for at least 3 consecutive days, considered the primary outcome. Compared with the vehicle, the active formulation significantly reduced the number of relapses and maintained the barrier homeostasis of the respective arm. To the best of knowledge, this is the first study to show prevention of the AD flares by the use of stand-alone emollient treatment, based on comparison with the corresponding vehicle while excluding concomitant/rescue medications. atopicdermatitis maintenancetreatment emollients skinbarrier licochalconeA omega-6fattyacids Dermatology Frank Rippke verfasserin aut Daniel Richter verfasserin aut Alexander Filbry verfasserin aut Craig Arrowitz verfasserin aut Teresa Weber verfasserin aut Tobias W. Fischer verfasserin aut Detlef Zillikens verfasserin aut In Acta Dermato-Venereologica Medical Journals Sweden, 2011 98(2018), 5, Seite 517-523 (DE-627)302725431 (DE-600)1492617-9 16512057 nnns volume:98 year:2018 number:5 pages:517-523 https://doi.org/10.2340/00015555-2882 kostenfrei https://doaj.org/article/96ca1b1a951e42d3816e884654276cf2 kostenfrei https://www.medicaljournals.se/acta/content/html/10.2340/00015555-2882 kostenfrei https://doaj.org/toc/0001-5555 Journal toc kostenfrei https://doaj.org/toc/1651-2057 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 98 2018 5 517-523
allfields_unstemmed	10.2340/00015555-2882 doi (DE-627)DOAJ061072761 (DE-599)DOAJ96ca1b1a951e42d3816e884654276cf2 DE-627 ger DE-627 rakwb eng RL1-803 Irena Angelova-Fischer verfasserin aut Stand-alone Emollient Treatment Reduces Flares After Discontinuation of Topical Steroid Treatment in Atopic Dermatitis: A Double-blind, Randomized, Vehicle-controlled, Left-right Comparison Study 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Prevention of the flares is a main goal in the long-term treatment of atopic dermatitis (AD). Therefore we investigated the efficacy of a water-in-oil emollient, containing licochalcone A, omega-6-fatty acids, ceramide 3 and glycerol, for prevention of the flares in adults with mild to moderately severe AD, treated with topical steroids, that led to clearing of the inflammatory lesions and had been discontinued prior to inclusion. The study was a 12-week, double-blind, randomized, vehicle-controlled, left-right comparison test with the number of relapses, defined as re-occurrence of erythema for at least 3 consecutive days, considered the primary outcome. Compared with the vehicle, the active formulation significantly reduced the number of relapses and maintained the barrier homeostasis of the respective arm. To the best of knowledge, this is the first study to show prevention of the AD flares by the use of stand-alone emollient treatment, based on comparison with the corresponding vehicle while excluding concomitant/rescue medications. atopicdermatitis maintenancetreatment emollients skinbarrier licochalconeA omega-6fattyacids Dermatology Frank Rippke verfasserin aut Daniel Richter verfasserin aut Alexander Filbry verfasserin aut Craig Arrowitz verfasserin aut Teresa Weber verfasserin aut Tobias W. Fischer verfasserin aut Detlef Zillikens verfasserin aut In Acta Dermato-Venereologica Medical Journals Sweden, 2011 98(2018), 5, Seite 517-523 (DE-627)302725431 (DE-600)1492617-9 16512057 nnns volume:98 year:2018 number:5 pages:517-523 https://doi.org/10.2340/00015555-2882 kostenfrei https://doaj.org/article/96ca1b1a951e42d3816e884654276cf2 kostenfrei https://www.medicaljournals.se/acta/content/html/10.2340/00015555-2882 kostenfrei https://doaj.org/toc/0001-5555 Journal toc kostenfrei https://doaj.org/toc/1651-2057 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 98 2018 5 517-523
allfieldsGer	10.2340/00015555-2882 doi (DE-627)DOAJ061072761 (DE-599)DOAJ96ca1b1a951e42d3816e884654276cf2 DE-627 ger DE-627 rakwb eng RL1-803 Irena Angelova-Fischer verfasserin aut Stand-alone Emollient Treatment Reduces Flares After Discontinuation of Topical Steroid Treatment in Atopic Dermatitis: A Double-blind, Randomized, Vehicle-controlled, Left-right Comparison Study 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Prevention of the flares is a main goal in the long-term treatment of atopic dermatitis (AD). Therefore we investigated the efficacy of a water-in-oil emollient, containing licochalcone A, omega-6-fatty acids, ceramide 3 and glycerol, for prevention of the flares in adults with mild to moderately severe AD, treated with topical steroids, that led to clearing of the inflammatory lesions and had been discontinued prior to inclusion. The study was a 12-week, double-blind, randomized, vehicle-controlled, left-right comparison test with the number of relapses, defined as re-occurrence of erythema for at least 3 consecutive days, considered the primary outcome. Compared with the vehicle, the active formulation significantly reduced the number of relapses and maintained the barrier homeostasis of the respective arm. To the best of knowledge, this is the first study to show prevention of the AD flares by the use of stand-alone emollient treatment, based on comparison with the corresponding vehicle while excluding concomitant/rescue medications. atopicdermatitis maintenancetreatment emollients skinbarrier licochalconeA omega-6fattyacids Dermatology Frank Rippke verfasserin aut Daniel Richter verfasserin aut Alexander Filbry verfasserin aut Craig Arrowitz verfasserin aut Teresa Weber verfasserin aut Tobias W. Fischer verfasserin aut Detlef Zillikens verfasserin aut In Acta Dermato-Venereologica Medical Journals Sweden, 2011 98(2018), 5, Seite 517-523 (DE-627)302725431 (DE-600)1492617-9 16512057 nnns volume:98 year:2018 number:5 pages:517-523 https://doi.org/10.2340/00015555-2882 kostenfrei https://doaj.org/article/96ca1b1a951e42d3816e884654276cf2 kostenfrei https://www.medicaljournals.se/acta/content/html/10.2340/00015555-2882 kostenfrei https://doaj.org/toc/0001-5555 Journal toc kostenfrei https://doaj.org/toc/1651-2057 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 98 2018 5 517-523
allfieldsSound	10.2340/00015555-2882 doi (DE-627)DOAJ061072761 (DE-599)DOAJ96ca1b1a951e42d3816e884654276cf2 DE-627 ger DE-627 rakwb eng RL1-803 Irena Angelova-Fischer verfasserin aut Stand-alone Emollient Treatment Reduces Flares After Discontinuation of Topical Steroid Treatment in Atopic Dermatitis: A Double-blind, Randomized, Vehicle-controlled, Left-right Comparison Study 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Prevention of the flares is a main goal in the long-term treatment of atopic dermatitis (AD). Therefore we investigated the efficacy of a water-in-oil emollient, containing licochalcone A, omega-6-fatty acids, ceramide 3 and glycerol, for prevention of the flares in adults with mild to moderately severe AD, treated with topical steroids, that led to clearing of the inflammatory lesions and had been discontinued prior to inclusion. The study was a 12-week, double-blind, randomized, vehicle-controlled, left-right comparison test with the number of relapses, defined as re-occurrence of erythema for at least 3 consecutive days, considered the primary outcome. Compared with the vehicle, the active formulation significantly reduced the number of relapses and maintained the barrier homeostasis of the respective arm. To the best of knowledge, this is the first study to show prevention of the AD flares by the use of stand-alone emollient treatment, based on comparison with the corresponding vehicle while excluding concomitant/rescue medications. atopicdermatitis maintenancetreatment emollients skinbarrier licochalconeA omega-6fattyacids Dermatology Frank Rippke verfasserin aut Daniel Richter verfasserin aut Alexander Filbry verfasserin aut Craig Arrowitz verfasserin aut Teresa Weber verfasserin aut Tobias W. Fischer verfasserin aut Detlef Zillikens verfasserin aut In Acta Dermato-Venereologica Medical Journals Sweden, 2011 98(2018), 5, Seite 517-523 (DE-627)302725431 (DE-600)1492617-9 16512057 nnns volume:98 year:2018 number:5 pages:517-523 https://doi.org/10.2340/00015555-2882 kostenfrei https://doaj.org/article/96ca1b1a951e42d3816e884654276cf2 kostenfrei https://www.medicaljournals.se/acta/content/html/10.2340/00015555-2882 kostenfrei https://doaj.org/toc/0001-5555 Journal toc kostenfrei https://doaj.org/toc/1651-2057 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 98 2018 5 517-523
language	English
source	In Acta Dermato-Venereologica 98(2018), 5, Seite 517-523 volume:98 year:2018 number:5 pages:517-523
sourceStr	In Acta Dermato-Venereologica 98(2018), 5, Seite 517-523 volume:98 year:2018 number:5 pages:517-523
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	atopicdermatitis maintenancetreatment emollients skinbarrier licochalconeA omega-6fattyacids Dermatology
isfreeaccess_bool	true
container_title	Acta Dermato-Venereologica
authorswithroles_txt_mv	Irena Angelova-Fischer @@aut@@ Frank Rippke @@aut@@ Daniel Richter @@aut@@ Alexander Filbry @@aut@@ Craig Arrowitz @@aut@@ Teresa Weber @@aut@@ Tobias W. Fischer @@aut@@ Detlef Zillikens @@aut@@
publishDateDaySort_date	2018-01-01T00:00:00Z
hierarchy_top_id	302725431
id	DOAJ061072761
language_de	englisch
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callnumber-first	R - Medicine
author	Irena Angelova-Fischer
spellingShingle	Irena Angelova-Fischer misc RL1-803 misc atopicdermatitis misc maintenancetreatment misc emollients misc skinbarrier misc licochalconeA misc omega-6fattyacids misc Dermatology Stand-alone Emollient Treatment Reduces Flares After Discontinuation of Topical Steroid Treatment in Atopic Dermatitis: A Double-blind, Randomized, Vehicle-controlled, Left-right Comparison Study
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topic_title	RL1-803 Stand-alone Emollient Treatment Reduces Flares After Discontinuation of Topical Steroid Treatment in Atopic Dermatitis: A Double-blind, Randomized, Vehicle-controlled, Left-right Comparison Study atopicdermatitis maintenancetreatment emollients skinbarrier licochalconeA omega-6fattyacids
topic	misc RL1-803 misc atopicdermatitis misc maintenancetreatment misc emollients misc skinbarrier misc licochalconeA misc omega-6fattyacids misc Dermatology
topic_unstemmed	misc RL1-803 misc atopicdermatitis misc maintenancetreatment misc emollients misc skinbarrier misc licochalconeA misc omega-6fattyacids misc Dermatology
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title	Stand-alone Emollient Treatment Reduces Flares After Discontinuation of Topical Steroid Treatment in Atopic Dermatitis: A Double-blind, Randomized, Vehicle-controlled, Left-right Comparison Study
ctrlnum	(DE-627)DOAJ061072761 (DE-599)DOAJ96ca1b1a951e42d3816e884654276cf2
title_full	Stand-alone Emollient Treatment Reduces Flares After Discontinuation of Topical Steroid Treatment in Atopic Dermatitis: A Double-blind, Randomized, Vehicle-controlled, Left-right Comparison Study
author_sort	Irena Angelova-Fischer
journal	Acta Dermato-Venereologica
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author_browse	Irena Angelova-Fischer Frank Rippke Daniel Richter Alexander Filbry Craig Arrowitz Teresa Weber Tobias W. Fischer Detlef Zillikens
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class	RL1-803
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author-letter	Irena Angelova-Fischer
doi_str_mv	10.2340/00015555-2882
author2-role	verfasserin
title_sort	stand-alone emollient treatment reduces flares after discontinuation of topical steroid treatment in atopic dermatitis: a double-blind, randomized, vehicle-controlled, left-right comparison study
callnumber	RL1-803
title_auth	Stand-alone Emollient Treatment Reduces Flares After Discontinuation of Topical Steroid Treatment in Atopic Dermatitis: A Double-blind, Randomized, Vehicle-controlled, Left-right Comparison Study
abstract	Prevention of the flares is a main goal in the long-term treatment of atopic dermatitis (AD). Therefore we investigated the efficacy of a water-in-oil emollient, containing licochalcone A, omega-6-fatty acids, ceramide 3 and glycerol, for prevention of the flares in adults with mild to moderately severe AD, treated with topical steroids, that led to clearing of the inflammatory lesions and had been discontinued prior to inclusion. The study was a 12-week, double-blind, randomized, vehicle-controlled, left-right comparison test with the number of relapses, defined as re-occurrence of erythema for at least 3 consecutive days, considered the primary outcome. Compared with the vehicle, the active formulation significantly reduced the number of relapses and maintained the barrier homeostasis of the respective arm. To the best of knowledge, this is the first study to show prevention of the AD flares by the use of stand-alone emollient treatment, based on comparison with the corresponding vehicle while excluding concomitant/rescue medications.
abstractGer	Prevention of the flares is a main goal in the long-term treatment of atopic dermatitis (AD). Therefore we investigated the efficacy of a water-in-oil emollient, containing licochalcone A, omega-6-fatty acids, ceramide 3 and glycerol, for prevention of the flares in adults with mild to moderately severe AD, treated with topical steroids, that led to clearing of the inflammatory lesions and had been discontinued prior to inclusion. The study was a 12-week, double-blind, randomized, vehicle-controlled, left-right comparison test with the number of relapses, defined as re-occurrence of erythema for at least 3 consecutive days, considered the primary outcome. Compared with the vehicle, the active formulation significantly reduced the number of relapses and maintained the barrier homeostasis of the respective arm. To the best of knowledge, this is the first study to show prevention of the AD flares by the use of stand-alone emollient treatment, based on comparison with the corresponding vehicle while excluding concomitant/rescue medications.
abstract_unstemmed	Prevention of the flares is a main goal in the long-term treatment of atopic dermatitis (AD). Therefore we investigated the efficacy of a water-in-oil emollient, containing licochalcone A, omega-6-fatty acids, ceramide 3 and glycerol, for prevention of the flares in adults with mild to moderately severe AD, treated with topical steroids, that led to clearing of the inflammatory lesions and had been discontinued prior to inclusion. The study was a 12-week, double-blind, randomized, vehicle-controlled, left-right comparison test with the number of relapses, defined as re-occurrence of erythema for at least 3 consecutive days, considered the primary outcome. Compared with the vehicle, the active formulation significantly reduced the number of relapses and maintained the barrier homeostasis of the respective arm. To the best of knowledge, this is the first study to show prevention of the AD flares by the use of stand-alone emollient treatment, based on comparison with the corresponding vehicle while excluding concomitant/rescue medications.
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container_issue	5
title_short	Stand-alone Emollient Treatment Reduces Flares After Discontinuation of Topical Steroid Treatment in Atopic Dermatitis: A Double-blind, Randomized, Vehicle-controlled, Left-right Comparison Study
url	https://doi.org/10.2340/00015555-2882 https://doaj.org/article/96ca1b1a951e42d3816e884654276cf2 https://www.medicaljournals.se/acta/content/html/10.2340/00015555-2882 https://doaj.org/toc/0001-5555 https://doaj.org/toc/1651-2057
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author2	Frank Rippke Daniel Richter Alexander Filbry Craig Arrowitz Teresa Weber Tobias W. Fischer Detlef Zillikens
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up_date	2024-07-03T18:40:40.633Z
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Stand-alone Emollient Treatment Reduces Flares After Discontinuation of Topical Steroid Treatment in Atopic Dermatitis: A Double-blind, Randomized, Vehicle-controlled, Left-right Comparison Study

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