Pro-metastatic collagen lysyl hydroxylase dimer assemblies stabilized by Fe2+-binding

Collagen lysyl hydroxylases promote cancer progression. Here the authors present the crystal structure of the lysyl hydroxylase domain of L230 from Acanthamoeba polyphaga mimivirus, which is of interest for LH inhibitor development, and show that ectopic expression of L230 in tumors promotes collage...
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Autor*in:	Hou-Fu Guo [verfasserIn] Chi-Lin Tsai [verfasserIn] Masahiko Terajima [verfasserIn] Xiaochao Tan [verfasserIn] Priyam Banerjee [verfasserIn] Mitchell D. Miller [verfasserIn] Xin Liu [verfasserIn] Jiang Yu [verfasserIn] Jovita Byemerwa [verfasserIn] Sarah Alvarado [verfasserIn] Tamer S. Kaoud [verfasserIn] Kevin N. Dalby [verfasserIn] Neus Bota-Rabassedas [verfasserIn] Yulong Chen [verfasserIn] Mitsuo Yamauchi [verfasserIn] John A. Tainer [verfasserIn] George N. Phillips [verfasserIn] Jonathan M. Kurie [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2018

Übergeordnetes Werk:	In: Nature Communications - Nature Portfolio, 2016, 9(2018), 1, Seite 9
Übergeordnetes Werk:	volume:9 ; year:2018 ; number:1 ; pages:9

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1038/s41467-018-02859-z

Katalog-ID:	DOAJ061125180

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Indexfelder

author_variant	h f g hfg c l t clt m t mt x t xt p b pb m d m mdm x l xl j y jy j b jb s a sa t s k tsk k n d knd n b r nbr y c yc m y my j a t jat g n p gnp j m k jmk
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allfields	10.1038/s41467-018-02859-z doi (DE-627)DOAJ061125180 (DE-599)DOAJ66b3577e6b604e7983c92825500bf879 DE-627 ger DE-627 rakwb eng Hou-Fu Guo verfasserin aut Pro-metastatic collagen lysyl hydroxylase dimer assemblies stabilized by Fe2+-binding 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Collagen lysyl hydroxylases promote cancer progression. Here the authors present the crystal structure of the lysyl hydroxylase domain of L230 from Acanthamoeba polyphaga mimivirus, which is of interest for LH inhibitor development, and show that ectopic expression of L230 in tumors promotes collagen cross-linking and metastasis. Science Q Chi-Lin Tsai verfasserin aut Masahiko Terajima verfasserin aut Xiaochao Tan verfasserin aut Priyam Banerjee verfasserin aut Mitchell D. Miller verfasserin aut Xin Liu verfasserin aut Jiang Yu verfasserin aut Jovita Byemerwa verfasserin aut Sarah Alvarado verfasserin aut Tamer S. Kaoud verfasserin aut Kevin N. Dalby verfasserin aut Neus Bota-Rabassedas verfasserin aut Yulong Chen verfasserin aut Mitsuo Yamauchi verfasserin aut John A. Tainer verfasserin aut George N. Phillips verfasserin aut Jonathan M. Kurie verfasserin aut In Nature Communications Nature Portfolio, 2016 9(2018), 1, Seite 9 (DE-627)626457688 (DE-600)2553671-0 20411723 nnns volume:9 year:2018 number:1 pages:9 https://doi.org/10.1038/s41467-018-02859-z kostenfrei https://doaj.org/article/66b3577e6b604e7983c92825500bf879 kostenfrei https://doi.org/10.1038/s41467-018-02859-z kostenfrei https://doaj.org/toc/2041-1723 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_211 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2110 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2018 1 9
spelling	10.1038/s41467-018-02859-z doi (DE-627)DOAJ061125180 (DE-599)DOAJ66b3577e6b604e7983c92825500bf879 DE-627 ger DE-627 rakwb eng Hou-Fu Guo verfasserin aut Pro-metastatic collagen lysyl hydroxylase dimer assemblies stabilized by Fe2+-binding 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Collagen lysyl hydroxylases promote cancer progression. Here the authors present the crystal structure of the lysyl hydroxylase domain of L230 from Acanthamoeba polyphaga mimivirus, which is of interest for LH inhibitor development, and show that ectopic expression of L230 in tumors promotes collagen cross-linking and metastasis. Science Q Chi-Lin Tsai verfasserin aut Masahiko Terajima verfasserin aut Xiaochao Tan verfasserin aut Priyam Banerjee verfasserin aut Mitchell D. Miller verfasserin aut Xin Liu verfasserin aut Jiang Yu verfasserin aut Jovita Byemerwa verfasserin aut Sarah Alvarado verfasserin aut Tamer S. Kaoud verfasserin aut Kevin N. Dalby verfasserin aut Neus Bota-Rabassedas verfasserin aut Yulong Chen verfasserin aut Mitsuo Yamauchi verfasserin aut John A. Tainer verfasserin aut George N. Phillips verfasserin aut Jonathan M. Kurie verfasserin aut In Nature Communications Nature Portfolio, 2016 9(2018), 1, Seite 9 (DE-627)626457688 (DE-600)2553671-0 20411723 nnns volume:9 year:2018 number:1 pages:9 https://doi.org/10.1038/s41467-018-02859-z kostenfrei https://doaj.org/article/66b3577e6b604e7983c92825500bf879 kostenfrei https://doi.org/10.1038/s41467-018-02859-z kostenfrei https://doaj.org/toc/2041-1723 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_211 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2110 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2018 1 9
allfields_unstemmed	10.1038/s41467-018-02859-z doi (DE-627)DOAJ061125180 (DE-599)DOAJ66b3577e6b604e7983c92825500bf879 DE-627 ger DE-627 rakwb eng Hou-Fu Guo verfasserin aut Pro-metastatic collagen lysyl hydroxylase dimer assemblies stabilized by Fe2+-binding 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Collagen lysyl hydroxylases promote cancer progression. Here the authors present the crystal structure of the lysyl hydroxylase domain of L230 from Acanthamoeba polyphaga mimivirus, which is of interest for LH inhibitor development, and show that ectopic expression of L230 in tumors promotes collagen cross-linking and metastasis. Science Q Chi-Lin Tsai verfasserin aut Masahiko Terajima verfasserin aut Xiaochao Tan verfasserin aut Priyam Banerjee verfasserin aut Mitchell D. Miller verfasserin aut Xin Liu verfasserin aut Jiang Yu verfasserin aut Jovita Byemerwa verfasserin aut Sarah Alvarado verfasserin aut Tamer S. Kaoud verfasserin aut Kevin N. Dalby verfasserin aut Neus Bota-Rabassedas verfasserin aut Yulong Chen verfasserin aut Mitsuo Yamauchi verfasserin aut John A. Tainer verfasserin aut George N. Phillips verfasserin aut Jonathan M. Kurie verfasserin aut In Nature Communications Nature Portfolio, 2016 9(2018), 1, Seite 9 (DE-627)626457688 (DE-600)2553671-0 20411723 nnns volume:9 year:2018 number:1 pages:9 https://doi.org/10.1038/s41467-018-02859-z kostenfrei https://doaj.org/article/66b3577e6b604e7983c92825500bf879 kostenfrei https://doi.org/10.1038/s41467-018-02859-z kostenfrei https://doaj.org/toc/2041-1723 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_211 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2110 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2018 1 9
allfieldsGer	10.1038/s41467-018-02859-z doi (DE-627)DOAJ061125180 (DE-599)DOAJ66b3577e6b604e7983c92825500bf879 DE-627 ger DE-627 rakwb eng Hou-Fu Guo verfasserin aut Pro-metastatic collagen lysyl hydroxylase dimer assemblies stabilized by Fe2+-binding 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Collagen lysyl hydroxylases promote cancer progression. Here the authors present the crystal structure of the lysyl hydroxylase domain of L230 from Acanthamoeba polyphaga mimivirus, which is of interest for LH inhibitor development, and show that ectopic expression of L230 in tumors promotes collagen cross-linking and metastasis. Science Q Chi-Lin Tsai verfasserin aut Masahiko Terajima verfasserin aut Xiaochao Tan verfasserin aut Priyam Banerjee verfasserin aut Mitchell D. Miller verfasserin aut Xin Liu verfasserin aut Jiang Yu verfasserin aut Jovita Byemerwa verfasserin aut Sarah Alvarado verfasserin aut Tamer S. Kaoud verfasserin aut Kevin N. Dalby verfasserin aut Neus Bota-Rabassedas verfasserin aut Yulong Chen verfasserin aut Mitsuo Yamauchi verfasserin aut John A. Tainer verfasserin aut George N. Phillips verfasserin aut Jonathan M. Kurie verfasserin aut In Nature Communications Nature Portfolio, 2016 9(2018), 1, Seite 9 (DE-627)626457688 (DE-600)2553671-0 20411723 nnns volume:9 year:2018 number:1 pages:9 https://doi.org/10.1038/s41467-018-02859-z kostenfrei https://doaj.org/article/66b3577e6b604e7983c92825500bf879 kostenfrei https://doi.org/10.1038/s41467-018-02859-z kostenfrei https://doaj.org/toc/2041-1723 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_211 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2110 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2018 1 9
allfieldsSound	10.1038/s41467-018-02859-z doi (DE-627)DOAJ061125180 (DE-599)DOAJ66b3577e6b604e7983c92825500bf879 DE-627 ger DE-627 rakwb eng Hou-Fu Guo verfasserin aut Pro-metastatic collagen lysyl hydroxylase dimer assemblies stabilized by Fe2+-binding 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Collagen lysyl hydroxylases promote cancer progression. Here the authors present the crystal structure of the lysyl hydroxylase domain of L230 from Acanthamoeba polyphaga mimivirus, which is of interest for LH inhibitor development, and show that ectopic expression of L230 in tumors promotes collagen cross-linking and metastasis. Science Q Chi-Lin Tsai verfasserin aut Masahiko Terajima verfasserin aut Xiaochao Tan verfasserin aut Priyam Banerjee verfasserin aut Mitchell D. Miller verfasserin aut Xin Liu verfasserin aut Jiang Yu verfasserin aut Jovita Byemerwa verfasserin aut Sarah Alvarado verfasserin aut Tamer S. Kaoud verfasserin aut Kevin N. Dalby verfasserin aut Neus Bota-Rabassedas verfasserin aut Yulong Chen verfasserin aut Mitsuo Yamauchi verfasserin aut John A. Tainer verfasserin aut George N. Phillips verfasserin aut Jonathan M. Kurie verfasserin aut In Nature Communications Nature Portfolio, 2016 9(2018), 1, Seite 9 (DE-627)626457688 (DE-600)2553671-0 20411723 nnns volume:9 year:2018 number:1 pages:9 https://doi.org/10.1038/s41467-018-02859-z kostenfrei https://doaj.org/article/66b3577e6b604e7983c92825500bf879 kostenfrei https://doi.org/10.1038/s41467-018-02859-z kostenfrei https://doaj.org/toc/2041-1723 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_211 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2110 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2018 1 9
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authorswithroles_txt_mv	Hou-Fu Guo @@aut@@ Chi-Lin Tsai @@aut@@ Masahiko Terajima @@aut@@ Xiaochao Tan @@aut@@ Priyam Banerjee @@aut@@ Mitchell D. Miller @@aut@@ Xin Liu @@aut@@ Jiang Yu @@aut@@ Jovita Byemerwa @@aut@@ Sarah Alvarado @@aut@@ Tamer S. Kaoud @@aut@@ Kevin N. Dalby @@aut@@ Neus Bota-Rabassedas @@aut@@ Yulong Chen @@aut@@ Mitsuo Yamauchi @@aut@@ John A. Tainer @@aut@@ George N. Phillips @@aut@@ Jonathan M. Kurie @@aut@@
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author	Hou-Fu Guo
spellingShingle	Hou-Fu Guo misc Science misc Q Pro-metastatic collagen lysyl hydroxylase dimer assemblies stabilized by Fe2+-binding
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topic_title	Pro-metastatic collagen lysyl hydroxylase dimer assemblies stabilized by Fe2+-binding
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title	Pro-metastatic collagen lysyl hydroxylase dimer assemblies stabilized by Fe2+-binding
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title_full	Pro-metastatic collagen lysyl hydroxylase dimer assemblies stabilized by Fe2+-binding
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author_browse	Hou-Fu Guo Chi-Lin Tsai Masahiko Terajima Xiaochao Tan Priyam Banerjee Mitchell D. Miller Xin Liu Jiang Yu Jovita Byemerwa Sarah Alvarado Tamer S. Kaoud Kevin N. Dalby Neus Bota-Rabassedas Yulong Chen Mitsuo Yamauchi John A. Tainer George N. Phillips Jonathan M. Kurie
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title_sort	pro-metastatic collagen lysyl hydroxylase dimer assemblies stabilized by fe2+-binding
title_auth	Pro-metastatic collagen lysyl hydroxylase dimer assemblies stabilized by Fe2+-binding
abstract	Collagen lysyl hydroxylases promote cancer progression. Here the authors present the crystal structure of the lysyl hydroxylase domain of L230 from Acanthamoeba polyphaga mimivirus, which is of interest for LH inhibitor development, and show that ectopic expression of L230 in tumors promotes collagen cross-linking and metastasis.
abstractGer	Collagen lysyl hydroxylases promote cancer progression. Here the authors present the crystal structure of the lysyl hydroxylase domain of L230 from Acanthamoeba polyphaga mimivirus, which is of interest for LH inhibitor development, and show that ectopic expression of L230 in tumors promotes collagen cross-linking and metastasis.
abstract_unstemmed	Collagen lysyl hydroxylases promote cancer progression. Here the authors present the crystal structure of the lysyl hydroxylase domain of L230 from Acanthamoeba polyphaga mimivirus, which is of interest for LH inhibitor development, and show that ectopic expression of L230 in tumors promotes collagen cross-linking and metastasis.
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title_short	Pro-metastatic collagen lysyl hydroxylase dimer assemblies stabilized by Fe2+-binding
url	https://doi.org/10.1038/s41467-018-02859-z https://doaj.org/article/66b3577e6b604e7983c92825500bf879 https://doaj.org/toc/2041-1723
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