Lactoferrin-induced growth factors and cytokines expression profile in pre-osteoblast MC3T3-E1 cell and LRP1 stable knockdown MC3T3-E1 cell
Lactoferrin (LF) has been reported to exert beneficial effects on bone health, however, the underlying mechanisms are still not fully understood. Here, we used antibody array to explore the growth factors and cytokines secretion profile in LF-stimulated MC3T3-E1 cell as well as low-density lipoprote...
Ausführliche Beschreibung
Autor*in: |
Wei Zhang [verfasserIn] Hongyan Wu [verfasserIn] Yixuan Li [verfasserIn] Fazheng Ren [verfasserIn] Huiyuan Guo [verfasserIn] |
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Format: |
E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2017 |
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Schlagwörter: |
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Übergeordnetes Werk: |
In: Journal of Functional Foods - Elsevier, 2021, 37(2017), Seite 147-156 |
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Übergeordnetes Werk: |
volume:37 ; year:2017 ; pages:147-156 |
Links: |
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DOI / URN: |
10.1016/j.jff.2017.07.023 |
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Katalog-ID: |
DOAJ061138371 |
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10.1016/j.jff.2017.07.023 doi (DE-627)DOAJ061138371 (DE-599)DOAJ8cb0faac2089472285843cce31cabcd3 DE-627 ger DE-627 rakwb eng TX341-641 Wei Zhang verfasserin aut Lactoferrin-induced growth factors and cytokines expression profile in pre-osteoblast MC3T3-E1 cell and LRP1 stable knockdown MC3T3-E1 cell 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Lactoferrin (LF) has been reported to exert beneficial effects on bone health, however, the underlying mechanisms are still not fully understood. Here, we used antibody array to explore the growth factors and cytokines secretion profile in LF-stimulated MC3T3-E1 cell as well as low-density lipoprotein receptor related protein 1 (LRP1) stable knockdown cell. We detected 83 growth factors and cytokines secreted by LF-treated osteoblast, and the levels of Thrombospondin-2 (THBS-2), Interleukin-6 (IL-6), Fibroblast growth factor-basic (FGF-basic), Cysteine-rich angiogenic inducer 61 (Cyr61), Serine protease inhibitor (Serpin) E1, Monocyte chemotactic protein 1 (MCP-1) and Platelet-derived growth factor AA (PDGF-AA) were up-regulated while the Serpin F1 was down-regulated. LF receptor LRP1 only partially involved in LF’s effect on THBS-2 and FGF-basic. This study will contribute to a more comprehensive understanding of the mechanisms by which LF exert beneficial effects on bone cells through the orchestration of cytokines and growth factors network. Lactoferrin Osteoblast Differentiation LRP1 Growth factors Cytokines Nutrition. Foods and food supply Hongyan Wu verfasserin aut Yixuan Li verfasserin aut Fazheng Ren verfasserin aut Huiyuan Guo verfasserin aut In Journal of Functional Foods Elsevier, 2021 37(2017), Seite 147-156 (DE-627)587138432 (DE-600)2467241-5 22149414 nnns volume:37 year:2017 pages:147-156 https://doi.org/10.1016/j.jff.2017.07.023 kostenfrei https://doaj.org/article/8cb0faac2089472285843cce31cabcd3 kostenfrei http://www.sciencedirect.com/science/article/pii/S1756464617304115 kostenfrei https://doaj.org/toc/1756-4646 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_165 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2098 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 37 2017 147-156 |
spelling |
10.1016/j.jff.2017.07.023 doi (DE-627)DOAJ061138371 (DE-599)DOAJ8cb0faac2089472285843cce31cabcd3 DE-627 ger DE-627 rakwb eng TX341-641 Wei Zhang verfasserin aut Lactoferrin-induced growth factors and cytokines expression profile in pre-osteoblast MC3T3-E1 cell and LRP1 stable knockdown MC3T3-E1 cell 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Lactoferrin (LF) has been reported to exert beneficial effects on bone health, however, the underlying mechanisms are still not fully understood. Here, we used antibody array to explore the growth factors and cytokines secretion profile in LF-stimulated MC3T3-E1 cell as well as low-density lipoprotein receptor related protein 1 (LRP1) stable knockdown cell. We detected 83 growth factors and cytokines secreted by LF-treated osteoblast, and the levels of Thrombospondin-2 (THBS-2), Interleukin-6 (IL-6), Fibroblast growth factor-basic (FGF-basic), Cysteine-rich angiogenic inducer 61 (Cyr61), Serine protease inhibitor (Serpin) E1, Monocyte chemotactic protein 1 (MCP-1) and Platelet-derived growth factor AA (PDGF-AA) were up-regulated while the Serpin F1 was down-regulated. LF receptor LRP1 only partially involved in LF’s effect on THBS-2 and FGF-basic. This study will contribute to a more comprehensive understanding of the mechanisms by which LF exert beneficial effects on bone cells through the orchestration of cytokines and growth factors network. Lactoferrin Osteoblast Differentiation LRP1 Growth factors Cytokines Nutrition. Foods and food supply Hongyan Wu verfasserin aut Yixuan Li verfasserin aut Fazheng Ren verfasserin aut Huiyuan Guo verfasserin aut In Journal of Functional Foods Elsevier, 2021 37(2017), Seite 147-156 (DE-627)587138432 (DE-600)2467241-5 22149414 nnns volume:37 year:2017 pages:147-156 https://doi.org/10.1016/j.jff.2017.07.023 kostenfrei https://doaj.org/article/8cb0faac2089472285843cce31cabcd3 kostenfrei http://www.sciencedirect.com/science/article/pii/S1756464617304115 kostenfrei https://doaj.org/toc/1756-4646 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_165 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2098 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 37 2017 147-156 |
allfields_unstemmed |
10.1016/j.jff.2017.07.023 doi (DE-627)DOAJ061138371 (DE-599)DOAJ8cb0faac2089472285843cce31cabcd3 DE-627 ger DE-627 rakwb eng TX341-641 Wei Zhang verfasserin aut Lactoferrin-induced growth factors and cytokines expression profile in pre-osteoblast MC3T3-E1 cell and LRP1 stable knockdown MC3T3-E1 cell 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Lactoferrin (LF) has been reported to exert beneficial effects on bone health, however, the underlying mechanisms are still not fully understood. Here, we used antibody array to explore the growth factors and cytokines secretion profile in LF-stimulated MC3T3-E1 cell as well as low-density lipoprotein receptor related protein 1 (LRP1) stable knockdown cell. We detected 83 growth factors and cytokines secreted by LF-treated osteoblast, and the levels of Thrombospondin-2 (THBS-2), Interleukin-6 (IL-6), Fibroblast growth factor-basic (FGF-basic), Cysteine-rich angiogenic inducer 61 (Cyr61), Serine protease inhibitor (Serpin) E1, Monocyte chemotactic protein 1 (MCP-1) and Platelet-derived growth factor AA (PDGF-AA) were up-regulated while the Serpin F1 was down-regulated. LF receptor LRP1 only partially involved in LF’s effect on THBS-2 and FGF-basic. This study will contribute to a more comprehensive understanding of the mechanisms by which LF exert beneficial effects on bone cells through the orchestration of cytokines and growth factors network. Lactoferrin Osteoblast Differentiation LRP1 Growth factors Cytokines Nutrition. Foods and food supply Hongyan Wu verfasserin aut Yixuan Li verfasserin aut Fazheng Ren verfasserin aut Huiyuan Guo verfasserin aut In Journal of Functional Foods Elsevier, 2021 37(2017), Seite 147-156 (DE-627)587138432 (DE-600)2467241-5 22149414 nnns volume:37 year:2017 pages:147-156 https://doi.org/10.1016/j.jff.2017.07.023 kostenfrei https://doaj.org/article/8cb0faac2089472285843cce31cabcd3 kostenfrei http://www.sciencedirect.com/science/article/pii/S1756464617304115 kostenfrei https://doaj.org/toc/1756-4646 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_165 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2098 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 37 2017 147-156 |
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T - Technology |
author |
Wei Zhang |
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Wei Zhang misc TX341-641 misc Lactoferrin misc Osteoblast misc Differentiation misc LRP1 misc Growth factors misc Cytokines misc Nutrition. Foods and food supply Lactoferrin-induced growth factors and cytokines expression profile in pre-osteoblast MC3T3-E1 cell and LRP1 stable knockdown MC3T3-E1 cell |
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TX341-641 Lactoferrin-induced growth factors and cytokines expression profile in pre-osteoblast MC3T3-E1 cell and LRP1 stable knockdown MC3T3-E1 cell Lactoferrin Osteoblast Differentiation LRP1 Growth factors Cytokines |
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misc TX341-641 misc Lactoferrin misc Osteoblast misc Differentiation misc LRP1 misc Growth factors misc Cytokines misc Nutrition. Foods and food supply |
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Lactoferrin-induced growth factors and cytokines expression profile in pre-osteoblast MC3T3-E1 cell and LRP1 stable knockdown MC3T3-E1 cell |
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Lactoferrin-induced growth factors and cytokines expression profile in pre-osteoblast MC3T3-E1 cell and LRP1 stable knockdown MC3T3-E1 cell |
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Wei Zhang Hongyan Wu Yixuan Li Fazheng Ren Huiyuan Guo |
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lactoferrin-induced growth factors and cytokines expression profile in pre-osteoblast mc3t3-e1 cell and lrp1 stable knockdown mc3t3-e1 cell |
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Lactoferrin-induced growth factors and cytokines expression profile in pre-osteoblast MC3T3-E1 cell and LRP1 stable knockdown MC3T3-E1 cell |
abstract |
Lactoferrin (LF) has been reported to exert beneficial effects on bone health, however, the underlying mechanisms are still not fully understood. Here, we used antibody array to explore the growth factors and cytokines secretion profile in LF-stimulated MC3T3-E1 cell as well as low-density lipoprotein receptor related protein 1 (LRP1) stable knockdown cell. We detected 83 growth factors and cytokines secreted by LF-treated osteoblast, and the levels of Thrombospondin-2 (THBS-2), Interleukin-6 (IL-6), Fibroblast growth factor-basic (FGF-basic), Cysteine-rich angiogenic inducer 61 (Cyr61), Serine protease inhibitor (Serpin) E1, Monocyte chemotactic protein 1 (MCP-1) and Platelet-derived growth factor AA (PDGF-AA) were up-regulated while the Serpin F1 was down-regulated. LF receptor LRP1 only partially involved in LF’s effect on THBS-2 and FGF-basic. This study will contribute to a more comprehensive understanding of the mechanisms by which LF exert beneficial effects on bone cells through the orchestration of cytokines and growth factors network. |
abstractGer |
Lactoferrin (LF) has been reported to exert beneficial effects on bone health, however, the underlying mechanisms are still not fully understood. Here, we used antibody array to explore the growth factors and cytokines secretion profile in LF-stimulated MC3T3-E1 cell as well as low-density lipoprotein receptor related protein 1 (LRP1) stable knockdown cell. We detected 83 growth factors and cytokines secreted by LF-treated osteoblast, and the levels of Thrombospondin-2 (THBS-2), Interleukin-6 (IL-6), Fibroblast growth factor-basic (FGF-basic), Cysteine-rich angiogenic inducer 61 (Cyr61), Serine protease inhibitor (Serpin) E1, Monocyte chemotactic protein 1 (MCP-1) and Platelet-derived growth factor AA (PDGF-AA) were up-regulated while the Serpin F1 was down-regulated. LF receptor LRP1 only partially involved in LF’s effect on THBS-2 and FGF-basic. This study will contribute to a more comprehensive understanding of the mechanisms by which LF exert beneficial effects on bone cells through the orchestration of cytokines and growth factors network. |
abstract_unstemmed |
Lactoferrin (LF) has been reported to exert beneficial effects on bone health, however, the underlying mechanisms are still not fully understood. Here, we used antibody array to explore the growth factors and cytokines secretion profile in LF-stimulated MC3T3-E1 cell as well as low-density lipoprotein receptor related protein 1 (LRP1) stable knockdown cell. We detected 83 growth factors and cytokines secreted by LF-treated osteoblast, and the levels of Thrombospondin-2 (THBS-2), Interleukin-6 (IL-6), Fibroblast growth factor-basic (FGF-basic), Cysteine-rich angiogenic inducer 61 (Cyr61), Serine protease inhibitor (Serpin) E1, Monocyte chemotactic protein 1 (MCP-1) and Platelet-derived growth factor AA (PDGF-AA) were up-regulated while the Serpin F1 was down-regulated. LF receptor LRP1 only partially involved in LF’s effect on THBS-2 and FGF-basic. This study will contribute to a more comprehensive understanding of the mechanisms by which LF exert beneficial effects on bone cells through the orchestration of cytokines and growth factors network. |
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title_short |
Lactoferrin-induced growth factors and cytokines expression profile in pre-osteoblast MC3T3-E1 cell and LRP1 stable knockdown MC3T3-E1 cell |
url |
https://doi.org/10.1016/j.jff.2017.07.023 https://doaj.org/article/8cb0faac2089472285843cce31cabcd3 http://www.sciencedirect.com/science/article/pii/S1756464617304115 https://doaj.org/toc/1756-4646 |
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