Diatomaceous earth/zinc oxide micro-composite assisted antibiotics in fungal therapy

Abstract As the second wave of COVID-19 hits South Asia, an increasing deadly complication ‘fungal infections (such as Mycosis, Candida and Aspergillus) outbreak’ has been raised concern about the insufficient technologies and medicals for its diagnosis and therapy. Biosilica based nano-therapy can...
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Autor*in:	Huifang Liu [verfasserIn] Zhen Qiao [verfasserIn] Yoon Ok Jang [verfasserIn] Myoung Gyu Kim [verfasserIn] Qingshuang Zou [verfasserIn] Hyo Joo Lee [verfasserIn] Bonhan Koo [verfasserIn] Sung-Han Kim [verfasserIn] Kyusik Yun [verfasserIn] Hyun-Soo Kim [verfasserIn] Yong Shin [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	Antifungal therapy Antibiotic efficacy Persistent therapy Synergistic effect Biocompatibility

Übergeordnetes Werk:	In: Nano Convergence - SpringerOpen, 2015, 8(2021), 1, Seite 14
Übergeordnetes Werk:	volume:8 ; year:2021 ; number:1 ; pages:14

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1186/s40580-021-00283-6

Katalog-ID:	DOAJ06114536X

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allfields	10.1186/s40580-021-00283-6 doi (DE-627)DOAJ06114536X (DE-599)DOAJ3be50e34f7164f529ef02edce60a9f9a DE-627 ger DE-627 rakwb eng TP1-1185 TP248.13-248.65 QC1-999 Huifang Liu verfasserin aut Diatomaceous earth/zinc oxide micro-composite assisted antibiotics in fungal therapy 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract As the second wave of COVID-19 hits South Asia, an increasing deadly complication ‘fungal infections (such as Mycosis, Candida and Aspergillus) outbreak’ has been raised concern about the insufficient technologies and medicals for its diagnosis and therapy. Biosilica based nano-therapy can be used for therapeutic efficacy, yet their direct role as antibiotic agent with biocompatibility and stability remains unclear. Here, we report that a diatomaceous earth (DE) framework semiconductor composite conjugated DE and in-house synthesized zinc oxide (DE-ZnO), as an antibiotic agent for the enhancement of antibiotic efficacy and persistence. We found that the DE-ZnO composite had enhanced antibiotic activity against fungi (A. fumigatus) and Gram-negative bacteria (E. coli, S. enterica). The DE-ZnO composite provides enhancing large surface areas for enhancement of target pathogen binding affinity, as well as produces active ions including reactive oxygen species and metal ion for breaking the cellular network of fungi and Gram-negative bacteria. Additionally, the toxicity of DE-ZnO with 3 time less amount of dosage is 6 times lower than the commercial SiO2-ZnO. Finally, a synergistic effect of DE-ZnO and existing antifungal agents (Itraconazole and Amphotericin B) showed a better antifungal activity, which could be reduced the side effects due to the antifungal agents overdose, than a single antibiotic agent use. We envision that this DE-ZnO composite can be used to enhance antibiotic activity and its persistence, with less-toxicity, biocompatibility and high stability against fungi and Gram-negative bacteria which could be a valuable candidate in medical science and industrial engineering. Antifungal therapy Antibiotic efficacy Persistent therapy Synergistic effect Biocompatibility Technology T Chemical technology Biotechnology Science Q Physics Zhen Qiao verfasserin aut Yoon Ok Jang verfasserin aut Myoung Gyu Kim verfasserin aut Qingshuang Zou verfasserin aut Hyo Joo Lee verfasserin aut Bonhan Koo verfasserin aut Sung-Han Kim verfasserin aut Kyusik Yun verfasserin aut Hyun-Soo Kim verfasserin aut Yong Shin verfasserin aut In Nano Convergence SpringerOpen, 2015 8(2021), 1, Seite 14 (DE-627)780378938 (DE-600)2760386-6 21965404 nnns volume:8 year:2021 number:1 pages:14 https://doi.org/10.1186/s40580-021-00283-6 kostenfrei https://doaj.org/article/3be50e34f7164f529ef02edce60a9f9a kostenfrei https://doi.org/10.1186/s40580-021-00283-6 kostenfrei https://doaj.org/toc/2196-5404 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2021 1 14
spelling	10.1186/s40580-021-00283-6 doi (DE-627)DOAJ06114536X (DE-599)DOAJ3be50e34f7164f529ef02edce60a9f9a DE-627 ger DE-627 rakwb eng TP1-1185 TP248.13-248.65 QC1-999 Huifang Liu verfasserin aut Diatomaceous earth/zinc oxide micro-composite assisted antibiotics in fungal therapy 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract As the second wave of COVID-19 hits South Asia, an increasing deadly complication ‘fungal infections (such as Mycosis, Candida and Aspergillus) outbreak’ has been raised concern about the insufficient technologies and medicals for its diagnosis and therapy. Biosilica based nano-therapy can be used for therapeutic efficacy, yet their direct role as antibiotic agent with biocompatibility and stability remains unclear. Here, we report that a diatomaceous earth (DE) framework semiconductor composite conjugated DE and in-house synthesized zinc oxide (DE-ZnO), as an antibiotic agent for the enhancement of antibiotic efficacy and persistence. We found that the DE-ZnO composite had enhanced antibiotic activity against fungi (A. fumigatus) and Gram-negative bacteria (E. coli, S. enterica). The DE-ZnO composite provides enhancing large surface areas for enhancement of target pathogen binding affinity, as well as produces active ions including reactive oxygen species and metal ion for breaking the cellular network of fungi and Gram-negative bacteria. Additionally, the toxicity of DE-ZnO with 3 time less amount of dosage is 6 times lower than the commercial SiO2-ZnO. Finally, a synergistic effect of DE-ZnO and existing antifungal agents (Itraconazole and Amphotericin B) showed a better antifungal activity, which could be reduced the side effects due to the antifungal agents overdose, than a single antibiotic agent use. We envision that this DE-ZnO composite can be used to enhance antibiotic activity and its persistence, with less-toxicity, biocompatibility and high stability against fungi and Gram-negative bacteria which could be a valuable candidate in medical science and industrial engineering. Antifungal therapy Antibiotic efficacy Persistent therapy Synergistic effect Biocompatibility Technology T Chemical technology Biotechnology Science Q Physics Zhen Qiao verfasserin aut Yoon Ok Jang verfasserin aut Myoung Gyu Kim verfasserin aut Qingshuang Zou verfasserin aut Hyo Joo Lee verfasserin aut Bonhan Koo verfasserin aut Sung-Han Kim verfasserin aut Kyusik Yun verfasserin aut Hyun-Soo Kim verfasserin aut Yong Shin verfasserin aut In Nano Convergence SpringerOpen, 2015 8(2021), 1, Seite 14 (DE-627)780378938 (DE-600)2760386-6 21965404 nnns volume:8 year:2021 number:1 pages:14 https://doi.org/10.1186/s40580-021-00283-6 kostenfrei https://doaj.org/article/3be50e34f7164f529ef02edce60a9f9a kostenfrei https://doi.org/10.1186/s40580-021-00283-6 kostenfrei https://doaj.org/toc/2196-5404 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2021 1 14
allfields_unstemmed	10.1186/s40580-021-00283-6 doi (DE-627)DOAJ06114536X (DE-599)DOAJ3be50e34f7164f529ef02edce60a9f9a DE-627 ger DE-627 rakwb eng TP1-1185 TP248.13-248.65 QC1-999 Huifang Liu verfasserin aut Diatomaceous earth/zinc oxide micro-composite assisted antibiotics in fungal therapy 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract As the second wave of COVID-19 hits South Asia, an increasing deadly complication ‘fungal infections (such as Mycosis, Candida and Aspergillus) outbreak’ has been raised concern about the insufficient technologies and medicals for its diagnosis and therapy. Biosilica based nano-therapy can be used for therapeutic efficacy, yet their direct role as antibiotic agent with biocompatibility and stability remains unclear. Here, we report that a diatomaceous earth (DE) framework semiconductor composite conjugated DE and in-house synthesized zinc oxide (DE-ZnO), as an antibiotic agent for the enhancement of antibiotic efficacy and persistence. We found that the DE-ZnO composite had enhanced antibiotic activity against fungi (A. fumigatus) and Gram-negative bacteria (E. coli, S. enterica). The DE-ZnO composite provides enhancing large surface areas for enhancement of target pathogen binding affinity, as well as produces active ions including reactive oxygen species and metal ion for breaking the cellular network of fungi and Gram-negative bacteria. Additionally, the toxicity of DE-ZnO with 3 time less amount of dosage is 6 times lower than the commercial SiO2-ZnO. Finally, a synergistic effect of DE-ZnO and existing antifungal agents (Itraconazole and Amphotericin B) showed a better antifungal activity, which could be reduced the side effects due to the antifungal agents overdose, than a single antibiotic agent use. We envision that this DE-ZnO composite can be used to enhance antibiotic activity and its persistence, with less-toxicity, biocompatibility and high stability against fungi and Gram-negative bacteria which could be a valuable candidate in medical science and industrial engineering. Antifungal therapy Antibiotic efficacy Persistent therapy Synergistic effect Biocompatibility Technology T Chemical technology Biotechnology Science Q Physics Zhen Qiao verfasserin aut Yoon Ok Jang verfasserin aut Myoung Gyu Kim verfasserin aut Qingshuang Zou verfasserin aut Hyo Joo Lee verfasserin aut Bonhan Koo verfasserin aut Sung-Han Kim verfasserin aut Kyusik Yun verfasserin aut Hyun-Soo Kim verfasserin aut Yong Shin verfasserin aut In Nano Convergence SpringerOpen, 2015 8(2021), 1, Seite 14 (DE-627)780378938 (DE-600)2760386-6 21965404 nnns volume:8 year:2021 number:1 pages:14 https://doi.org/10.1186/s40580-021-00283-6 kostenfrei https://doaj.org/article/3be50e34f7164f529ef02edce60a9f9a kostenfrei https://doi.org/10.1186/s40580-021-00283-6 kostenfrei https://doaj.org/toc/2196-5404 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2021 1 14
allfieldsGer	10.1186/s40580-021-00283-6 doi (DE-627)DOAJ06114536X (DE-599)DOAJ3be50e34f7164f529ef02edce60a9f9a DE-627 ger DE-627 rakwb eng TP1-1185 TP248.13-248.65 QC1-999 Huifang Liu verfasserin aut Diatomaceous earth/zinc oxide micro-composite assisted antibiotics in fungal therapy 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract As the second wave of COVID-19 hits South Asia, an increasing deadly complication ‘fungal infections (such as Mycosis, Candida and Aspergillus) outbreak’ has been raised concern about the insufficient technologies and medicals for its diagnosis and therapy. Biosilica based nano-therapy can be used for therapeutic efficacy, yet their direct role as antibiotic agent with biocompatibility and stability remains unclear. Here, we report that a diatomaceous earth (DE) framework semiconductor composite conjugated DE and in-house synthesized zinc oxide (DE-ZnO), as an antibiotic agent for the enhancement of antibiotic efficacy and persistence. We found that the DE-ZnO composite had enhanced antibiotic activity against fungi (A. fumigatus) and Gram-negative bacteria (E. coli, S. enterica). The DE-ZnO composite provides enhancing large surface areas for enhancement of target pathogen binding affinity, as well as produces active ions including reactive oxygen species and metal ion for breaking the cellular network of fungi and Gram-negative bacteria. Additionally, the toxicity of DE-ZnO with 3 time less amount of dosage is 6 times lower than the commercial SiO2-ZnO. Finally, a synergistic effect of DE-ZnO and existing antifungal agents (Itraconazole and Amphotericin B) showed a better antifungal activity, which could be reduced the side effects due to the antifungal agents overdose, than a single antibiotic agent use. We envision that this DE-ZnO composite can be used to enhance antibiotic activity and its persistence, with less-toxicity, biocompatibility and high stability against fungi and Gram-negative bacteria which could be a valuable candidate in medical science and industrial engineering. Antifungal therapy Antibiotic efficacy Persistent therapy Synergistic effect Biocompatibility Technology T Chemical technology Biotechnology Science Q Physics Zhen Qiao verfasserin aut Yoon Ok Jang verfasserin aut Myoung Gyu Kim verfasserin aut Qingshuang Zou verfasserin aut Hyo Joo Lee verfasserin aut Bonhan Koo verfasserin aut Sung-Han Kim verfasserin aut Kyusik Yun verfasserin aut Hyun-Soo Kim verfasserin aut Yong Shin verfasserin aut In Nano Convergence SpringerOpen, 2015 8(2021), 1, Seite 14 (DE-627)780378938 (DE-600)2760386-6 21965404 nnns volume:8 year:2021 number:1 pages:14 https://doi.org/10.1186/s40580-021-00283-6 kostenfrei https://doaj.org/article/3be50e34f7164f529ef02edce60a9f9a kostenfrei https://doi.org/10.1186/s40580-021-00283-6 kostenfrei https://doaj.org/toc/2196-5404 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2021 1 14
allfieldsSound	10.1186/s40580-021-00283-6 doi (DE-627)DOAJ06114536X (DE-599)DOAJ3be50e34f7164f529ef02edce60a9f9a DE-627 ger DE-627 rakwb eng TP1-1185 TP248.13-248.65 QC1-999 Huifang Liu verfasserin aut Diatomaceous earth/zinc oxide micro-composite assisted antibiotics in fungal therapy 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract As the second wave of COVID-19 hits South Asia, an increasing deadly complication ‘fungal infections (such as Mycosis, Candida and Aspergillus) outbreak’ has been raised concern about the insufficient technologies and medicals for its diagnosis and therapy. Biosilica based nano-therapy can be used for therapeutic efficacy, yet their direct role as antibiotic agent with biocompatibility and stability remains unclear. Here, we report that a diatomaceous earth (DE) framework semiconductor composite conjugated DE and in-house synthesized zinc oxide (DE-ZnO), as an antibiotic agent for the enhancement of antibiotic efficacy and persistence. We found that the DE-ZnO composite had enhanced antibiotic activity against fungi (A. fumigatus) and Gram-negative bacteria (E. coli, S. enterica). The DE-ZnO composite provides enhancing large surface areas for enhancement of target pathogen binding affinity, as well as produces active ions including reactive oxygen species and metal ion for breaking the cellular network of fungi and Gram-negative bacteria. Additionally, the toxicity of DE-ZnO with 3 time less amount of dosage is 6 times lower than the commercial SiO2-ZnO. Finally, a synergistic effect of DE-ZnO and existing antifungal agents (Itraconazole and Amphotericin B) showed a better antifungal activity, which could be reduced the side effects due to the antifungal agents overdose, than a single antibiotic agent use. We envision that this DE-ZnO composite can be used to enhance antibiotic activity and its persistence, with less-toxicity, biocompatibility and high stability against fungi and Gram-negative bacteria which could be a valuable candidate in medical science and industrial engineering. Antifungal therapy Antibiotic efficacy Persistent therapy Synergistic effect Biocompatibility Technology T Chemical technology Biotechnology Science Q Physics Zhen Qiao verfasserin aut Yoon Ok Jang verfasserin aut Myoung Gyu Kim verfasserin aut Qingshuang Zou verfasserin aut Hyo Joo Lee verfasserin aut Bonhan Koo verfasserin aut Sung-Han Kim verfasserin aut Kyusik Yun verfasserin aut Hyun-Soo Kim verfasserin aut Yong Shin verfasserin aut In Nano Convergence SpringerOpen, 2015 8(2021), 1, Seite 14 (DE-627)780378938 (DE-600)2760386-6 21965404 nnns volume:8 year:2021 number:1 pages:14 https://doi.org/10.1186/s40580-021-00283-6 kostenfrei https://doaj.org/article/3be50e34f7164f529ef02edce60a9f9a kostenfrei https://doi.org/10.1186/s40580-021-00283-6 kostenfrei https://doaj.org/toc/2196-5404 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2021 1 14
language	English
source	In Nano Convergence 8(2021), 1, Seite 14 volume:8 year:2021 number:1 pages:14
sourceStr	In Nano Convergence 8(2021), 1, Seite 14 volume:8 year:2021 number:1 pages:14
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Antifungal therapy Antibiotic efficacy Persistent therapy Synergistic effect Biocompatibility Technology T Chemical technology Biotechnology Science Q Physics
isfreeaccess_bool	true
container_title	Nano Convergence
authorswithroles_txt_mv	Huifang Liu @@aut@@ Zhen Qiao @@aut@@ Yoon Ok Jang @@aut@@ Myoung Gyu Kim @@aut@@ Qingshuang Zou @@aut@@ Hyo Joo Lee @@aut@@ Bonhan Koo @@aut@@ Sung-Han Kim @@aut@@ Kyusik Yun @@aut@@ Hyun-Soo Kim @@aut@@ Yong Shin @@aut@@
publishDateDaySort_date	2021-01-01T00:00:00Z
hierarchy_top_id	780378938
id	DOAJ06114536X
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callnumber-first	T - Technology
author	Huifang Liu
spellingShingle	Huifang Liu misc TP1-1185 misc TP248.13-248.65 misc QC1-999 misc Antifungal therapy misc Antibiotic efficacy misc Persistent therapy misc Synergistic effect misc Biocompatibility misc Technology misc T misc Chemical technology misc Biotechnology misc Science misc Q misc Physics Diatomaceous earth/zinc oxide micro-composite assisted antibiotics in fungal therapy
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topic_title	TP1-1185 TP248.13-248.65 QC1-999 Diatomaceous earth/zinc oxide micro-composite assisted antibiotics in fungal therapy Antifungal therapy Antibiotic efficacy Persistent therapy Synergistic effect Biocompatibility
topic	misc TP1-1185 misc TP248.13-248.65 misc QC1-999 misc Antifungal therapy misc Antibiotic efficacy misc Persistent therapy misc Synergistic effect misc Biocompatibility misc Technology misc T misc Chemical technology misc Biotechnology misc Science misc Q misc Physics
topic_unstemmed	misc TP1-1185 misc TP248.13-248.65 misc QC1-999 misc Antifungal therapy misc Antibiotic efficacy misc Persistent therapy misc Synergistic effect misc Biocompatibility misc Technology misc T misc Chemical technology misc Biotechnology misc Science misc Q misc Physics
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title	Diatomaceous earth/zinc oxide micro-composite assisted antibiotics in fungal therapy
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title_full	Diatomaceous earth/zinc oxide micro-composite assisted antibiotics in fungal therapy
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author_browse	Huifang Liu Zhen Qiao Yoon Ok Jang Myoung Gyu Kim Qingshuang Zou Hyo Joo Lee Bonhan Koo Sung-Han Kim Kyusik Yun Hyun-Soo Kim Yong Shin
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title_sort	diatomaceous earth/zinc oxide micro-composite assisted antibiotics in fungal therapy
callnumber	TP1-1185
title_auth	Diatomaceous earth/zinc oxide micro-composite assisted antibiotics in fungal therapy
abstract	Abstract As the second wave of COVID-19 hits South Asia, an increasing deadly complication ‘fungal infections (such as Mycosis, Candida and Aspergillus) outbreak’ has been raised concern about the insufficient technologies and medicals for its diagnosis and therapy. Biosilica based nano-therapy can be used for therapeutic efficacy, yet their direct role as antibiotic agent with biocompatibility and stability remains unclear. Here, we report that a diatomaceous earth (DE) framework semiconductor composite conjugated DE and in-house synthesized zinc oxide (DE-ZnO), as an antibiotic agent for the enhancement of antibiotic efficacy and persistence. We found that the DE-ZnO composite had enhanced antibiotic activity against fungi (A. fumigatus) and Gram-negative bacteria (E. coli, S. enterica). The DE-ZnO composite provides enhancing large surface areas for enhancement of target pathogen binding affinity, as well as produces active ions including reactive oxygen species and metal ion for breaking the cellular network of fungi and Gram-negative bacteria. Additionally, the toxicity of DE-ZnO with 3 time less amount of dosage is 6 times lower than the commercial SiO2-ZnO. Finally, a synergistic effect of DE-ZnO and existing antifungal agents (Itraconazole and Amphotericin B) showed a better antifungal activity, which could be reduced the side effects due to the antifungal agents overdose, than a single antibiotic agent use. We envision that this DE-ZnO composite can be used to enhance antibiotic activity and its persistence, with less-toxicity, biocompatibility and high stability against fungi and Gram-negative bacteria which could be a valuable candidate in medical science and industrial engineering.
abstractGer	Abstract As the second wave of COVID-19 hits South Asia, an increasing deadly complication ‘fungal infections (such as Mycosis, Candida and Aspergillus) outbreak’ has been raised concern about the insufficient technologies and medicals for its diagnosis and therapy. Biosilica based nano-therapy can be used for therapeutic efficacy, yet their direct role as antibiotic agent with biocompatibility and stability remains unclear. Here, we report that a diatomaceous earth (DE) framework semiconductor composite conjugated DE and in-house synthesized zinc oxide (DE-ZnO), as an antibiotic agent for the enhancement of antibiotic efficacy and persistence. We found that the DE-ZnO composite had enhanced antibiotic activity against fungi (A. fumigatus) and Gram-negative bacteria (E. coli, S. enterica). The DE-ZnO composite provides enhancing large surface areas for enhancement of target pathogen binding affinity, as well as produces active ions including reactive oxygen species and metal ion for breaking the cellular network of fungi and Gram-negative bacteria. Additionally, the toxicity of DE-ZnO with 3 time less amount of dosage is 6 times lower than the commercial SiO2-ZnO. Finally, a synergistic effect of DE-ZnO and existing antifungal agents (Itraconazole and Amphotericin B) showed a better antifungal activity, which could be reduced the side effects due to the antifungal agents overdose, than a single antibiotic agent use. We envision that this DE-ZnO composite can be used to enhance antibiotic activity and its persistence, with less-toxicity, biocompatibility and high stability against fungi and Gram-negative bacteria which could be a valuable candidate in medical science and industrial engineering.
abstract_unstemmed	Abstract As the second wave of COVID-19 hits South Asia, an increasing deadly complication ‘fungal infections (such as Mycosis, Candida and Aspergillus) outbreak’ has been raised concern about the insufficient technologies and medicals for its diagnosis and therapy. Biosilica based nano-therapy can be used for therapeutic efficacy, yet their direct role as antibiotic agent with biocompatibility and stability remains unclear. Here, we report that a diatomaceous earth (DE) framework semiconductor composite conjugated DE and in-house synthesized zinc oxide (DE-ZnO), as an antibiotic agent for the enhancement of antibiotic efficacy and persistence. We found that the DE-ZnO composite had enhanced antibiotic activity against fungi (A. fumigatus) and Gram-negative bacteria (E. coli, S. enterica). The DE-ZnO composite provides enhancing large surface areas for enhancement of target pathogen binding affinity, as well as produces active ions including reactive oxygen species and metal ion for breaking the cellular network of fungi and Gram-negative bacteria. Additionally, the toxicity of DE-ZnO with 3 time less amount of dosage is 6 times lower than the commercial SiO2-ZnO. Finally, a synergistic effect of DE-ZnO and existing antifungal agents (Itraconazole and Amphotericin B) showed a better antifungal activity, which could be reduced the side effects due to the antifungal agents overdose, than a single antibiotic agent use. We envision that this DE-ZnO composite can be used to enhance antibiotic activity and its persistence, with less-toxicity, biocompatibility and high stability against fungi and Gram-negative bacteria which could be a valuable candidate in medical science and industrial engineering.
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title_short	Diatomaceous earth/zinc oxide micro-composite assisted antibiotics in fungal therapy
url	https://doi.org/10.1186/s40580-021-00283-6 https://doaj.org/article/3be50e34f7164f529ef02edce60a9f9a https://doaj.org/toc/2196-5404
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author2	Zhen Qiao Yoon Ok Jang Myoung Gyu Kim Qingshuang Zou Hyo Joo Lee Bonhan Koo Sung-Han Kim Kyusik Yun Hyun-Soo Kim Yong Shin
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up_date	2024-07-03T19:05:28.071Z
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