Molecular Epidemiology of Rotavirus Strains in Symptomatic and Asymptomatic Children in Manhiça District, Southern Mozambique 2008–2019

Group A rotaviruses remain the leading cause of diarrhoea in children aged <5 years. Mozambique introduced rotavirus vaccine (Rotarix<sup<®</sup<) in September 2015. We report rotavirus genotypes circulating among symptomatic and asymptomatic children in Manhiça District, Mozambique,...
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Autor*in:	Filomena Manjate [verfasserIn] Eva D. João [verfasserIn] Percina Chirinda [verfasserIn] Marcelino Garrine [verfasserIn] Delfino Vubil [verfasserIn] Nélio Nobela [verfasserIn] Karen Kotloff [verfasserIn] James P. Nataro [verfasserIn] Tacilta Nhampossa [verfasserIn] Sozinho Acácio [verfasserIn] Jacqueline E. Tate [verfasserIn] Umesh Parashar [verfasserIn] Jason M. Mwenda [verfasserIn] Pedro L. Alonso [verfasserIn] Martin Nyaga [verfasserIn] Celso Cunha [verfasserIn] Inácio Mandomando [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	rotavirus A genotypes case-control study Mozambique

Übergeordnetes Werk:	In: Viruses - MDPI AG, 2009, 14(2022), 1, p 134
Übergeordnetes Werk:	volume:14 ; year:2022 ; number:1, p 134

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/v14010134

Katalog-ID:	DOAJ061161942

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Indexfelder

author_variant	f m fm e d j edj p c pc m g mg d v dv n n nn k k kk j p n jpn t n tn s a sa j e t jet u p up j m m jmm p l a pla m n mn c c cc i m im
matchkey_str	article:19994915:2022----::oeuaeieilgortvrstanismtmtcnaypoaicideimnids
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publishDate	2022
allfields	10.3390/v14010134 doi (DE-627)DOAJ061161942 (DE-599)DOAJ330074d2a89e4db6bc9a5ec7fc8b3731 DE-627 ger DE-627 rakwb eng QR1-502 Filomena Manjate verfasserin aut Molecular Epidemiology of Rotavirus Strains in Symptomatic and Asymptomatic Children in Manhiça District, Southern Mozambique 2008–2019 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Group A rotaviruses remain the leading cause of diarrhoea in children aged <5 years. Mozambique introduced rotavirus vaccine (Rotarix<sup<®</sup<) in September 2015. We report rotavirus genotypes circulating among symptomatic and asymptomatic children in Manhiça District, Mozambique, pre- and post-vaccine introduction. Stool was collected from enrolled children and screened for rotavirus by enzyme-immuno-sorbent assay. Positive specimens were genotyped for VP7 (G genotypes) and VP4 (P genotypes) by the conventional reverse transcriptase polymerase chain reaction. The combination G12P[8] was more frequently observed in pre-vaccine than in post-vaccine introduction, in moderate to severe diarrhoea (34%, 61/177 vs. 0, <i<p</i< < 0.0001) and controls (23%, 26/113 vs. 0, <i<p</i< = 0.0013) and mixed genotypes (36%, 24/67 vs. 7% 4/58, <i<p</i< = 0.0003) in less severe diarrhoea. We observed changes in post-vaccine compared to pre-vaccine introduction, where G3P[4] and G3P[8] were prevalent in moderate to severe diarrhoea (10%, 5/49 vs. 0, <i<p</i< = 0.0002; and 14%, 7/49 vs. 1%, 1/177, <i<p</i< < 0.0001; respectively), and in less severe diarrhoea (21%, 12/58 vs. 0, <i<p</i< = 0.003; and 24%, 14/58 vs. 0, <i<p</i< < 0.0001; respectively). Our surveillance demonstrated the circulation of similar genotypes contemporaneously among cases and controls, as well as switching from pre- to post-vaccine introduction. Continuous surveillance is needed to evaluate the dynamics of the changes in genotypes following vaccine introduction. rotavirus A genotypes case-control study Mozambique Microbiology Eva D. João verfasserin aut Percina Chirinda verfasserin aut Marcelino Garrine verfasserin aut Delfino Vubil verfasserin aut Nélio Nobela verfasserin aut Karen Kotloff verfasserin aut James P. Nataro verfasserin aut Tacilta Nhampossa verfasserin aut Sozinho Acácio verfasserin aut Jacqueline E. Tate verfasserin aut Umesh Parashar verfasserin aut Jason M. Mwenda verfasserin aut Pedro L. Alonso verfasserin aut Martin Nyaga verfasserin aut Celso Cunha verfasserin aut Inácio Mandomando verfasserin aut In Viruses MDPI AG, 2009 14(2022), 1, p 134 (DE-627)609775871 (DE-600)2516098-9 19994915 nnns volume:14 year:2022 number:1, p 134 https://doi.org/10.3390/v14010134 kostenfrei https://doaj.org/article/330074d2a89e4db6bc9a5ec7fc8b3731 kostenfrei https://www.mdpi.com/1999-4915/14/1/134 kostenfrei https://doaj.org/toc/1999-4915 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2022 1, p 134
spelling	10.3390/v14010134 doi (DE-627)DOAJ061161942 (DE-599)DOAJ330074d2a89e4db6bc9a5ec7fc8b3731 DE-627 ger DE-627 rakwb eng QR1-502 Filomena Manjate verfasserin aut Molecular Epidemiology of Rotavirus Strains in Symptomatic and Asymptomatic Children in Manhiça District, Southern Mozambique 2008–2019 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Group A rotaviruses remain the leading cause of diarrhoea in children aged <5 years. Mozambique introduced rotavirus vaccine (Rotarix<sup<®</sup<) in September 2015. We report rotavirus genotypes circulating among symptomatic and asymptomatic children in Manhiça District, Mozambique, pre- and post-vaccine introduction. Stool was collected from enrolled children and screened for rotavirus by enzyme-immuno-sorbent assay. Positive specimens were genotyped for VP7 (G genotypes) and VP4 (P genotypes) by the conventional reverse transcriptase polymerase chain reaction. The combination G12P[8] was more frequently observed in pre-vaccine than in post-vaccine introduction, in moderate to severe diarrhoea (34%, 61/177 vs. 0, <i<p</i< < 0.0001) and controls (23%, 26/113 vs. 0, <i<p</i< = 0.0013) and mixed genotypes (36%, 24/67 vs. 7% 4/58, <i<p</i< = 0.0003) in less severe diarrhoea. We observed changes in post-vaccine compared to pre-vaccine introduction, where G3P[4] and G3P[8] were prevalent in moderate to severe diarrhoea (10%, 5/49 vs. 0, <i<p</i< = 0.0002; and 14%, 7/49 vs. 1%, 1/177, <i<p</i< < 0.0001; respectively), and in less severe diarrhoea (21%, 12/58 vs. 0, <i<p</i< = 0.003; and 24%, 14/58 vs. 0, <i<p</i< < 0.0001; respectively). Our surveillance demonstrated the circulation of similar genotypes contemporaneously among cases and controls, as well as switching from pre- to post-vaccine introduction. Continuous surveillance is needed to evaluate the dynamics of the changes in genotypes following vaccine introduction. rotavirus A genotypes case-control study Mozambique Microbiology Eva D. João verfasserin aut Percina Chirinda verfasserin aut Marcelino Garrine verfasserin aut Delfino Vubil verfasserin aut Nélio Nobela verfasserin aut Karen Kotloff verfasserin aut James P. Nataro verfasserin aut Tacilta Nhampossa verfasserin aut Sozinho Acácio verfasserin aut Jacqueline E. Tate verfasserin aut Umesh Parashar verfasserin aut Jason M. Mwenda verfasserin aut Pedro L. Alonso verfasserin aut Martin Nyaga verfasserin aut Celso Cunha verfasserin aut Inácio Mandomando verfasserin aut In Viruses MDPI AG, 2009 14(2022), 1, p 134 (DE-627)609775871 (DE-600)2516098-9 19994915 nnns volume:14 year:2022 number:1, p 134 https://doi.org/10.3390/v14010134 kostenfrei https://doaj.org/article/330074d2a89e4db6bc9a5ec7fc8b3731 kostenfrei https://www.mdpi.com/1999-4915/14/1/134 kostenfrei https://doaj.org/toc/1999-4915 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2022 1, p 134
allfields_unstemmed	10.3390/v14010134 doi (DE-627)DOAJ061161942 (DE-599)DOAJ330074d2a89e4db6bc9a5ec7fc8b3731 DE-627 ger DE-627 rakwb eng QR1-502 Filomena Manjate verfasserin aut Molecular Epidemiology of Rotavirus Strains in Symptomatic and Asymptomatic Children in Manhiça District, Southern Mozambique 2008–2019 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Group A rotaviruses remain the leading cause of diarrhoea in children aged <5 years. Mozambique introduced rotavirus vaccine (Rotarix<sup<®</sup<) in September 2015. We report rotavirus genotypes circulating among symptomatic and asymptomatic children in Manhiça District, Mozambique, pre- and post-vaccine introduction. Stool was collected from enrolled children and screened for rotavirus by enzyme-immuno-sorbent assay. Positive specimens were genotyped for VP7 (G genotypes) and VP4 (P genotypes) by the conventional reverse transcriptase polymerase chain reaction. The combination G12P[8] was more frequently observed in pre-vaccine than in post-vaccine introduction, in moderate to severe diarrhoea (34%, 61/177 vs. 0, <i<p</i< < 0.0001) and controls (23%, 26/113 vs. 0, <i<p</i< = 0.0013) and mixed genotypes (36%, 24/67 vs. 7% 4/58, <i<p</i< = 0.0003) in less severe diarrhoea. We observed changes in post-vaccine compared to pre-vaccine introduction, where G3P[4] and G3P[8] were prevalent in moderate to severe diarrhoea (10%, 5/49 vs. 0, <i<p</i< = 0.0002; and 14%, 7/49 vs. 1%, 1/177, <i<p</i< < 0.0001; respectively), and in less severe diarrhoea (21%, 12/58 vs. 0, <i<p</i< = 0.003; and 24%, 14/58 vs. 0, <i<p</i< < 0.0001; respectively). Our surveillance demonstrated the circulation of similar genotypes contemporaneously among cases and controls, as well as switching from pre- to post-vaccine introduction. Continuous surveillance is needed to evaluate the dynamics of the changes in genotypes following vaccine introduction. rotavirus A genotypes case-control study Mozambique Microbiology Eva D. João verfasserin aut Percina Chirinda verfasserin aut Marcelino Garrine verfasserin aut Delfino Vubil verfasserin aut Nélio Nobela verfasserin aut Karen Kotloff verfasserin aut James P. Nataro verfasserin aut Tacilta Nhampossa verfasserin aut Sozinho Acácio verfasserin aut Jacqueline E. Tate verfasserin aut Umesh Parashar verfasserin aut Jason M. Mwenda verfasserin aut Pedro L. Alonso verfasserin aut Martin Nyaga verfasserin aut Celso Cunha verfasserin aut Inácio Mandomando verfasserin aut In Viruses MDPI AG, 2009 14(2022), 1, p 134 (DE-627)609775871 (DE-600)2516098-9 19994915 nnns volume:14 year:2022 number:1, p 134 https://doi.org/10.3390/v14010134 kostenfrei https://doaj.org/article/330074d2a89e4db6bc9a5ec7fc8b3731 kostenfrei https://www.mdpi.com/1999-4915/14/1/134 kostenfrei https://doaj.org/toc/1999-4915 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2022 1, p 134
allfieldsGer	10.3390/v14010134 doi (DE-627)DOAJ061161942 (DE-599)DOAJ330074d2a89e4db6bc9a5ec7fc8b3731 DE-627 ger DE-627 rakwb eng QR1-502 Filomena Manjate verfasserin aut Molecular Epidemiology of Rotavirus Strains in Symptomatic and Asymptomatic Children in Manhiça District, Southern Mozambique 2008–2019 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Group A rotaviruses remain the leading cause of diarrhoea in children aged <5 years. Mozambique introduced rotavirus vaccine (Rotarix<sup<®</sup<) in September 2015. We report rotavirus genotypes circulating among symptomatic and asymptomatic children in Manhiça District, Mozambique, pre- and post-vaccine introduction. Stool was collected from enrolled children and screened for rotavirus by enzyme-immuno-sorbent assay. Positive specimens were genotyped for VP7 (G genotypes) and VP4 (P genotypes) by the conventional reverse transcriptase polymerase chain reaction. The combination G12P[8] was more frequently observed in pre-vaccine than in post-vaccine introduction, in moderate to severe diarrhoea (34%, 61/177 vs. 0, <i<p</i< < 0.0001) and controls (23%, 26/113 vs. 0, <i<p</i< = 0.0013) and mixed genotypes (36%, 24/67 vs. 7% 4/58, <i<p</i< = 0.0003) in less severe diarrhoea. We observed changes in post-vaccine compared to pre-vaccine introduction, where G3P[4] and G3P[8] were prevalent in moderate to severe diarrhoea (10%, 5/49 vs. 0, <i<p</i< = 0.0002; and 14%, 7/49 vs. 1%, 1/177, <i<p</i< < 0.0001; respectively), and in less severe diarrhoea (21%, 12/58 vs. 0, <i<p</i< = 0.003; and 24%, 14/58 vs. 0, <i<p</i< < 0.0001; respectively). Our surveillance demonstrated the circulation of similar genotypes contemporaneously among cases and controls, as well as switching from pre- to post-vaccine introduction. Continuous surveillance is needed to evaluate the dynamics of the changes in genotypes following vaccine introduction. rotavirus A genotypes case-control study Mozambique Microbiology Eva D. João verfasserin aut Percina Chirinda verfasserin aut Marcelino Garrine verfasserin aut Delfino Vubil verfasserin aut Nélio Nobela verfasserin aut Karen Kotloff verfasserin aut James P. Nataro verfasserin aut Tacilta Nhampossa verfasserin aut Sozinho Acácio verfasserin aut Jacqueline E. Tate verfasserin aut Umesh Parashar verfasserin aut Jason M. Mwenda verfasserin aut Pedro L. Alonso verfasserin aut Martin Nyaga verfasserin aut Celso Cunha verfasserin aut Inácio Mandomando verfasserin aut In Viruses MDPI AG, 2009 14(2022), 1, p 134 (DE-627)609775871 (DE-600)2516098-9 19994915 nnns volume:14 year:2022 number:1, p 134 https://doi.org/10.3390/v14010134 kostenfrei https://doaj.org/article/330074d2a89e4db6bc9a5ec7fc8b3731 kostenfrei https://www.mdpi.com/1999-4915/14/1/134 kostenfrei https://doaj.org/toc/1999-4915 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2022 1, p 134
allfieldsSound	10.3390/v14010134 doi (DE-627)DOAJ061161942 (DE-599)DOAJ330074d2a89e4db6bc9a5ec7fc8b3731 DE-627 ger DE-627 rakwb eng QR1-502 Filomena Manjate verfasserin aut Molecular Epidemiology of Rotavirus Strains in Symptomatic and Asymptomatic Children in Manhiça District, Southern Mozambique 2008–2019 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Group A rotaviruses remain the leading cause of diarrhoea in children aged <5 years. Mozambique introduced rotavirus vaccine (Rotarix<sup<®</sup<) in September 2015. We report rotavirus genotypes circulating among symptomatic and asymptomatic children in Manhiça District, Mozambique, pre- and post-vaccine introduction. Stool was collected from enrolled children and screened for rotavirus by enzyme-immuno-sorbent assay. Positive specimens were genotyped for VP7 (G genotypes) and VP4 (P genotypes) by the conventional reverse transcriptase polymerase chain reaction. The combination G12P[8] was more frequently observed in pre-vaccine than in post-vaccine introduction, in moderate to severe diarrhoea (34%, 61/177 vs. 0, <i<p</i< < 0.0001) and controls (23%, 26/113 vs. 0, <i<p</i< = 0.0013) and mixed genotypes (36%, 24/67 vs. 7% 4/58, <i<p</i< = 0.0003) in less severe diarrhoea. We observed changes in post-vaccine compared to pre-vaccine introduction, where G3P[4] and G3P[8] were prevalent in moderate to severe diarrhoea (10%, 5/49 vs. 0, <i<p</i< = 0.0002; and 14%, 7/49 vs. 1%, 1/177, <i<p</i< < 0.0001; respectively), and in less severe diarrhoea (21%, 12/58 vs. 0, <i<p</i< = 0.003; and 24%, 14/58 vs. 0, <i<p</i< < 0.0001; respectively). Our surveillance demonstrated the circulation of similar genotypes contemporaneously among cases and controls, as well as switching from pre- to post-vaccine introduction. Continuous surveillance is needed to evaluate the dynamics of the changes in genotypes following vaccine introduction. rotavirus A genotypes case-control study Mozambique Microbiology Eva D. João verfasserin aut Percina Chirinda verfasserin aut Marcelino Garrine verfasserin aut Delfino Vubil verfasserin aut Nélio Nobela verfasserin aut Karen Kotloff verfasserin aut James P. Nataro verfasserin aut Tacilta Nhampossa verfasserin aut Sozinho Acácio verfasserin aut Jacqueline E. Tate verfasserin aut Umesh Parashar verfasserin aut Jason M. Mwenda verfasserin aut Pedro L. Alonso verfasserin aut Martin Nyaga verfasserin aut Celso Cunha verfasserin aut Inácio Mandomando verfasserin aut In Viruses MDPI AG, 2009 14(2022), 1, p 134 (DE-627)609775871 (DE-600)2516098-9 19994915 nnns volume:14 year:2022 number:1, p 134 https://doi.org/10.3390/v14010134 kostenfrei https://doaj.org/article/330074d2a89e4db6bc9a5ec7fc8b3731 kostenfrei https://www.mdpi.com/1999-4915/14/1/134 kostenfrei https://doaj.org/toc/1999-4915 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2022 1, p 134
language	English
source	In Viruses 14(2022), 1, p 134 volume:14 year:2022 number:1, p 134
sourceStr	In Viruses 14(2022), 1, p 134 volume:14 year:2022 number:1, p 134
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	rotavirus A genotypes case-control study Mozambique Microbiology
isfreeaccess_bool	true
container_title	Viruses
authorswithroles_txt_mv	Filomena Manjate @@aut@@ Eva D. João @@aut@@ Percina Chirinda @@aut@@ Marcelino Garrine @@aut@@ Delfino Vubil @@aut@@ Nélio Nobela @@aut@@ Karen Kotloff @@aut@@ James P. Nataro @@aut@@ Tacilta Nhampossa @@aut@@ Sozinho Acácio @@aut@@ Jacqueline E. Tate @@aut@@ Umesh Parashar @@aut@@ Jason M. Mwenda @@aut@@ Pedro L. Alonso @@aut@@ Martin Nyaga @@aut@@ Celso Cunha @@aut@@ Inácio Mandomando @@aut@@
publishDateDaySort_date	2022-01-01T00:00:00Z
hierarchy_top_id	609775871
id	DOAJ061161942
language_de	englisch
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callnumber-first	Q - Science
author	Filomena Manjate
spellingShingle	Filomena Manjate misc QR1-502 misc rotavirus A misc genotypes misc case-control study misc Mozambique misc Microbiology Molecular Epidemiology of Rotavirus Strains in Symptomatic and Asymptomatic Children in Manhiça District, Southern Mozambique 2008–2019
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topic_title	QR1-502 Molecular Epidemiology of Rotavirus Strains in Symptomatic and Asymptomatic Children in Manhiça District, Southern Mozambique 2008–2019 rotavirus A genotypes case-control study Mozambique
topic	misc QR1-502 misc rotavirus A misc genotypes misc case-control study misc Mozambique misc Microbiology
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title	Molecular Epidemiology of Rotavirus Strains in Symptomatic and Asymptomatic Children in Manhiça District, Southern Mozambique 2008–2019
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title_full	Molecular Epidemiology of Rotavirus Strains in Symptomatic and Asymptomatic Children in Manhiça District, Southern Mozambique 2008–2019
author_sort	Filomena Manjate
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author_browse	Filomena Manjate Eva D. João Percina Chirinda Marcelino Garrine Delfino Vubil Nélio Nobela Karen Kotloff James P. Nataro Tacilta Nhampossa Sozinho Acácio Jacqueline E. Tate Umesh Parashar Jason M. Mwenda Pedro L. Alonso Martin Nyaga Celso Cunha Inácio Mandomando
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title_sort	molecular epidemiology of rotavirus strains in symptomatic and asymptomatic children in manhiça district, southern mozambique 2008–2019
callnumber	QR1-502
title_auth	Molecular Epidemiology of Rotavirus Strains in Symptomatic and Asymptomatic Children in Manhiça District, Southern Mozambique 2008–2019
abstract	Group A rotaviruses remain the leading cause of diarrhoea in children aged <5 years. Mozambique introduced rotavirus vaccine (Rotarix<sup<®</sup<) in September 2015. We report rotavirus genotypes circulating among symptomatic and asymptomatic children in Manhiça District, Mozambique, pre- and post-vaccine introduction. Stool was collected from enrolled children and screened for rotavirus by enzyme-immuno-sorbent assay. Positive specimens were genotyped for VP7 (G genotypes) and VP4 (P genotypes) by the conventional reverse transcriptase polymerase chain reaction. The combination G12P[8] was more frequently observed in pre-vaccine than in post-vaccine introduction, in moderate to severe diarrhoea (34%, 61/177 vs. 0, <i<p</i< < 0.0001) and controls (23%, 26/113 vs. 0, <i<p</i< = 0.0013) and mixed genotypes (36%, 24/67 vs. 7% 4/58, <i<p</i< = 0.0003) in less severe diarrhoea. We observed changes in post-vaccine compared to pre-vaccine introduction, where G3P[4] and G3P[8] were prevalent in moderate to severe diarrhoea (10%, 5/49 vs. 0, <i<p</i< = 0.0002; and 14%, 7/49 vs. 1%, 1/177, <i<p</i< < 0.0001; respectively), and in less severe diarrhoea (21%, 12/58 vs. 0, <i<p</i< = 0.003; and 24%, 14/58 vs. 0, <i<p</i< < 0.0001; respectively). Our surveillance demonstrated the circulation of similar genotypes contemporaneously among cases and controls, as well as switching from pre- to post-vaccine introduction. Continuous surveillance is needed to evaluate the dynamics of the changes in genotypes following vaccine introduction.
abstractGer	Group A rotaviruses remain the leading cause of diarrhoea in children aged <5 years. Mozambique introduced rotavirus vaccine (Rotarix<sup<®</sup<) in September 2015. We report rotavirus genotypes circulating among symptomatic and asymptomatic children in Manhiça District, Mozambique, pre- and post-vaccine introduction. Stool was collected from enrolled children and screened for rotavirus by enzyme-immuno-sorbent assay. Positive specimens were genotyped for VP7 (G genotypes) and VP4 (P genotypes) by the conventional reverse transcriptase polymerase chain reaction. The combination G12P[8] was more frequently observed in pre-vaccine than in post-vaccine introduction, in moderate to severe diarrhoea (34%, 61/177 vs. 0, <i<p</i< < 0.0001) and controls (23%, 26/113 vs. 0, <i<p</i< = 0.0013) and mixed genotypes (36%, 24/67 vs. 7% 4/58, <i<p</i< = 0.0003) in less severe diarrhoea. We observed changes in post-vaccine compared to pre-vaccine introduction, where G3P[4] and G3P[8] were prevalent in moderate to severe diarrhoea (10%, 5/49 vs. 0, <i<p</i< = 0.0002; and 14%, 7/49 vs. 1%, 1/177, <i<p</i< < 0.0001; respectively), and in less severe diarrhoea (21%, 12/58 vs. 0, <i<p</i< = 0.003; and 24%, 14/58 vs. 0, <i<p</i< < 0.0001; respectively). Our surveillance demonstrated the circulation of similar genotypes contemporaneously among cases and controls, as well as switching from pre- to post-vaccine introduction. Continuous surveillance is needed to evaluate the dynamics of the changes in genotypes following vaccine introduction.
abstract_unstemmed	Group A rotaviruses remain the leading cause of diarrhoea in children aged <5 years. Mozambique introduced rotavirus vaccine (Rotarix<sup<®</sup<) in September 2015. We report rotavirus genotypes circulating among symptomatic and asymptomatic children in Manhiça District, Mozambique, pre- and post-vaccine introduction. Stool was collected from enrolled children and screened for rotavirus by enzyme-immuno-sorbent assay. Positive specimens were genotyped for VP7 (G genotypes) and VP4 (P genotypes) by the conventional reverse transcriptase polymerase chain reaction. The combination G12P[8] was more frequently observed in pre-vaccine than in post-vaccine introduction, in moderate to severe diarrhoea (34%, 61/177 vs. 0, <i<p</i< < 0.0001) and controls (23%, 26/113 vs. 0, <i<p</i< = 0.0013) and mixed genotypes (36%, 24/67 vs. 7% 4/58, <i<p</i< = 0.0003) in less severe diarrhoea. We observed changes in post-vaccine compared to pre-vaccine introduction, where G3P[4] and G3P[8] were prevalent in moderate to severe diarrhoea (10%, 5/49 vs. 0, <i<p</i< = 0.0002; and 14%, 7/49 vs. 1%, 1/177, <i<p</i< < 0.0001; respectively), and in less severe diarrhoea (21%, 12/58 vs. 0, <i<p</i< = 0.003; and 24%, 14/58 vs. 0, <i<p</i< < 0.0001; respectively). Our surveillance demonstrated the circulation of similar genotypes contemporaneously among cases and controls, as well as switching from pre- to post-vaccine introduction. Continuous surveillance is needed to evaluate the dynamics of the changes in genotypes following vaccine introduction.
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title_short	Molecular Epidemiology of Rotavirus Strains in Symptomatic and Asymptomatic Children in Manhiça District, Southern Mozambique 2008–2019
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Molecular Epidemiology of Rotavirus Strains in Symptomatic and Asymptomatic Children in Manhiça District, Southern Mozambique 2008–2019

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