Genomic and transcriptomic correlates of immunotherapy response within the tumor microenvironment of leptomeningeal metastases

Leptomeningeal disease (LMD) is a serious complication of metastatic solid tumors with a poor prognosis. Here, by using single-cell RNA sequencing of cerebrospinal fluid, the authors report genomic and immune correlates of response to immunotherapy in two cohorts of patients with LMD treated with im...
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Autor*in:	Sanjay M. Prakadan [verfasserIn] Christopher A. Alvarez-Breckenridge [verfasserIn] Samuel C. Markson [verfasserIn] Albert E. Kim [verfasserIn] Robert H. Klein [verfasserIn] Naema Nayyar [verfasserIn] Andrew W. Navia [verfasserIn] Benjamin M. Kuter [verfasserIn] Kellie E. Kolb [verfasserIn] Ivanna Bihun [verfasserIn] Joana L. Mora [verfasserIn] Mia Solana Bertalan [verfasserIn] Brian Shaw [verfasserIn] Michael White [verfasserIn] Alexander Kaplan [verfasserIn] Jackson H. Stocking [verfasserIn] Marc H. Wadsworth [verfasserIn] Eudocia Q. Lee [verfasserIn] Ugonma Chukwueke [verfasserIn] Nancy Wang [verfasserIn] Megha Subramanian [verfasserIn] Denisse Rotem [verfasserIn] Daniel P. Cahill [verfasserIn] Viktor A. Adalsteinsson [verfasserIn] Jeffrey W. Miller [verfasserIn] Ryan J. Sullivan [verfasserIn] Scott L. Carter [verfasserIn] Priscilla K. Brastianos [verfasserIn] Alex K. Shalek [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Übergeordnetes Werk:	In: Nature Communications - Nature Portfolio, 2016, 12(2021), 1, Seite 10
Übergeordnetes Werk:	volume:12 ; year:2021 ; number:1 ; pages:10

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1038/s41467-021-25860-5

Katalog-ID:	DOAJ061216658

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allfields	10.1038/s41467-021-25860-5 doi (DE-627)DOAJ061216658 (DE-599)DOAJ687017c072604770afffff35e85435f2 DE-627 ger DE-627 rakwb eng Sanjay M. Prakadan verfasserin aut Genomic and transcriptomic correlates of immunotherapy response within the tumor microenvironment of leptomeningeal metastases 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Leptomeningeal disease (LMD) is a serious complication of metastatic solid tumors with a poor prognosis. Here, by using single-cell RNA sequencing of cerebrospinal fluid, the authors report genomic and immune correlates of response to immunotherapy in two cohorts of patients with LMD treated with immune checkpoint inhibitors. Science Q Christopher A. Alvarez-Breckenridge verfasserin aut Samuel C. Markson verfasserin aut Albert E. Kim verfasserin aut Robert H. Klein verfasserin aut Naema Nayyar verfasserin aut Andrew W. Navia verfasserin aut Benjamin M. Kuter verfasserin aut Kellie E. Kolb verfasserin aut Ivanna Bihun verfasserin aut Joana L. Mora verfasserin aut Mia Solana Bertalan verfasserin aut Brian Shaw verfasserin aut Michael White verfasserin aut Alexander Kaplan verfasserin aut Jackson H. Stocking verfasserin aut Marc H. Wadsworth verfasserin aut Eudocia Q. Lee verfasserin aut Ugonma Chukwueke verfasserin aut Nancy Wang verfasserin aut Megha Subramanian verfasserin aut Denisse Rotem verfasserin aut Daniel P. Cahill verfasserin aut Viktor A. Adalsteinsson verfasserin aut Jeffrey W. Miller verfasserin aut Ryan J. Sullivan verfasserin aut Scott L. Carter verfasserin aut Priscilla K. Brastianos verfasserin aut Alex K. Shalek verfasserin aut In Nature Communications Nature Portfolio, 2016 12(2021), 1, Seite 10 (DE-627)626457688 (DE-600)2553671-0 20411723 nnns volume:12 year:2021 number:1 pages:10 https://doi.org/10.1038/s41467-021-25860-5 kostenfrei https://doaj.org/article/687017c072604770afffff35e85435f2 kostenfrei https://doi.org/10.1038/s41467-021-25860-5 kostenfrei https://doaj.org/toc/2041-1723 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_211 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2110 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2021 1 10
spelling	10.1038/s41467-021-25860-5 doi (DE-627)DOAJ061216658 (DE-599)DOAJ687017c072604770afffff35e85435f2 DE-627 ger DE-627 rakwb eng Sanjay M. Prakadan verfasserin aut Genomic and transcriptomic correlates of immunotherapy response within the tumor microenvironment of leptomeningeal metastases 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Leptomeningeal disease (LMD) is a serious complication of metastatic solid tumors with a poor prognosis. Here, by using single-cell RNA sequencing of cerebrospinal fluid, the authors report genomic and immune correlates of response to immunotherapy in two cohorts of patients with LMD treated with immune checkpoint inhibitors. Science Q Christopher A. Alvarez-Breckenridge verfasserin aut Samuel C. Markson verfasserin aut Albert E. Kim verfasserin aut Robert H. Klein verfasserin aut Naema Nayyar verfasserin aut Andrew W. Navia verfasserin aut Benjamin M. Kuter verfasserin aut Kellie E. Kolb verfasserin aut Ivanna Bihun verfasserin aut Joana L. Mora verfasserin aut Mia Solana Bertalan verfasserin aut Brian Shaw verfasserin aut Michael White verfasserin aut Alexander Kaplan verfasserin aut Jackson H. Stocking verfasserin aut Marc H. Wadsworth verfasserin aut Eudocia Q. Lee verfasserin aut Ugonma Chukwueke verfasserin aut Nancy Wang verfasserin aut Megha Subramanian verfasserin aut Denisse Rotem verfasserin aut Daniel P. Cahill verfasserin aut Viktor A. Adalsteinsson verfasserin aut Jeffrey W. Miller verfasserin aut Ryan J. Sullivan verfasserin aut Scott L. Carter verfasserin aut Priscilla K. Brastianos verfasserin aut Alex K. Shalek verfasserin aut In Nature Communications Nature Portfolio, 2016 12(2021), 1, Seite 10 (DE-627)626457688 (DE-600)2553671-0 20411723 nnns volume:12 year:2021 number:1 pages:10 https://doi.org/10.1038/s41467-021-25860-5 kostenfrei https://doaj.org/article/687017c072604770afffff35e85435f2 kostenfrei https://doi.org/10.1038/s41467-021-25860-5 kostenfrei https://doaj.org/toc/2041-1723 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_211 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2110 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2021 1 10
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author	Sanjay M. Prakadan
spellingShingle	Sanjay M. Prakadan misc Science misc Q Genomic and transcriptomic correlates of immunotherapy response within the tumor microenvironment of leptomeningeal metastases
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topic_title	Genomic and transcriptomic correlates of immunotherapy response within the tumor microenvironment of leptomeningeal metastases
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title	Genomic and transcriptomic correlates of immunotherapy response within the tumor microenvironment of leptomeningeal metastases
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title_full	Genomic and transcriptomic correlates of immunotherapy response within the tumor microenvironment of leptomeningeal metastases
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author_browse	Sanjay M. Prakadan Christopher A. Alvarez-Breckenridge Samuel C. Markson Albert E. Kim Robert H. Klein Naema Nayyar Andrew W. Navia Benjamin M. Kuter Kellie E. Kolb Ivanna Bihun Joana L. Mora Mia Solana Bertalan Brian Shaw Michael White Alexander Kaplan Jackson H. Stocking Marc H. Wadsworth Eudocia Q. Lee Ugonma Chukwueke Nancy Wang Megha Subramanian Denisse Rotem Daniel P. Cahill Viktor A. Adalsteinsson Jeffrey W. Miller Ryan J. Sullivan Scott L. Carter Priscilla K. Brastianos Alex K. Shalek
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title_sort	genomic and transcriptomic correlates of immunotherapy response within the tumor microenvironment of leptomeningeal metastases
title_auth	Genomic and transcriptomic correlates of immunotherapy response within the tumor microenvironment of leptomeningeal metastases
abstract	Leptomeningeal disease (LMD) is a serious complication of metastatic solid tumors with a poor prognosis. Here, by using single-cell RNA sequencing of cerebrospinal fluid, the authors report genomic and immune correlates of response to immunotherapy in two cohorts of patients with LMD treated with immune checkpoint inhibitors.
abstractGer	Leptomeningeal disease (LMD) is a serious complication of metastatic solid tumors with a poor prognosis. Here, by using single-cell RNA sequencing of cerebrospinal fluid, the authors report genomic and immune correlates of response to immunotherapy in two cohorts of patients with LMD treated with immune checkpoint inhibitors.
abstract_unstemmed	Leptomeningeal disease (LMD) is a serious complication of metastatic solid tumors with a poor prognosis. Here, by using single-cell RNA sequencing of cerebrospinal fluid, the authors report genomic and immune correlates of response to immunotherapy in two cohorts of patients with LMD treated with immune checkpoint inhibitors.
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title_short	Genomic and transcriptomic correlates of immunotherapy response within the tumor microenvironment of leptomeningeal metastases
url	https://doi.org/10.1038/s41467-021-25860-5 https://doaj.org/article/687017c072604770afffff35e85435f2 https://doaj.org/toc/2041-1723
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Genomic and transcriptomic correlates of immunotherapy response within the tumor microenvironment of leptomeningeal metastases

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