Identification of a Bioactive Compound against Adult T-cell Leukaemia from Bitter Gourd Seeds

In our previous report, an 80% ethanol bitter gourd seed extract (BGSE) was found to suppress proliferation of adult T-cell leukemia (ATL) cell lines. The present study aimed to identify the bioactive compounds from BGSE specific against ATL. From the result of an HPLC-MS analysis, α-eleostearic aci...
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Autor*in:	Hisahiro Kai [verfasserIn] Ena Akamatsu [verfasserIn] Eri Torii [verfasserIn] Hiroko Kodama [verfasserIn] Chizuko Yukizaki [verfasserIn] Isao Akagi [verfasserIn] Hisatoshi Ino [verfasserIn] Yoichi Sakakibara [verfasserIn] Masahito Suiko [verfasserIn] Ikuo Yamamoto [verfasserIn] Akihiko Okayama [verfasserIn] Kazuhiro Morishita [verfasserIn] Hiroaki Kataoka [verfasserIn] Koji Matsuno [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2013

Schlagwörter:	adult T-cell leukemia bitter gourd seed extract α-eleostearic acid phytohemagglutinin-activated human peripheral blood mononuclear cell

Übergeordnetes Werk:	In: Plants - MDPI AG, 2013, 3(2013), 1, Seite 18-26
Übergeordnetes Werk:	volume:3 ; year:2013 ; number:1 ; pages:18-26

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/plants3010018

Katalog-ID:	DOAJ061224766

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authorswithroles_txt_mv	Hisahiro Kai @@aut@@ Ena Akamatsu @@aut@@ Eri Torii @@aut@@ Hiroko Kodama @@aut@@ Chizuko Yukizaki @@aut@@ Isao Akagi @@aut@@ Hisatoshi Ino @@aut@@ Yoichi Sakakibara @@aut@@ Masahito Suiko @@aut@@ Ikuo Yamamoto @@aut@@ Akihiko Okayama @@aut@@ Kazuhiro Morishita @@aut@@ Hiroaki Kataoka @@aut@@ Koji Matsuno @@aut@@
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callnumber-first	Q - Science
author	Hisahiro Kai
spellingShingle	Hisahiro Kai misc QK1-989 misc adult T-cell leukemia misc bitter gourd seed extract misc α-eleostearic acid misc phytohemagglutinin-activated human peripheral blood mononuclear cell misc Botany Identification of a Bioactive Compound against Adult T-cell Leukaemia from Bitter Gourd Seeds
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topic_title	QK1-989 Identification of a Bioactive Compound against Adult T-cell Leukaemia from Bitter Gourd Seeds adult T-cell leukemia bitter gourd seed extract α-eleostearic acid phytohemagglutinin-activated human peripheral blood mononuclear cell
topic	misc QK1-989 misc adult T-cell leukemia misc bitter gourd seed extract misc α-eleostearic acid misc phytohemagglutinin-activated human peripheral blood mononuclear cell misc Botany
topic_unstemmed	misc QK1-989 misc adult T-cell leukemia misc bitter gourd seed extract misc α-eleostearic acid misc phytohemagglutinin-activated human peripheral blood mononuclear cell misc Botany
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title	Identification of a Bioactive Compound against Adult T-cell Leukaemia from Bitter Gourd Seeds
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title_full	Identification of a Bioactive Compound against Adult T-cell Leukaemia from Bitter Gourd Seeds
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author_browse	Hisahiro Kai Ena Akamatsu Eri Torii Hiroko Kodama Chizuko Yukizaki Isao Akagi Hisatoshi Ino Yoichi Sakakibara Masahito Suiko Ikuo Yamamoto Akihiko Okayama Kazuhiro Morishita Hiroaki Kataoka Koji Matsuno
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title_sort	identification of a bioactive compound against adult t-cell leukaemia from bitter gourd seeds
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title_auth	Identification of a Bioactive Compound against Adult T-cell Leukaemia from Bitter Gourd Seeds
abstract	In our previous report, an 80% ethanol bitter gourd seed extract (BGSE) was found to suppress proliferation of adult T-cell leukemia (ATL) cell lines. The present study aimed to identify the bioactive compounds from BGSE specific against ATL. From the result of an HPLC-MS analysis, α-eleostearic acid (α-ESA) was present in BGSE at 0.68% ± 0.0022% (±SD, n = 5). In the cell proliferation test, α-ESA potently suppressed proliferation of two ATL cell lines (ED and Su9T01; IC50 = 8.9 and 29.3 µM, respectively) more than several other octadecanoic acids. However, α-ESA moderately inhibited phytohemagglutinin-activated human peripheral blood mononuclear cells (PBMC; IC50 = 31.0 µM). These results suggest that BGSE-derived α-ESA has potential as a functional food constituent because of its activity against ATL, particularly against ED cells. Moreover, α-ESA might be effective for the prevention of moderate adverse effects of ATL on normal T cells.
abstractGer	In our previous report, an 80% ethanol bitter gourd seed extract (BGSE) was found to suppress proliferation of adult T-cell leukemia (ATL) cell lines. The present study aimed to identify the bioactive compounds from BGSE specific against ATL. From the result of an HPLC-MS analysis, α-eleostearic acid (α-ESA) was present in BGSE at 0.68% ± 0.0022% (±SD, n = 5). In the cell proliferation test, α-ESA potently suppressed proliferation of two ATL cell lines (ED and Su9T01; IC50 = 8.9 and 29.3 µM, respectively) more than several other octadecanoic acids. However, α-ESA moderately inhibited phytohemagglutinin-activated human peripheral blood mononuclear cells (PBMC; IC50 = 31.0 µM). These results suggest that BGSE-derived α-ESA has potential as a functional food constituent because of its activity against ATL, particularly against ED cells. Moreover, α-ESA might be effective for the prevention of moderate adverse effects of ATL on normal T cells.
abstract_unstemmed	In our previous report, an 80% ethanol bitter gourd seed extract (BGSE) was found to suppress proliferation of adult T-cell leukemia (ATL) cell lines. The present study aimed to identify the bioactive compounds from BGSE specific against ATL. From the result of an HPLC-MS analysis, α-eleostearic acid (α-ESA) was present in BGSE at 0.68% ± 0.0022% (±SD, n = 5). In the cell proliferation test, α-ESA potently suppressed proliferation of two ATL cell lines (ED and Su9T01; IC50 = 8.9 and 29.3 µM, respectively) more than several other octadecanoic acids. However, α-ESA moderately inhibited phytohemagglutinin-activated human peripheral blood mononuclear cells (PBMC; IC50 = 31.0 µM). These results suggest that BGSE-derived α-ESA has potential as a functional food constituent because of its activity against ATL, particularly against ED cells. Moreover, α-ESA might be effective for the prevention of moderate adverse effects of ATL on normal T cells.
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title_short	Identification of a Bioactive Compound against Adult T-cell Leukaemia from Bitter Gourd Seeds
url	https://doi.org/10.3390/plants3010018 https://doaj.org/article/6f952e8abdf14ddb9dd66f8a1adaabdb http://www.mdpi.com/2223-7747/3/1/18 https://doaj.org/toc/2223-7747
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author2	Ena Akamatsu Eri Torii Hiroko Kodama Chizuko Yukizaki Isao Akagi Hisatoshi Ino Yoichi Sakakibara Masahito Suiko Ikuo Yamamoto Akihiko Okayama Kazuhiro Morishita Hiroaki Kataoka Koji Matsuno
author2Str	Ena Akamatsu Eri Torii Hiroko Kodama Chizuko Yukizaki Isao Akagi Hisatoshi Ino Yoichi Sakakibara Masahito Suiko Ikuo Yamamoto Akihiko Okayama Kazuhiro Morishita Hiroaki Kataoka Koji Matsuno
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up_date	2024-07-03T19:32:10.923Z
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Identification of a Bioactive Compound against Adult T-cell Leukaemia from Bitter Gourd Seeds

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