Case Report: Liver Cysts and SARS-CoV-2: No Evidence of Virus in Cystic Fluid

Background: In December 2019, an outbreak of pneumonia, caused by a new type of coronavirus, named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It quickly spread worldwide, resulting in a pandemic. The clinical manifestations of SARS-CoV-2 range from mild non-specific symptoms to se...
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Autor*in:	Francesco Enrico D'Amico [verfasserIn] Dajana Glavas [verfasserIn] Giulia Noaro [verfasserIn] Domenico Bassi [verfasserIn] Riccardo Boetto [verfasserIn] Enrico Gringeri [verfasserIn] Maurizio De Luca [verfasserIn] Umberto Cillo [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	liver cyst infection liver benign disease CoV-2 jaundice fenestration cyst

Übergeordnetes Werk:	In: Frontiers in Surgery - Frontiers Media S.A., 2014, 8(2021)
Übergeordnetes Werk:	volume:8 ; year:2021

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fsurg.2021.677889

Katalog-ID:	DOAJ061269980

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allfields	10.3389/fsurg.2021.677889 doi (DE-627)DOAJ061269980 (DE-599)DOAJ1cebcd5d435b4d33a9c9f46e5f732f9a DE-627 ger DE-627 rakwb eng RD1-811 Francesco Enrico D'Amico verfasserin aut Case Report: Liver Cysts and SARS-CoV-2: No Evidence of Virus in Cystic Fluid 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: In December 2019, an outbreak of pneumonia, caused by a new type of coronavirus, named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It quickly spread worldwide, resulting in a pandemic. The clinical manifestations of SARS-CoV-2 range from mild non-specific symptoms to severe pneumonia with organ function damage. In addition, up to 60% of patients have liver impairment or dysfunction, confirmed by several studies by the presence of SARS-CoV-2 in the liver tissue.Methods: We report two cases of symptomatic liver cyst requiring fenestration after recent SARS-CoV-2 infection. Both patients had hospital admission due to documented SARS-CoV-2 infection. Recently, after the infection, they developed symptoms caused by an enlarged hepatic cyst: one had abdominal pain, and the other had jaundice. They underwent surgery after two negative swab tests for SARS-CoV-2.Results: Cystic fluid was sent for microbiological test, and real-time fluorescence polymerase chain reaction COVID-19 nucleic-acid assay of the cyst fluid was found to be negative in both cases.Discussion: Although there are no current data that can document a viral contamination of cystic fluid, there are data that document a hepatotropism of COVID-19 virus. Herein we report that after viral clearance at pharyngeal and nasal swab, there is no evidence of viral load in such potential viral reservoir. liver cyst infection liver benign disease CoV-2 jaundice fenestration cyst Surgery Francesco Enrico D'Amico verfasserin aut Dajana Glavas verfasserin aut Dajana Glavas verfasserin aut Giulia Noaro verfasserin aut Domenico Bassi verfasserin aut Riccardo Boetto verfasserin aut Enrico Gringeri verfasserin aut Enrico Gringeri verfasserin aut Maurizio De Luca verfasserin aut Umberto Cillo verfasserin aut Umberto Cillo verfasserin aut In Frontiers in Surgery Frontiers Media S.A., 2014 8(2021) (DE-627)788288954 (DE-600)2773823-1 2296875X nnns volume:8 year:2021 https://doi.org/10.3389/fsurg.2021.677889 kostenfrei https://doaj.org/article/1cebcd5d435b4d33a9c9f46e5f732f9a kostenfrei https://www.frontiersin.org/articles/10.3389/fsurg.2021.677889/full kostenfrei https://doaj.org/toc/2296-875X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_2446 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2021
spelling	10.3389/fsurg.2021.677889 doi (DE-627)DOAJ061269980 (DE-599)DOAJ1cebcd5d435b4d33a9c9f46e5f732f9a DE-627 ger DE-627 rakwb eng RD1-811 Francesco Enrico D'Amico verfasserin aut Case Report: Liver Cysts and SARS-CoV-2: No Evidence of Virus in Cystic Fluid 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: In December 2019, an outbreak of pneumonia, caused by a new type of coronavirus, named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It quickly spread worldwide, resulting in a pandemic. The clinical manifestations of SARS-CoV-2 range from mild non-specific symptoms to severe pneumonia with organ function damage. In addition, up to 60% of patients have liver impairment or dysfunction, confirmed by several studies by the presence of SARS-CoV-2 in the liver tissue.Methods: We report two cases of symptomatic liver cyst requiring fenestration after recent SARS-CoV-2 infection. Both patients had hospital admission due to documented SARS-CoV-2 infection. Recently, after the infection, they developed symptoms caused by an enlarged hepatic cyst: one had abdominal pain, and the other had jaundice. They underwent surgery after two negative swab tests for SARS-CoV-2.Results: Cystic fluid was sent for microbiological test, and real-time fluorescence polymerase chain reaction COVID-19 nucleic-acid assay of the cyst fluid was found to be negative in both cases.Discussion: Although there are no current data that can document a viral contamination of cystic fluid, there are data that document a hepatotropism of COVID-19 virus. Herein we report that after viral clearance at pharyngeal and nasal swab, there is no evidence of viral load in such potential viral reservoir. liver cyst infection liver benign disease CoV-2 jaundice fenestration cyst Surgery Francesco Enrico D'Amico verfasserin aut Dajana Glavas verfasserin aut Dajana Glavas verfasserin aut Giulia Noaro verfasserin aut Domenico Bassi verfasserin aut Riccardo Boetto verfasserin aut Enrico Gringeri verfasserin aut Enrico Gringeri verfasserin aut Maurizio De Luca verfasserin aut Umberto Cillo verfasserin aut Umberto Cillo verfasserin aut In Frontiers in Surgery Frontiers Media S.A., 2014 8(2021) (DE-627)788288954 (DE-600)2773823-1 2296875X nnns volume:8 year:2021 https://doi.org/10.3389/fsurg.2021.677889 kostenfrei https://doaj.org/article/1cebcd5d435b4d33a9c9f46e5f732f9a kostenfrei https://www.frontiersin.org/articles/10.3389/fsurg.2021.677889/full kostenfrei https://doaj.org/toc/2296-875X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_2446 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2021
allfields_unstemmed	10.3389/fsurg.2021.677889 doi (DE-627)DOAJ061269980 (DE-599)DOAJ1cebcd5d435b4d33a9c9f46e5f732f9a DE-627 ger DE-627 rakwb eng RD1-811 Francesco Enrico D'Amico verfasserin aut Case Report: Liver Cysts and SARS-CoV-2: No Evidence of Virus in Cystic Fluid 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: In December 2019, an outbreak of pneumonia, caused by a new type of coronavirus, named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It quickly spread worldwide, resulting in a pandemic. The clinical manifestations of SARS-CoV-2 range from mild non-specific symptoms to severe pneumonia with organ function damage. In addition, up to 60% of patients have liver impairment or dysfunction, confirmed by several studies by the presence of SARS-CoV-2 in the liver tissue.Methods: We report two cases of symptomatic liver cyst requiring fenestration after recent SARS-CoV-2 infection. Both patients had hospital admission due to documented SARS-CoV-2 infection. Recently, after the infection, they developed symptoms caused by an enlarged hepatic cyst: one had abdominal pain, and the other had jaundice. They underwent surgery after two negative swab tests for SARS-CoV-2.Results: Cystic fluid was sent for microbiological test, and real-time fluorescence polymerase chain reaction COVID-19 nucleic-acid assay of the cyst fluid was found to be negative in both cases.Discussion: Although there are no current data that can document a viral contamination of cystic fluid, there are data that document a hepatotropism of COVID-19 virus. Herein we report that after viral clearance at pharyngeal and nasal swab, there is no evidence of viral load in such potential viral reservoir. liver cyst infection liver benign disease CoV-2 jaundice fenestration cyst Surgery Francesco Enrico D'Amico verfasserin aut Dajana Glavas verfasserin aut Dajana Glavas verfasserin aut Giulia Noaro verfasserin aut Domenico Bassi verfasserin aut Riccardo Boetto verfasserin aut Enrico Gringeri verfasserin aut Enrico Gringeri verfasserin aut Maurizio De Luca verfasserin aut Umberto Cillo verfasserin aut Umberto Cillo verfasserin aut In Frontiers in Surgery Frontiers Media S.A., 2014 8(2021) (DE-627)788288954 (DE-600)2773823-1 2296875X nnns volume:8 year:2021 https://doi.org/10.3389/fsurg.2021.677889 kostenfrei https://doaj.org/article/1cebcd5d435b4d33a9c9f46e5f732f9a kostenfrei https://www.frontiersin.org/articles/10.3389/fsurg.2021.677889/full kostenfrei https://doaj.org/toc/2296-875X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_2446 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2021
allfieldsGer	10.3389/fsurg.2021.677889 doi (DE-627)DOAJ061269980 (DE-599)DOAJ1cebcd5d435b4d33a9c9f46e5f732f9a DE-627 ger DE-627 rakwb eng RD1-811 Francesco Enrico D'Amico verfasserin aut Case Report: Liver Cysts and SARS-CoV-2: No Evidence of Virus in Cystic Fluid 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: In December 2019, an outbreak of pneumonia, caused by a new type of coronavirus, named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It quickly spread worldwide, resulting in a pandemic. The clinical manifestations of SARS-CoV-2 range from mild non-specific symptoms to severe pneumonia with organ function damage. In addition, up to 60% of patients have liver impairment or dysfunction, confirmed by several studies by the presence of SARS-CoV-2 in the liver tissue.Methods: We report two cases of symptomatic liver cyst requiring fenestration after recent SARS-CoV-2 infection. Both patients had hospital admission due to documented SARS-CoV-2 infection. Recently, after the infection, they developed symptoms caused by an enlarged hepatic cyst: one had abdominal pain, and the other had jaundice. They underwent surgery after two negative swab tests for SARS-CoV-2.Results: Cystic fluid was sent for microbiological test, and real-time fluorescence polymerase chain reaction COVID-19 nucleic-acid assay of the cyst fluid was found to be negative in both cases.Discussion: Although there are no current data that can document a viral contamination of cystic fluid, there are data that document a hepatotropism of COVID-19 virus. Herein we report that after viral clearance at pharyngeal and nasal swab, there is no evidence of viral load in such potential viral reservoir. liver cyst infection liver benign disease CoV-2 jaundice fenestration cyst Surgery Francesco Enrico D'Amico verfasserin aut Dajana Glavas verfasserin aut Dajana Glavas verfasserin aut Giulia Noaro verfasserin aut Domenico Bassi verfasserin aut Riccardo Boetto verfasserin aut Enrico Gringeri verfasserin aut Enrico Gringeri verfasserin aut Maurizio De Luca verfasserin aut Umberto Cillo verfasserin aut Umberto Cillo verfasserin aut In Frontiers in Surgery Frontiers Media S.A., 2014 8(2021) (DE-627)788288954 (DE-600)2773823-1 2296875X nnns volume:8 year:2021 https://doi.org/10.3389/fsurg.2021.677889 kostenfrei https://doaj.org/article/1cebcd5d435b4d33a9c9f46e5f732f9a kostenfrei https://www.frontiersin.org/articles/10.3389/fsurg.2021.677889/full kostenfrei https://doaj.org/toc/2296-875X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_2446 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2021
allfieldsSound	10.3389/fsurg.2021.677889 doi (DE-627)DOAJ061269980 (DE-599)DOAJ1cebcd5d435b4d33a9c9f46e5f732f9a DE-627 ger DE-627 rakwb eng RD1-811 Francesco Enrico D'Amico verfasserin aut Case Report: Liver Cysts and SARS-CoV-2: No Evidence of Virus in Cystic Fluid 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: In December 2019, an outbreak of pneumonia, caused by a new type of coronavirus, named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It quickly spread worldwide, resulting in a pandemic. The clinical manifestations of SARS-CoV-2 range from mild non-specific symptoms to severe pneumonia with organ function damage. In addition, up to 60% of patients have liver impairment or dysfunction, confirmed by several studies by the presence of SARS-CoV-2 in the liver tissue.Methods: We report two cases of symptomatic liver cyst requiring fenestration after recent SARS-CoV-2 infection. Both patients had hospital admission due to documented SARS-CoV-2 infection. Recently, after the infection, they developed symptoms caused by an enlarged hepatic cyst: one had abdominal pain, and the other had jaundice. They underwent surgery after two negative swab tests for SARS-CoV-2.Results: Cystic fluid was sent for microbiological test, and real-time fluorescence polymerase chain reaction COVID-19 nucleic-acid assay of the cyst fluid was found to be negative in both cases.Discussion: Although there are no current data that can document a viral contamination of cystic fluid, there are data that document a hepatotropism of COVID-19 virus. Herein we report that after viral clearance at pharyngeal and nasal swab, there is no evidence of viral load in such potential viral reservoir. liver cyst infection liver benign disease CoV-2 jaundice fenestration cyst Surgery Francesco Enrico D'Amico verfasserin aut Dajana Glavas verfasserin aut Dajana Glavas verfasserin aut Giulia Noaro verfasserin aut Domenico Bassi verfasserin aut Riccardo Boetto verfasserin aut Enrico Gringeri verfasserin aut Enrico Gringeri verfasserin aut Maurizio De Luca verfasserin aut Umberto Cillo verfasserin aut Umberto Cillo verfasserin aut In Frontiers in Surgery Frontiers Media S.A., 2014 8(2021) (DE-627)788288954 (DE-600)2773823-1 2296875X nnns volume:8 year:2021 https://doi.org/10.3389/fsurg.2021.677889 kostenfrei https://doaj.org/article/1cebcd5d435b4d33a9c9f46e5f732f9a kostenfrei https://www.frontiersin.org/articles/10.3389/fsurg.2021.677889/full kostenfrei https://doaj.org/toc/2296-875X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_2446 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2021
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callnumber-first	R - Medicine
author	Francesco Enrico D'Amico
spellingShingle	Francesco Enrico D'Amico misc RD1-811 misc liver cyst infection misc liver benign disease misc CoV-2 misc jaundice misc fenestration cyst misc Surgery Case Report: Liver Cysts and SARS-CoV-2: No Evidence of Virus in Cystic Fluid
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topic_title	RD1-811 Case Report: Liver Cysts and SARS-CoV-2: No Evidence of Virus in Cystic Fluid liver cyst infection liver benign disease CoV-2 jaundice fenestration cyst
topic	misc RD1-811 misc liver cyst infection misc liver benign disease misc CoV-2 misc jaundice misc fenestration cyst misc Surgery
topic_unstemmed	misc RD1-811 misc liver cyst infection misc liver benign disease misc CoV-2 misc jaundice misc fenestration cyst misc Surgery
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title	Case Report: Liver Cysts and SARS-CoV-2: No Evidence of Virus in Cystic Fluid
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title_full	Case Report: Liver Cysts and SARS-CoV-2: No Evidence of Virus in Cystic Fluid
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title_sort	case report: liver cysts and sars-cov-2: no evidence of virus in cystic fluid
callnumber	RD1-811
title_auth	Case Report: Liver Cysts and SARS-CoV-2: No Evidence of Virus in Cystic Fluid
abstract	Background: In December 2019, an outbreak of pneumonia, caused by a new type of coronavirus, named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It quickly spread worldwide, resulting in a pandemic. The clinical manifestations of SARS-CoV-2 range from mild non-specific symptoms to severe pneumonia with organ function damage. In addition, up to 60% of patients have liver impairment or dysfunction, confirmed by several studies by the presence of SARS-CoV-2 in the liver tissue.Methods: We report two cases of symptomatic liver cyst requiring fenestration after recent SARS-CoV-2 infection. Both patients had hospital admission due to documented SARS-CoV-2 infection. Recently, after the infection, they developed symptoms caused by an enlarged hepatic cyst: one had abdominal pain, and the other had jaundice. They underwent surgery after two negative swab tests for SARS-CoV-2.Results: Cystic fluid was sent for microbiological test, and real-time fluorescence polymerase chain reaction COVID-19 nucleic-acid assay of the cyst fluid was found to be negative in both cases.Discussion: Although there are no current data that can document a viral contamination of cystic fluid, there are data that document a hepatotropism of COVID-19 virus. Herein we report that after viral clearance at pharyngeal and nasal swab, there is no evidence of viral load in such potential viral reservoir.
abstractGer	Background: In December 2019, an outbreak of pneumonia, caused by a new type of coronavirus, named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It quickly spread worldwide, resulting in a pandemic. The clinical manifestations of SARS-CoV-2 range from mild non-specific symptoms to severe pneumonia with organ function damage. In addition, up to 60% of patients have liver impairment or dysfunction, confirmed by several studies by the presence of SARS-CoV-2 in the liver tissue.Methods: We report two cases of symptomatic liver cyst requiring fenestration after recent SARS-CoV-2 infection. Both patients had hospital admission due to documented SARS-CoV-2 infection. Recently, after the infection, they developed symptoms caused by an enlarged hepatic cyst: one had abdominal pain, and the other had jaundice. They underwent surgery after two negative swab tests for SARS-CoV-2.Results: Cystic fluid was sent for microbiological test, and real-time fluorescence polymerase chain reaction COVID-19 nucleic-acid assay of the cyst fluid was found to be negative in both cases.Discussion: Although there are no current data that can document a viral contamination of cystic fluid, there are data that document a hepatotropism of COVID-19 virus. Herein we report that after viral clearance at pharyngeal and nasal swab, there is no evidence of viral load in such potential viral reservoir.
abstract_unstemmed	Background: In December 2019, an outbreak of pneumonia, caused by a new type of coronavirus, named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It quickly spread worldwide, resulting in a pandemic. The clinical manifestations of SARS-CoV-2 range from mild non-specific symptoms to severe pneumonia with organ function damage. In addition, up to 60% of patients have liver impairment or dysfunction, confirmed by several studies by the presence of SARS-CoV-2 in the liver tissue.Methods: We report two cases of symptomatic liver cyst requiring fenestration after recent SARS-CoV-2 infection. Both patients had hospital admission due to documented SARS-CoV-2 infection. Recently, after the infection, they developed symptoms caused by an enlarged hepatic cyst: one had abdominal pain, and the other had jaundice. They underwent surgery after two negative swab tests for SARS-CoV-2.Results: Cystic fluid was sent for microbiological test, and real-time fluorescence polymerase chain reaction COVID-19 nucleic-acid assay of the cyst fluid was found to be negative in both cases.Discussion: Although there are no current data that can document a viral contamination of cystic fluid, there are data that document a hepatotropism of COVID-19 virus. Herein we report that after viral clearance at pharyngeal and nasal swab, there is no evidence of viral load in such potential viral reservoir.
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title_short	Case Report: Liver Cysts and SARS-CoV-2: No Evidence of Virus in Cystic Fluid
url	https://doi.org/10.3389/fsurg.2021.677889 https://doaj.org/article/1cebcd5d435b4d33a9c9f46e5f732f9a https://www.frontiersin.org/articles/10.3389/fsurg.2021.677889/full https://doaj.org/toc/2296-875X
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author2	Francesco Enrico D'Amico Dajana Glavas Giulia Noaro Domenico Bassi Riccardo Boetto Enrico Gringeri Maurizio De Luca Umberto Cillo
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up_date	2024-07-03T19:47:04.342Z
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They underwent surgery after two negative swab tests for SARS-CoV-2.Results: Cystic fluid was sent for microbiological test, and real-time fluorescence polymerase chain reaction COVID-19 nucleic-acid assay of the cyst fluid was found to be negative in both cases.Discussion: Although there are no current data that can document a viral contamination of cystic fluid, there are data that document a hepatotropism of COVID-19 virus. 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Case Report: Liver Cysts and SARS-CoV-2: No Evidence of Virus in Cystic Fluid

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