Association study between BGLAP RS1800247-polymorphic variant and type 2 diabetes mellitus development among hypertensive and non-hypertensive Ukrainians
The risk of type 2 diabetes mellitus (T2DM) development depends on a hereditary predisposition. According to the current data, bone tissue enhances insulin gene expression in pancreatic β-cells as well as increases insulin sensitivity of adipocytes, myocytes and hepatocytes through the secretion of...
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| Autor*in: |
Ya. D. Chumachenko [verfasserIn] M. O. Kyrychenko [verfasserIn] D. M. Ramazanova [verfasserIn] M. V. Smiianova [verfasserIn] V. Yu. Harbuzova [verfasserIn] O. V. Ataman [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch ; Russisch ; Ukrainisch |
| Erschienen: |
2021 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
In: Zaporožskij Medicinskij Žurnal - Zaporozhye State Medical University, 2016, 23(2021), 3, Seite 338-342 |
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| Übergeordnetes Werk: |
volume:23 ; year:2021 ; number:3 ; pages:338-342 |
| Links: |
Link aufrufen |
|---|
| DOI / URN: |
10.14739/2310-1210.2021.3.220651 |
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| Katalog-ID: |
DOAJ061418498 |
|---|
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| 520 | |a The risk of type 2 diabetes mellitus (T2DM) development depends on a hereditary predisposition. According to the current data, bone tissue enhances insulin gene expression in pancreatic β-cells as well as increases insulin sensitivity of adipocytes, myocytes and hepatocytes through the secretion of undercarboxylated osteocalcin (unOCN). The aim. To analyze the relation between rs1800247 SNP and T2DM occurrence depending on the arterial hypertension (AH) presence, as well as association between rs1800247 and systolic, diastolic, pulse, mean blood pressure among patients with T2DM. Materials and methods. This study included 153 patients with diagnosed T2DM and 311 individuals without any carbohydrate metabolism disorders. Polymerase chain reaction-restriction fragment length polymorphism analysis (PCR-RFLP) was used for BGLAP rs1800247-genotyping. Logistic regression with interaction term “genotype × AH” was used to estimate the association between BGLAP rs1800247-genotypes and T2DM development in dominant, recessive, over-dominant and additive models of inheritance. Linear regression was performed to examine the influence of minor C-allele on the arterial blood pressure. Lipid profile characteristics of T2DM patients were stratified by rs1800247-genotype using ANOVA with Bonferroni post hoc test. All calculations were performed using Statistical Package for the Social Sciences software (SPSS, version 22.0, Chicago, IL, USA). A value of P ˂ 0.05 was considered as significant. Results. No association was found between rs1800247 single nucleotide polymorphism and T2DM development neither in AH patients, nor in subjects without AH (Paint b < 0.05). There was no impact of rs1800247 genotypes on systolic, diastolic, pulse and mean blood pressure among patients with T2DM (P < 0.05). It was showed that T2DM non-hypertensive CC-carriers had significantly lower levels of total cholesterol (P = 0.012) and LDL cholesterol (P = 0.04), but higher concentration of HDL cholesterol (P = 0.015) compared to the TT-genotype. Conclusions. It was showed that CC-carriers had more favorable parameters of lipid metabolism among T2DM non-hypertensive Ukrainians. However, there was no association between rs1800247 SNP and T2DM development as well as blood pressure parameters. | ||
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10.14739/2310-1210.2021.3.220651 doi (DE-627)DOAJ061418498 (DE-599)DOAJ19e603f0ee4d4884aecb2731973579a4 DE-627 ger DE-627 rakwb eng rus ukr Ya. D. Chumachenko verfasserin aut Association study between BGLAP RS1800247-polymorphic variant and type 2 diabetes mellitus development among hypertensive and non-hypertensive Ukrainians 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The risk of type 2 diabetes mellitus (T2DM) development depends on a hereditary predisposition. According to the current data, bone tissue enhances insulin gene expression in pancreatic β-cells as well as increases insulin sensitivity of adipocytes, myocytes and hepatocytes through the secretion of undercarboxylated osteocalcin (unOCN). The aim. To analyze the relation between rs1800247 SNP and T2DM occurrence depending on the arterial hypertension (AH) presence, as well as association between rs1800247 and systolic, diastolic, pulse, mean blood pressure among patients with T2DM. Materials and methods. This study included 153 patients with diagnosed T2DM and 311 individuals without any carbohydrate metabolism disorders. Polymerase chain reaction-restriction fragment length polymorphism analysis (PCR-RFLP) was used for BGLAP rs1800247-genotyping. Logistic regression with interaction term “genotype × AH” was used to estimate the association between BGLAP rs1800247-genotypes and T2DM development in dominant, recessive, over-dominant and additive models of inheritance. Linear regression was performed to examine the influence of minor C-allele on the arterial blood pressure. Lipid profile characteristics of T2DM patients were stratified by rs1800247-genotype using ANOVA with Bonferroni post hoc test. All calculations were performed using Statistical Package for the Social Sciences software (SPSS, version 22.0, Chicago, IL, USA). A value of P ˂ 0.05 was considered as significant. Results. No association was found between rs1800247 single nucleotide polymorphism and T2DM development neither in AH patients, nor in subjects without AH (Paint b < 0.05). There was no impact of rs1800247 genotypes on systolic, diastolic, pulse and mean blood pressure among patients with T2DM (P < 0.05). It was showed that T2DM non-hypertensive CC-carriers had significantly lower levels of total cholesterol (P = 0.012) and LDL cholesterol (P = 0.04), but higher concentration of HDL cholesterol (P = 0.015) compared to the TT-genotype. Conclusions. It was showed that CC-carriers had more favorable parameters of lipid metabolism among T2DM non-hypertensive Ukrainians. However, there was no association between rs1800247 SNP and T2DM development as well as blood pressure parameters. type 2 diabetes mellitus hypertension osteocalcin single nucleotide polymorphism tt-homozygote tc-heterozygote cc-homozygote Medicine R M. O. Kyrychenko verfasserin aut D. M. Ramazanova verfasserin aut M. V. Smiianova verfasserin aut V. Yu. Harbuzova verfasserin aut O. V. Ataman verfasserin aut In Zaporožskij Medicinskij Žurnal Zaporozhye State Medical University, 2016 23(2021), 3, Seite 338-342 (DE-627)176064269X 23101210 nnns volume:23 year:2021 number:3 pages:338-342 https://doi.org/10.14739/2310-1210.2021.3.220651 kostenfrei https://doaj.org/article/19e603f0ee4d4884aecb2731973579a4 kostenfrei http://zmj.zsmu.edu.ua/article/view/220651/232308 kostenfrei https://doaj.org/toc/2306-4145 Journal toc kostenfrei https://doaj.org/toc/2310-1210 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 23 2021 3 338-342 |
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10.14739/2310-1210.2021.3.220651 doi (DE-627)DOAJ061418498 (DE-599)DOAJ19e603f0ee4d4884aecb2731973579a4 DE-627 ger DE-627 rakwb eng rus ukr Ya. D. Chumachenko verfasserin aut Association study between BGLAP RS1800247-polymorphic variant and type 2 diabetes mellitus development among hypertensive and non-hypertensive Ukrainians 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The risk of type 2 diabetes mellitus (T2DM) development depends on a hereditary predisposition. According to the current data, bone tissue enhances insulin gene expression in pancreatic β-cells as well as increases insulin sensitivity of adipocytes, myocytes and hepatocytes through the secretion of undercarboxylated osteocalcin (unOCN). The aim. To analyze the relation between rs1800247 SNP and T2DM occurrence depending on the arterial hypertension (AH) presence, as well as association between rs1800247 and systolic, diastolic, pulse, mean blood pressure among patients with T2DM. Materials and methods. This study included 153 patients with diagnosed T2DM and 311 individuals without any carbohydrate metabolism disorders. Polymerase chain reaction-restriction fragment length polymorphism analysis (PCR-RFLP) was used for BGLAP rs1800247-genotyping. Logistic regression with interaction term “genotype × AH” was used to estimate the association between BGLAP rs1800247-genotypes and T2DM development in dominant, recessive, over-dominant and additive models of inheritance. Linear regression was performed to examine the influence of minor C-allele on the arterial blood pressure. Lipid profile characteristics of T2DM patients were stratified by rs1800247-genotype using ANOVA with Bonferroni post hoc test. All calculations were performed using Statistical Package for the Social Sciences software (SPSS, version 22.0, Chicago, IL, USA). A value of P ˂ 0.05 was considered as significant. Results. No association was found between rs1800247 single nucleotide polymorphism and T2DM development neither in AH patients, nor in subjects without AH (Paint b < 0.05). There was no impact of rs1800247 genotypes on systolic, diastolic, pulse and mean blood pressure among patients with T2DM (P < 0.05). It was showed that T2DM non-hypertensive CC-carriers had significantly lower levels of total cholesterol (P = 0.012) and LDL cholesterol (P = 0.04), but higher concentration of HDL cholesterol (P = 0.015) compared to the TT-genotype. Conclusions. It was showed that CC-carriers had more favorable parameters of lipid metabolism among T2DM non-hypertensive Ukrainians. However, there was no association between rs1800247 SNP and T2DM development as well as blood pressure parameters. type 2 diabetes mellitus hypertension osteocalcin single nucleotide polymorphism tt-homozygote tc-heterozygote cc-homozygote Medicine R M. O. Kyrychenko verfasserin aut D. M. Ramazanova verfasserin aut M. V. Smiianova verfasserin aut V. Yu. Harbuzova verfasserin aut O. V. Ataman verfasserin aut In Zaporožskij Medicinskij Žurnal Zaporozhye State Medical University, 2016 23(2021), 3, Seite 338-342 (DE-627)176064269X 23101210 nnns volume:23 year:2021 number:3 pages:338-342 https://doi.org/10.14739/2310-1210.2021.3.220651 kostenfrei https://doaj.org/article/19e603f0ee4d4884aecb2731973579a4 kostenfrei http://zmj.zsmu.edu.ua/article/view/220651/232308 kostenfrei https://doaj.org/toc/2306-4145 Journal toc kostenfrei https://doaj.org/toc/2310-1210 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 23 2021 3 338-342 |
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10.14739/2310-1210.2021.3.220651 doi (DE-627)DOAJ061418498 (DE-599)DOAJ19e603f0ee4d4884aecb2731973579a4 DE-627 ger DE-627 rakwb eng rus ukr Ya. D. Chumachenko verfasserin aut Association study between BGLAP RS1800247-polymorphic variant and type 2 diabetes mellitus development among hypertensive and non-hypertensive Ukrainians 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The risk of type 2 diabetes mellitus (T2DM) development depends on a hereditary predisposition. According to the current data, bone tissue enhances insulin gene expression in pancreatic β-cells as well as increases insulin sensitivity of adipocytes, myocytes and hepatocytes through the secretion of undercarboxylated osteocalcin (unOCN). The aim. To analyze the relation between rs1800247 SNP and T2DM occurrence depending on the arterial hypertension (AH) presence, as well as association between rs1800247 and systolic, diastolic, pulse, mean blood pressure among patients with T2DM. Materials and methods. This study included 153 patients with diagnosed T2DM and 311 individuals without any carbohydrate metabolism disorders. Polymerase chain reaction-restriction fragment length polymorphism analysis (PCR-RFLP) was used for BGLAP rs1800247-genotyping. Logistic regression with interaction term “genotype × AH” was used to estimate the association between BGLAP rs1800247-genotypes and T2DM development in dominant, recessive, over-dominant and additive models of inheritance. Linear regression was performed to examine the influence of minor C-allele on the arterial blood pressure. Lipid profile characteristics of T2DM patients were stratified by rs1800247-genotype using ANOVA with Bonferroni post hoc test. All calculations were performed using Statistical Package for the Social Sciences software (SPSS, version 22.0, Chicago, IL, USA). A value of P ˂ 0.05 was considered as significant. Results. No association was found between rs1800247 single nucleotide polymorphism and T2DM development neither in AH patients, nor in subjects without AH (Paint b < 0.05). There was no impact of rs1800247 genotypes on systolic, diastolic, pulse and mean blood pressure among patients with T2DM (P < 0.05). It was showed that T2DM non-hypertensive CC-carriers had significantly lower levels of total cholesterol (P = 0.012) and LDL cholesterol (P = 0.04), but higher concentration of HDL cholesterol (P = 0.015) compared to the TT-genotype. Conclusions. It was showed that CC-carriers had more favorable parameters of lipid metabolism among T2DM non-hypertensive Ukrainians. However, there was no association between rs1800247 SNP and T2DM development as well as blood pressure parameters. type 2 diabetes mellitus hypertension osteocalcin single nucleotide polymorphism tt-homozygote tc-heterozygote cc-homozygote Medicine R M. O. Kyrychenko verfasserin aut D. M. Ramazanova verfasserin aut M. V. Smiianova verfasserin aut V. Yu. Harbuzova verfasserin aut O. V. Ataman verfasserin aut In Zaporožskij Medicinskij Žurnal Zaporozhye State Medical University, 2016 23(2021), 3, Seite 338-342 (DE-627)176064269X 23101210 nnns volume:23 year:2021 number:3 pages:338-342 https://doi.org/10.14739/2310-1210.2021.3.220651 kostenfrei https://doaj.org/article/19e603f0ee4d4884aecb2731973579a4 kostenfrei http://zmj.zsmu.edu.ua/article/view/220651/232308 kostenfrei https://doaj.org/toc/2306-4145 Journal toc kostenfrei https://doaj.org/toc/2310-1210 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 23 2021 3 338-342 |
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10.14739/2310-1210.2021.3.220651 doi (DE-627)DOAJ061418498 (DE-599)DOAJ19e603f0ee4d4884aecb2731973579a4 DE-627 ger DE-627 rakwb eng rus ukr Ya. D. Chumachenko verfasserin aut Association study between BGLAP RS1800247-polymorphic variant and type 2 diabetes mellitus development among hypertensive and non-hypertensive Ukrainians 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The risk of type 2 diabetes mellitus (T2DM) development depends on a hereditary predisposition. According to the current data, bone tissue enhances insulin gene expression in pancreatic β-cells as well as increases insulin sensitivity of adipocytes, myocytes and hepatocytes through the secretion of undercarboxylated osteocalcin (unOCN). The aim. To analyze the relation between rs1800247 SNP and T2DM occurrence depending on the arterial hypertension (AH) presence, as well as association between rs1800247 and systolic, diastolic, pulse, mean blood pressure among patients with T2DM. Materials and methods. This study included 153 patients with diagnosed T2DM and 311 individuals without any carbohydrate metabolism disorders. Polymerase chain reaction-restriction fragment length polymorphism analysis (PCR-RFLP) was used for BGLAP rs1800247-genotyping. Logistic regression with interaction term “genotype × AH” was used to estimate the association between BGLAP rs1800247-genotypes and T2DM development in dominant, recessive, over-dominant and additive models of inheritance. Linear regression was performed to examine the influence of minor C-allele on the arterial blood pressure. Lipid profile characteristics of T2DM patients were stratified by rs1800247-genotype using ANOVA with Bonferroni post hoc test. All calculations were performed using Statistical Package for the Social Sciences software (SPSS, version 22.0, Chicago, IL, USA). A value of P ˂ 0.05 was considered as significant. Results. No association was found between rs1800247 single nucleotide polymorphism and T2DM development neither in AH patients, nor in subjects without AH (Paint b < 0.05). There was no impact of rs1800247 genotypes on systolic, diastolic, pulse and mean blood pressure among patients with T2DM (P < 0.05). It was showed that T2DM non-hypertensive CC-carriers had significantly lower levels of total cholesterol (P = 0.012) and LDL cholesterol (P = 0.04), but higher concentration of HDL cholesterol (P = 0.015) compared to the TT-genotype. Conclusions. It was showed that CC-carriers had more favorable parameters of lipid metabolism among T2DM non-hypertensive Ukrainians. However, there was no association between rs1800247 SNP and T2DM development as well as blood pressure parameters. type 2 diabetes mellitus hypertension osteocalcin single nucleotide polymorphism tt-homozygote tc-heterozygote cc-homozygote Medicine R M. O. Kyrychenko verfasserin aut D. M. Ramazanova verfasserin aut M. V. Smiianova verfasserin aut V. Yu. Harbuzova verfasserin aut O. V. Ataman verfasserin aut In Zaporožskij Medicinskij Žurnal Zaporozhye State Medical University, 2016 23(2021), 3, Seite 338-342 (DE-627)176064269X 23101210 nnns volume:23 year:2021 number:3 pages:338-342 https://doi.org/10.14739/2310-1210.2021.3.220651 kostenfrei https://doaj.org/article/19e603f0ee4d4884aecb2731973579a4 kostenfrei http://zmj.zsmu.edu.ua/article/view/220651/232308 kostenfrei https://doaj.org/toc/2306-4145 Journal toc kostenfrei https://doaj.org/toc/2310-1210 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 23 2021 3 338-342 |
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10.14739/2310-1210.2021.3.220651 doi (DE-627)DOAJ061418498 (DE-599)DOAJ19e603f0ee4d4884aecb2731973579a4 DE-627 ger DE-627 rakwb eng rus ukr Ya. D. Chumachenko verfasserin aut Association study between BGLAP RS1800247-polymorphic variant and type 2 diabetes mellitus development among hypertensive and non-hypertensive Ukrainians 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The risk of type 2 diabetes mellitus (T2DM) development depends on a hereditary predisposition. According to the current data, bone tissue enhances insulin gene expression in pancreatic β-cells as well as increases insulin sensitivity of adipocytes, myocytes and hepatocytes through the secretion of undercarboxylated osteocalcin (unOCN). The aim. To analyze the relation between rs1800247 SNP and T2DM occurrence depending on the arterial hypertension (AH) presence, as well as association between rs1800247 and systolic, diastolic, pulse, mean blood pressure among patients with T2DM. Materials and methods. This study included 153 patients with diagnosed T2DM and 311 individuals without any carbohydrate metabolism disorders. Polymerase chain reaction-restriction fragment length polymorphism analysis (PCR-RFLP) was used for BGLAP rs1800247-genotyping. Logistic regression with interaction term “genotype × AH” was used to estimate the association between BGLAP rs1800247-genotypes and T2DM development in dominant, recessive, over-dominant and additive models of inheritance. Linear regression was performed to examine the influence of minor C-allele on the arterial blood pressure. Lipid profile characteristics of T2DM patients were stratified by rs1800247-genotype using ANOVA with Bonferroni post hoc test. All calculations were performed using Statistical Package for the Social Sciences software (SPSS, version 22.0, Chicago, IL, USA). A value of P ˂ 0.05 was considered as significant. Results. No association was found between rs1800247 single nucleotide polymorphism and T2DM development neither in AH patients, nor in subjects without AH (Paint b < 0.05). There was no impact of rs1800247 genotypes on systolic, diastolic, pulse and mean blood pressure among patients with T2DM (P < 0.05). It was showed that T2DM non-hypertensive CC-carriers had significantly lower levels of total cholesterol (P = 0.012) and LDL cholesterol (P = 0.04), but higher concentration of HDL cholesterol (P = 0.015) compared to the TT-genotype. Conclusions. It was showed that CC-carriers had more favorable parameters of lipid metabolism among T2DM non-hypertensive Ukrainians. However, there was no association between rs1800247 SNP and T2DM development as well as blood pressure parameters. type 2 diabetes mellitus hypertension osteocalcin single nucleotide polymorphism tt-homozygote tc-heterozygote cc-homozygote Medicine R M. O. Kyrychenko verfasserin aut D. M. Ramazanova verfasserin aut M. V. Smiianova verfasserin aut V. Yu. Harbuzova verfasserin aut O. V. Ataman verfasserin aut In Zaporožskij Medicinskij Žurnal Zaporozhye State Medical University, 2016 23(2021), 3, Seite 338-342 (DE-627)176064269X 23101210 nnns volume:23 year:2021 number:3 pages:338-342 https://doi.org/10.14739/2310-1210.2021.3.220651 kostenfrei https://doaj.org/article/19e603f0ee4d4884aecb2731973579a4 kostenfrei http://zmj.zsmu.edu.ua/article/view/220651/232308 kostenfrei https://doaj.org/toc/2306-4145 Journal toc kostenfrei https://doaj.org/toc/2310-1210 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 23 2021 3 338-342 |
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According to the current data, bone tissue enhances insulin gene expression in pancreatic β-cells as well as increases insulin sensitivity of adipocytes, myocytes and hepatocytes through the secretion of undercarboxylated osteocalcin (unOCN). The aim. To analyze the relation between rs1800247 SNP and T2DM occurrence depending on the arterial hypertension (AH) presence, as well as association between rs1800247 and systolic, diastolic, pulse, mean blood pressure among patients with T2DM. Materials and methods. This study included 153 patients with diagnosed T2DM and 311 individuals without any carbohydrate metabolism disorders. Polymerase chain reaction-restriction fragment length polymorphism analysis (PCR-RFLP) was used for BGLAP rs1800247-genotyping. Logistic regression with interaction term “genotype × AH” was used to estimate the association between BGLAP rs1800247-genotypes and T2DM development in dominant, recessive, over-dominant and additive models of inheritance. Linear regression was performed to examine the influence of minor C-allele on the arterial blood pressure. Lipid profile characteristics of T2DM patients were stratified by rs1800247-genotype using ANOVA with Bonferroni post hoc test. All calculations were performed using Statistical Package for the Social Sciences software (SPSS, version 22.0, Chicago, IL, USA). A value of P ˂ 0.05 was considered as significant. Results. No association was found between rs1800247 single nucleotide polymorphism and T2DM development neither in AH patients, nor in subjects without AH (Paint b < 0.05). There was no impact of rs1800247 genotypes on systolic, diastolic, pulse and mean blood pressure among patients with T2DM (P < 0.05). It was showed that T2DM non-hypertensive CC-carriers had significantly lower levels of total cholesterol (P = 0.012) and LDL cholesterol (P = 0.04), but higher concentration of HDL cholesterol (P = 0.015) compared to the TT-genotype. Conclusions. It was showed that CC-carriers had more favorable parameters of lipid metabolism among T2DM non-hypertensive Ukrainians. 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Association study between BGLAP RS1800247-polymorphic variant and type 2 diabetes mellitus development among hypertensive and non-hypertensive Ukrainians type 2 diabetes mellitus hypertension osteocalcin single nucleotide polymorphism tt-homozygote tc-heterozygote cc-homozygote |
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Association study between BGLAP RS1800247-polymorphic variant and type 2 diabetes mellitus development among hypertensive and non-hypertensive Ukrainians |
| abstract |
The risk of type 2 diabetes mellitus (T2DM) development depends on a hereditary predisposition. According to the current data, bone tissue enhances insulin gene expression in pancreatic β-cells as well as increases insulin sensitivity of adipocytes, myocytes and hepatocytes through the secretion of undercarboxylated osteocalcin (unOCN). The aim. To analyze the relation between rs1800247 SNP and T2DM occurrence depending on the arterial hypertension (AH) presence, as well as association between rs1800247 and systolic, diastolic, pulse, mean blood pressure among patients with T2DM. Materials and methods. This study included 153 patients with diagnosed T2DM and 311 individuals without any carbohydrate metabolism disorders. Polymerase chain reaction-restriction fragment length polymorphism analysis (PCR-RFLP) was used for BGLAP rs1800247-genotyping. Logistic regression with interaction term “genotype × AH” was used to estimate the association between BGLAP rs1800247-genotypes and T2DM development in dominant, recessive, over-dominant and additive models of inheritance. Linear regression was performed to examine the influence of minor C-allele on the arterial blood pressure. Lipid profile characteristics of T2DM patients were stratified by rs1800247-genotype using ANOVA with Bonferroni post hoc test. All calculations were performed using Statistical Package for the Social Sciences software (SPSS, version 22.0, Chicago, IL, USA). A value of P ˂ 0.05 was considered as significant. Results. No association was found between rs1800247 single nucleotide polymorphism and T2DM development neither in AH patients, nor in subjects without AH (Paint b < 0.05). There was no impact of rs1800247 genotypes on systolic, diastolic, pulse and mean blood pressure among patients with T2DM (P < 0.05). It was showed that T2DM non-hypertensive CC-carriers had significantly lower levels of total cholesterol (P = 0.012) and LDL cholesterol (P = 0.04), but higher concentration of HDL cholesterol (P = 0.015) compared to the TT-genotype. Conclusions. It was showed that CC-carriers had more favorable parameters of lipid metabolism among T2DM non-hypertensive Ukrainians. However, there was no association between rs1800247 SNP and T2DM development as well as blood pressure parameters. |
| abstractGer |
The risk of type 2 diabetes mellitus (T2DM) development depends on a hereditary predisposition. According to the current data, bone tissue enhances insulin gene expression in pancreatic β-cells as well as increases insulin sensitivity of adipocytes, myocytes and hepatocytes through the secretion of undercarboxylated osteocalcin (unOCN). The aim. To analyze the relation between rs1800247 SNP and T2DM occurrence depending on the arterial hypertension (AH) presence, as well as association between rs1800247 and systolic, diastolic, pulse, mean blood pressure among patients with T2DM. Materials and methods. This study included 153 patients with diagnosed T2DM and 311 individuals without any carbohydrate metabolism disorders. Polymerase chain reaction-restriction fragment length polymorphism analysis (PCR-RFLP) was used for BGLAP rs1800247-genotyping. Logistic regression with interaction term “genotype × AH” was used to estimate the association between BGLAP rs1800247-genotypes and T2DM development in dominant, recessive, over-dominant and additive models of inheritance. Linear regression was performed to examine the influence of minor C-allele on the arterial blood pressure. Lipid profile characteristics of T2DM patients were stratified by rs1800247-genotype using ANOVA with Bonferroni post hoc test. All calculations were performed using Statistical Package for the Social Sciences software (SPSS, version 22.0, Chicago, IL, USA). A value of P ˂ 0.05 was considered as significant. Results. No association was found between rs1800247 single nucleotide polymorphism and T2DM development neither in AH patients, nor in subjects without AH (Paint b < 0.05). There was no impact of rs1800247 genotypes on systolic, diastolic, pulse and mean blood pressure among patients with T2DM (P < 0.05). It was showed that T2DM non-hypertensive CC-carriers had significantly lower levels of total cholesterol (P = 0.012) and LDL cholesterol (P = 0.04), but higher concentration of HDL cholesterol (P = 0.015) compared to the TT-genotype. Conclusions. It was showed that CC-carriers had more favorable parameters of lipid metabolism among T2DM non-hypertensive Ukrainians. However, there was no association between rs1800247 SNP and T2DM development as well as blood pressure parameters. |
| abstract_unstemmed |
The risk of type 2 diabetes mellitus (T2DM) development depends on a hereditary predisposition. According to the current data, bone tissue enhances insulin gene expression in pancreatic β-cells as well as increases insulin sensitivity of adipocytes, myocytes and hepatocytes through the secretion of undercarboxylated osteocalcin (unOCN). The aim. To analyze the relation between rs1800247 SNP and T2DM occurrence depending on the arterial hypertension (AH) presence, as well as association between rs1800247 and systolic, diastolic, pulse, mean blood pressure among patients with T2DM. Materials and methods. This study included 153 patients with diagnosed T2DM and 311 individuals without any carbohydrate metabolism disorders. Polymerase chain reaction-restriction fragment length polymorphism analysis (PCR-RFLP) was used for BGLAP rs1800247-genotyping. Logistic regression with interaction term “genotype × AH” was used to estimate the association between BGLAP rs1800247-genotypes and T2DM development in dominant, recessive, over-dominant and additive models of inheritance. Linear regression was performed to examine the influence of minor C-allele on the arterial blood pressure. Lipid profile characteristics of T2DM patients were stratified by rs1800247-genotype using ANOVA with Bonferroni post hoc test. All calculations were performed using Statistical Package for the Social Sciences software (SPSS, version 22.0, Chicago, IL, USA). A value of P ˂ 0.05 was considered as significant. Results. No association was found between rs1800247 single nucleotide polymorphism and T2DM development neither in AH patients, nor in subjects without AH (Paint b < 0.05). There was no impact of rs1800247 genotypes on systolic, diastolic, pulse and mean blood pressure among patients with T2DM (P < 0.05). It was showed that T2DM non-hypertensive CC-carriers had significantly lower levels of total cholesterol (P = 0.012) and LDL cholesterol (P = 0.04), but higher concentration of HDL cholesterol (P = 0.015) compared to the TT-genotype. Conclusions. It was showed that CC-carriers had more favorable parameters of lipid metabolism among T2DM non-hypertensive Ukrainians. However, there was no association between rs1800247 SNP and T2DM development as well as blood pressure parameters. |
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