Soluble CD146 as a Potential Target for Preventing Triple Negative Breast Cancer MDA-MB-231 Cell Growth and Dissemination

<b<Background:</b< Triple Negative Breast Cancers (TNBC) are the most aggressive breast cancers and lead to poor prognoses. This is due to a high resistance to therapies, mainly because of the presence of Cancer Stem Cells (CSCs). Plasticity, a feature of CSCs, is acquired through the Ep...
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Autor*in:	Akshita Sharma [verfasserIn] Ahmad Joshkon [verfasserIn] Aymen Ladjimi [verfasserIn] Waël Traboulsi [verfasserIn] Richard Bachelier [verfasserIn] Stéphane Robert [verfasserIn] Alexandrine Foucault-Bertaud [verfasserIn] Aurélie S. Leroyer [verfasserIn] Nathalie Bardin [verfasserIn] Indumathi Somasundaram [verfasserIn] Marcel Blot-Chabaud [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	CD146 triple negative breast cancer treatment

Übergeordnetes Werk:	In: International Journal of Molecular Sciences - MDPI AG, 2003, 23(2022), 2, p 974
Übergeordnetes Werk:	volume:23 ; year:2022 ; number:2, p 974

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.3390/ijms23020974

Katalog-ID:	DOAJ061496413

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allfields	10.3390/ijms23020974 doi (DE-627)DOAJ061496413 (DE-599)DOAJ282399a0986140df924c94e8e53b32fe DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Akshita Sharma verfasserin aut Soluble CD146 as a Potential Target for Preventing Triple Negative Breast Cancer MDA-MB-231 Cell Growth and Dissemination 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <b<Background:</b< Triple Negative Breast Cancers (TNBC) are the most aggressive breast cancers and lead to poor prognoses. This is due to a high resistance to therapies, mainly because of the presence of Cancer Stem Cells (CSCs). Plasticity, a feature of CSCs, is acquired through the Epithelial to Mesenchymal Transition (EMT), a process that has been recently shown to be regulated by a key molecule, CD146. Of interest, CD146 is over-expressed in TNBC. <b<Methods:</b< The MDA-MB-231 TNBC cell line was used as a model to study the role of CD146 and its secreted soluble form (sCD146) in the development and dissemination of TNBC using in vitro and in vivo studies. <b<Results:</b< High expression of CD146 in a majority of MDA-MB-231 cells leads to an increased secretion of sCD146 that up-regulates the expression of EMT and CSC markers on the cells. These effects can be blocked with a specific anti-sCD146 antibody, M2J-1 mAb. M2J-1 mAb was able to reduce tumour development and dissemination in a model of cells xenografted in nude mice and an experimental model of metastasis, respectively, in part through its effects on CSC. <b<Conclusion:</b< We propose that M2J-1 mAb could be used as an additional therapeutic approach to fight TNBC. CD146 triple negative breast cancer treatment Biology (General) Chemistry Ahmad Joshkon verfasserin aut Aymen Ladjimi verfasserin aut Waël Traboulsi verfasserin aut Richard Bachelier verfasserin aut Stéphane Robert verfasserin aut Alexandrine Foucault-Bertaud verfasserin aut Aurélie S. Leroyer verfasserin aut Nathalie Bardin verfasserin aut Indumathi Somasundaram verfasserin aut Marcel Blot-Chabaud verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 23(2022), 2, p 974 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:23 year:2022 number:2, p 974 https://doi.org/10.3390/ijms23020974 kostenfrei https://doaj.org/article/282399a0986140df924c94e8e53b32fe kostenfrei https://www.mdpi.com/1422-0067/23/2/974 kostenfrei https://doaj.org/toc/1661-6596 Journal toc kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 23 2022 2, p 974
spelling	10.3390/ijms23020974 doi (DE-627)DOAJ061496413 (DE-599)DOAJ282399a0986140df924c94e8e53b32fe DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Akshita Sharma verfasserin aut Soluble CD146 as a Potential Target for Preventing Triple Negative Breast Cancer MDA-MB-231 Cell Growth and Dissemination 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <b<Background:</b< Triple Negative Breast Cancers (TNBC) are the most aggressive breast cancers and lead to poor prognoses. This is due to a high resistance to therapies, mainly because of the presence of Cancer Stem Cells (CSCs). Plasticity, a feature of CSCs, is acquired through the Epithelial to Mesenchymal Transition (EMT), a process that has been recently shown to be regulated by a key molecule, CD146. Of interest, CD146 is over-expressed in TNBC. <b<Methods:</b< The MDA-MB-231 TNBC cell line was used as a model to study the role of CD146 and its secreted soluble form (sCD146) in the development and dissemination of TNBC using in vitro and in vivo studies. <b<Results:</b< High expression of CD146 in a majority of MDA-MB-231 cells leads to an increased secretion of sCD146 that up-regulates the expression of EMT and CSC markers on the cells. These effects can be blocked with a specific anti-sCD146 antibody, M2J-1 mAb. M2J-1 mAb was able to reduce tumour development and dissemination in a model of cells xenografted in nude mice and an experimental model of metastasis, respectively, in part through its effects on CSC. <b<Conclusion:</b< We propose that M2J-1 mAb could be used as an additional therapeutic approach to fight TNBC. CD146 triple negative breast cancer treatment Biology (General) Chemistry Ahmad Joshkon verfasserin aut Aymen Ladjimi verfasserin aut Waël Traboulsi verfasserin aut Richard Bachelier verfasserin aut Stéphane Robert verfasserin aut Alexandrine Foucault-Bertaud verfasserin aut Aurélie S. Leroyer verfasserin aut Nathalie Bardin verfasserin aut Indumathi Somasundaram verfasserin aut Marcel Blot-Chabaud verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 23(2022), 2, p 974 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:23 year:2022 number:2, p 974 https://doi.org/10.3390/ijms23020974 kostenfrei https://doaj.org/article/282399a0986140df924c94e8e53b32fe kostenfrei https://www.mdpi.com/1422-0067/23/2/974 kostenfrei https://doaj.org/toc/1661-6596 Journal toc kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 23 2022 2, p 974
allfields_unstemmed	10.3390/ijms23020974 doi (DE-627)DOAJ061496413 (DE-599)DOAJ282399a0986140df924c94e8e53b32fe DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Akshita Sharma verfasserin aut Soluble CD146 as a Potential Target for Preventing Triple Negative Breast Cancer MDA-MB-231 Cell Growth and Dissemination 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <b<Background:</b< Triple Negative Breast Cancers (TNBC) are the most aggressive breast cancers and lead to poor prognoses. This is due to a high resistance to therapies, mainly because of the presence of Cancer Stem Cells (CSCs). Plasticity, a feature of CSCs, is acquired through the Epithelial to Mesenchymal Transition (EMT), a process that has been recently shown to be regulated by a key molecule, CD146. Of interest, CD146 is over-expressed in TNBC. <b<Methods:</b< The MDA-MB-231 TNBC cell line was used as a model to study the role of CD146 and its secreted soluble form (sCD146) in the development and dissemination of TNBC using in vitro and in vivo studies. <b<Results:</b< High expression of CD146 in a majority of MDA-MB-231 cells leads to an increased secretion of sCD146 that up-regulates the expression of EMT and CSC markers on the cells. These effects can be blocked with a specific anti-sCD146 antibody, M2J-1 mAb. M2J-1 mAb was able to reduce tumour development and dissemination in a model of cells xenografted in nude mice and an experimental model of metastasis, respectively, in part through its effects on CSC. <b<Conclusion:</b< We propose that M2J-1 mAb could be used as an additional therapeutic approach to fight TNBC. CD146 triple negative breast cancer treatment Biology (General) Chemistry Ahmad Joshkon verfasserin aut Aymen Ladjimi verfasserin aut Waël Traboulsi verfasserin aut Richard Bachelier verfasserin aut Stéphane Robert verfasserin aut Alexandrine Foucault-Bertaud verfasserin aut Aurélie S. Leroyer verfasserin aut Nathalie Bardin verfasserin aut Indumathi Somasundaram verfasserin aut Marcel Blot-Chabaud verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 23(2022), 2, p 974 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:23 year:2022 number:2, p 974 https://doi.org/10.3390/ijms23020974 kostenfrei https://doaj.org/article/282399a0986140df924c94e8e53b32fe kostenfrei https://www.mdpi.com/1422-0067/23/2/974 kostenfrei https://doaj.org/toc/1661-6596 Journal toc kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 23 2022 2, p 974
allfieldsGer	10.3390/ijms23020974 doi (DE-627)DOAJ061496413 (DE-599)DOAJ282399a0986140df924c94e8e53b32fe DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Akshita Sharma verfasserin aut Soluble CD146 as a Potential Target for Preventing Triple Negative Breast Cancer MDA-MB-231 Cell Growth and Dissemination 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <b<Background:</b< Triple Negative Breast Cancers (TNBC) are the most aggressive breast cancers and lead to poor prognoses. This is due to a high resistance to therapies, mainly because of the presence of Cancer Stem Cells (CSCs). Plasticity, a feature of CSCs, is acquired through the Epithelial to Mesenchymal Transition (EMT), a process that has been recently shown to be regulated by a key molecule, CD146. Of interest, CD146 is over-expressed in TNBC. <b<Methods:</b< The MDA-MB-231 TNBC cell line was used as a model to study the role of CD146 and its secreted soluble form (sCD146) in the development and dissemination of TNBC using in vitro and in vivo studies. <b<Results:</b< High expression of CD146 in a majority of MDA-MB-231 cells leads to an increased secretion of sCD146 that up-regulates the expression of EMT and CSC markers on the cells. These effects can be blocked with a specific anti-sCD146 antibody, M2J-1 mAb. M2J-1 mAb was able to reduce tumour development and dissemination in a model of cells xenografted in nude mice and an experimental model of metastasis, respectively, in part through its effects on CSC. <b<Conclusion:</b< We propose that M2J-1 mAb could be used as an additional therapeutic approach to fight TNBC. CD146 triple negative breast cancer treatment Biology (General) Chemistry Ahmad Joshkon verfasserin aut Aymen Ladjimi verfasserin aut Waël Traboulsi verfasserin aut Richard Bachelier verfasserin aut Stéphane Robert verfasserin aut Alexandrine Foucault-Bertaud verfasserin aut Aurélie S. Leroyer verfasserin aut Nathalie Bardin verfasserin aut Indumathi Somasundaram verfasserin aut Marcel Blot-Chabaud verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 23(2022), 2, p 974 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:23 year:2022 number:2, p 974 https://doi.org/10.3390/ijms23020974 kostenfrei https://doaj.org/article/282399a0986140df924c94e8e53b32fe kostenfrei https://www.mdpi.com/1422-0067/23/2/974 kostenfrei https://doaj.org/toc/1661-6596 Journal toc kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 23 2022 2, p 974
allfieldsSound	10.3390/ijms23020974 doi (DE-627)DOAJ061496413 (DE-599)DOAJ282399a0986140df924c94e8e53b32fe DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Akshita Sharma verfasserin aut Soluble CD146 as a Potential Target for Preventing Triple Negative Breast Cancer MDA-MB-231 Cell Growth and Dissemination 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <b<Background:</b< Triple Negative Breast Cancers (TNBC) are the most aggressive breast cancers and lead to poor prognoses. This is due to a high resistance to therapies, mainly because of the presence of Cancer Stem Cells (CSCs). Plasticity, a feature of CSCs, is acquired through the Epithelial to Mesenchymal Transition (EMT), a process that has been recently shown to be regulated by a key molecule, CD146. Of interest, CD146 is over-expressed in TNBC. <b<Methods:</b< The MDA-MB-231 TNBC cell line was used as a model to study the role of CD146 and its secreted soluble form (sCD146) in the development and dissemination of TNBC using in vitro and in vivo studies. <b<Results:</b< High expression of CD146 in a majority of MDA-MB-231 cells leads to an increased secretion of sCD146 that up-regulates the expression of EMT and CSC markers on the cells. These effects can be blocked with a specific anti-sCD146 antibody, M2J-1 mAb. M2J-1 mAb was able to reduce tumour development and dissemination in a model of cells xenografted in nude mice and an experimental model of metastasis, respectively, in part through its effects on CSC. <b<Conclusion:</b< We propose that M2J-1 mAb could be used as an additional therapeutic approach to fight TNBC. CD146 triple negative breast cancer treatment Biology (General) Chemistry Ahmad Joshkon verfasserin aut Aymen Ladjimi verfasserin aut Waël Traboulsi verfasserin aut Richard Bachelier verfasserin aut Stéphane Robert verfasserin aut Alexandrine Foucault-Bertaud verfasserin aut Aurélie S. Leroyer verfasserin aut Nathalie Bardin verfasserin aut Indumathi Somasundaram verfasserin aut Marcel Blot-Chabaud verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 23(2022), 2, p 974 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:23 year:2022 number:2, p 974 https://doi.org/10.3390/ijms23020974 kostenfrei https://doaj.org/article/282399a0986140df924c94e8e53b32fe kostenfrei https://www.mdpi.com/1422-0067/23/2/974 kostenfrei https://doaj.org/toc/1661-6596 Journal toc kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 23 2022 2, p 974
language	English
source	In International Journal of Molecular Sciences 23(2022), 2, p 974 volume:23 year:2022 number:2, p 974
sourceStr	In International Journal of Molecular Sciences 23(2022), 2, p 974 volume:23 year:2022 number:2, p 974
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	CD146 triple negative breast cancer treatment Biology (General) Chemistry
isfreeaccess_bool	true
container_title	International Journal of Molecular Sciences
authorswithroles_txt_mv	Akshita Sharma @@aut@@ Ahmad Joshkon @@aut@@ Aymen Ladjimi @@aut@@ Waël Traboulsi @@aut@@ Richard Bachelier @@aut@@ Stéphane Robert @@aut@@ Alexandrine Foucault-Bertaud @@aut@@ Aurélie S. Leroyer @@aut@@ Nathalie Bardin @@aut@@ Indumathi Somasundaram @@aut@@ Marcel Blot-Chabaud @@aut@@
publishDateDaySort_date	2022-01-01T00:00:00Z
hierarchy_top_id	316340715
id	DOAJ061496413
language_de	englisch
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callnumber-first	Q - Science
author	Akshita Sharma
spellingShingle	Akshita Sharma misc QH301-705.5 misc QD1-999 misc CD146 misc triple negative breast cancer misc treatment misc Biology (General) misc Chemistry Soluble CD146 as a Potential Target for Preventing Triple Negative Breast Cancer MDA-MB-231 Cell Growth and Dissemination
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topic_title	QH301-705.5 QD1-999 Soluble CD146 as a Potential Target for Preventing Triple Negative Breast Cancer MDA-MB-231 Cell Growth and Dissemination CD146 triple negative breast cancer treatment
topic	misc QH301-705.5 misc QD1-999 misc CD146 misc triple negative breast cancer misc treatment misc Biology (General) misc Chemistry
topic_unstemmed	misc QH301-705.5 misc QD1-999 misc CD146 misc triple negative breast cancer misc treatment misc Biology (General) misc Chemistry
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title	Soluble CD146 as a Potential Target for Preventing Triple Negative Breast Cancer MDA-MB-231 Cell Growth and Dissemination
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title_full	Soluble CD146 as a Potential Target for Preventing Triple Negative Breast Cancer MDA-MB-231 Cell Growth and Dissemination
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journal	International Journal of Molecular Sciences
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author_browse	Akshita Sharma Ahmad Joshkon Aymen Ladjimi Waël Traboulsi Richard Bachelier Stéphane Robert Alexandrine Foucault-Bertaud Aurélie S. Leroyer Nathalie Bardin Indumathi Somasundaram Marcel Blot-Chabaud
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title_sort	soluble cd146 as a potential target for preventing triple negative breast cancer mda-mb-231 cell growth and dissemination
callnumber	QH301-705.5
title_auth	Soluble CD146 as a Potential Target for Preventing Triple Negative Breast Cancer MDA-MB-231 Cell Growth and Dissemination
abstract	<b<Background:</b< Triple Negative Breast Cancers (TNBC) are the most aggressive breast cancers and lead to poor prognoses. This is due to a high resistance to therapies, mainly because of the presence of Cancer Stem Cells (CSCs). Plasticity, a feature of CSCs, is acquired through the Epithelial to Mesenchymal Transition (EMT), a process that has been recently shown to be regulated by a key molecule, CD146. Of interest, CD146 is over-expressed in TNBC. <b<Methods:</b< The MDA-MB-231 TNBC cell line was used as a model to study the role of CD146 and its secreted soluble form (sCD146) in the development and dissemination of TNBC using in vitro and in vivo studies. <b<Results:</b< High expression of CD146 in a majority of MDA-MB-231 cells leads to an increased secretion of sCD146 that up-regulates the expression of EMT and CSC markers on the cells. These effects can be blocked with a specific anti-sCD146 antibody, M2J-1 mAb. M2J-1 mAb was able to reduce tumour development and dissemination in a model of cells xenografted in nude mice and an experimental model of metastasis, respectively, in part through its effects on CSC. <b<Conclusion:</b< We propose that M2J-1 mAb could be used as an additional therapeutic approach to fight TNBC.
abstractGer	<b<Background:</b< Triple Negative Breast Cancers (TNBC) are the most aggressive breast cancers and lead to poor prognoses. This is due to a high resistance to therapies, mainly because of the presence of Cancer Stem Cells (CSCs). Plasticity, a feature of CSCs, is acquired through the Epithelial to Mesenchymal Transition (EMT), a process that has been recently shown to be regulated by a key molecule, CD146. Of interest, CD146 is over-expressed in TNBC. <b<Methods:</b< The MDA-MB-231 TNBC cell line was used as a model to study the role of CD146 and its secreted soluble form (sCD146) in the development and dissemination of TNBC using in vitro and in vivo studies. <b<Results:</b< High expression of CD146 in a majority of MDA-MB-231 cells leads to an increased secretion of sCD146 that up-regulates the expression of EMT and CSC markers on the cells. These effects can be blocked with a specific anti-sCD146 antibody, M2J-1 mAb. M2J-1 mAb was able to reduce tumour development and dissemination in a model of cells xenografted in nude mice and an experimental model of metastasis, respectively, in part through its effects on CSC. <b<Conclusion:</b< We propose that M2J-1 mAb could be used as an additional therapeutic approach to fight TNBC.
abstract_unstemmed	<b<Background:</b< Triple Negative Breast Cancers (TNBC) are the most aggressive breast cancers and lead to poor prognoses. This is due to a high resistance to therapies, mainly because of the presence of Cancer Stem Cells (CSCs). Plasticity, a feature of CSCs, is acquired through the Epithelial to Mesenchymal Transition (EMT), a process that has been recently shown to be regulated by a key molecule, CD146. Of interest, CD146 is over-expressed in TNBC. <b<Methods:</b< The MDA-MB-231 TNBC cell line was used as a model to study the role of CD146 and its secreted soluble form (sCD146) in the development and dissemination of TNBC using in vitro and in vivo studies. <b<Results:</b< High expression of CD146 in a majority of MDA-MB-231 cells leads to an increased secretion of sCD146 that up-regulates the expression of EMT and CSC markers on the cells. These effects can be blocked with a specific anti-sCD146 antibody, M2J-1 mAb. M2J-1 mAb was able to reduce tumour development and dissemination in a model of cells xenografted in nude mice and an experimental model of metastasis, respectively, in part through its effects on CSC. <b<Conclusion:</b< We propose that M2J-1 mAb could be used as an additional therapeutic approach to fight TNBC.
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title_short	Soluble CD146 as a Potential Target for Preventing Triple Negative Breast Cancer MDA-MB-231 Cell Growth and Dissemination
url	https://doi.org/10.3390/ijms23020974 https://doaj.org/article/282399a0986140df924c94e8e53b32fe https://www.mdpi.com/1422-0067/23/2/974 https://doaj.org/toc/1661-6596 https://doaj.org/toc/1422-0067
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