Molecular characterization and evolution of a gene family encoding male-specific reproductive proteins in the African malaria vector <it<Anopheles gambiae</it<
<p<Abstract</p< <p<Background</p< <p<During copulation, the major Afro-tropical malaria vector <it<Anopheles gambiae </it<s.s. transfers male accessory gland (MAG) proteins to females as a solid mass (i.e. the "mating plug"). These proteins are pos...
Ausführliche Beschreibung
Autor*in: |
Sharakhov Igor V [verfasserIn] Masiga Daniel [verfasserIn] Morlais Isabelle [verfasserIn] George Phillip [verfasserIn] Serrao Aurelio [verfasserIn] Calzetta Maria [verfasserIn] Tammaro Federica [verfasserIn] Baldini Francesco [verfasserIn] Mancini Emiliano [verfasserIn] Rogers David W [verfasserIn] Catteruccia Flaminia [verfasserIn] della Torre Alessandra [verfasserIn] |
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Format: |
E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2011 |
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Übergeordnetes Werk: |
In: BMC Evolutionary Biology - BMC, 2003, 11(2011), 1, p 292 |
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Übergeordnetes Werk: |
volume:11 ; year:2011 ; number:1, p 292 |
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DOI / URN: |
10.1186/1471-2148-11-292 |
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Katalog-ID: |
DOAJ06149691X |
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520 | |a <p<Abstract</p< <p<Background</p< <p<During copulation, the major Afro-tropical malaria vector <it<Anopheles gambiae </it<s.s. transfers male accessory gland (MAG) proteins to females as a solid mass (i.e. the "mating plug"). These proteins are postulated to function as important modulators of female post-mating responses. To understand the role of selective forces underlying the evolution of these proteins in the <it<A. gambiae </it<complex, we carried out an evolutionary analysis of gene sequence and expression divergence on a pair of paralog genes called <it<AgAcp34A-1 </it<and <it<AgAcp34A-2</it<. These encode MAG-specific proteins which, based on homology with <it<Drosophila</it<, have been hypothesized to play a role in sperm viability and function.</p< <p<Results</p< <p<Genetic analysis of 6 species of the <it<A. gambiae </it<complex revealed the existence of a third paralog (68-78% of identity), that we named <it<AgAcp34A-3</it<. FISH assays showed that this gene maps in the same division (34A) of chromosome-3R as the other two paralogs. In particular, immuno-fluorescence assays targeting the C-terminals of <it<AgAcp34A-2 </it<and <it<AgAcp34A-3 </it<revealed that these two proteins are localized in the posterior part of the MAG and concentrated at the apical portion of the mating plug. When transferred to females, this part of the plug lies in proximity to the duct connecting the spermatheca to the uterus, suggesting a potential role for these proteins in regulating sperm motility. <it<AgAcp34A-3 </it<is more polymorphic than the other two paralogs, possibly because of relaxation of purifying selection. Since both unequal crossing-over and gene conversion likely homogenized the members of this gene family, the interpretation of the evolutionary patterns is not straightforward. Although several haplotypes of the three paralogs are shared by most <it<A. gambiae </it<s.l. species, some fixed species-specific replacements (mainly placed in the N- and C-terminal portions of the secreted peptides) were also observed, suggesting some lineage-specific adaptation.</p< <p<Conclusions</p< <p<Progress in understanding the signaling cascade in the <it<A. gambiae </it<reproductive pathway will elucidate the interaction of this MAG-specific protein family with their female counterparts. This knowledge will allow a better evaluation of the relative importance of genes involved in the reproductive isolation and fertility of <it<A. gambiae </it<species and could help the interpretation of the observed evolutionary patterns.</p< | ||
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10.1186/1471-2148-11-292 doi (DE-627)DOAJ06149691X (DE-599)DOAJf21ab54fa1584d85b1500673fff812b1 DE-627 ger DE-627 rakwb eng QH359-425 Sharakhov Igor V verfasserin aut Molecular characterization and evolution of a gene family encoding male-specific reproductive proteins in the African malaria vector <it<Anopheles gambiae</it< 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<During copulation, the major Afro-tropical malaria vector <it<Anopheles gambiae </it<s.s. transfers male accessory gland (MAG) proteins to females as a solid mass (i.e. the "mating plug"). These proteins are postulated to function as important modulators of female post-mating responses. To understand the role of selective forces underlying the evolution of these proteins in the <it<A. gambiae </it<complex, we carried out an evolutionary analysis of gene sequence and expression divergence on a pair of paralog genes called <it<AgAcp34A-1 </it<and <it<AgAcp34A-2</it<. These encode MAG-specific proteins which, based on homology with <it<Drosophila</it<, have been hypothesized to play a role in sperm viability and function.</p< <p<Results</p< <p<Genetic analysis of 6 species of the <it<A. gambiae </it<complex revealed the existence of a third paralog (68-78% of identity), that we named <it<AgAcp34A-3</it<. FISH assays showed that this gene maps in the same division (34A) of chromosome-3R as the other two paralogs. In particular, immuno-fluorescence assays targeting the C-terminals of <it<AgAcp34A-2 </it<and <it<AgAcp34A-3 </it<revealed that these two proteins are localized in the posterior part of the MAG and concentrated at the apical portion of the mating plug. When transferred to females, this part of the plug lies in proximity to the duct connecting the spermatheca to the uterus, suggesting a potential role for these proteins in regulating sperm motility. <it<AgAcp34A-3 </it<is more polymorphic than the other two paralogs, possibly because of relaxation of purifying selection. Since both unequal crossing-over and gene conversion likely homogenized the members of this gene family, the interpretation of the evolutionary patterns is not straightforward. Although several haplotypes of the three paralogs are shared by most <it<A. gambiae </it<s.l. species, some fixed species-specific replacements (mainly placed in the N- and C-terminal portions of the secreted peptides) were also observed, suggesting some lineage-specific adaptation.</p< <p<Conclusions</p< <p<Progress in understanding the signaling cascade in the <it<A. gambiae </it<reproductive pathway will elucidate the interaction of this MAG-specific protein family with their female counterparts. This knowledge will allow a better evaluation of the relative importance of genes involved in the reproductive isolation and fertility of <it<A. gambiae </it<species and could help the interpretation of the observed evolutionary patterns.</p< Evolution Masiga Daniel verfasserin aut Morlais Isabelle verfasserin aut George Phillip verfasserin aut Serrao Aurelio verfasserin aut Calzetta Maria verfasserin aut Tammaro Federica verfasserin aut Baldini Francesco verfasserin aut Mancini Emiliano verfasserin aut Rogers David W verfasserin aut Catteruccia Flaminia verfasserin aut della Torre Alessandra verfasserin aut In BMC Evolutionary Biology BMC, 2003 11(2011), 1, p 292 (DE-627)32664489X (DE-600)2041493-6 14712148 nnns volume:11 year:2011 number:1, p 292 https://doi.org/10.1186/1471-2148-11-292 kostenfrei https://doaj.org/article/f21ab54fa1584d85b1500673fff812b1 kostenfrei http://www.biomedcentral.com/1471-2148/11/292 kostenfrei https://doaj.org/toc/1471-2148 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2011 1, p 292 |
spelling |
10.1186/1471-2148-11-292 doi (DE-627)DOAJ06149691X (DE-599)DOAJf21ab54fa1584d85b1500673fff812b1 DE-627 ger DE-627 rakwb eng QH359-425 Sharakhov Igor V verfasserin aut Molecular characterization and evolution of a gene family encoding male-specific reproductive proteins in the African malaria vector <it<Anopheles gambiae</it< 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<During copulation, the major Afro-tropical malaria vector <it<Anopheles gambiae </it<s.s. transfers male accessory gland (MAG) proteins to females as a solid mass (i.e. the "mating plug"). These proteins are postulated to function as important modulators of female post-mating responses. To understand the role of selective forces underlying the evolution of these proteins in the <it<A. gambiae </it<complex, we carried out an evolutionary analysis of gene sequence and expression divergence on a pair of paralog genes called <it<AgAcp34A-1 </it<and <it<AgAcp34A-2</it<. These encode MAG-specific proteins which, based on homology with <it<Drosophila</it<, have been hypothesized to play a role in sperm viability and function.</p< <p<Results</p< <p<Genetic analysis of 6 species of the <it<A. gambiae </it<complex revealed the existence of a third paralog (68-78% of identity), that we named <it<AgAcp34A-3</it<. FISH assays showed that this gene maps in the same division (34A) of chromosome-3R as the other two paralogs. In particular, immuno-fluorescence assays targeting the C-terminals of <it<AgAcp34A-2 </it<and <it<AgAcp34A-3 </it<revealed that these two proteins are localized in the posterior part of the MAG and concentrated at the apical portion of the mating plug. When transferred to females, this part of the plug lies in proximity to the duct connecting the spermatheca to the uterus, suggesting a potential role for these proteins in regulating sperm motility. <it<AgAcp34A-3 </it<is more polymorphic than the other two paralogs, possibly because of relaxation of purifying selection. Since both unequal crossing-over and gene conversion likely homogenized the members of this gene family, the interpretation of the evolutionary patterns is not straightforward. Although several haplotypes of the three paralogs are shared by most <it<A. gambiae </it<s.l. species, some fixed species-specific replacements (mainly placed in the N- and C-terminal portions of the secreted peptides) were also observed, suggesting some lineage-specific adaptation.</p< <p<Conclusions</p< <p<Progress in understanding the signaling cascade in the <it<A. gambiae </it<reproductive pathway will elucidate the interaction of this MAG-specific protein family with their female counterparts. This knowledge will allow a better evaluation of the relative importance of genes involved in the reproductive isolation and fertility of <it<A. gambiae </it<species and could help the interpretation of the observed evolutionary patterns.</p< Evolution Masiga Daniel verfasserin aut Morlais Isabelle verfasserin aut George Phillip verfasserin aut Serrao Aurelio verfasserin aut Calzetta Maria verfasserin aut Tammaro Federica verfasserin aut Baldini Francesco verfasserin aut Mancini Emiliano verfasserin aut Rogers David W verfasserin aut Catteruccia Flaminia verfasserin aut della Torre Alessandra verfasserin aut In BMC Evolutionary Biology BMC, 2003 11(2011), 1, p 292 (DE-627)32664489X (DE-600)2041493-6 14712148 nnns volume:11 year:2011 number:1, p 292 https://doi.org/10.1186/1471-2148-11-292 kostenfrei https://doaj.org/article/f21ab54fa1584d85b1500673fff812b1 kostenfrei http://www.biomedcentral.com/1471-2148/11/292 kostenfrei https://doaj.org/toc/1471-2148 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2011 1, p 292 |
allfields_unstemmed |
10.1186/1471-2148-11-292 doi (DE-627)DOAJ06149691X (DE-599)DOAJf21ab54fa1584d85b1500673fff812b1 DE-627 ger DE-627 rakwb eng QH359-425 Sharakhov Igor V verfasserin aut Molecular characterization and evolution of a gene family encoding male-specific reproductive proteins in the African malaria vector <it<Anopheles gambiae</it< 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<During copulation, the major Afro-tropical malaria vector <it<Anopheles gambiae </it<s.s. transfers male accessory gland (MAG) proteins to females as a solid mass (i.e. the "mating plug"). These proteins are postulated to function as important modulators of female post-mating responses. To understand the role of selective forces underlying the evolution of these proteins in the <it<A. gambiae </it<complex, we carried out an evolutionary analysis of gene sequence and expression divergence on a pair of paralog genes called <it<AgAcp34A-1 </it<and <it<AgAcp34A-2</it<. These encode MAG-specific proteins which, based on homology with <it<Drosophila</it<, have been hypothesized to play a role in sperm viability and function.</p< <p<Results</p< <p<Genetic analysis of 6 species of the <it<A. gambiae </it<complex revealed the existence of a third paralog (68-78% of identity), that we named <it<AgAcp34A-3</it<. FISH assays showed that this gene maps in the same division (34A) of chromosome-3R as the other two paralogs. In particular, immuno-fluorescence assays targeting the C-terminals of <it<AgAcp34A-2 </it<and <it<AgAcp34A-3 </it<revealed that these two proteins are localized in the posterior part of the MAG and concentrated at the apical portion of the mating plug. When transferred to females, this part of the plug lies in proximity to the duct connecting the spermatheca to the uterus, suggesting a potential role for these proteins in regulating sperm motility. <it<AgAcp34A-3 </it<is more polymorphic than the other two paralogs, possibly because of relaxation of purifying selection. Since both unequal crossing-over and gene conversion likely homogenized the members of this gene family, the interpretation of the evolutionary patterns is not straightforward. Although several haplotypes of the three paralogs are shared by most <it<A. gambiae </it<s.l. species, some fixed species-specific replacements (mainly placed in the N- and C-terminal portions of the secreted peptides) were also observed, suggesting some lineage-specific adaptation.</p< <p<Conclusions</p< <p<Progress in understanding the signaling cascade in the <it<A. gambiae </it<reproductive pathway will elucidate the interaction of this MAG-specific protein family with their female counterparts. This knowledge will allow a better evaluation of the relative importance of genes involved in the reproductive isolation and fertility of <it<A. gambiae </it<species and could help the interpretation of the observed evolutionary patterns.</p< Evolution Masiga Daniel verfasserin aut Morlais Isabelle verfasserin aut George Phillip verfasserin aut Serrao Aurelio verfasserin aut Calzetta Maria verfasserin aut Tammaro Federica verfasserin aut Baldini Francesco verfasserin aut Mancini Emiliano verfasserin aut Rogers David W verfasserin aut Catteruccia Flaminia verfasserin aut della Torre Alessandra verfasserin aut In BMC Evolutionary Biology BMC, 2003 11(2011), 1, p 292 (DE-627)32664489X (DE-600)2041493-6 14712148 nnns volume:11 year:2011 number:1, p 292 https://doi.org/10.1186/1471-2148-11-292 kostenfrei https://doaj.org/article/f21ab54fa1584d85b1500673fff812b1 kostenfrei http://www.biomedcentral.com/1471-2148/11/292 kostenfrei https://doaj.org/toc/1471-2148 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2011 1, p 292 |
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10.1186/1471-2148-11-292 doi (DE-627)DOAJ06149691X (DE-599)DOAJf21ab54fa1584d85b1500673fff812b1 DE-627 ger DE-627 rakwb eng QH359-425 Sharakhov Igor V verfasserin aut Molecular characterization and evolution of a gene family encoding male-specific reproductive proteins in the African malaria vector <it<Anopheles gambiae</it< 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<During copulation, the major Afro-tropical malaria vector <it<Anopheles gambiae </it<s.s. transfers male accessory gland (MAG) proteins to females as a solid mass (i.e. the "mating plug"). These proteins are postulated to function as important modulators of female post-mating responses. To understand the role of selective forces underlying the evolution of these proteins in the <it<A. gambiae </it<complex, we carried out an evolutionary analysis of gene sequence and expression divergence on a pair of paralog genes called <it<AgAcp34A-1 </it<and <it<AgAcp34A-2</it<. These encode MAG-specific proteins which, based on homology with <it<Drosophila</it<, have been hypothesized to play a role in sperm viability and function.</p< <p<Results</p< <p<Genetic analysis of 6 species of the <it<A. gambiae </it<complex revealed the existence of a third paralog (68-78% of identity), that we named <it<AgAcp34A-3</it<. FISH assays showed that this gene maps in the same division (34A) of chromosome-3R as the other two paralogs. In particular, immuno-fluorescence assays targeting the C-terminals of <it<AgAcp34A-2 </it<and <it<AgAcp34A-3 </it<revealed that these two proteins are localized in the posterior part of the MAG and concentrated at the apical portion of the mating plug. When transferred to females, this part of the plug lies in proximity to the duct connecting the spermatheca to the uterus, suggesting a potential role for these proteins in regulating sperm motility. <it<AgAcp34A-3 </it<is more polymorphic than the other two paralogs, possibly because of relaxation of purifying selection. Since both unequal crossing-over and gene conversion likely homogenized the members of this gene family, the interpretation of the evolutionary patterns is not straightforward. Although several haplotypes of the three paralogs are shared by most <it<A. gambiae </it<s.l. species, some fixed species-specific replacements (mainly placed in the N- and C-terminal portions of the secreted peptides) were also observed, suggesting some lineage-specific adaptation.</p< <p<Conclusions</p< <p<Progress in understanding the signaling cascade in the <it<A. gambiae </it<reproductive pathway will elucidate the interaction of this MAG-specific protein family with their female counterparts. This knowledge will allow a better evaluation of the relative importance of genes involved in the reproductive isolation and fertility of <it<A. gambiae </it<species and could help the interpretation of the observed evolutionary patterns.</p< Evolution Masiga Daniel verfasserin aut Morlais Isabelle verfasserin aut George Phillip verfasserin aut Serrao Aurelio verfasserin aut Calzetta Maria verfasserin aut Tammaro Federica verfasserin aut Baldini Francesco verfasserin aut Mancini Emiliano verfasserin aut Rogers David W verfasserin aut Catteruccia Flaminia verfasserin aut della Torre Alessandra verfasserin aut In BMC Evolutionary Biology BMC, 2003 11(2011), 1, p 292 (DE-627)32664489X (DE-600)2041493-6 14712148 nnns volume:11 year:2011 number:1, p 292 https://doi.org/10.1186/1471-2148-11-292 kostenfrei https://doaj.org/article/f21ab54fa1584d85b1500673fff812b1 kostenfrei http://www.biomedcentral.com/1471-2148/11/292 kostenfrei https://doaj.org/toc/1471-2148 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2011 1, p 292 |
allfieldsSound |
10.1186/1471-2148-11-292 doi (DE-627)DOAJ06149691X (DE-599)DOAJf21ab54fa1584d85b1500673fff812b1 DE-627 ger DE-627 rakwb eng QH359-425 Sharakhov Igor V verfasserin aut Molecular characterization and evolution of a gene family encoding male-specific reproductive proteins in the African malaria vector <it<Anopheles gambiae</it< 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<During copulation, the major Afro-tropical malaria vector <it<Anopheles gambiae </it<s.s. transfers male accessory gland (MAG) proteins to females as a solid mass (i.e. the "mating plug"). These proteins are postulated to function as important modulators of female post-mating responses. To understand the role of selective forces underlying the evolution of these proteins in the <it<A. gambiae </it<complex, we carried out an evolutionary analysis of gene sequence and expression divergence on a pair of paralog genes called <it<AgAcp34A-1 </it<and <it<AgAcp34A-2</it<. These encode MAG-specific proteins which, based on homology with <it<Drosophila</it<, have been hypothesized to play a role in sperm viability and function.</p< <p<Results</p< <p<Genetic analysis of 6 species of the <it<A. gambiae </it<complex revealed the existence of a third paralog (68-78% of identity), that we named <it<AgAcp34A-3</it<. FISH assays showed that this gene maps in the same division (34A) of chromosome-3R as the other two paralogs. In particular, immuno-fluorescence assays targeting the C-terminals of <it<AgAcp34A-2 </it<and <it<AgAcp34A-3 </it<revealed that these two proteins are localized in the posterior part of the MAG and concentrated at the apical portion of the mating plug. When transferred to females, this part of the plug lies in proximity to the duct connecting the spermatheca to the uterus, suggesting a potential role for these proteins in regulating sperm motility. <it<AgAcp34A-3 </it<is more polymorphic than the other two paralogs, possibly because of relaxation of purifying selection. Since both unequal crossing-over and gene conversion likely homogenized the members of this gene family, the interpretation of the evolutionary patterns is not straightforward. Although several haplotypes of the three paralogs are shared by most <it<A. gambiae </it<s.l. species, some fixed species-specific replacements (mainly placed in the N- and C-terminal portions of the secreted peptides) were also observed, suggesting some lineage-specific adaptation.</p< <p<Conclusions</p< <p<Progress in understanding the signaling cascade in the <it<A. gambiae </it<reproductive pathway will elucidate the interaction of this MAG-specific protein family with their female counterparts. This knowledge will allow a better evaluation of the relative importance of genes involved in the reproductive isolation and fertility of <it<A. gambiae </it<species and could help the interpretation of the observed evolutionary patterns.</p< Evolution Masiga Daniel verfasserin aut Morlais Isabelle verfasserin aut George Phillip verfasserin aut Serrao Aurelio verfasserin aut Calzetta Maria verfasserin aut Tammaro Federica verfasserin aut Baldini Francesco verfasserin aut Mancini Emiliano verfasserin aut Rogers David W verfasserin aut Catteruccia Flaminia verfasserin aut della Torre Alessandra verfasserin aut In BMC Evolutionary Biology BMC, 2003 11(2011), 1, p 292 (DE-627)32664489X (DE-600)2041493-6 14712148 nnns volume:11 year:2011 number:1, p 292 https://doi.org/10.1186/1471-2148-11-292 kostenfrei https://doaj.org/article/f21ab54fa1584d85b1500673fff812b1 kostenfrei http://www.biomedcentral.com/1471-2148/11/292 kostenfrei https://doaj.org/toc/1471-2148 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2011 1, p 292 |
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Sharakhov Igor V @@aut@@ Masiga Daniel @@aut@@ Morlais Isabelle @@aut@@ George Phillip @@aut@@ Serrao Aurelio @@aut@@ Calzetta Maria @@aut@@ Tammaro Federica @@aut@@ Baldini Francesco @@aut@@ Mancini Emiliano @@aut@@ Rogers David W @@aut@@ Catteruccia Flaminia @@aut@@ della Torre Alessandra @@aut@@ |
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QH359-425 Molecular characterization and evolution of a gene family encoding male-specific reproductive proteins in the African malaria vector <it<Anopheles gambiae</it< |
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Molecular characterization and evolution of a gene family encoding male-specific reproductive proteins in the African malaria vector <it<Anopheles gambiae</it< |
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Molecular characterization and evolution of a gene family encoding male-specific reproductive proteins in the African malaria vector <it<Anopheles gambiae</it< |
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Sharakhov Igor V Masiga Daniel Morlais Isabelle George Phillip Serrao Aurelio Calzetta Maria Tammaro Federica Baldini Francesco Mancini Emiliano Rogers David W Catteruccia Flaminia della Torre Alessandra |
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molecular characterization and evolution of a gene family encoding male-specific reproductive proteins in the african malaria vector <it<anopheles gambiae</it< |
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Molecular characterization and evolution of a gene family encoding male-specific reproductive proteins in the African malaria vector <it<Anopheles gambiae</it< |
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<p<Abstract</p< <p<Background</p< <p<During copulation, the major Afro-tropical malaria vector <it<Anopheles gambiae </it<s.s. transfers male accessory gland (MAG) proteins to females as a solid mass (i.e. the "mating plug"). These proteins are postulated to function as important modulators of female post-mating responses. To understand the role of selective forces underlying the evolution of these proteins in the <it<A. gambiae </it<complex, we carried out an evolutionary analysis of gene sequence and expression divergence on a pair of paralog genes called <it<AgAcp34A-1 </it<and <it<AgAcp34A-2</it<. These encode MAG-specific proteins which, based on homology with <it<Drosophila</it<, have been hypothesized to play a role in sperm viability and function.</p< <p<Results</p< <p<Genetic analysis of 6 species of the <it<A. gambiae </it<complex revealed the existence of a third paralog (68-78% of identity), that we named <it<AgAcp34A-3</it<. FISH assays showed that this gene maps in the same division (34A) of chromosome-3R as the other two paralogs. In particular, immuno-fluorescence assays targeting the C-terminals of <it<AgAcp34A-2 </it<and <it<AgAcp34A-3 </it<revealed that these two proteins are localized in the posterior part of the MAG and concentrated at the apical portion of the mating plug. When transferred to females, this part of the plug lies in proximity to the duct connecting the spermatheca to the uterus, suggesting a potential role for these proteins in regulating sperm motility. <it<AgAcp34A-3 </it<is more polymorphic than the other two paralogs, possibly because of relaxation of purifying selection. Since both unequal crossing-over and gene conversion likely homogenized the members of this gene family, the interpretation of the evolutionary patterns is not straightforward. Although several haplotypes of the three paralogs are shared by most <it<A. gambiae </it<s.l. species, some fixed species-specific replacements (mainly placed in the N- and C-terminal portions of the secreted peptides) were also observed, suggesting some lineage-specific adaptation.</p< <p<Conclusions</p< <p<Progress in understanding the signaling cascade in the <it<A. gambiae </it<reproductive pathway will elucidate the interaction of this MAG-specific protein family with their female counterparts. This knowledge will allow a better evaluation of the relative importance of genes involved in the reproductive isolation and fertility of <it<A. gambiae </it<species and could help the interpretation of the observed evolutionary patterns.</p< |
abstractGer |
<p<Abstract</p< <p<Background</p< <p<During copulation, the major Afro-tropical malaria vector <it<Anopheles gambiae </it<s.s. transfers male accessory gland (MAG) proteins to females as a solid mass (i.e. the "mating plug"). These proteins are postulated to function as important modulators of female post-mating responses. To understand the role of selective forces underlying the evolution of these proteins in the <it<A. gambiae </it<complex, we carried out an evolutionary analysis of gene sequence and expression divergence on a pair of paralog genes called <it<AgAcp34A-1 </it<and <it<AgAcp34A-2</it<. These encode MAG-specific proteins which, based on homology with <it<Drosophila</it<, have been hypothesized to play a role in sperm viability and function.</p< <p<Results</p< <p<Genetic analysis of 6 species of the <it<A. gambiae </it<complex revealed the existence of a third paralog (68-78% of identity), that we named <it<AgAcp34A-3</it<. FISH assays showed that this gene maps in the same division (34A) of chromosome-3R as the other two paralogs. In particular, immuno-fluorescence assays targeting the C-terminals of <it<AgAcp34A-2 </it<and <it<AgAcp34A-3 </it<revealed that these two proteins are localized in the posterior part of the MAG and concentrated at the apical portion of the mating plug. When transferred to females, this part of the plug lies in proximity to the duct connecting the spermatheca to the uterus, suggesting a potential role for these proteins in regulating sperm motility. <it<AgAcp34A-3 </it<is more polymorphic than the other two paralogs, possibly because of relaxation of purifying selection. Since both unequal crossing-over and gene conversion likely homogenized the members of this gene family, the interpretation of the evolutionary patterns is not straightforward. Although several haplotypes of the three paralogs are shared by most <it<A. gambiae </it<s.l. species, some fixed species-specific replacements (mainly placed in the N- and C-terminal portions of the secreted peptides) were also observed, suggesting some lineage-specific adaptation.</p< <p<Conclusions</p< <p<Progress in understanding the signaling cascade in the <it<A. gambiae </it<reproductive pathway will elucidate the interaction of this MAG-specific protein family with their female counterparts. This knowledge will allow a better evaluation of the relative importance of genes involved in the reproductive isolation and fertility of <it<A. gambiae </it<species and could help the interpretation of the observed evolutionary patterns.</p< |
abstract_unstemmed |
<p<Abstract</p< <p<Background</p< <p<During copulation, the major Afro-tropical malaria vector <it<Anopheles gambiae </it<s.s. transfers male accessory gland (MAG) proteins to females as a solid mass (i.e. the "mating plug"). These proteins are postulated to function as important modulators of female post-mating responses. To understand the role of selective forces underlying the evolution of these proteins in the <it<A. gambiae </it<complex, we carried out an evolutionary analysis of gene sequence and expression divergence on a pair of paralog genes called <it<AgAcp34A-1 </it<and <it<AgAcp34A-2</it<. These encode MAG-specific proteins which, based on homology with <it<Drosophila</it<, have been hypothesized to play a role in sperm viability and function.</p< <p<Results</p< <p<Genetic analysis of 6 species of the <it<A. gambiae </it<complex revealed the existence of a third paralog (68-78% of identity), that we named <it<AgAcp34A-3</it<. FISH assays showed that this gene maps in the same division (34A) of chromosome-3R as the other two paralogs. In particular, immuno-fluorescence assays targeting the C-terminals of <it<AgAcp34A-2 </it<and <it<AgAcp34A-3 </it<revealed that these two proteins are localized in the posterior part of the MAG and concentrated at the apical portion of the mating plug. When transferred to females, this part of the plug lies in proximity to the duct connecting the spermatheca to the uterus, suggesting a potential role for these proteins in regulating sperm motility. <it<AgAcp34A-3 </it<is more polymorphic than the other two paralogs, possibly because of relaxation of purifying selection. Since both unequal crossing-over and gene conversion likely homogenized the members of this gene family, the interpretation of the evolutionary patterns is not straightforward. Although several haplotypes of the three paralogs are shared by most <it<A. gambiae </it<s.l. species, some fixed species-specific replacements (mainly placed in the N- and C-terminal portions of the secreted peptides) were also observed, suggesting some lineage-specific adaptation.</p< <p<Conclusions</p< <p<Progress in understanding the signaling cascade in the <it<A. gambiae </it<reproductive pathway will elucidate the interaction of this MAG-specific protein family with their female counterparts. This knowledge will allow a better evaluation of the relative importance of genes involved in the reproductive isolation and fertility of <it<A. gambiae </it<species and could help the interpretation of the observed evolutionary patterns.</p< |
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Molecular characterization and evolution of a gene family encoding male-specific reproductive proteins in the African malaria vector <it<Anopheles gambiae</it< |
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In particular, immuno-fluorescence assays targeting the C-terminals of <it<AgAcp34A-2 </it<and <it<AgAcp34A-3 </it<revealed that these two proteins are localized in the posterior part of the MAG and concentrated at the apical portion of the mating plug. When transferred to females, this part of the plug lies in proximity to the duct connecting the spermatheca to the uterus, suggesting a potential role for these proteins in regulating sperm motility. <it<AgAcp34A-3 </it<is more polymorphic than the other two paralogs, possibly because of relaxation of purifying selection. Since both unequal crossing-over and gene conversion likely homogenized the members of this gene family, the interpretation of the evolutionary patterns is not straightforward. Although several haplotypes of the three paralogs are shared by most <it<A. gambiae </it<s.l. species, some fixed species-specific replacements (mainly placed in the N- and C-terminal portions of the secreted peptides) were also observed, suggesting some lineage-specific adaptation.</p< <p<Conclusions</p< <p<Progress in understanding the signaling cascade in the <it<A. gambiae </it<reproductive pathway will elucidate the interaction of this MAG-specific protein family with their female counterparts. 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