Interleukin-36 Cytokines in Infectious and Non-Infectious Lung Diseases

The IL-36 family of cytokines were identified in the early 2000’s as a new subfamily of the IL-1 cytokine family, and since then, the role of IL-36 cytokines during various inflammatory processes has been characterized. While most of the research has focused on the role of these cytokines in autoimm...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Hernán F. Peñaloza [verfasserIn] Rick van der Geest [verfasserIn] Joel A. Ybe [verfasserIn] Theodore J. Standiford [verfasserIn] Janet S. Lee [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	interleukin-36 cytokines IL-1Rrp2 host/microbe proteases inflammatory response amplification lung infectious diseases lung inflammation

Übergeordnetes Werk:	In: Frontiers in Immunology - Frontiers Media S.A., 2011, 12(2021)
Übergeordnetes Werk:	volume:12 ; year:2021

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fimmu.2021.754702

Katalog-ID:	DOAJ061549657

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520			\|a The IL-36 family of cytokines were identified in the early 2000’s as a new subfamily of the IL-1 cytokine family, and since then, the role of IL-36 cytokines during various inflammatory processes has been characterized. While most of the research has focused on the role of these cytokines in autoimmune skin diseases such as psoriasis and dermatitis, recent studies have also shown the importance of IL-36 cytokines in the lung inflammatory response during infectious and non-infectious diseases. In this review, we discuss the biology of IL-36 cytokines in terms of how they are produced and activated, as well as their effects on myeloid and lymphoid cells during inflammation. We also discuss the role of these cytokines during lung infectious diseases caused by bacteria and influenza virus, as well as other inflammatory conditions in the lungs such as allergic asthma, lung fibrosis, chronic obstructive pulmonary disease, cystic fibrosis and cancer. Finally, we discuss the current therapeutic advances that target the IL-36 pathway and the possibility to extend these tools to treat lung inflammatory diseases.
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allfields	10.3389/fimmu.2021.754702 doi (DE-627)DOAJ061549657 (DE-599)DOAJ7515a4e4023b479f9acd42feaa6c8494 DE-627 ger DE-627 rakwb eng RC581-607 Hernán F. Peñaloza verfasserin aut Interleukin-36 Cytokines in Infectious and Non-Infectious Lung Diseases 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The IL-36 family of cytokines were identified in the early 2000’s as a new subfamily of the IL-1 cytokine family, and since then, the role of IL-36 cytokines during various inflammatory processes has been characterized. While most of the research has focused on the role of these cytokines in autoimmune skin diseases such as psoriasis and dermatitis, recent studies have also shown the importance of IL-36 cytokines in the lung inflammatory response during infectious and non-infectious diseases. In this review, we discuss the biology of IL-36 cytokines in terms of how they are produced and activated, as well as their effects on myeloid and lymphoid cells during inflammation. We also discuss the role of these cytokines during lung infectious diseases caused by bacteria and influenza virus, as well as other inflammatory conditions in the lungs such as allergic asthma, lung fibrosis, chronic obstructive pulmonary disease, cystic fibrosis and cancer. Finally, we discuss the current therapeutic advances that target the IL-36 pathway and the possibility to extend these tools to treat lung inflammatory diseases. interleukin-36 cytokines IL-1Rrp2 host/microbe proteases inflammatory response amplification lung infectious diseases lung inflammation Immunologic diseases. Allergy Rick van der Geest verfasserin aut Joel A. Ybe verfasserin aut Theodore J. Standiford verfasserin aut Janet S. Lee verfasserin aut Janet S. Lee verfasserin aut In Frontiers in Immunology Frontiers Media S.A., 2011 12(2021) (DE-627)657998354 (DE-600)2606827-8 16643224 nnns volume:12 year:2021 https://doi.org/10.3389/fimmu.2021.754702 kostenfrei https://doaj.org/article/7515a4e4023b479f9acd42feaa6c8494 kostenfrei https://www.frontiersin.org/articles/10.3389/fimmu.2021.754702/full kostenfrei https://doaj.org/toc/1664-3224 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2021
spelling	10.3389/fimmu.2021.754702 doi (DE-627)DOAJ061549657 (DE-599)DOAJ7515a4e4023b479f9acd42feaa6c8494 DE-627 ger DE-627 rakwb eng RC581-607 Hernán F. Peñaloza verfasserin aut Interleukin-36 Cytokines in Infectious and Non-Infectious Lung Diseases 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The IL-36 family of cytokines were identified in the early 2000’s as a new subfamily of the IL-1 cytokine family, and since then, the role of IL-36 cytokines during various inflammatory processes has been characterized. While most of the research has focused on the role of these cytokines in autoimmune skin diseases such as psoriasis and dermatitis, recent studies have also shown the importance of IL-36 cytokines in the lung inflammatory response during infectious and non-infectious diseases. In this review, we discuss the biology of IL-36 cytokines in terms of how they are produced and activated, as well as their effects on myeloid and lymphoid cells during inflammation. We also discuss the role of these cytokines during lung infectious diseases caused by bacteria and influenza virus, as well as other inflammatory conditions in the lungs such as allergic asthma, lung fibrosis, chronic obstructive pulmonary disease, cystic fibrosis and cancer. Finally, we discuss the current therapeutic advances that target the IL-36 pathway and the possibility to extend these tools to treat lung inflammatory diseases. interleukin-36 cytokines IL-1Rrp2 host/microbe proteases inflammatory response amplification lung infectious diseases lung inflammation Immunologic diseases. Allergy Rick van der Geest verfasserin aut Joel A. Ybe verfasserin aut Theodore J. Standiford verfasserin aut Janet S. Lee verfasserin aut Janet S. Lee verfasserin aut In Frontiers in Immunology Frontiers Media S.A., 2011 12(2021) (DE-627)657998354 (DE-600)2606827-8 16643224 nnns volume:12 year:2021 https://doi.org/10.3389/fimmu.2021.754702 kostenfrei https://doaj.org/article/7515a4e4023b479f9acd42feaa6c8494 kostenfrei https://www.frontiersin.org/articles/10.3389/fimmu.2021.754702/full kostenfrei https://doaj.org/toc/1664-3224 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2021
allfields_unstemmed	10.3389/fimmu.2021.754702 doi (DE-627)DOAJ061549657 (DE-599)DOAJ7515a4e4023b479f9acd42feaa6c8494 DE-627 ger DE-627 rakwb eng RC581-607 Hernán F. Peñaloza verfasserin aut Interleukin-36 Cytokines in Infectious and Non-Infectious Lung Diseases 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The IL-36 family of cytokines were identified in the early 2000’s as a new subfamily of the IL-1 cytokine family, and since then, the role of IL-36 cytokines during various inflammatory processes has been characterized. While most of the research has focused on the role of these cytokines in autoimmune skin diseases such as psoriasis and dermatitis, recent studies have also shown the importance of IL-36 cytokines in the lung inflammatory response during infectious and non-infectious diseases. In this review, we discuss the biology of IL-36 cytokines in terms of how they are produced and activated, as well as their effects on myeloid and lymphoid cells during inflammation. We also discuss the role of these cytokines during lung infectious diseases caused by bacteria and influenza virus, as well as other inflammatory conditions in the lungs such as allergic asthma, lung fibrosis, chronic obstructive pulmonary disease, cystic fibrosis and cancer. Finally, we discuss the current therapeutic advances that target the IL-36 pathway and the possibility to extend these tools to treat lung inflammatory diseases. interleukin-36 cytokines IL-1Rrp2 host/microbe proteases inflammatory response amplification lung infectious diseases lung inflammation Immunologic diseases. Allergy Rick van der Geest verfasserin aut Joel A. Ybe verfasserin aut Theodore J. Standiford verfasserin aut Janet S. Lee verfasserin aut Janet S. Lee verfasserin aut In Frontiers in Immunology Frontiers Media S.A., 2011 12(2021) (DE-627)657998354 (DE-600)2606827-8 16643224 nnns volume:12 year:2021 https://doi.org/10.3389/fimmu.2021.754702 kostenfrei https://doaj.org/article/7515a4e4023b479f9acd42feaa6c8494 kostenfrei https://www.frontiersin.org/articles/10.3389/fimmu.2021.754702/full kostenfrei https://doaj.org/toc/1664-3224 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2021
allfieldsGer	10.3389/fimmu.2021.754702 doi (DE-627)DOAJ061549657 (DE-599)DOAJ7515a4e4023b479f9acd42feaa6c8494 DE-627 ger DE-627 rakwb eng RC581-607 Hernán F. Peñaloza verfasserin aut Interleukin-36 Cytokines in Infectious and Non-Infectious Lung Diseases 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The IL-36 family of cytokines were identified in the early 2000’s as a new subfamily of the IL-1 cytokine family, and since then, the role of IL-36 cytokines during various inflammatory processes has been characterized. While most of the research has focused on the role of these cytokines in autoimmune skin diseases such as psoriasis and dermatitis, recent studies have also shown the importance of IL-36 cytokines in the lung inflammatory response during infectious and non-infectious diseases. In this review, we discuss the biology of IL-36 cytokines in terms of how they are produced and activated, as well as their effects on myeloid and lymphoid cells during inflammation. We also discuss the role of these cytokines during lung infectious diseases caused by bacteria and influenza virus, as well as other inflammatory conditions in the lungs such as allergic asthma, lung fibrosis, chronic obstructive pulmonary disease, cystic fibrosis and cancer. Finally, we discuss the current therapeutic advances that target the IL-36 pathway and the possibility to extend these tools to treat lung inflammatory diseases. interleukin-36 cytokines IL-1Rrp2 host/microbe proteases inflammatory response amplification lung infectious diseases lung inflammation Immunologic diseases. Allergy Rick van der Geest verfasserin aut Joel A. Ybe verfasserin aut Theodore J. Standiford verfasserin aut Janet S. Lee verfasserin aut Janet S. Lee verfasserin aut In Frontiers in Immunology Frontiers Media S.A., 2011 12(2021) (DE-627)657998354 (DE-600)2606827-8 16643224 nnns volume:12 year:2021 https://doi.org/10.3389/fimmu.2021.754702 kostenfrei https://doaj.org/article/7515a4e4023b479f9acd42feaa6c8494 kostenfrei https://www.frontiersin.org/articles/10.3389/fimmu.2021.754702/full kostenfrei https://doaj.org/toc/1664-3224 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2021
allfieldsSound	10.3389/fimmu.2021.754702 doi (DE-627)DOAJ061549657 (DE-599)DOAJ7515a4e4023b479f9acd42feaa6c8494 DE-627 ger DE-627 rakwb eng RC581-607 Hernán F. Peñaloza verfasserin aut Interleukin-36 Cytokines in Infectious and Non-Infectious Lung Diseases 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The IL-36 family of cytokines were identified in the early 2000’s as a new subfamily of the IL-1 cytokine family, and since then, the role of IL-36 cytokines during various inflammatory processes has been characterized. While most of the research has focused on the role of these cytokines in autoimmune skin diseases such as psoriasis and dermatitis, recent studies have also shown the importance of IL-36 cytokines in the lung inflammatory response during infectious and non-infectious diseases. In this review, we discuss the biology of IL-36 cytokines in terms of how they are produced and activated, as well as their effects on myeloid and lymphoid cells during inflammation. We also discuss the role of these cytokines during lung infectious diseases caused by bacteria and influenza virus, as well as other inflammatory conditions in the lungs such as allergic asthma, lung fibrosis, chronic obstructive pulmonary disease, cystic fibrosis and cancer. Finally, we discuss the current therapeutic advances that target the IL-36 pathway and the possibility to extend these tools to treat lung inflammatory diseases. interleukin-36 cytokines IL-1Rrp2 host/microbe proteases inflammatory response amplification lung infectious diseases lung inflammation Immunologic diseases. Allergy Rick van der Geest verfasserin aut Joel A. Ybe verfasserin aut Theodore J. Standiford verfasserin aut Janet S. Lee verfasserin aut Janet S. Lee verfasserin aut In Frontiers in Immunology Frontiers Media S.A., 2011 12(2021) (DE-627)657998354 (DE-600)2606827-8 16643224 nnns volume:12 year:2021 https://doi.org/10.3389/fimmu.2021.754702 kostenfrei https://doaj.org/article/7515a4e4023b479f9acd42feaa6c8494 kostenfrei https://www.frontiersin.org/articles/10.3389/fimmu.2021.754702/full kostenfrei https://doaj.org/toc/1664-3224 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2021
language	English
source	In Frontiers in Immunology 12(2021) volume:12 year:2021
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topic_facet	interleukin-36 cytokines IL-1Rrp2 host/microbe proteases inflammatory response amplification lung infectious diseases lung inflammation Immunologic diseases. Allergy
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container_title	Frontiers in Immunology
authorswithroles_txt_mv	Hernán F. Peñaloza @@aut@@ Rick van der Geest @@aut@@ Joel A. Ybe @@aut@@ Theodore J. Standiford @@aut@@ Janet S. Lee @@aut@@
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callnumber-first	R - Medicine
author	Hernán F. Peñaloza
spellingShingle	Hernán F. Peñaloza misc RC581-607 misc interleukin-36 cytokines misc IL-1Rrp2 misc host/microbe proteases misc inflammatory response amplification misc lung infectious diseases misc lung inflammation misc Immunologic diseases. Allergy Interleukin-36 Cytokines in Infectious and Non-Infectious Lung Diseases
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topic_title	RC581-607 Interleukin-36 Cytokines in Infectious and Non-Infectious Lung Diseases interleukin-36 cytokines IL-1Rrp2 host/microbe proteases inflammatory response amplification lung infectious diseases lung inflammation
topic	misc RC581-607 misc interleukin-36 cytokines misc IL-1Rrp2 misc host/microbe proteases misc inflammatory response amplification misc lung infectious diseases misc lung inflammation misc Immunologic diseases. Allergy
topic_unstemmed	misc RC581-607 misc interleukin-36 cytokines misc IL-1Rrp2 misc host/microbe proteases misc inflammatory response amplification misc lung infectious diseases misc lung inflammation misc Immunologic diseases. Allergy
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title	Interleukin-36 Cytokines in Infectious and Non-Infectious Lung Diseases
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title_full	Interleukin-36 Cytokines in Infectious and Non-Infectious Lung Diseases
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title_sort	interleukin-36 cytokines in infectious and non-infectious lung diseases
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title_auth	Interleukin-36 Cytokines in Infectious and Non-Infectious Lung Diseases
abstract	The IL-36 family of cytokines were identified in the early 2000’s as a new subfamily of the IL-1 cytokine family, and since then, the role of IL-36 cytokines during various inflammatory processes has been characterized. While most of the research has focused on the role of these cytokines in autoimmune skin diseases such as psoriasis and dermatitis, recent studies have also shown the importance of IL-36 cytokines in the lung inflammatory response during infectious and non-infectious diseases. In this review, we discuss the biology of IL-36 cytokines in terms of how they are produced and activated, as well as their effects on myeloid and lymphoid cells during inflammation. We also discuss the role of these cytokines during lung infectious diseases caused by bacteria and influenza virus, as well as other inflammatory conditions in the lungs such as allergic asthma, lung fibrosis, chronic obstructive pulmonary disease, cystic fibrosis and cancer. Finally, we discuss the current therapeutic advances that target the IL-36 pathway and the possibility to extend these tools to treat lung inflammatory diseases.
abstractGer	The IL-36 family of cytokines were identified in the early 2000’s as a new subfamily of the IL-1 cytokine family, and since then, the role of IL-36 cytokines during various inflammatory processes has been characterized. While most of the research has focused on the role of these cytokines in autoimmune skin diseases such as psoriasis and dermatitis, recent studies have also shown the importance of IL-36 cytokines in the lung inflammatory response during infectious and non-infectious diseases. In this review, we discuss the biology of IL-36 cytokines in terms of how they are produced and activated, as well as their effects on myeloid and lymphoid cells during inflammation. We also discuss the role of these cytokines during lung infectious diseases caused by bacteria and influenza virus, as well as other inflammatory conditions in the lungs such as allergic asthma, lung fibrosis, chronic obstructive pulmonary disease, cystic fibrosis and cancer. Finally, we discuss the current therapeutic advances that target the IL-36 pathway and the possibility to extend these tools to treat lung inflammatory diseases.
abstract_unstemmed	The IL-36 family of cytokines were identified in the early 2000’s as a new subfamily of the IL-1 cytokine family, and since then, the role of IL-36 cytokines during various inflammatory processes has been characterized. While most of the research has focused on the role of these cytokines in autoimmune skin diseases such as psoriasis and dermatitis, recent studies have also shown the importance of IL-36 cytokines in the lung inflammatory response during infectious and non-infectious diseases. In this review, we discuss the biology of IL-36 cytokines in terms of how they are produced and activated, as well as their effects on myeloid and lymphoid cells during inflammation. We also discuss the role of these cytokines during lung infectious diseases caused by bacteria and influenza virus, as well as other inflammatory conditions in the lungs such as allergic asthma, lung fibrosis, chronic obstructive pulmonary disease, cystic fibrosis and cancer. Finally, we discuss the current therapeutic advances that target the IL-36 pathway and the possibility to extend these tools to treat lung inflammatory diseases.
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title_short	Interleukin-36 Cytokines in Infectious and Non-Infectious Lung Diseases
url	https://doi.org/10.3389/fimmu.2021.754702 https://doaj.org/article/7515a4e4023b479f9acd42feaa6c8494 https://www.frontiersin.org/articles/10.3389/fimmu.2021.754702/full https://doaj.org/toc/1664-3224
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