Robust antigen-specific CD8 T cell tolerance to a model prostate cancer neoantigen

Immunotherapy has shown limited success in prostate cancer; this may be partially explained by its immunosuppressive tumor microenvironment (TME). Although androgen-deprivation therapy (ADT), the most common treatment for prostate cancer, initially promotes a robust T cell infiltrate, T cell respons...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Zoila A. Lopez-Bujanda [verfasserIn] Matthew G. Chaimowitz [verfasserIn] Todd D. Armstrong [verfasserIn] Jeremy B. Foote [verfasserIn] Leisha A. Emens [verfasserIn] Charles G. Drake [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	cd8 tolerance neoantigen prostate her-2/neu androgen-deprivation therapy castration-resistance

Übergeordnetes Werk:	In: OncoImmunology - Taylor & Francis Group, 2020, 9(2020), 1
Übergeordnetes Werk:	volume:9 ; year:2020 ; number:1

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1080/2162402X.2020.1809926

Katalog-ID:	DOAJ061561002

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spelling	10.1080/2162402X.2020.1809926 doi (DE-627)DOAJ061561002 (DE-599)DOAJ62899deb7ed141a49f8b381e321fce93 DE-627 ger DE-627 rakwb eng RC581-607 RC254-282 Zoila A. Lopez-Bujanda verfasserin aut Robust antigen-specific CD8 T cell tolerance to a model prostate cancer neoantigen 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Immunotherapy has shown limited success in prostate cancer; this may be partially explained by its immunosuppressive tumor microenvironment (TME). Although androgen-deprivation therapy (ADT), the most common treatment for prostate cancer, initially promotes a robust T cell infiltrate, T cell responses are later attenuated. Based on the castration-sensitive Myc-CaP model, we developed an antigen-specific system to study CD8 T cell tolerance to prostate tumors. This model is unique in that CD8 T cells recognize a bona-fide tumor antigen (Her-2/neu), rather than an overexpressed xenogenic antigen like chicken ovalbumin or influenza hemagglutinin. Using this novel model, we demonstrate robust tolerance that is not alleviated by TLR agonists or ADT. This model may serve as a novel and useful tool to further interrogate methods by which to augment anti-tumor cancer immune responses to prostate cancer. Significance Prostate cancer is a leading cause of cancer-related death in men worldwide, with an estimated 33,000 deaths projected in the U.S. in 2020. Although primary (localized) tumors can be cured by surgery or radiation, approximately 40% of patients eventually develop recurrent disease. While initially responsive to androgen-deprivation, many patients with recurrent prostate cancer eventually progress to a more advanced disease state known as metastatic castration-resistant prostate cancer (mCRPC); this is the lethal phenotype. These studies describe a novel androgen-responsive murine cell line that expresses a bona-fide tumor antigen (Her-2/neu). Pre-clinical work with this model shows robust and antigen-specific CD8 T cell tolerance, providing a novel preclinical model to study CD8 T cell tolerance to prostate tumors. cd8 tolerance neoantigen prostate her-2/neu androgen-deprivation therapy castration-resistance Immunologic diseases. Allergy Neoplasms. Tumors. Oncology. Including cancer and carcinogens Matthew G. Chaimowitz verfasserin aut Todd D. Armstrong verfasserin aut Jeremy B. Foote verfasserin aut Leisha A. Emens verfasserin aut Charles G. Drake verfasserin aut In OncoImmunology Taylor & Francis Group, 2020 9(2020), 1 (DE-627)683365428 (DE-600)2645309-5 2162402X nnns volume:9 year:2020 number:1 https://doi.org/10.1080/2162402X.2020.1809926 kostenfrei https://doaj.org/article/62899deb7ed141a49f8b381e321fce93 kostenfrei http://dx.doi.org/10.1080/2162402X.2020.1809926 kostenfrei https://doaj.org/toc/2162-402X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2020 1
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allfieldsGer	10.1080/2162402X.2020.1809926 doi (DE-627)DOAJ061561002 (DE-599)DOAJ62899deb7ed141a49f8b381e321fce93 DE-627 ger DE-627 rakwb eng RC581-607 RC254-282 Zoila A. Lopez-Bujanda verfasserin aut Robust antigen-specific CD8 T cell tolerance to a model prostate cancer neoantigen 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Immunotherapy has shown limited success in prostate cancer; this may be partially explained by its immunosuppressive tumor microenvironment (TME). Although androgen-deprivation therapy (ADT), the most common treatment for prostate cancer, initially promotes a robust T cell infiltrate, T cell responses are later attenuated. Based on the castration-sensitive Myc-CaP model, we developed an antigen-specific system to study CD8 T cell tolerance to prostate tumors. This model is unique in that CD8 T cells recognize a bona-fide tumor antigen (Her-2/neu), rather than an overexpressed xenogenic antigen like chicken ovalbumin or influenza hemagglutinin. Using this novel model, we demonstrate robust tolerance that is not alleviated by TLR agonists or ADT. This model may serve as a novel and useful tool to further interrogate methods by which to augment anti-tumor cancer immune responses to prostate cancer. Significance Prostate cancer is a leading cause of cancer-related death in men worldwide, with an estimated 33,000 deaths projected in the U.S. in 2020. Although primary (localized) tumors can be cured by surgery or radiation, approximately 40% of patients eventually develop recurrent disease. While initially responsive to androgen-deprivation, many patients with recurrent prostate cancer eventually progress to a more advanced disease state known as metastatic castration-resistant prostate cancer (mCRPC); this is the lethal phenotype. These studies describe a novel androgen-responsive murine cell line that expresses a bona-fide tumor antigen (Her-2/neu). Pre-clinical work with this model shows robust and antigen-specific CD8 T cell tolerance, providing a novel preclinical model to study CD8 T cell tolerance to prostate tumors. cd8 tolerance neoantigen prostate her-2/neu androgen-deprivation therapy castration-resistance Immunologic diseases. Allergy Neoplasms. Tumors. Oncology. Including cancer and carcinogens Matthew G. Chaimowitz verfasserin aut Todd D. Armstrong verfasserin aut Jeremy B. Foote verfasserin aut Leisha A. Emens verfasserin aut Charles G. Drake verfasserin aut In OncoImmunology Taylor & Francis Group, 2020 9(2020), 1 (DE-627)683365428 (DE-600)2645309-5 2162402X nnns volume:9 year:2020 number:1 https://doi.org/10.1080/2162402X.2020.1809926 kostenfrei https://doaj.org/article/62899deb7ed141a49f8b381e321fce93 kostenfrei http://dx.doi.org/10.1080/2162402X.2020.1809926 kostenfrei https://doaj.org/toc/2162-402X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2020 1
allfieldsSound	10.1080/2162402X.2020.1809926 doi (DE-627)DOAJ061561002 (DE-599)DOAJ62899deb7ed141a49f8b381e321fce93 DE-627 ger DE-627 rakwb eng RC581-607 RC254-282 Zoila A. Lopez-Bujanda verfasserin aut Robust antigen-specific CD8 T cell tolerance to a model prostate cancer neoantigen 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Immunotherapy has shown limited success in prostate cancer; this may be partially explained by its immunosuppressive tumor microenvironment (TME). Although androgen-deprivation therapy (ADT), the most common treatment for prostate cancer, initially promotes a robust T cell infiltrate, T cell responses are later attenuated. Based on the castration-sensitive Myc-CaP model, we developed an antigen-specific system to study CD8 T cell tolerance to prostate tumors. This model is unique in that CD8 T cells recognize a bona-fide tumor antigen (Her-2/neu), rather than an overexpressed xenogenic antigen like chicken ovalbumin or influenza hemagglutinin. Using this novel model, we demonstrate robust tolerance that is not alleviated by TLR agonists or ADT. This model may serve as a novel and useful tool to further interrogate methods by which to augment anti-tumor cancer immune responses to prostate cancer. Significance Prostate cancer is a leading cause of cancer-related death in men worldwide, with an estimated 33,000 deaths projected in the U.S. in 2020. Although primary (localized) tumors can be cured by surgery or radiation, approximately 40% of patients eventually develop recurrent disease. While initially responsive to androgen-deprivation, many patients with recurrent prostate cancer eventually progress to a more advanced disease state known as metastatic castration-resistant prostate cancer (mCRPC); this is the lethal phenotype. These studies describe a novel androgen-responsive murine cell line that expresses a bona-fide tumor antigen (Her-2/neu). Pre-clinical work with this model shows robust and antigen-specific CD8 T cell tolerance, providing a novel preclinical model to study CD8 T cell tolerance to prostate tumors. cd8 tolerance neoantigen prostate her-2/neu androgen-deprivation therapy castration-resistance Immunologic diseases. Allergy Neoplasms. Tumors. Oncology. Including cancer and carcinogens Matthew G. Chaimowitz verfasserin aut Todd D. Armstrong verfasserin aut Jeremy B. Foote verfasserin aut Leisha A. Emens verfasserin aut Charles G. Drake verfasserin aut In OncoImmunology Taylor & Francis Group, 2020 9(2020), 1 (DE-627)683365428 (DE-600)2645309-5 2162402X nnns volume:9 year:2020 number:1 https://doi.org/10.1080/2162402X.2020.1809926 kostenfrei https://doaj.org/article/62899deb7ed141a49f8b381e321fce93 kostenfrei http://dx.doi.org/10.1080/2162402X.2020.1809926 kostenfrei https://doaj.org/toc/2162-402X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2020 1
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topic_facet	cd8 tolerance neoantigen prostate her-2/neu androgen-deprivation therapy castration-resistance Immunologic diseases. Allergy Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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callnumber-first	R - Medicine
author	Zoila A. Lopez-Bujanda
spellingShingle	Zoila A. Lopez-Bujanda misc RC581-607 misc RC254-282 misc cd8 misc tolerance misc neoantigen misc prostate misc her-2/neu misc androgen-deprivation therapy misc castration-resistance misc Immunologic diseases. Allergy misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens Robust antigen-specific CD8 T cell tolerance to a model prostate cancer neoantigen
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topic_title	RC581-607 RC254-282 Robust antigen-specific CD8 T cell tolerance to a model prostate cancer neoantigen cd8 tolerance neoantigen prostate her-2/neu androgen-deprivation therapy castration-resistance
topic	misc RC581-607 misc RC254-282 misc cd8 misc tolerance misc neoantigen misc prostate misc her-2/neu misc androgen-deprivation therapy misc castration-resistance misc Immunologic diseases. Allergy misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_unstemmed	misc RC581-607 misc RC254-282 misc cd8 misc tolerance misc neoantigen misc prostate misc her-2/neu misc androgen-deprivation therapy misc castration-resistance misc Immunologic diseases. Allergy misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_browse	misc RC581-607 misc RC254-282 misc cd8 misc tolerance misc neoantigen misc prostate misc her-2/neu misc androgen-deprivation therapy misc castration-resistance misc Immunologic diseases. Allergy misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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title	Robust antigen-specific CD8 T cell tolerance to a model prostate cancer neoantigen
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title_sort	robust antigen-specific cd8 t cell tolerance to a model prostate cancer neoantigen
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title_auth	Robust antigen-specific CD8 T cell tolerance to a model prostate cancer neoantigen
abstract	Immunotherapy has shown limited success in prostate cancer; this may be partially explained by its immunosuppressive tumor microenvironment (TME). Although androgen-deprivation therapy (ADT), the most common treatment for prostate cancer, initially promotes a robust T cell infiltrate, T cell responses are later attenuated. Based on the castration-sensitive Myc-CaP model, we developed an antigen-specific system to study CD8 T cell tolerance to prostate tumors. This model is unique in that CD8 T cells recognize a bona-fide tumor antigen (Her-2/neu), rather than an overexpressed xenogenic antigen like chicken ovalbumin or influenza hemagglutinin. Using this novel model, we demonstrate robust tolerance that is not alleviated by TLR agonists or ADT. This model may serve as a novel and useful tool to further interrogate methods by which to augment anti-tumor cancer immune responses to prostate cancer. Significance Prostate cancer is a leading cause of cancer-related death in men worldwide, with an estimated 33,000 deaths projected in the U.S. in 2020. Although primary (localized) tumors can be cured by surgery or radiation, approximately 40% of patients eventually develop recurrent disease. While initially responsive to androgen-deprivation, many patients with recurrent prostate cancer eventually progress to a more advanced disease state known as metastatic castration-resistant prostate cancer (mCRPC); this is the lethal phenotype. These studies describe a novel androgen-responsive murine cell line that expresses a bona-fide tumor antigen (Her-2/neu). Pre-clinical work with this model shows robust and antigen-specific CD8 T cell tolerance, providing a novel preclinical model to study CD8 T cell tolerance to prostate tumors.
abstractGer	Immunotherapy has shown limited success in prostate cancer; this may be partially explained by its immunosuppressive tumor microenvironment (TME). Although androgen-deprivation therapy (ADT), the most common treatment for prostate cancer, initially promotes a robust T cell infiltrate, T cell responses are later attenuated. Based on the castration-sensitive Myc-CaP model, we developed an antigen-specific system to study CD8 T cell tolerance to prostate tumors. This model is unique in that CD8 T cells recognize a bona-fide tumor antigen (Her-2/neu), rather than an overexpressed xenogenic antigen like chicken ovalbumin or influenza hemagglutinin. Using this novel model, we demonstrate robust tolerance that is not alleviated by TLR agonists or ADT. This model may serve as a novel and useful tool to further interrogate methods by which to augment anti-tumor cancer immune responses to prostate cancer. Significance Prostate cancer is a leading cause of cancer-related death in men worldwide, with an estimated 33,000 deaths projected in the U.S. in 2020. Although primary (localized) tumors can be cured by surgery or radiation, approximately 40% of patients eventually develop recurrent disease. While initially responsive to androgen-deprivation, many patients with recurrent prostate cancer eventually progress to a more advanced disease state known as metastatic castration-resistant prostate cancer (mCRPC); this is the lethal phenotype. These studies describe a novel androgen-responsive murine cell line that expresses a bona-fide tumor antigen (Her-2/neu). Pre-clinical work with this model shows robust and antigen-specific CD8 T cell tolerance, providing a novel preclinical model to study CD8 T cell tolerance to prostate tumors.
abstract_unstemmed	Immunotherapy has shown limited success in prostate cancer; this may be partially explained by its immunosuppressive tumor microenvironment (TME). Although androgen-deprivation therapy (ADT), the most common treatment for prostate cancer, initially promotes a robust T cell infiltrate, T cell responses are later attenuated. Based on the castration-sensitive Myc-CaP model, we developed an antigen-specific system to study CD8 T cell tolerance to prostate tumors. This model is unique in that CD8 T cells recognize a bona-fide tumor antigen (Her-2/neu), rather than an overexpressed xenogenic antigen like chicken ovalbumin or influenza hemagglutinin. Using this novel model, we demonstrate robust tolerance that is not alleviated by TLR agonists or ADT. This model may serve as a novel and useful tool to further interrogate methods by which to augment anti-tumor cancer immune responses to prostate cancer. Significance Prostate cancer is a leading cause of cancer-related death in men worldwide, with an estimated 33,000 deaths projected in the U.S. in 2020. Although primary (localized) tumors can be cured by surgery or radiation, approximately 40% of patients eventually develop recurrent disease. While initially responsive to androgen-deprivation, many patients with recurrent prostate cancer eventually progress to a more advanced disease state known as metastatic castration-resistant prostate cancer (mCRPC); this is the lethal phenotype. These studies describe a novel androgen-responsive murine cell line that expresses a bona-fide tumor antigen (Her-2/neu). Pre-clinical work with this model shows robust and antigen-specific CD8 T cell tolerance, providing a novel preclinical model to study CD8 T cell tolerance to prostate tumors.
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title_short	Robust antigen-specific CD8 T cell tolerance to a model prostate cancer neoantigen
url	https://doi.org/10.1080/2162402X.2020.1809926 https://doaj.org/article/62899deb7ed141a49f8b381e321fce93 http://dx.doi.org/10.1080/2162402X.2020.1809926 https://doaj.org/toc/2162-402X
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Although primary (localized) tumors can be cured by surgery or radiation, approximately 40% of patients eventually develop recurrent disease. While initially responsive to androgen-deprivation, many patients with recurrent prostate cancer eventually progress to a more advanced disease state known as metastatic castration-resistant prostate cancer (mCRPC); this is the lethal phenotype. These studies describe a novel androgen-responsive murine cell line that expresses a bona-fide tumor antigen (Her-2/neu). 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Robust antigen-specific CD8 T cell tolerance to a model prostate cancer neoantigen

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