Large genome-wide association study identifies three novel risk variants for restless legs syndrome

Didriksen, Nawaz, et al. identify three novel genetic risk variants for restless legs syndrome and confirm 19 out of 20 previously reported variants through a genome-wide association meta-analysis including nearly half a million individuals. Using expression QTL analysis, they also find that a subse...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Maria Didriksen [verfasserIn] Muhammad Sulaman Nawaz [verfasserIn] Joseph Dowsett [verfasserIn] Steven Bell [verfasserIn] Christian Erikstrup [verfasserIn] Ole B. Pedersen [verfasserIn] Erik Sørensen [verfasserIn] Poul J. Jennum [verfasserIn] Kristoffer S. Burgdorf [verfasserIn] Brendan Burchell [verfasserIn] Adam S. Butterworth [verfasserIn] Nicole Soranzo [verfasserIn] David B. Rye [verfasserIn] Lynn Marie Trotti [verfasserIn] Prabhjyot Saini [verfasserIn] Lilja Stefansdottir [verfasserIn] Sigurdur H. Magnusson [verfasserIn] Gudmar Thorleifsson [verfasserIn] Thordur Sigmundsson [verfasserIn] Albert P. Sigurdsson [verfasserIn] Katja Van Den Hurk [verfasserIn] Franke Quee [verfasserIn] Michael W. T. Tanck [verfasserIn] Willem H. Ouwehand [verfasserIn] David J. Roberts [verfasserIn] Eric J. Earley [verfasserIn] Michael P. Busch [verfasserIn] Alan E. Mast [verfasserIn] Grier P. Page [verfasserIn] John Danesh [verfasserIn] Emanuele Di Angelantonio [verfasserIn] Hreinn Stefansson [verfasserIn] Henrik Ullum [verfasserIn] Kari Stefansson [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Übergeordnetes Werk:	In: Communications Biology - Nature Portfolio, 2018, 3(2020), 1, Seite 9
Übergeordnetes Werk:	volume:3 ; year:2020 ; number:1 ; pages:9

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1038/s42003-020-01430-1

Katalog-ID:	DOAJ061566667

Internformat


LEADER	01000caa a22002652 4500
001	DOAJ061566667
003	DE-627
005	20230309012642.0
007	cr uuu---uuuuu
008	230228s2020 xx \|\|\|\|\|o 00\| \|\|eng c
024	7		\|a 10.1038/s42003-020-01430-1 \|2 doi
035			\|a (DE-627)DOAJ061566667
035			\|a (DE-599)DOAJb804eef352554c768c94ad94c5a8a74a
040			\|a DE-627 \|b ger \|c DE-627 \|e rakwb
041			\|a eng
050		0	\|a QH301-705.5
100	0		\|a Maria Didriksen \|e verfasserin \|4 aut
245	1	0	\|a Large genome-wide association study identifies three novel risk variants for restless legs syndrome
264		1	\|c 2020
336			\|a Text \|b txt \|2 rdacontent
337			\|a Computermedien \|b c \|2 rdamedia
338			\|a Online-Ressource \|b cr \|2 rdacarrier
520			\|a Didriksen, Nawaz, et al. identify three novel genetic risk variants for restless legs syndrome and confirm 19 out of 20 previously reported variants through a genome-wide association meta-analysis including nearly half a million individuals. Using expression QTL analysis, they also find that a subset of these loci may have a causal effect on nearby gene expression.
653		0	\|a Biology (General)
700	0		\|a Muhammad Sulaman Nawaz \|e verfasserin \|4 aut
700	0		\|a Joseph Dowsett \|e verfasserin \|4 aut
700	0		\|a Steven Bell \|e verfasserin \|4 aut
700	0		\|a Christian Erikstrup \|e verfasserin \|4 aut
700	0		\|a Ole B. Pedersen \|e verfasserin \|4 aut
700	0		\|a Erik Sørensen \|e verfasserin \|4 aut
700	0		\|a Poul J. Jennum \|e verfasserin \|4 aut
700	0		\|a Kristoffer S. Burgdorf \|e verfasserin \|4 aut
700	0		\|a Brendan Burchell \|e verfasserin \|4 aut
700	0		\|a Adam S. Butterworth \|e verfasserin \|4 aut
700	0		\|a Nicole Soranzo \|e verfasserin \|4 aut
700	0		\|a David B. Rye \|e verfasserin \|4 aut
700	0		\|a Lynn Marie Trotti \|e verfasserin \|4 aut
700	0		\|a Prabhjyot Saini \|e verfasserin \|4 aut
700	0		\|a Lilja Stefansdottir \|e verfasserin \|4 aut
700	0		\|a Sigurdur H. Magnusson \|e verfasserin \|4 aut
700	0		\|a Gudmar Thorleifsson \|e verfasserin \|4 aut
700	0		\|a Thordur Sigmundsson \|e verfasserin \|4 aut
700	0		\|a Albert P. Sigurdsson \|e verfasserin \|4 aut
700	0		\|a Katja Van Den Hurk \|e verfasserin \|4 aut
700	0		\|a Franke Quee \|e verfasserin \|4 aut
700	0		\|a Michael W. T. Tanck \|e verfasserin \|4 aut
700	0		\|a Willem H. Ouwehand \|e verfasserin \|4 aut
700	0		\|a David J. Roberts \|e verfasserin \|4 aut
700	0		\|a Eric J. Earley \|e verfasserin \|4 aut
700	0		\|a Michael P. Busch \|e verfasserin \|4 aut
700	0		\|a Alan E. Mast \|e verfasserin \|4 aut
700	0		\|a Grier P. Page \|e verfasserin \|4 aut
700	0		\|a John Danesh \|e verfasserin \|4 aut
700	0		\|a Emanuele Di Angelantonio \|e verfasserin \|4 aut
700	0		\|a Hreinn Stefansson \|e verfasserin \|4 aut
700	0		\|a Henrik Ullum \|e verfasserin \|4 aut
700	0		\|a Kari Stefansson \|e verfasserin \|4 aut
773	0	8	\|i In \|t Communications Biology \|d Nature Portfolio, 2018 \|g 3(2020), 1, Seite 9 \|w (DE-627)101369080X \|x 23993642 \|7 nnns
773	1	8	\|g volume:3 \|g year:2020 \|g number:1 \|g pages:9
856	4	0	\|u https://doi.org/10.1038/s42003-020-01430-1 \|z kostenfrei
856	4	0	\|u https://doaj.org/article/b804eef352554c768c94ad94c5a8a74a \|z kostenfrei
856	4	0	\|u https://doi.org/10.1038/s42003-020-01430-1 \|z kostenfrei
856	4	2	\|u https://doaj.org/toc/2399-3642 \|y Journal toc \|z kostenfrei
912			\|a GBV_USEFLAG_A
912			\|a SYSFLAG_A
912			\|a GBV_DOAJ
912			\|a GBV_ILN_20
912			\|a GBV_ILN_22
912			\|a GBV_ILN_23
912			\|a GBV_ILN_24
912			\|a GBV_ILN_31
912			\|a GBV_ILN_39
912			\|a GBV_ILN_40
912			\|a GBV_ILN_62
912			\|a GBV_ILN_63
912			\|a GBV_ILN_65
912			\|a GBV_ILN_69
912			\|a GBV_ILN_70
912			\|a GBV_ILN_73
912			\|a GBV_ILN_74
912			\|a GBV_ILN_95
912			\|a GBV_ILN_105
912			\|a GBV_ILN_110
912			\|a GBV_ILN_151
912			\|a GBV_ILN_161
912			\|a GBV_ILN_170
912			\|a GBV_ILN_213
912			\|a GBV_ILN_230
912			\|a GBV_ILN_285
912			\|a GBV_ILN_293
912			\|a GBV_ILN_602
912			\|a GBV_ILN_2005
912			\|a GBV_ILN_2009
912			\|a GBV_ILN_2014
912			\|a GBV_ILN_2055
912			\|a GBV_ILN_2111
912			\|a GBV_ILN_4012
912			\|a GBV_ILN_4037
912			\|a GBV_ILN_4112
912			\|a GBV_ILN_4125
912			\|a GBV_ILN_4126
912			\|a GBV_ILN_4249
912			\|a GBV_ILN_4305
912			\|a GBV_ILN_4306
912			\|a GBV_ILN_4307
912			\|a GBV_ILN_4313
912			\|a GBV_ILN_4322
912			\|a GBV_ILN_4323
912			\|a GBV_ILN_4324
912			\|a GBV_ILN_4325
912			\|a GBV_ILN_4338
912			\|a GBV_ILN_4367
912			\|a GBV_ILN_4700
951			\|a AR
952			\|d 3 \|j 2020 \|e 1 \|h 9

Indexfelder

author_variant	m d md m s n msn j d jd s b sb c e ce o b p obp e s es p j j pjj k s b ksb b b bb a s b asb n s ns d b r dbr l m t lmt p s ps l s ls s h m shm g t gt t s ts a p s aps k v d h kvdh f q fq m w t t mwtt w h o who d j r djr e j e eje m p b mpb a e m aem g p p gpp j d jd e d a eda h s hs h u hu k s ks
matchkey_str	article:23993642:2020----::aggnmwdascaintdietfetreoersvrat
hierarchy_sort_str	2020
callnumber-subject-code	QH
publishDate	2020
allfields	10.1038/s42003-020-01430-1 doi (DE-627)DOAJ061566667 (DE-599)DOAJb804eef352554c768c94ad94c5a8a74a DE-627 ger DE-627 rakwb eng QH301-705.5 Maria Didriksen verfasserin aut Large genome-wide association study identifies three novel risk variants for restless legs syndrome 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Didriksen, Nawaz, et al. identify three novel genetic risk variants for restless legs syndrome and confirm 19 out of 20 previously reported variants through a genome-wide association meta-analysis including nearly half a million individuals. Using expression QTL analysis, they also find that a subset of these loci may have a causal effect on nearby gene expression. Biology (General) Muhammad Sulaman Nawaz verfasserin aut Joseph Dowsett verfasserin aut Steven Bell verfasserin aut Christian Erikstrup verfasserin aut Ole B. Pedersen verfasserin aut Erik Sørensen verfasserin aut Poul J. Jennum verfasserin aut Kristoffer S. Burgdorf verfasserin aut Brendan Burchell verfasserin aut Adam S. Butterworth verfasserin aut Nicole Soranzo verfasserin aut David B. Rye verfasserin aut Lynn Marie Trotti verfasserin aut Prabhjyot Saini verfasserin aut Lilja Stefansdottir verfasserin aut Sigurdur H. Magnusson verfasserin aut Gudmar Thorleifsson verfasserin aut Thordur Sigmundsson verfasserin aut Albert P. Sigurdsson verfasserin aut Katja Van Den Hurk verfasserin aut Franke Quee verfasserin aut Michael W. T. Tanck verfasserin aut Willem H. Ouwehand verfasserin aut David J. Roberts verfasserin aut Eric J. Earley verfasserin aut Michael P. Busch verfasserin aut Alan E. Mast verfasserin aut Grier P. Page verfasserin aut John Danesh verfasserin aut Emanuele Di Angelantonio verfasserin aut Hreinn Stefansson verfasserin aut Henrik Ullum verfasserin aut Kari Stefansson verfasserin aut In Communications Biology Nature Portfolio, 2018 3(2020), 1, Seite 9 (DE-627)101369080X 23993642 nnns volume:3 year:2020 number:1 pages:9 https://doi.org/10.1038/s42003-020-01430-1 kostenfrei https://doaj.org/article/b804eef352554c768c94ad94c5a8a74a kostenfrei https://doi.org/10.1038/s42003-020-01430-1 kostenfrei https://doaj.org/toc/2399-3642 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 3 2020 1 9
spelling	10.1038/s42003-020-01430-1 doi (DE-627)DOAJ061566667 (DE-599)DOAJb804eef352554c768c94ad94c5a8a74a DE-627 ger DE-627 rakwb eng QH301-705.5 Maria Didriksen verfasserin aut Large genome-wide association study identifies three novel risk variants for restless legs syndrome 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Didriksen, Nawaz, et al. identify three novel genetic risk variants for restless legs syndrome and confirm 19 out of 20 previously reported variants through a genome-wide association meta-analysis including nearly half a million individuals. Using expression QTL analysis, they also find that a subset of these loci may have a causal effect on nearby gene expression. Biology (General) Muhammad Sulaman Nawaz verfasserin aut Joseph Dowsett verfasserin aut Steven Bell verfasserin aut Christian Erikstrup verfasserin aut Ole B. Pedersen verfasserin aut Erik Sørensen verfasserin aut Poul J. Jennum verfasserin aut Kristoffer S. Burgdorf verfasserin aut Brendan Burchell verfasserin aut Adam S. Butterworth verfasserin aut Nicole Soranzo verfasserin aut David B. Rye verfasserin aut Lynn Marie Trotti verfasserin aut Prabhjyot Saini verfasserin aut Lilja Stefansdottir verfasserin aut Sigurdur H. Magnusson verfasserin aut Gudmar Thorleifsson verfasserin aut Thordur Sigmundsson verfasserin aut Albert P. Sigurdsson verfasserin aut Katja Van Den Hurk verfasserin aut Franke Quee verfasserin aut Michael W. T. Tanck verfasserin aut Willem H. Ouwehand verfasserin aut David J. Roberts verfasserin aut Eric J. Earley verfasserin aut Michael P. Busch verfasserin aut Alan E. Mast verfasserin aut Grier P. Page verfasserin aut John Danesh verfasserin aut Emanuele Di Angelantonio verfasserin aut Hreinn Stefansson verfasserin aut Henrik Ullum verfasserin aut Kari Stefansson verfasserin aut In Communications Biology Nature Portfolio, 2018 3(2020), 1, Seite 9 (DE-627)101369080X 23993642 nnns volume:3 year:2020 number:1 pages:9 https://doi.org/10.1038/s42003-020-01430-1 kostenfrei https://doaj.org/article/b804eef352554c768c94ad94c5a8a74a kostenfrei https://doi.org/10.1038/s42003-020-01430-1 kostenfrei https://doaj.org/toc/2399-3642 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 3 2020 1 9
allfields_unstemmed	10.1038/s42003-020-01430-1 doi (DE-627)DOAJ061566667 (DE-599)DOAJb804eef352554c768c94ad94c5a8a74a DE-627 ger DE-627 rakwb eng QH301-705.5 Maria Didriksen verfasserin aut Large genome-wide association study identifies three novel risk variants for restless legs syndrome 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Didriksen, Nawaz, et al. identify three novel genetic risk variants for restless legs syndrome and confirm 19 out of 20 previously reported variants through a genome-wide association meta-analysis including nearly half a million individuals. Using expression QTL analysis, they also find that a subset of these loci may have a causal effect on nearby gene expression. Biology (General) Muhammad Sulaman Nawaz verfasserin aut Joseph Dowsett verfasserin aut Steven Bell verfasserin aut Christian Erikstrup verfasserin aut Ole B. Pedersen verfasserin aut Erik Sørensen verfasserin aut Poul J. Jennum verfasserin aut Kristoffer S. Burgdorf verfasserin aut Brendan Burchell verfasserin aut Adam S. Butterworth verfasserin aut Nicole Soranzo verfasserin aut David B. Rye verfasserin aut Lynn Marie Trotti verfasserin aut Prabhjyot Saini verfasserin aut Lilja Stefansdottir verfasserin aut Sigurdur H. Magnusson verfasserin aut Gudmar Thorleifsson verfasserin aut Thordur Sigmundsson verfasserin aut Albert P. Sigurdsson verfasserin aut Katja Van Den Hurk verfasserin aut Franke Quee verfasserin aut Michael W. T. Tanck verfasserin aut Willem H. Ouwehand verfasserin aut David J. Roberts verfasserin aut Eric J. Earley verfasserin aut Michael P. Busch verfasserin aut Alan E. Mast verfasserin aut Grier P. Page verfasserin aut John Danesh verfasserin aut Emanuele Di Angelantonio verfasserin aut Hreinn Stefansson verfasserin aut Henrik Ullum verfasserin aut Kari Stefansson verfasserin aut In Communications Biology Nature Portfolio, 2018 3(2020), 1, Seite 9 (DE-627)101369080X 23993642 nnns volume:3 year:2020 number:1 pages:9 https://doi.org/10.1038/s42003-020-01430-1 kostenfrei https://doaj.org/article/b804eef352554c768c94ad94c5a8a74a kostenfrei https://doi.org/10.1038/s42003-020-01430-1 kostenfrei https://doaj.org/toc/2399-3642 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 3 2020 1 9
allfieldsGer	10.1038/s42003-020-01430-1 doi (DE-627)DOAJ061566667 (DE-599)DOAJb804eef352554c768c94ad94c5a8a74a DE-627 ger DE-627 rakwb eng QH301-705.5 Maria Didriksen verfasserin aut Large genome-wide association study identifies three novel risk variants for restless legs syndrome 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Didriksen, Nawaz, et al. identify three novel genetic risk variants for restless legs syndrome and confirm 19 out of 20 previously reported variants through a genome-wide association meta-analysis including nearly half a million individuals. Using expression QTL analysis, they also find that a subset of these loci may have a causal effect on nearby gene expression. Biology (General) Muhammad Sulaman Nawaz verfasserin aut Joseph Dowsett verfasserin aut Steven Bell verfasserin aut Christian Erikstrup verfasserin aut Ole B. Pedersen verfasserin aut Erik Sørensen verfasserin aut Poul J. Jennum verfasserin aut Kristoffer S. Burgdorf verfasserin aut Brendan Burchell verfasserin aut Adam S. Butterworth verfasserin aut Nicole Soranzo verfasserin aut David B. Rye verfasserin aut Lynn Marie Trotti verfasserin aut Prabhjyot Saini verfasserin aut Lilja Stefansdottir verfasserin aut Sigurdur H. Magnusson verfasserin aut Gudmar Thorleifsson verfasserin aut Thordur Sigmundsson verfasserin aut Albert P. Sigurdsson verfasserin aut Katja Van Den Hurk verfasserin aut Franke Quee verfasserin aut Michael W. T. Tanck verfasserin aut Willem H. Ouwehand verfasserin aut David J. Roberts verfasserin aut Eric J. Earley verfasserin aut Michael P. Busch verfasserin aut Alan E. Mast verfasserin aut Grier P. Page verfasserin aut John Danesh verfasserin aut Emanuele Di Angelantonio verfasserin aut Hreinn Stefansson verfasserin aut Henrik Ullum verfasserin aut Kari Stefansson verfasserin aut In Communications Biology Nature Portfolio, 2018 3(2020), 1, Seite 9 (DE-627)101369080X 23993642 nnns volume:3 year:2020 number:1 pages:9 https://doi.org/10.1038/s42003-020-01430-1 kostenfrei https://doaj.org/article/b804eef352554c768c94ad94c5a8a74a kostenfrei https://doi.org/10.1038/s42003-020-01430-1 kostenfrei https://doaj.org/toc/2399-3642 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 3 2020 1 9
allfieldsSound	10.1038/s42003-020-01430-1 doi (DE-627)DOAJ061566667 (DE-599)DOAJb804eef352554c768c94ad94c5a8a74a DE-627 ger DE-627 rakwb eng QH301-705.5 Maria Didriksen verfasserin aut Large genome-wide association study identifies three novel risk variants for restless legs syndrome 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Didriksen, Nawaz, et al. identify three novel genetic risk variants for restless legs syndrome and confirm 19 out of 20 previously reported variants through a genome-wide association meta-analysis including nearly half a million individuals. Using expression QTL analysis, they also find that a subset of these loci may have a causal effect on nearby gene expression. Biology (General) Muhammad Sulaman Nawaz verfasserin aut Joseph Dowsett verfasserin aut Steven Bell verfasserin aut Christian Erikstrup verfasserin aut Ole B. Pedersen verfasserin aut Erik Sørensen verfasserin aut Poul J. Jennum verfasserin aut Kristoffer S. Burgdorf verfasserin aut Brendan Burchell verfasserin aut Adam S. Butterworth verfasserin aut Nicole Soranzo verfasserin aut David B. Rye verfasserin aut Lynn Marie Trotti verfasserin aut Prabhjyot Saini verfasserin aut Lilja Stefansdottir verfasserin aut Sigurdur H. Magnusson verfasserin aut Gudmar Thorleifsson verfasserin aut Thordur Sigmundsson verfasserin aut Albert P. Sigurdsson verfasserin aut Katja Van Den Hurk verfasserin aut Franke Quee verfasserin aut Michael W. T. Tanck verfasserin aut Willem H. Ouwehand verfasserin aut David J. Roberts verfasserin aut Eric J. Earley verfasserin aut Michael P. Busch verfasserin aut Alan E. Mast verfasserin aut Grier P. Page verfasserin aut John Danesh verfasserin aut Emanuele Di Angelantonio verfasserin aut Hreinn Stefansson verfasserin aut Henrik Ullum verfasserin aut Kari Stefansson verfasserin aut In Communications Biology Nature Portfolio, 2018 3(2020), 1, Seite 9 (DE-627)101369080X 23993642 nnns volume:3 year:2020 number:1 pages:9 https://doi.org/10.1038/s42003-020-01430-1 kostenfrei https://doaj.org/article/b804eef352554c768c94ad94c5a8a74a kostenfrei https://doi.org/10.1038/s42003-020-01430-1 kostenfrei https://doaj.org/toc/2399-3642 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 3 2020 1 9
language	English
source	In Communications Biology 3(2020), 1, Seite 9 volume:3 year:2020 number:1 pages:9
sourceStr	In Communications Biology 3(2020), 1, Seite 9 volume:3 year:2020 number:1 pages:9
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Biology (General)
isfreeaccess_bool	true
container_title	Communications Biology
authorswithroles_txt_mv	Maria Didriksen @@aut@@ Muhammad Sulaman Nawaz @@aut@@ Joseph Dowsett @@aut@@ Steven Bell @@aut@@ Christian Erikstrup @@aut@@ Ole B. Pedersen @@aut@@ Erik Sørensen @@aut@@ Poul J. Jennum @@aut@@ Kristoffer S. Burgdorf @@aut@@ Brendan Burchell @@aut@@ Adam S. Butterworth @@aut@@ Nicole Soranzo @@aut@@ David B. Rye @@aut@@ Lynn Marie Trotti @@aut@@ Prabhjyot Saini @@aut@@ Lilja Stefansdottir @@aut@@ Sigurdur H. Magnusson @@aut@@ Gudmar Thorleifsson @@aut@@ Thordur Sigmundsson @@aut@@ Albert P. Sigurdsson @@aut@@ Katja Van Den Hurk @@aut@@ Franke Quee @@aut@@ Michael W. T. Tanck @@aut@@ Willem H. Ouwehand @@aut@@ David J. Roberts @@aut@@ Eric J. Earley @@aut@@ Michael P. Busch @@aut@@ Alan E. Mast @@aut@@ Grier P. Page @@aut@@ John Danesh @@aut@@ Emanuele Di Angelantonio @@aut@@ Hreinn Stefansson @@aut@@ Henrik Ullum @@aut@@ Kari Stefansson @@aut@@
publishDateDaySort_date	2020-01-01T00:00:00Z
hierarchy_top_id	101369080X
id	DOAJ061566667
language_de	englisch
fullrecord	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">DOAJ061566667</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230309012642.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230228s2020 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1038/s42003-020-01430-1</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)DOAJ061566667</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DOAJb804eef352554c768c94ad94c5a8a74a</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">QH301-705.5</subfield></datafield><datafield tag="100" ind1="0" ind2=" "><subfield code="a">Maria Didriksen</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Large genome-wide association study identifies three novel risk variants for restless legs syndrome</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2020</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Didriksen, Nawaz, et al. identify three novel genetic risk variants for restless legs syndrome and confirm 19 out of 20 previously reported variants through a genome-wide association meta-analysis including nearly half a million individuals. Using expression QTL analysis, they also find that a subset of these loci may have a causal effect on nearby gene expression.</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Biology (General)</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Muhammad Sulaman Nawaz</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Joseph Dowsett</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Steven Bell</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Christian Erikstrup</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Ole B. Pedersen</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Erik Sørensen</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Poul J. Jennum</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Kristoffer S. Burgdorf</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Brendan Burchell</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Adam S. Butterworth</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Nicole Soranzo</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">David B. Rye</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Lynn Marie Trotti</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Prabhjyot Saini</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Lilja Stefansdottir</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Sigurdur H. Magnusson</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Gudmar Thorleifsson</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Thordur Sigmundsson</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Albert P. Sigurdsson</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Katja Van Den Hurk</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Franke Quee</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Michael W. T. Tanck</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Willem H. Ouwehand</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">David J. Roberts</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Eric J. Earley</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Michael P. Busch</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Alan E. Mast</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Grier P. Page</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">John Danesh</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Emanuele Di Angelantonio</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Hreinn Stefansson</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Henrik Ullum</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Kari Stefansson</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">In</subfield><subfield code="t">Communications Biology</subfield><subfield code="d">Nature Portfolio, 2018</subfield><subfield code="g">3(2020), 1, Seite 9</subfield><subfield code="w">(DE-627)101369080X</subfield><subfield code="x">23993642</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:3</subfield><subfield code="g">year:2020</subfield><subfield code="g">number:1</subfield><subfield code="g">pages:9</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doi.org/10.1038/s42003-020-01430-1</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doaj.org/article/b804eef352554c768c94ad94c5a8a74a</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doi.org/10.1038/s42003-020-01430-1</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="u">https://doaj.org/toc/2399-3642</subfield><subfield code="y">Journal toc</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_DOAJ</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_20</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_22</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_23</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_24</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_31</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_39</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_40</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_62</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_63</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_65</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_69</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_70</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_73</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_74</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_95</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_105</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_110</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_151</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_161</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_170</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_213</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_230</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_285</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_293</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_602</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2005</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2009</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2014</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2055</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2111</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4012</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4037</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4112</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4125</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4126</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4249</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4305</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4306</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4307</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4313</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4322</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4323</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4324</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4325</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4338</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4367</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4700</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">3</subfield><subfield code="j">2020</subfield><subfield code="e">1</subfield><subfield code="h">9</subfield></datafield></record></collection>
callnumber-first	Q - Science
author	Maria Didriksen
spellingShingle	Maria Didriksen misc QH301-705.5 misc Biology (General) Large genome-wide association study identifies three novel risk variants for restless legs syndrome
authorStr	Maria Didriksen
ppnlink_with_tag_str_mv	@@773@@(DE-627)101369080X
format	electronic Article
delete_txt_mv	keep
author_role	aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut
collection	DOAJ
remote_str	true
callnumber-label	QH301-705
illustrated	Not Illustrated
issn	23993642
topic_title	QH301-705.5 Large genome-wide association study identifies three novel risk variants for restless legs syndrome
topic	misc QH301-705.5 misc Biology (General)
topic_unstemmed	misc QH301-705.5 misc Biology (General)
topic_browse	misc QH301-705.5 misc Biology (General)
format_facet	Elektronische Aufsätze Aufsätze Elektronische Ressource
format_main_str_mv	Text Zeitschrift/Artikel
carriertype_str_mv	cr
hierarchy_parent_title	Communications Biology
hierarchy_parent_id	101369080X
hierarchy_top_title	Communications Biology
isfreeaccess_txt	true
familylinks_str_mv	(DE-627)101369080X
title	Large genome-wide association study identifies three novel risk variants for restless legs syndrome
ctrlnum	(DE-627)DOAJ061566667 (DE-599)DOAJb804eef352554c768c94ad94c5a8a74a
title_full	Large genome-wide association study identifies three novel risk variants for restless legs syndrome
author_sort	Maria Didriksen
journal	Communications Biology
journalStr	Communications Biology
callnumber-first-code	Q
lang_code	eng
isOA_bool	true
recordtype	marc
publishDateSort	2020
contenttype_str_mv	txt
container_start_page	9
author_browse	Maria Didriksen Muhammad Sulaman Nawaz Joseph Dowsett Steven Bell Christian Erikstrup Ole B. Pedersen Erik Sørensen Poul J. Jennum Kristoffer S. Burgdorf Brendan Burchell Adam S. Butterworth Nicole Soranzo David B. Rye Lynn Marie Trotti Prabhjyot Saini Lilja Stefansdottir Sigurdur H. Magnusson Gudmar Thorleifsson Thordur Sigmundsson Albert P. Sigurdsson Katja Van Den Hurk Franke Quee Michael W. T. Tanck Willem H. Ouwehand David J. Roberts Eric J. Earley Michael P. Busch Alan E. Mast Grier P. Page John Danesh Emanuele Di Angelantonio Hreinn Stefansson Henrik Ullum Kari Stefansson
container_volume	3
class	QH301-705.5
format_se	Elektronische Aufsätze
author-letter	Maria Didriksen
doi_str_mv	10.1038/s42003-020-01430-1
author2-role	verfasserin
title_sort	large genome-wide association study identifies three novel risk variants for restless legs syndrome
callnumber	QH301-705.5
title_auth	Large genome-wide association study identifies three novel risk variants for restless legs syndrome
abstract	Didriksen, Nawaz, et al. identify three novel genetic risk variants for restless legs syndrome and confirm 19 out of 20 previously reported variants through a genome-wide association meta-analysis including nearly half a million individuals. Using expression QTL analysis, they also find that a subset of these loci may have a causal effect on nearby gene expression.
abstractGer	Didriksen, Nawaz, et al. identify three novel genetic risk variants for restless legs syndrome and confirm 19 out of 20 previously reported variants through a genome-wide association meta-analysis including nearly half a million individuals. Using expression QTL analysis, they also find that a subset of these loci may have a causal effect on nearby gene expression.
abstract_unstemmed	Didriksen, Nawaz, et al. identify three novel genetic risk variants for restless legs syndrome and confirm 19 out of 20 previously reported variants through a genome-wide association meta-analysis including nearly half a million individuals. Using expression QTL analysis, they also find that a subset of these loci may have a causal effect on nearby gene expression.
collection_details	GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700
container_issue	1
title_short	Large genome-wide association study identifies three novel risk variants for restless legs syndrome
url	https://doi.org/10.1038/s42003-020-01430-1 https://doaj.org/article/b804eef352554c768c94ad94c5a8a74a https://doaj.org/toc/2399-3642
remote_bool	true
author2	Muhammad Sulaman Nawaz Joseph Dowsett Steven Bell Christian Erikstrup Ole B. Pedersen Erik Sørensen Poul J. Jennum Kristoffer S. Burgdorf Brendan Burchell Adam S. Butterworth Nicole Soranzo David B. Rye Lynn Marie Trotti Prabhjyot Saini Lilja Stefansdottir Sigurdur H. Magnusson Gudmar Thorleifsson Thordur Sigmundsson Albert P. Sigurdsson Katja Van Den Hurk Franke Quee Michael W. T. Tanck Willem H. Ouwehand David J. Roberts Eric J. Earley Michael P. Busch Alan E. Mast Grier P. Page John Danesh Emanuele Di Angelantonio Hreinn Stefansson Henrik Ullum Kari Stefansson
author2Str	Muhammad Sulaman Nawaz Joseph Dowsett Steven Bell Christian Erikstrup Ole B. Pedersen Erik Sørensen Poul J. Jennum Kristoffer S. Burgdorf Brendan Burchell Adam S. Butterworth Nicole Soranzo David B. Rye Lynn Marie Trotti Prabhjyot Saini Lilja Stefansdottir Sigurdur H. Magnusson Gudmar Thorleifsson Thordur Sigmundsson Albert P. Sigurdsson Katja Van Den Hurk Franke Quee Michael W. T. Tanck Willem H. Ouwehand David J. Roberts Eric J. Earley Michael P. Busch Alan E. Mast Grier P. Page John Danesh Emanuele Di Angelantonio Hreinn Stefansson Henrik Ullum Kari Stefansson
ppnlink	101369080X
callnumber-subject	QH - Natural History and Biology
mediatype_str_mv	c
isOA_txt	true
hochschulschrift_bool	false
doi_str	10.1038/s42003-020-01430-1
callnumber-a	QH301-705.5
up_date	2024-07-03T21:27:25.922Z
_version_	1803594808350998528
fullrecord_marcxml	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">DOAJ061566667</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230309012642.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230228s2020 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1038/s42003-020-01430-1</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)DOAJ061566667</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DOAJb804eef352554c768c94ad94c5a8a74a</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">QH301-705.5</subfield></datafield><datafield tag="100" ind1="0" ind2=" "><subfield code="a">Maria Didriksen</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Large genome-wide association study identifies three novel risk variants for restless legs syndrome</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2020</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Didriksen, Nawaz, et al. identify three novel genetic risk variants for restless legs syndrome and confirm 19 out of 20 previously reported variants through a genome-wide association meta-analysis including nearly half a million individuals. Using expression QTL analysis, they also find that a subset of these loci may have a causal effect on nearby gene expression.</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Biology (General)</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Muhammad Sulaman Nawaz</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Joseph Dowsett</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Steven Bell</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Christian Erikstrup</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Ole B. Pedersen</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Erik Sørensen</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Poul J. Jennum</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Kristoffer S. Burgdorf</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Brendan Burchell</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Adam S. Butterworth</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Nicole Soranzo</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">David B. Rye</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Lynn Marie Trotti</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Prabhjyot Saini</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Lilja Stefansdottir</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Sigurdur H. Magnusson</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Gudmar Thorleifsson</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Thordur Sigmundsson</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Albert P. Sigurdsson</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Katja Van Den Hurk</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Franke Quee</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Michael W. T. Tanck</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Willem H. Ouwehand</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">David J. Roberts</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Eric J. Earley</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Michael P. Busch</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Alan E. Mast</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Grier P. Page</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">John Danesh</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Emanuele Di Angelantonio</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Hreinn Stefansson</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Henrik Ullum</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Kari Stefansson</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">In</subfield><subfield code="t">Communications Biology</subfield><subfield code="d">Nature Portfolio, 2018</subfield><subfield code="g">3(2020), 1, Seite 9</subfield><subfield code="w">(DE-627)101369080X</subfield><subfield code="x">23993642</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:3</subfield><subfield code="g">year:2020</subfield><subfield code="g">number:1</subfield><subfield code="g">pages:9</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doi.org/10.1038/s42003-020-01430-1</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doaj.org/article/b804eef352554c768c94ad94c5a8a74a</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doi.org/10.1038/s42003-020-01430-1</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="u">https://doaj.org/toc/2399-3642</subfield><subfield code="y">Journal toc</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_DOAJ</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_20</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_22</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_23</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_24</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_31</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_39</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_40</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_62</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_63</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_65</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_69</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_70</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_73</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_74</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_95</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_105</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_110</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_151</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_161</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_170</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_213</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_230</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_285</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_293</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_602</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2005</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2009</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2014</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2055</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2111</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4012</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4037</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4112</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4125</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4126</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4249</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4305</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4306</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4307</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4313</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4322</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4323</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4324</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4325</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4338</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4367</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4700</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">3</subfield><subfield code="j">2020</subfield><subfield code="e">1</subfield><subfield code="h">9</subfield></datafield></record></collection>
score	7.3995066

Nicht das Richtige dabei?

Schreiben Sie uns!

Large genome-wide association study identifies three novel risk variants for restless legs syndrome

Nicht das Richtige dabei?

Zugang & Verfügbarkeit

Vorhandene Bände

Nicht das Richtige dabei?