Aspergillus nidulans: A rare cause of brain abscess

Fungal infections of the central nervous system (CNS) are rarely encountered, and their development largely depends on the interplay between the virulence factors of various fungi and host's immune system. Recently, there has been an increase in the number of organ transplants, chemotherapies,...
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Autor*in:	Anita Kumari Gupta [verfasserIn] Rajendra Singh Parihar [verfasserIn] Saloni Garg [verfasserIn] Satya Prakash Jindal [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	aspergillus nidulans brain abscess central nervous system fungal infection cerebral abscess fungal brain abscess

Übergeordnetes Werk:	In: Apollo Medicine - Wolters Kluwer Medknow Publications, 2021, 17(2020), 2, Seite 120-123
Übergeordnetes Werk:	volume:17 ; year:2020 ; number:2 ; pages:120-123

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.4103/am.am_34_20

Katalog-ID:	DOAJ061584479

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author	Anita Kumari Gupta
spellingShingle	Anita Kumari Gupta misc aspergillus nidulans misc brain abscess misc central nervous system fungal infection misc cerebral abscess misc fungal brain abscess misc Medicine misc R Aspergillus nidulans: A rare cause of brain abscess
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topic_title	Aspergillus nidulans: A rare cause of brain abscess aspergillus nidulans brain abscess central nervous system fungal infection cerebral abscess fungal brain abscess
topic	misc aspergillus nidulans misc brain abscess misc central nervous system fungal infection misc cerebral abscess misc fungal brain abscess misc Medicine misc R
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title	Aspergillus nidulans: A rare cause of brain abscess
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title_full	Aspergillus nidulans: A rare cause of brain abscess
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title_sort	aspergillus nidulans: a rare cause of brain abscess
title_auth	Aspergillus nidulans: A rare cause of brain abscess
abstract	Fungal infections of the central nervous system (CNS) are rarely encountered, and their development largely depends on the interplay between the virulence factors of various fungi and host's immune system. Recently, there has been an increase in the number of organ transplants, chemotherapies, and human immunodeficiency virus infections due to which the incidence of fungal brain abscess has increased. Aspergillus species is the most common cause of fungal brain abscess and generally occurs in patients with hematological malignancies and cancer chemotherapy. More than 100 Aspergillus species are known, and among these, the most virulent one is Aspergillus fumigatus, but Aspergillus niger, Aspergillus flavus, and Aspergillus terreus (which is relatively amphotericin resistant) can also cause human disease. Aspergillus nidulans is a species of Aspergillus, which is more virulent than other species and has a high mortality rate. Here, we report a case of brain abscess in a 35-year-old young female caused by A. nidulans presenting with symptoms of cerebral mass effect. On potassium hydroxide examination, thin branched septate hyphae were seen, and culture showed the growth of A. nidulans. Given the complexity of the patients at risk and the diverse array of fungal pathogens, CNS fungal infection poses a considerable diagnostic and therapeutic challenge. Although outcome is frequently fatal in patients with fungal brain abscess, early diagnosis, and appropriate antifungal therapy may reduce morbidity and mortality.
abstractGer	Fungal infections of the central nervous system (CNS) are rarely encountered, and their development largely depends on the interplay between the virulence factors of various fungi and host's immune system. Recently, there has been an increase in the number of organ transplants, chemotherapies, and human immunodeficiency virus infections due to which the incidence of fungal brain abscess has increased. Aspergillus species is the most common cause of fungal brain abscess and generally occurs in patients with hematological malignancies and cancer chemotherapy. More than 100 Aspergillus species are known, and among these, the most virulent one is Aspergillus fumigatus, but Aspergillus niger, Aspergillus flavus, and Aspergillus terreus (which is relatively amphotericin resistant) can also cause human disease. Aspergillus nidulans is a species of Aspergillus, which is more virulent than other species and has a high mortality rate. Here, we report a case of brain abscess in a 35-year-old young female caused by A. nidulans presenting with symptoms of cerebral mass effect. On potassium hydroxide examination, thin branched septate hyphae were seen, and culture showed the growth of A. nidulans. Given the complexity of the patients at risk and the diverse array of fungal pathogens, CNS fungal infection poses a considerable diagnostic and therapeutic challenge. Although outcome is frequently fatal in patients with fungal brain abscess, early diagnosis, and appropriate antifungal therapy may reduce morbidity and mortality.
abstract_unstemmed	Fungal infections of the central nervous system (CNS) are rarely encountered, and their development largely depends on the interplay between the virulence factors of various fungi and host's immune system. Recently, there has been an increase in the number of organ transplants, chemotherapies, and human immunodeficiency virus infections due to which the incidence of fungal brain abscess has increased. Aspergillus species is the most common cause of fungal brain abscess and generally occurs in patients with hematological malignancies and cancer chemotherapy. More than 100 Aspergillus species are known, and among these, the most virulent one is Aspergillus fumigatus, but Aspergillus niger, Aspergillus flavus, and Aspergillus terreus (which is relatively amphotericin resistant) can also cause human disease. Aspergillus nidulans is a species of Aspergillus, which is more virulent than other species and has a high mortality rate. Here, we report a case of brain abscess in a 35-year-old young female caused by A. nidulans presenting with symptoms of cerebral mass effect. On potassium hydroxide examination, thin branched septate hyphae were seen, and culture showed the growth of A. nidulans. Given the complexity of the patients at risk and the diverse array of fungal pathogens, CNS fungal infection poses a considerable diagnostic and therapeutic challenge. Although outcome is frequently fatal in patients with fungal brain abscess, early diagnosis, and appropriate antifungal therapy may reduce morbidity and mortality.
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title_short	Aspergillus nidulans: A rare cause of brain abscess
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up_date	2024-07-03T21:33:20.416Z
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Aspergillus nidulans: A rare cause of brain abscess

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