Aspergillus nidulans: A rare cause of brain abscess
Fungal infections of the central nervous system (CNS) are rarely encountered, and their development largely depends on the interplay between the virulence factors of various fungi and host's immune system. Recently, there has been an increase in the number of organ transplants, chemotherapies,...
Ausführliche Beschreibung
Autor*in: |
Anita Kumari Gupta [verfasserIn] Rajendra Singh Parihar [verfasserIn] Saloni Garg [verfasserIn] Satya Prakash Jindal [verfasserIn] |
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E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2020 |
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Übergeordnetes Werk: |
In: Apollo Medicine - Wolters Kluwer Medknow Publications, 2021, 17(2020), 2, Seite 120-123 |
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Übergeordnetes Werk: |
volume:17 ; year:2020 ; number:2 ; pages:120-123 |
Links: |
Link aufrufen |
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DOI / URN: |
10.4103/am.am_34_20 |
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Katalog-ID: |
DOAJ061584479 |
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10.4103/am.am_34_20 doi (DE-627)DOAJ061584479 (DE-599)DOAJ83dc54ab0d6b42c1845c0282aa3eeaaf DE-627 ger DE-627 rakwb eng Anita Kumari Gupta verfasserin aut Aspergillus nidulans: A rare cause of brain abscess 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Fungal infections of the central nervous system (CNS) are rarely encountered, and their development largely depends on the interplay between the virulence factors of various fungi and host's immune system. Recently, there has been an increase in the number of organ transplants, chemotherapies, and human immunodeficiency virus infections due to which the incidence of fungal brain abscess has increased. Aspergillus species is the most common cause of fungal brain abscess and generally occurs in patients with hematological malignancies and cancer chemotherapy. More than 100 Aspergillus species are known, and among these, the most virulent one is Aspergillus fumigatus, but Aspergillus niger, Aspergillus flavus, and Aspergillus terreus (which is relatively amphotericin resistant) can also cause human disease. Aspergillus nidulans is a species of Aspergillus, which is more virulent than other species and has a high mortality rate. Here, we report a case of brain abscess in a 35-year-old young female caused by A. nidulans presenting with symptoms of cerebral mass effect. On potassium hydroxide examination, thin branched septate hyphae were seen, and culture showed the growth of A. nidulans. Given the complexity of the patients at risk and the diverse array of fungal pathogens, CNS fungal infection poses a considerable diagnostic and therapeutic challenge. Although outcome is frequently fatal in patients with fungal brain abscess, early diagnosis, and appropriate antifungal therapy may reduce morbidity and mortality. aspergillus nidulans brain abscess central nervous system fungal infection cerebral abscess fungal brain abscess Medicine R Rajendra Singh Parihar verfasserin aut Saloni Garg verfasserin aut Satya Prakash Jindal verfasserin aut In Apollo Medicine Wolters Kluwer Medknow Publications, 2021 17(2020), 2, Seite 120-123 (DE-627)687719186 (DE-600)2652144-1 22133682 nnns volume:17 year:2020 number:2 pages:120-123 https://doi.org/10.4103/am.am_34_20 kostenfrei https://doaj.org/article/83dc54ab0d6b42c1845c0282aa3eeaaf kostenfrei http://www.apollomedicine.org/article.asp?issn=0976-0016;year=2020;volume=17;issue=2;spage=120;epage=123;aulast=Gupta kostenfrei https://doaj.org/toc/0976-0016 Journal toc kostenfrei https://doaj.org/toc/2213-3682 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2014 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2020 2 120-123 |
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10.4103/am.am_34_20 doi (DE-627)DOAJ061584479 (DE-599)DOAJ83dc54ab0d6b42c1845c0282aa3eeaaf DE-627 ger DE-627 rakwb eng Anita Kumari Gupta verfasserin aut Aspergillus nidulans: A rare cause of brain abscess 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Fungal infections of the central nervous system (CNS) are rarely encountered, and their development largely depends on the interplay between the virulence factors of various fungi and host's immune system. Recently, there has been an increase in the number of organ transplants, chemotherapies, and human immunodeficiency virus infections due to which the incidence of fungal brain abscess has increased. Aspergillus species is the most common cause of fungal brain abscess and generally occurs in patients with hematological malignancies and cancer chemotherapy. More than 100 Aspergillus species are known, and among these, the most virulent one is Aspergillus fumigatus, but Aspergillus niger, Aspergillus flavus, and Aspergillus terreus (which is relatively amphotericin resistant) can also cause human disease. Aspergillus nidulans is a species of Aspergillus, which is more virulent than other species and has a high mortality rate. Here, we report a case of brain abscess in a 35-year-old young female caused by A. nidulans presenting with symptoms of cerebral mass effect. On potassium hydroxide examination, thin branched septate hyphae were seen, and culture showed the growth of A. nidulans. Given the complexity of the patients at risk and the diverse array of fungal pathogens, CNS fungal infection poses a considerable diagnostic and therapeutic challenge. Although outcome is frequently fatal in patients with fungal brain abscess, early diagnosis, and appropriate antifungal therapy may reduce morbidity and mortality. aspergillus nidulans brain abscess central nervous system fungal infection cerebral abscess fungal brain abscess Medicine R Rajendra Singh Parihar verfasserin aut Saloni Garg verfasserin aut Satya Prakash Jindal verfasserin aut In Apollo Medicine Wolters Kluwer Medknow Publications, 2021 17(2020), 2, Seite 120-123 (DE-627)687719186 (DE-600)2652144-1 22133682 nnns volume:17 year:2020 number:2 pages:120-123 https://doi.org/10.4103/am.am_34_20 kostenfrei https://doaj.org/article/83dc54ab0d6b42c1845c0282aa3eeaaf kostenfrei http://www.apollomedicine.org/article.asp?issn=0976-0016;year=2020;volume=17;issue=2;spage=120;epage=123;aulast=Gupta kostenfrei https://doaj.org/toc/0976-0016 Journal toc kostenfrei https://doaj.org/toc/2213-3682 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2014 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2020 2 120-123 |
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10.4103/am.am_34_20 doi (DE-627)DOAJ061584479 (DE-599)DOAJ83dc54ab0d6b42c1845c0282aa3eeaaf DE-627 ger DE-627 rakwb eng Anita Kumari Gupta verfasserin aut Aspergillus nidulans: A rare cause of brain abscess 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Fungal infections of the central nervous system (CNS) are rarely encountered, and their development largely depends on the interplay between the virulence factors of various fungi and host's immune system. Recently, there has been an increase in the number of organ transplants, chemotherapies, and human immunodeficiency virus infections due to which the incidence of fungal brain abscess has increased. Aspergillus species is the most common cause of fungal brain abscess and generally occurs in patients with hematological malignancies and cancer chemotherapy. More than 100 Aspergillus species are known, and among these, the most virulent one is Aspergillus fumigatus, but Aspergillus niger, Aspergillus flavus, and Aspergillus terreus (which is relatively amphotericin resistant) can also cause human disease. Aspergillus nidulans is a species of Aspergillus, which is more virulent than other species and has a high mortality rate. Here, we report a case of brain abscess in a 35-year-old young female caused by A. nidulans presenting with symptoms of cerebral mass effect. On potassium hydroxide examination, thin branched septate hyphae were seen, and culture showed the growth of A. nidulans. Given the complexity of the patients at risk and the diverse array of fungal pathogens, CNS fungal infection poses a considerable diagnostic and therapeutic challenge. Although outcome is frequently fatal in patients with fungal brain abscess, early diagnosis, and appropriate antifungal therapy may reduce morbidity and mortality. aspergillus nidulans brain abscess central nervous system fungal infection cerebral abscess fungal brain abscess Medicine R Rajendra Singh Parihar verfasserin aut Saloni Garg verfasserin aut Satya Prakash Jindal verfasserin aut In Apollo Medicine Wolters Kluwer Medknow Publications, 2021 17(2020), 2, Seite 120-123 (DE-627)687719186 (DE-600)2652144-1 22133682 nnns volume:17 year:2020 number:2 pages:120-123 https://doi.org/10.4103/am.am_34_20 kostenfrei https://doaj.org/article/83dc54ab0d6b42c1845c0282aa3eeaaf kostenfrei http://www.apollomedicine.org/article.asp?issn=0976-0016;year=2020;volume=17;issue=2;spage=120;epage=123;aulast=Gupta kostenfrei https://doaj.org/toc/0976-0016 Journal toc kostenfrei https://doaj.org/toc/2213-3682 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2014 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2020 2 120-123 |
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10.4103/am.am_34_20 doi (DE-627)DOAJ061584479 (DE-599)DOAJ83dc54ab0d6b42c1845c0282aa3eeaaf DE-627 ger DE-627 rakwb eng Anita Kumari Gupta verfasserin aut Aspergillus nidulans: A rare cause of brain abscess 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Fungal infections of the central nervous system (CNS) are rarely encountered, and their development largely depends on the interplay between the virulence factors of various fungi and host's immune system. Recently, there has been an increase in the number of organ transplants, chemotherapies, and human immunodeficiency virus infections due to which the incidence of fungal brain abscess has increased. Aspergillus species is the most common cause of fungal brain abscess and generally occurs in patients with hematological malignancies and cancer chemotherapy. More than 100 Aspergillus species are known, and among these, the most virulent one is Aspergillus fumigatus, but Aspergillus niger, Aspergillus flavus, and Aspergillus terreus (which is relatively amphotericin resistant) can also cause human disease. Aspergillus nidulans is a species of Aspergillus, which is more virulent than other species and has a high mortality rate. Here, we report a case of brain abscess in a 35-year-old young female caused by A. nidulans presenting with symptoms of cerebral mass effect. On potassium hydroxide examination, thin branched septate hyphae were seen, and culture showed the growth of A. nidulans. Given the complexity of the patients at risk and the diverse array of fungal pathogens, CNS fungal infection poses a considerable diagnostic and therapeutic challenge. Although outcome is frequently fatal in patients with fungal brain abscess, early diagnosis, and appropriate antifungal therapy may reduce morbidity and mortality. aspergillus nidulans brain abscess central nervous system fungal infection cerebral abscess fungal brain abscess Medicine R Rajendra Singh Parihar verfasserin aut Saloni Garg verfasserin aut Satya Prakash Jindal verfasserin aut In Apollo Medicine Wolters Kluwer Medknow Publications, 2021 17(2020), 2, Seite 120-123 (DE-627)687719186 (DE-600)2652144-1 22133682 nnns volume:17 year:2020 number:2 pages:120-123 https://doi.org/10.4103/am.am_34_20 kostenfrei https://doaj.org/article/83dc54ab0d6b42c1845c0282aa3eeaaf kostenfrei http://www.apollomedicine.org/article.asp?issn=0976-0016;year=2020;volume=17;issue=2;spage=120;epage=123;aulast=Gupta kostenfrei https://doaj.org/toc/0976-0016 Journal toc kostenfrei https://doaj.org/toc/2213-3682 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2014 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2020 2 120-123 |
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10.4103/am.am_34_20 doi (DE-627)DOAJ061584479 (DE-599)DOAJ83dc54ab0d6b42c1845c0282aa3eeaaf DE-627 ger DE-627 rakwb eng Anita Kumari Gupta verfasserin aut Aspergillus nidulans: A rare cause of brain abscess 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Fungal infections of the central nervous system (CNS) are rarely encountered, and their development largely depends on the interplay between the virulence factors of various fungi and host's immune system. Recently, there has been an increase in the number of organ transplants, chemotherapies, and human immunodeficiency virus infections due to which the incidence of fungal brain abscess has increased. Aspergillus species is the most common cause of fungal brain abscess and generally occurs in patients with hematological malignancies and cancer chemotherapy. More than 100 Aspergillus species are known, and among these, the most virulent one is Aspergillus fumigatus, but Aspergillus niger, Aspergillus flavus, and Aspergillus terreus (which is relatively amphotericin resistant) can also cause human disease. Aspergillus nidulans is a species of Aspergillus, which is more virulent than other species and has a high mortality rate. Here, we report a case of brain abscess in a 35-year-old young female caused by A. nidulans presenting with symptoms of cerebral mass effect. On potassium hydroxide examination, thin branched septate hyphae were seen, and culture showed the growth of A. nidulans. Given the complexity of the patients at risk and the diverse array of fungal pathogens, CNS fungal infection poses a considerable diagnostic and therapeutic challenge. Although outcome is frequently fatal in patients with fungal brain abscess, early diagnosis, and appropriate antifungal therapy may reduce morbidity and mortality. aspergillus nidulans brain abscess central nervous system fungal infection cerebral abscess fungal brain abscess Medicine R Rajendra Singh Parihar verfasserin aut Saloni Garg verfasserin aut Satya Prakash Jindal verfasserin aut In Apollo Medicine Wolters Kluwer Medknow Publications, 2021 17(2020), 2, Seite 120-123 (DE-627)687719186 (DE-600)2652144-1 22133682 nnns volume:17 year:2020 number:2 pages:120-123 https://doi.org/10.4103/am.am_34_20 kostenfrei https://doaj.org/article/83dc54ab0d6b42c1845c0282aa3eeaaf kostenfrei http://www.apollomedicine.org/article.asp?issn=0976-0016;year=2020;volume=17;issue=2;spage=120;epage=123;aulast=Gupta kostenfrei https://doaj.org/toc/0976-0016 Journal toc kostenfrei https://doaj.org/toc/2213-3682 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2014 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2020 2 120-123 |
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Fungal infections of the central nervous system (CNS) are rarely encountered, and their development largely depends on the interplay between the virulence factors of various fungi and host's immune system. Recently, there has been an increase in the number of organ transplants, chemotherapies, and human immunodeficiency virus infections due to which the incidence of fungal brain abscess has increased. Aspergillus species is the most common cause of fungal brain abscess and generally occurs in patients with hematological malignancies and cancer chemotherapy. More than 100 Aspergillus species are known, and among these, the most virulent one is Aspergillus fumigatus, but Aspergillus niger, Aspergillus flavus, and Aspergillus terreus (which is relatively amphotericin resistant) can also cause human disease. Aspergillus nidulans is a species of Aspergillus, which is more virulent than other species and has a high mortality rate. Here, we report a case of brain abscess in a 35-year-old young female caused by A. nidulans presenting with symptoms of cerebral mass effect. On potassium hydroxide examination, thin branched septate hyphae were seen, and culture showed the growth of A. nidulans. Given the complexity of the patients at risk and the diverse array of fungal pathogens, CNS fungal infection poses a considerable diagnostic and therapeutic challenge. Although outcome is frequently fatal in patients with fungal brain abscess, early diagnosis, and appropriate antifungal therapy may reduce morbidity and mortality. |
abstractGer |
Fungal infections of the central nervous system (CNS) are rarely encountered, and their development largely depends on the interplay between the virulence factors of various fungi and host's immune system. Recently, there has been an increase in the number of organ transplants, chemotherapies, and human immunodeficiency virus infections due to which the incidence of fungal brain abscess has increased. Aspergillus species is the most common cause of fungal brain abscess and generally occurs in patients with hematological malignancies and cancer chemotherapy. More than 100 Aspergillus species are known, and among these, the most virulent one is Aspergillus fumigatus, but Aspergillus niger, Aspergillus flavus, and Aspergillus terreus (which is relatively amphotericin resistant) can also cause human disease. Aspergillus nidulans is a species of Aspergillus, which is more virulent than other species and has a high mortality rate. Here, we report a case of brain abscess in a 35-year-old young female caused by A. nidulans presenting with symptoms of cerebral mass effect. On potassium hydroxide examination, thin branched septate hyphae were seen, and culture showed the growth of A. nidulans. Given the complexity of the patients at risk and the diverse array of fungal pathogens, CNS fungal infection poses a considerable diagnostic and therapeutic challenge. Although outcome is frequently fatal in patients with fungal brain abscess, early diagnosis, and appropriate antifungal therapy may reduce morbidity and mortality. |
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Fungal infections of the central nervous system (CNS) are rarely encountered, and their development largely depends on the interplay between the virulence factors of various fungi and host's immune system. Recently, there has been an increase in the number of organ transplants, chemotherapies, and human immunodeficiency virus infections due to which the incidence of fungal brain abscess has increased. Aspergillus species is the most common cause of fungal brain abscess and generally occurs in patients with hematological malignancies and cancer chemotherapy. More than 100 Aspergillus species are known, and among these, the most virulent one is Aspergillus fumigatus, but Aspergillus niger, Aspergillus flavus, and Aspergillus terreus (which is relatively amphotericin resistant) can also cause human disease. Aspergillus nidulans is a species of Aspergillus, which is more virulent than other species and has a high mortality rate. Here, we report a case of brain abscess in a 35-year-old young female caused by A. nidulans presenting with symptoms of cerebral mass effect. On potassium hydroxide examination, thin branched septate hyphae were seen, and culture showed the growth of A. nidulans. Given the complexity of the patients at risk and the diverse array of fungal pathogens, CNS fungal infection poses a considerable diagnostic and therapeutic challenge. Although outcome is frequently fatal in patients with fungal brain abscess, early diagnosis, and appropriate antifungal therapy may reduce morbidity and mortality. |
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