Efficacy of a Therapeutic Lifestyle Change/Step 2 diet in moderately hypercholesterolemic middle-aged and elderly female and male subjects

Lifestyle modification to decrease cardiovascular disease (CVD) risk has recently been reaffirmed by both the National Cholesterol Education Program and American Heart Association (AHA). Using a randomized crossover design, the Therapeutic Lifestyle Change (TLC)/Step 2 diet relative to a typical Wes...
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Autor*in:	Alice H. Lichtenstein [verfasserIn] Lynne M. Ausman [verfasserIn] Susan M. Jalbert [verfasserIn] Montserrat Vilella-Bach [verfasserIn] Matti Jauhiainen [verfasserIn] Sandra McGladdery [verfasserIn] Arja T. Erkkilä [verfasserIn] Christian Ehnholm [verfasserIn] Jiri Frohlich [verfasserIn] Ernst J. Schaefer [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2002

Schlagwörter:	therapeutic lifestyle change diet Step 2 diet saturated fat cholesterol low-density lipoprotein cholesterol high-density lipoprotein cholesterol

Übergeordnetes Werk:	In: Journal of Lipid Research - Elsevier, 2021, 43(2002), 2, Seite 264-273
Übergeordnetes Werk:	volume:43 ; year:2002 ; number:2 ; pages:264-273

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1016/S0022-2275(20)30168-1

Katalog-ID:	DOAJ061595543

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allfieldsGer	10.1016/S0022-2275(20)30168-1 doi (DE-627)DOAJ061595543 (DE-599)DOAJa2ce85fc7ddf43faa21eca29255884de DE-627 ger DE-627 rakwb eng QD415-436 Alice H. Lichtenstein verfasserin aut Efficacy of a Therapeutic Lifestyle Change/Step 2 diet in moderately hypercholesterolemic middle-aged and elderly female and male subjects 2002 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Lifestyle modification to decrease cardiovascular disease (CVD) risk has recently been reaffirmed by both the National Cholesterol Education Program and American Heart Association (AHA). Using a randomized crossover design, the Therapeutic Lifestyle Change (TLC)/Step 2 diet relative to a typical Western diet was assessed in 36 moderately hypercholesterolemic subjects in a clinical setting under iso-weight conditions. Mean lipoprotein and apolipoprotein levels (fasting and non-fasting), fatty acid profiles, parameters of HDL metabolism, and glucose homeostasis were determined. Relative to the Western diet, the TLC/Step 2 diet resulted in 11% and 7% lower LDL cholesterol (LDL-C) and HDL cholesterol (HDL-C), respectively, with no significant change in TG levels or total cholesterol-HDL-C ratio. Similar responses were observed in the non-fasting state. Linoleic (18:2n-6c) and α-linolenic (18:3n-3) acids increased at the expense of oleic acid (18:1n-9c) in the cholesteryl ester, TG, and phospholipid subfractions. The dietary changes had no significant effect on fractional esterification rate of HDL, phospholipid transfer protein (PLTP), or cholesterol ester transfer protein activities, or glucose and insulin levels. Female and male subjects responded similarly. The TLC/Step 2 diet resulted in a decrease in some CVD risk factors and no apparent adverse effects in others.—Lichtenstein, A. H., L. M. Ausman, S. M. Jalbert, M. Vilella-Bach, M. Jauhiainen, S. McGladdery, A. T. Erkkilä, C. Ehnholm, J. Frohlich, and E. J. Schaefer. Efficacy of a Therapeutic Lifestyle Change/Step 2 diet in moderately hypercholesterolemic middle-aged and elderly female and male subjects. therapeutic lifestyle change diet Step 2 diet saturated fat cholesterol low-density lipoprotein cholesterol high-density lipoprotein cholesterol Biochemistry Lynne M. Ausman verfasserin aut Susan M. Jalbert verfasserin aut Montserrat Vilella-Bach verfasserin aut Matti Jauhiainen verfasserin aut Sandra McGladdery verfasserin aut Arja T. Erkkilä verfasserin aut Christian Ehnholm verfasserin aut Jiri Frohlich verfasserin aut Ernst J. Schaefer verfasserin aut In Journal of Lipid Research Elsevier, 2021 43(2002), 2, Seite 264-273 (DE-627)26601593X (DE-600)1466675-3 15397262 nnns volume:43 year:2002 number:2 pages:264-273 https://doi.org/10.1016/S0022-2275(20)30168-1 kostenfrei https://doaj.org/article/a2ce85fc7ddf43faa21eca29255884de kostenfrei http://www.sciencedirect.com/science/article/pii/S0022227520301681 kostenfrei https://doaj.org/toc/0022-2275 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_252 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2006 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 43 2002 2 264-273
allfieldsSound	10.1016/S0022-2275(20)30168-1 doi (DE-627)DOAJ061595543 (DE-599)DOAJa2ce85fc7ddf43faa21eca29255884de DE-627 ger DE-627 rakwb eng QD415-436 Alice H. Lichtenstein verfasserin aut Efficacy of a Therapeutic Lifestyle Change/Step 2 diet in moderately hypercholesterolemic middle-aged and elderly female and male subjects 2002 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Lifestyle modification to decrease cardiovascular disease (CVD) risk has recently been reaffirmed by both the National Cholesterol Education Program and American Heart Association (AHA). Using a randomized crossover design, the Therapeutic Lifestyle Change (TLC)/Step 2 diet relative to a typical Western diet was assessed in 36 moderately hypercholesterolemic subjects in a clinical setting under iso-weight conditions. Mean lipoprotein and apolipoprotein levels (fasting and non-fasting), fatty acid profiles, parameters of HDL metabolism, and glucose homeostasis were determined. Relative to the Western diet, the TLC/Step 2 diet resulted in 11% and 7% lower LDL cholesterol (LDL-C) and HDL cholesterol (HDL-C), respectively, with no significant change in TG levels or total cholesterol-HDL-C ratio. Similar responses were observed in the non-fasting state. Linoleic (18:2n-6c) and α-linolenic (18:3n-3) acids increased at the expense of oleic acid (18:1n-9c) in the cholesteryl ester, TG, and phospholipid subfractions. The dietary changes had no significant effect on fractional esterification rate of HDL, phospholipid transfer protein (PLTP), or cholesterol ester transfer protein activities, or glucose and insulin levels. Female and male subjects responded similarly. The TLC/Step 2 diet resulted in a decrease in some CVD risk factors and no apparent adverse effects in others.—Lichtenstein, A. H., L. M. Ausman, S. M. Jalbert, M. Vilella-Bach, M. Jauhiainen, S. McGladdery, A. T. Erkkilä, C. Ehnholm, J. Frohlich, and E. J. Schaefer. Efficacy of a Therapeutic Lifestyle Change/Step 2 diet in moderately hypercholesterolemic middle-aged and elderly female and male subjects. therapeutic lifestyle change diet Step 2 diet saturated fat cholesterol low-density lipoprotein cholesterol high-density lipoprotein cholesterol Biochemistry Lynne M. Ausman verfasserin aut Susan M. Jalbert verfasserin aut Montserrat Vilella-Bach verfasserin aut Matti Jauhiainen verfasserin aut Sandra McGladdery verfasserin aut Arja T. Erkkilä verfasserin aut Christian Ehnholm verfasserin aut Jiri Frohlich verfasserin aut Ernst J. Schaefer verfasserin aut In Journal of Lipid Research Elsevier, 2021 43(2002), 2, Seite 264-273 (DE-627)26601593X (DE-600)1466675-3 15397262 nnns volume:43 year:2002 number:2 pages:264-273 https://doi.org/10.1016/S0022-2275(20)30168-1 kostenfrei https://doaj.org/article/a2ce85fc7ddf43faa21eca29255884de kostenfrei http://www.sciencedirect.com/science/article/pii/S0022227520301681 kostenfrei https://doaj.org/toc/0022-2275 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_252 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2006 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 43 2002 2 264-273
language	English
source	In Journal of Lipid Research 43(2002), 2, Seite 264-273 volume:43 year:2002 number:2 pages:264-273
sourceStr	In Journal of Lipid Research 43(2002), 2, Seite 264-273 volume:43 year:2002 number:2 pages:264-273
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	therapeutic lifestyle change diet Step 2 diet saturated fat cholesterol low-density lipoprotein cholesterol high-density lipoprotein cholesterol Biochemistry
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container_title	Journal of Lipid Research
authorswithroles_txt_mv	Alice H. Lichtenstein @@aut@@ Lynne M. Ausman @@aut@@ Susan M. Jalbert @@aut@@ Montserrat Vilella-Bach @@aut@@ Matti Jauhiainen @@aut@@ Sandra McGladdery @@aut@@ Arja T. Erkkilä @@aut@@ Christian Ehnholm @@aut@@ Jiri Frohlich @@aut@@ Ernst J. Schaefer @@aut@@
publishDateDaySort_date	2002-01-01T00:00:00Z
hierarchy_top_id	26601593X
id	DOAJ061595543
language_de	englisch
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callnumber-first	Q - Science
author	Alice H. Lichtenstein
spellingShingle	Alice H. Lichtenstein misc QD415-436 misc therapeutic lifestyle change diet misc Step 2 diet misc saturated fat misc cholesterol misc low-density lipoprotein cholesterol misc high-density lipoprotein cholesterol misc Biochemistry Efficacy of a Therapeutic Lifestyle Change/Step 2 diet in moderately hypercholesterolemic middle-aged and elderly female and male subjects
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topic_title	QD415-436 Efficacy of a Therapeutic Lifestyle Change/Step 2 diet in moderately hypercholesterolemic middle-aged and elderly female and male subjects therapeutic lifestyle change diet Step 2 diet saturated fat cholesterol low-density lipoprotein cholesterol high-density lipoprotein cholesterol
topic	misc QD415-436 misc therapeutic lifestyle change diet misc Step 2 diet misc saturated fat misc cholesterol misc low-density lipoprotein cholesterol misc high-density lipoprotein cholesterol misc Biochemistry
topic_unstemmed	misc QD415-436 misc therapeutic lifestyle change diet misc Step 2 diet misc saturated fat misc cholesterol misc low-density lipoprotein cholesterol misc high-density lipoprotein cholesterol misc Biochemistry
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title	Efficacy of a Therapeutic Lifestyle Change/Step 2 diet in moderately hypercholesterolemic middle-aged and elderly female and male subjects
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title_full	Efficacy of a Therapeutic Lifestyle Change/Step 2 diet in moderately hypercholesterolemic middle-aged and elderly female and male subjects
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author_browse	Alice H. Lichtenstein Lynne M. Ausman Susan M. Jalbert Montserrat Vilella-Bach Matti Jauhiainen Sandra McGladdery Arja T. Erkkilä Christian Ehnholm Jiri Frohlich Ernst J. Schaefer
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title_sort	efficacy of a therapeutic lifestyle change/step 2 diet in moderately hypercholesterolemic middle-aged and elderly female and male subjects
callnumber	QD415-436
title_auth	Efficacy of a Therapeutic Lifestyle Change/Step 2 diet in moderately hypercholesterolemic middle-aged and elderly female and male subjects
abstract	Lifestyle modification to decrease cardiovascular disease (CVD) risk has recently been reaffirmed by both the National Cholesterol Education Program and American Heart Association (AHA). Using a randomized crossover design, the Therapeutic Lifestyle Change (TLC)/Step 2 diet relative to a typical Western diet was assessed in 36 moderately hypercholesterolemic subjects in a clinical setting under iso-weight conditions. Mean lipoprotein and apolipoprotein levels (fasting and non-fasting), fatty acid profiles, parameters of HDL metabolism, and glucose homeostasis were determined. Relative to the Western diet, the TLC/Step 2 diet resulted in 11% and 7% lower LDL cholesterol (LDL-C) and HDL cholesterol (HDL-C), respectively, with no significant change in TG levels or total cholesterol-HDL-C ratio. Similar responses were observed in the non-fasting state. Linoleic (18:2n-6c) and α-linolenic (18:3n-3) acids increased at the expense of oleic acid (18:1n-9c) in the cholesteryl ester, TG, and phospholipid subfractions. The dietary changes had no significant effect on fractional esterification rate of HDL, phospholipid transfer protein (PLTP), or cholesterol ester transfer protein activities, or glucose and insulin levels. Female and male subjects responded similarly. The TLC/Step 2 diet resulted in a decrease in some CVD risk factors and no apparent adverse effects in others.—Lichtenstein, A. H., L. M. Ausman, S. M. Jalbert, M. Vilella-Bach, M. Jauhiainen, S. McGladdery, A. T. Erkkilä, C. Ehnholm, J. Frohlich, and E. J. Schaefer. Efficacy of a Therapeutic Lifestyle Change/Step 2 diet in moderately hypercholesterolemic middle-aged and elderly female and male subjects.
abstractGer	Lifestyle modification to decrease cardiovascular disease (CVD) risk has recently been reaffirmed by both the National Cholesterol Education Program and American Heart Association (AHA). Using a randomized crossover design, the Therapeutic Lifestyle Change (TLC)/Step 2 diet relative to a typical Western diet was assessed in 36 moderately hypercholesterolemic subjects in a clinical setting under iso-weight conditions. Mean lipoprotein and apolipoprotein levels (fasting and non-fasting), fatty acid profiles, parameters of HDL metabolism, and glucose homeostasis were determined. Relative to the Western diet, the TLC/Step 2 diet resulted in 11% and 7% lower LDL cholesterol (LDL-C) and HDL cholesterol (HDL-C), respectively, with no significant change in TG levels or total cholesterol-HDL-C ratio. Similar responses were observed in the non-fasting state. Linoleic (18:2n-6c) and α-linolenic (18:3n-3) acids increased at the expense of oleic acid (18:1n-9c) in the cholesteryl ester, TG, and phospholipid subfractions. The dietary changes had no significant effect on fractional esterification rate of HDL, phospholipid transfer protein (PLTP), or cholesterol ester transfer protein activities, or glucose and insulin levels. Female and male subjects responded similarly. The TLC/Step 2 diet resulted in a decrease in some CVD risk factors and no apparent adverse effects in others.—Lichtenstein, A. H., L. M. Ausman, S. M. Jalbert, M. Vilella-Bach, M. Jauhiainen, S. McGladdery, A. T. Erkkilä, C. Ehnholm, J. Frohlich, and E. J. Schaefer. Efficacy of a Therapeutic Lifestyle Change/Step 2 diet in moderately hypercholesterolemic middle-aged and elderly female and male subjects.
abstract_unstemmed	Lifestyle modification to decrease cardiovascular disease (CVD) risk has recently been reaffirmed by both the National Cholesterol Education Program and American Heart Association (AHA). Using a randomized crossover design, the Therapeutic Lifestyle Change (TLC)/Step 2 diet relative to a typical Western diet was assessed in 36 moderately hypercholesterolemic subjects in a clinical setting under iso-weight conditions. Mean lipoprotein and apolipoprotein levels (fasting and non-fasting), fatty acid profiles, parameters of HDL metabolism, and glucose homeostasis were determined. Relative to the Western diet, the TLC/Step 2 diet resulted in 11% and 7% lower LDL cholesterol (LDL-C) and HDL cholesterol (HDL-C), respectively, with no significant change in TG levels or total cholesterol-HDL-C ratio. Similar responses were observed in the non-fasting state. Linoleic (18:2n-6c) and α-linolenic (18:3n-3) acids increased at the expense of oleic acid (18:1n-9c) in the cholesteryl ester, TG, and phospholipid subfractions. The dietary changes had no significant effect on fractional esterification rate of HDL, phospholipid transfer protein (PLTP), or cholesterol ester transfer protein activities, or glucose and insulin levels. Female and male subjects responded similarly. The TLC/Step 2 diet resulted in a decrease in some CVD risk factors and no apparent adverse effects in others.—Lichtenstein, A. H., L. M. Ausman, S. M. Jalbert, M. Vilella-Bach, M. Jauhiainen, S. McGladdery, A. T. Erkkilä, C. Ehnholm, J. Frohlich, and E. J. Schaefer. Efficacy of a Therapeutic Lifestyle Change/Step 2 diet in moderately hypercholesterolemic middle-aged and elderly female and male subjects.
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title_short	Efficacy of a Therapeutic Lifestyle Change/Step 2 diet in moderately hypercholesterolemic middle-aged and elderly female and male subjects
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