Herpes Simplex Virus Cell Entry Mechanisms: An Update

Herpes simplex virus (HSV) can infect a broad host range and cause mild to life threating infections in humans. The surface glycoproteins of HSV are evolutionarily conserved and show an extraordinary ability to bind more than one receptor on the host cell surface. Following attachment, the virus fus...
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Autor*in:	Krishnaraju Madavaraju [verfasserIn] Raghuram Koganti [verfasserIn] Ipsita Volety [verfasserIn] Tejabhiram Yadavalli [verfasserIn] Deepak Shukla [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	herpesvirus HSV entry mechanism endocytosis

Übergeordnetes Werk:	In: Frontiers in Cellular and Infection Microbiology - Frontiers Media S.A., 2016, 10(2021)
Übergeordnetes Werk:	volume:10 ; year:2021

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fcimb.2020.617578

Katalog-ID:	DOAJ061711136

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520			\|a Herpes simplex virus (HSV) can infect a broad host range and cause mild to life threating infections in humans. The surface glycoproteins of HSV are evolutionarily conserved and show an extraordinary ability to bind more than one receptor on the host cell surface. Following attachment, the virus fuses its lipid envelope with the host cell membrane and releases its nucleocapsid along with tegument proteins into the cytosol. With the help of tegument proteins and host cell factors, the nucleocapsid is then docked into the nuclear pore. The viral double stranded DNA is then released into the host cell’s nucleus. Released viral DNA either replicates rapidly (more commonly in non-neuronal cells) or stays latent inside the nucleus (in sensory neurons). The fusion of the viral envelope with host cell membrane is a key step. Blocking this step can prevent entry of HSV into the host cell and the subsequent interactions that ultimately lead to production of viral progeny and cell death or latency. In this review, we have discussed viral entry mechanisms including the pH-independent as well as pH-dependent endocytic entry, cell to cell spread of HSV and use of viral glycoproteins as an antiviral target.
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spelling	10.3389/fcimb.2020.617578 doi (DE-627)DOAJ061711136 (DE-599)DOAJdcf8697019ce484c98fd9aeccf1e73ea DE-627 ger DE-627 rakwb eng QR1-502 Krishnaraju Madavaraju verfasserin aut Herpes Simplex Virus Cell Entry Mechanisms: An Update 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Herpes simplex virus (HSV) can infect a broad host range and cause mild to life threating infections in humans. The surface glycoproteins of HSV are evolutionarily conserved and show an extraordinary ability to bind more than one receptor on the host cell surface. Following attachment, the virus fuses its lipid envelope with the host cell membrane and releases its nucleocapsid along with tegument proteins into the cytosol. With the help of tegument proteins and host cell factors, the nucleocapsid is then docked into the nuclear pore. The viral double stranded DNA is then released into the host cell’s nucleus. Released viral DNA either replicates rapidly (more commonly in non-neuronal cells) or stays latent inside the nucleus (in sensory neurons). The fusion of the viral envelope with host cell membrane is a key step. Blocking this step can prevent entry of HSV into the host cell and the subsequent interactions that ultimately lead to production of viral progeny and cell death or latency. In this review, we have discussed viral entry mechanisms including the pH-independent as well as pH-dependent endocytic entry, cell to cell spread of HSV and use of viral glycoproteins as an antiviral target. herpesvirus HSV entry mechanism endocytosis Microbiology Raghuram Koganti verfasserin aut Ipsita Volety verfasserin aut Tejabhiram Yadavalli verfasserin aut Deepak Shukla verfasserin aut Deepak Shukla verfasserin aut In Frontiers in Cellular and Infection Microbiology Frontiers Media S.A., 2016 10(2021) (DE-627)664968554 (DE-600)2619676-1 22352988 nnns volume:10 year:2021 https://doi.org/10.3389/fcimb.2020.617578 kostenfrei https://doaj.org/article/dcf8697019ce484c98fd9aeccf1e73ea kostenfrei https://www.frontiersin.org/articles/10.3389/fcimb.2020.617578/full kostenfrei https://doaj.org/toc/2235-2988 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2021
allfields_unstemmed	10.3389/fcimb.2020.617578 doi (DE-627)DOAJ061711136 (DE-599)DOAJdcf8697019ce484c98fd9aeccf1e73ea DE-627 ger DE-627 rakwb eng QR1-502 Krishnaraju Madavaraju verfasserin aut Herpes Simplex Virus Cell Entry Mechanisms: An Update 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Herpes simplex virus (HSV) can infect a broad host range and cause mild to life threating infections in humans. The surface glycoproteins of HSV are evolutionarily conserved and show an extraordinary ability to bind more than one receptor on the host cell surface. Following attachment, the virus fuses its lipid envelope with the host cell membrane and releases its nucleocapsid along with tegument proteins into the cytosol. With the help of tegument proteins and host cell factors, the nucleocapsid is then docked into the nuclear pore. The viral double stranded DNA is then released into the host cell’s nucleus. Released viral DNA either replicates rapidly (more commonly in non-neuronal cells) or stays latent inside the nucleus (in sensory neurons). The fusion of the viral envelope with host cell membrane is a key step. Blocking this step can prevent entry of HSV into the host cell and the subsequent interactions that ultimately lead to production of viral progeny and cell death or latency. In this review, we have discussed viral entry mechanisms including the pH-independent as well as pH-dependent endocytic entry, cell to cell spread of HSV and use of viral glycoproteins as an antiviral target. herpesvirus HSV entry mechanism endocytosis Microbiology Raghuram Koganti verfasserin aut Ipsita Volety verfasserin aut Tejabhiram Yadavalli verfasserin aut Deepak Shukla verfasserin aut Deepak Shukla verfasserin aut In Frontiers in Cellular and Infection Microbiology Frontiers Media S.A., 2016 10(2021) (DE-627)664968554 (DE-600)2619676-1 22352988 nnns volume:10 year:2021 https://doi.org/10.3389/fcimb.2020.617578 kostenfrei https://doaj.org/article/dcf8697019ce484c98fd9aeccf1e73ea kostenfrei https://www.frontiersin.org/articles/10.3389/fcimb.2020.617578/full kostenfrei https://doaj.org/toc/2235-2988 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2021
allfieldsGer	10.3389/fcimb.2020.617578 doi (DE-627)DOAJ061711136 (DE-599)DOAJdcf8697019ce484c98fd9aeccf1e73ea DE-627 ger DE-627 rakwb eng QR1-502 Krishnaraju Madavaraju verfasserin aut Herpes Simplex Virus Cell Entry Mechanisms: An Update 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Herpes simplex virus (HSV) can infect a broad host range and cause mild to life threating infections in humans. The surface glycoproteins of HSV are evolutionarily conserved and show an extraordinary ability to bind more than one receptor on the host cell surface. Following attachment, the virus fuses its lipid envelope with the host cell membrane and releases its nucleocapsid along with tegument proteins into the cytosol. With the help of tegument proteins and host cell factors, the nucleocapsid is then docked into the nuclear pore. The viral double stranded DNA is then released into the host cell’s nucleus. Released viral DNA either replicates rapidly (more commonly in non-neuronal cells) or stays latent inside the nucleus (in sensory neurons). The fusion of the viral envelope with host cell membrane is a key step. Blocking this step can prevent entry of HSV into the host cell and the subsequent interactions that ultimately lead to production of viral progeny and cell death or latency. In this review, we have discussed viral entry mechanisms including the pH-independent as well as pH-dependent endocytic entry, cell to cell spread of HSV and use of viral glycoproteins as an antiviral target. herpesvirus HSV entry mechanism endocytosis Microbiology Raghuram Koganti verfasserin aut Ipsita Volety verfasserin aut Tejabhiram Yadavalli verfasserin aut Deepak Shukla verfasserin aut Deepak Shukla verfasserin aut In Frontiers in Cellular and Infection Microbiology Frontiers Media S.A., 2016 10(2021) (DE-627)664968554 (DE-600)2619676-1 22352988 nnns volume:10 year:2021 https://doi.org/10.3389/fcimb.2020.617578 kostenfrei https://doaj.org/article/dcf8697019ce484c98fd9aeccf1e73ea kostenfrei https://www.frontiersin.org/articles/10.3389/fcimb.2020.617578/full kostenfrei https://doaj.org/toc/2235-2988 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2021
allfieldsSound	10.3389/fcimb.2020.617578 doi (DE-627)DOAJ061711136 (DE-599)DOAJdcf8697019ce484c98fd9aeccf1e73ea DE-627 ger DE-627 rakwb eng QR1-502 Krishnaraju Madavaraju verfasserin aut Herpes Simplex Virus Cell Entry Mechanisms: An Update 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Herpes simplex virus (HSV) can infect a broad host range and cause mild to life threating infections in humans. The surface glycoproteins of HSV are evolutionarily conserved and show an extraordinary ability to bind more than one receptor on the host cell surface. Following attachment, the virus fuses its lipid envelope with the host cell membrane and releases its nucleocapsid along with tegument proteins into the cytosol. With the help of tegument proteins and host cell factors, the nucleocapsid is then docked into the nuclear pore. The viral double stranded DNA is then released into the host cell’s nucleus. Released viral DNA either replicates rapidly (more commonly in non-neuronal cells) or stays latent inside the nucleus (in sensory neurons). The fusion of the viral envelope with host cell membrane is a key step. Blocking this step can prevent entry of HSV into the host cell and the subsequent interactions that ultimately lead to production of viral progeny and cell death or latency. In this review, we have discussed viral entry mechanisms including the pH-independent as well as pH-dependent endocytic entry, cell to cell spread of HSV and use of viral glycoproteins as an antiviral target. herpesvirus HSV entry mechanism endocytosis Microbiology Raghuram Koganti verfasserin aut Ipsita Volety verfasserin aut Tejabhiram Yadavalli verfasserin aut Deepak Shukla verfasserin aut Deepak Shukla verfasserin aut In Frontiers in Cellular and Infection Microbiology Frontiers Media S.A., 2016 10(2021) (DE-627)664968554 (DE-600)2619676-1 22352988 nnns volume:10 year:2021 https://doi.org/10.3389/fcimb.2020.617578 kostenfrei https://doaj.org/article/dcf8697019ce484c98fd9aeccf1e73ea kostenfrei https://www.frontiersin.org/articles/10.3389/fcimb.2020.617578/full kostenfrei https://doaj.org/toc/2235-2988 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2021
language	English
source	In Frontiers in Cellular and Infection Microbiology 10(2021) volume:10 year:2021
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institution	findex.gbv.de
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container_title	Frontiers in Cellular and Infection Microbiology
authorswithroles_txt_mv	Krishnaraju Madavaraju @@aut@@ Raghuram Koganti @@aut@@ Ipsita Volety @@aut@@ Tejabhiram Yadavalli @@aut@@ Deepak Shukla @@aut@@
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callnumber-first	Q - Science
author	Krishnaraju Madavaraju
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title	Herpes Simplex Virus Cell Entry Mechanisms: An Update
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title_full	Herpes Simplex Virus Cell Entry Mechanisms: An Update
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title_sort	herpes simplex virus cell entry mechanisms: an update
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title_auth	Herpes Simplex Virus Cell Entry Mechanisms: An Update
abstract	Herpes simplex virus (HSV) can infect a broad host range and cause mild to life threating infections in humans. The surface glycoproteins of HSV are evolutionarily conserved and show an extraordinary ability to bind more than one receptor on the host cell surface. Following attachment, the virus fuses its lipid envelope with the host cell membrane and releases its nucleocapsid along with tegument proteins into the cytosol. With the help of tegument proteins and host cell factors, the nucleocapsid is then docked into the nuclear pore. The viral double stranded DNA is then released into the host cell’s nucleus. Released viral DNA either replicates rapidly (more commonly in non-neuronal cells) or stays latent inside the nucleus (in sensory neurons). The fusion of the viral envelope with host cell membrane is a key step. Blocking this step can prevent entry of HSV into the host cell and the subsequent interactions that ultimately lead to production of viral progeny and cell death or latency. In this review, we have discussed viral entry mechanisms including the pH-independent as well as pH-dependent endocytic entry, cell to cell spread of HSV and use of viral glycoproteins as an antiviral target.
abstractGer	Herpes simplex virus (HSV) can infect a broad host range and cause mild to life threating infections in humans. The surface glycoproteins of HSV are evolutionarily conserved and show an extraordinary ability to bind more than one receptor on the host cell surface. Following attachment, the virus fuses its lipid envelope with the host cell membrane and releases its nucleocapsid along with tegument proteins into the cytosol. With the help of tegument proteins and host cell factors, the nucleocapsid is then docked into the nuclear pore. The viral double stranded DNA is then released into the host cell’s nucleus. Released viral DNA either replicates rapidly (more commonly in non-neuronal cells) or stays latent inside the nucleus (in sensory neurons). The fusion of the viral envelope with host cell membrane is a key step. Blocking this step can prevent entry of HSV into the host cell and the subsequent interactions that ultimately lead to production of viral progeny and cell death or latency. In this review, we have discussed viral entry mechanisms including the pH-independent as well as pH-dependent endocytic entry, cell to cell spread of HSV and use of viral glycoproteins as an antiviral target.
abstract_unstemmed	Herpes simplex virus (HSV) can infect a broad host range and cause mild to life threating infections in humans. The surface glycoproteins of HSV are evolutionarily conserved and show an extraordinary ability to bind more than one receptor on the host cell surface. Following attachment, the virus fuses its lipid envelope with the host cell membrane and releases its nucleocapsid along with tegument proteins into the cytosol. With the help of tegument proteins and host cell factors, the nucleocapsid is then docked into the nuclear pore. The viral double stranded DNA is then released into the host cell’s nucleus. Released viral DNA either replicates rapidly (more commonly in non-neuronal cells) or stays latent inside the nucleus (in sensory neurons). The fusion of the viral envelope with host cell membrane is a key step. Blocking this step can prevent entry of HSV into the host cell and the subsequent interactions that ultimately lead to production of viral progeny and cell death or latency. In this review, we have discussed viral entry mechanisms including the pH-independent as well as pH-dependent endocytic entry, cell to cell spread of HSV and use of viral glycoproteins as an antiviral target.
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title_short	Herpes Simplex Virus Cell Entry Mechanisms: An Update
url	https://doi.org/10.3389/fcimb.2020.617578 https://doaj.org/article/dcf8697019ce484c98fd9aeccf1e73ea https://www.frontiersin.org/articles/10.3389/fcimb.2020.617578/full https://doaj.org/toc/2235-2988
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