Baseline iron status and presence of anaemia determine the course of systemic Salmonella infection following oral iron supplementation in mice

Background: Iron deficiency anaemia (IDA) is a major health concern. However, preventive iron supplementation in regions with high burden of infectious diseases resulted in an increase of infection related morbidity and mortality. Methods: We fed male C57BL/6N mice with either an iron deficient or a...
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Autor*in:	Alexander Hoffmann [verfasserIn] David Haschka [verfasserIn] Lara Valente de Souza [verfasserIn] Piotr Tymoszuk [verfasserIn] Markus Seifert [verfasserIn] Laura von Raffay [verfasserIn] Richard Hilbe [verfasserIn] Verena Petzer [verfasserIn] Patrizia L Moser [verfasserIn] Manfred Nairz [verfasserIn] Günter Weiss [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	Iron deficiency anaemia Salmonella infection Iron supplementation Macrophages

Übergeordnetes Werk:	In: EBioMedicine - Elsevier, 2015, 71(2021), Seite 103568-
Übergeordnetes Werk:	volume:71 ; year:2021 ; pages:103568-

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1016/j.ebiom.2021.103568

Katalog-ID:	DOAJ061717975

Internformat


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520			\|a Background: Iron deficiency anaemia (IDA) is a major health concern. However, preventive iron supplementation in regions with high burden of infectious diseases resulted in an increase of infection related morbidity and mortality. Methods: We fed male C57BL/6N mice with either an iron deficient or an iron adequate diet. Next, they received oral iron supplementation or placebo followed by intraperitoneal infection with Salmonella Typhimurium (S.Tm). Findings: We found that mice with IDA had a poorer clinical outcome than mice on an iron adequate diet. Interestingly, iron supplementation of IDA mice resulted in higher bacterial burden in organs and shortened survival. Increased transferrin saturation and non-transferrin bound iron in the circulation together with low expression of ferroportin facilitated the access of the pathogen to iron and promoted bacterial growth. Anaemia, independent of iron supplementation, was correlated with reduced neutrophil counts and cytotoxic T cells. With iron supplementation, anaemia additionally correlated with increased splenic levels of the cytokine IL-10, which is suggestive for a weakened immune control to S.Tm infection. Interpretation: Supplementing iron to anaemic mice worsens the clinical course of bacterial infection. This can be traced back to increased iron delivery to bacteria along with an impaired anti-microbial immune response. Our findings may have important implications for iron supplementation strategies in areas with high endemic burden of infections, putting those individuals, who potentially profit most from iron supplementation for anaemia, at the highest risk for infections. Funding: Financial support by the Christian Doppler Laboratory for Iron Metabolism and Anemia Research.
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700	0		\|a Günter Weiss \|e verfasserin \|4 aut
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allfields	10.1016/j.ebiom.2021.103568 doi (DE-627)DOAJ061717975 (DE-599)DOAJ1d6b2d16a7a84326b7da1c3c21f6d632 DE-627 ger DE-627 rakwb eng R5-920 Alexander Hoffmann verfasserin aut Baseline iron status and presence of anaemia determine the course of systemic Salmonella infection following oral iron supplementation in mice 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Iron deficiency anaemia (IDA) is a major health concern. However, preventive iron supplementation in regions with high burden of infectious diseases resulted in an increase of infection related morbidity and mortality. Methods: We fed male C57BL/6N mice with either an iron deficient or an iron adequate diet. Next, they received oral iron supplementation or placebo followed by intraperitoneal infection with Salmonella Typhimurium (S.Tm). Findings: We found that mice with IDA had a poorer clinical outcome than mice on an iron adequate diet. Interestingly, iron supplementation of IDA mice resulted in higher bacterial burden in organs and shortened survival. Increased transferrin saturation and non-transferrin bound iron in the circulation together with low expression of ferroportin facilitated the access of the pathogen to iron and promoted bacterial growth. Anaemia, independent of iron supplementation, was correlated with reduced neutrophil counts and cytotoxic T cells. With iron supplementation, anaemia additionally correlated with increased splenic levels of the cytokine IL-10, which is suggestive for a weakened immune control to S.Tm infection. Interpretation: Supplementing iron to anaemic mice worsens the clinical course of bacterial infection. This can be traced back to increased iron delivery to bacteria along with an impaired anti-microbial immune response. Our findings may have important implications for iron supplementation strategies in areas with high endemic burden of infections, putting those individuals, who potentially profit most from iron supplementation for anaemia, at the highest risk for infections. Funding: Financial support by the Christian Doppler Laboratory for Iron Metabolism and Anemia Research. Iron deficiency anaemia Salmonella infection Iron supplementation Macrophages Medicine R Medicine (General) David Haschka verfasserin aut Lara Valente de Souza verfasserin aut Piotr Tymoszuk verfasserin aut Markus Seifert verfasserin aut Laura von Raffay verfasserin aut Richard Hilbe verfasserin aut Verena Petzer verfasserin aut Patrizia L Moser verfasserin aut Manfred Nairz verfasserin aut Günter Weiss verfasserin aut In EBioMedicine Elsevier, 2015 71(2021), Seite 103568- (DE-627)802540074 (DE-600)2799017-5 23523964 nnns volume:71 year:2021 pages:103568- https://doi.org/10.1016/j.ebiom.2021.103568 kostenfrei https://doaj.org/article/1d6b2d16a7a84326b7da1c3c21f6d632 kostenfrei http://www.sciencedirect.com/science/article/pii/S2352396421003613 kostenfrei https://doaj.org/toc/2352-3964 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 71 2021 103568-
spelling	10.1016/j.ebiom.2021.103568 doi (DE-627)DOAJ061717975 (DE-599)DOAJ1d6b2d16a7a84326b7da1c3c21f6d632 DE-627 ger DE-627 rakwb eng R5-920 Alexander Hoffmann verfasserin aut Baseline iron status and presence of anaemia determine the course of systemic Salmonella infection following oral iron supplementation in mice 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Iron deficiency anaemia (IDA) is a major health concern. However, preventive iron supplementation in regions with high burden of infectious diseases resulted in an increase of infection related morbidity and mortality. Methods: We fed male C57BL/6N mice with either an iron deficient or an iron adequate diet. Next, they received oral iron supplementation or placebo followed by intraperitoneal infection with Salmonella Typhimurium (S.Tm). Findings: We found that mice with IDA had a poorer clinical outcome than mice on an iron adequate diet. Interestingly, iron supplementation of IDA mice resulted in higher bacterial burden in organs and shortened survival. Increased transferrin saturation and non-transferrin bound iron in the circulation together with low expression of ferroportin facilitated the access of the pathogen to iron and promoted bacterial growth. Anaemia, independent of iron supplementation, was correlated with reduced neutrophil counts and cytotoxic T cells. With iron supplementation, anaemia additionally correlated with increased splenic levels of the cytokine IL-10, which is suggestive for a weakened immune control to S.Tm infection. Interpretation: Supplementing iron to anaemic mice worsens the clinical course of bacterial infection. This can be traced back to increased iron delivery to bacteria along with an impaired anti-microbial immune response. Our findings may have important implications for iron supplementation strategies in areas with high endemic burden of infections, putting those individuals, who potentially profit most from iron supplementation for anaemia, at the highest risk for infections. Funding: Financial support by the Christian Doppler Laboratory for Iron Metabolism and Anemia Research. Iron deficiency anaemia Salmonella infection Iron supplementation Macrophages Medicine R Medicine (General) David Haschka verfasserin aut Lara Valente de Souza verfasserin aut Piotr Tymoszuk verfasserin aut Markus Seifert verfasserin aut Laura von Raffay verfasserin aut Richard Hilbe verfasserin aut Verena Petzer verfasserin aut Patrizia L Moser verfasserin aut Manfred Nairz verfasserin aut Günter Weiss verfasserin aut In EBioMedicine Elsevier, 2015 71(2021), Seite 103568- (DE-627)802540074 (DE-600)2799017-5 23523964 nnns volume:71 year:2021 pages:103568- https://doi.org/10.1016/j.ebiom.2021.103568 kostenfrei https://doaj.org/article/1d6b2d16a7a84326b7da1c3c21f6d632 kostenfrei http://www.sciencedirect.com/science/article/pii/S2352396421003613 kostenfrei https://doaj.org/toc/2352-3964 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 71 2021 103568-
allfields_unstemmed	10.1016/j.ebiom.2021.103568 doi (DE-627)DOAJ061717975 (DE-599)DOAJ1d6b2d16a7a84326b7da1c3c21f6d632 DE-627 ger DE-627 rakwb eng R5-920 Alexander Hoffmann verfasserin aut Baseline iron status and presence of anaemia determine the course of systemic Salmonella infection following oral iron supplementation in mice 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Iron deficiency anaemia (IDA) is a major health concern. However, preventive iron supplementation in regions with high burden of infectious diseases resulted in an increase of infection related morbidity and mortality. Methods: We fed male C57BL/6N mice with either an iron deficient or an iron adequate diet. Next, they received oral iron supplementation or placebo followed by intraperitoneal infection with Salmonella Typhimurium (S.Tm). Findings: We found that mice with IDA had a poorer clinical outcome than mice on an iron adequate diet. Interestingly, iron supplementation of IDA mice resulted in higher bacterial burden in organs and shortened survival. Increased transferrin saturation and non-transferrin bound iron in the circulation together with low expression of ferroportin facilitated the access of the pathogen to iron and promoted bacterial growth. Anaemia, independent of iron supplementation, was correlated with reduced neutrophil counts and cytotoxic T cells. With iron supplementation, anaemia additionally correlated with increased splenic levels of the cytokine IL-10, which is suggestive for a weakened immune control to S.Tm infection. Interpretation: Supplementing iron to anaemic mice worsens the clinical course of bacterial infection. This can be traced back to increased iron delivery to bacteria along with an impaired anti-microbial immune response. Our findings may have important implications for iron supplementation strategies in areas with high endemic burden of infections, putting those individuals, who potentially profit most from iron supplementation for anaemia, at the highest risk for infections. Funding: Financial support by the Christian Doppler Laboratory for Iron Metabolism and Anemia Research. Iron deficiency anaemia Salmonella infection Iron supplementation Macrophages Medicine R Medicine (General) David Haschka verfasserin aut Lara Valente de Souza verfasserin aut Piotr Tymoszuk verfasserin aut Markus Seifert verfasserin aut Laura von Raffay verfasserin aut Richard Hilbe verfasserin aut Verena Petzer verfasserin aut Patrizia L Moser verfasserin aut Manfred Nairz verfasserin aut Günter Weiss verfasserin aut In EBioMedicine Elsevier, 2015 71(2021), Seite 103568- (DE-627)802540074 (DE-600)2799017-5 23523964 nnns volume:71 year:2021 pages:103568- https://doi.org/10.1016/j.ebiom.2021.103568 kostenfrei https://doaj.org/article/1d6b2d16a7a84326b7da1c3c21f6d632 kostenfrei http://www.sciencedirect.com/science/article/pii/S2352396421003613 kostenfrei https://doaj.org/toc/2352-3964 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 71 2021 103568-
allfieldsGer	10.1016/j.ebiom.2021.103568 doi (DE-627)DOAJ061717975 (DE-599)DOAJ1d6b2d16a7a84326b7da1c3c21f6d632 DE-627 ger DE-627 rakwb eng R5-920 Alexander Hoffmann verfasserin aut Baseline iron status and presence of anaemia determine the course of systemic Salmonella infection following oral iron supplementation in mice 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Iron deficiency anaemia (IDA) is a major health concern. However, preventive iron supplementation in regions with high burden of infectious diseases resulted in an increase of infection related morbidity and mortality. Methods: We fed male C57BL/6N mice with either an iron deficient or an iron adequate diet. Next, they received oral iron supplementation or placebo followed by intraperitoneal infection with Salmonella Typhimurium (S.Tm). Findings: We found that mice with IDA had a poorer clinical outcome than mice on an iron adequate diet. Interestingly, iron supplementation of IDA mice resulted in higher bacterial burden in organs and shortened survival. Increased transferrin saturation and non-transferrin bound iron in the circulation together with low expression of ferroportin facilitated the access of the pathogen to iron and promoted bacterial growth. Anaemia, independent of iron supplementation, was correlated with reduced neutrophil counts and cytotoxic T cells. With iron supplementation, anaemia additionally correlated with increased splenic levels of the cytokine IL-10, which is suggestive for a weakened immune control to S.Tm infection. Interpretation: Supplementing iron to anaemic mice worsens the clinical course of bacterial infection. This can be traced back to increased iron delivery to bacteria along with an impaired anti-microbial immune response. Our findings may have important implications for iron supplementation strategies in areas with high endemic burden of infections, putting those individuals, who potentially profit most from iron supplementation for anaemia, at the highest risk for infections. Funding: Financial support by the Christian Doppler Laboratory for Iron Metabolism and Anemia Research. Iron deficiency anaemia Salmonella infection Iron supplementation Macrophages Medicine R Medicine (General) David Haschka verfasserin aut Lara Valente de Souza verfasserin aut Piotr Tymoszuk verfasserin aut Markus Seifert verfasserin aut Laura von Raffay verfasserin aut Richard Hilbe verfasserin aut Verena Petzer verfasserin aut Patrizia L Moser verfasserin aut Manfred Nairz verfasserin aut Günter Weiss verfasserin aut In EBioMedicine Elsevier, 2015 71(2021), Seite 103568- (DE-627)802540074 (DE-600)2799017-5 23523964 nnns volume:71 year:2021 pages:103568- https://doi.org/10.1016/j.ebiom.2021.103568 kostenfrei https://doaj.org/article/1d6b2d16a7a84326b7da1c3c21f6d632 kostenfrei http://www.sciencedirect.com/science/article/pii/S2352396421003613 kostenfrei https://doaj.org/toc/2352-3964 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 71 2021 103568-
allfieldsSound	10.1016/j.ebiom.2021.103568 doi (DE-627)DOAJ061717975 (DE-599)DOAJ1d6b2d16a7a84326b7da1c3c21f6d632 DE-627 ger DE-627 rakwb eng R5-920 Alexander Hoffmann verfasserin aut Baseline iron status and presence of anaemia determine the course of systemic Salmonella infection following oral iron supplementation in mice 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Iron deficiency anaemia (IDA) is a major health concern. However, preventive iron supplementation in regions with high burden of infectious diseases resulted in an increase of infection related morbidity and mortality. Methods: We fed male C57BL/6N mice with either an iron deficient or an iron adequate diet. Next, they received oral iron supplementation or placebo followed by intraperitoneal infection with Salmonella Typhimurium (S.Tm). Findings: We found that mice with IDA had a poorer clinical outcome than mice on an iron adequate diet. Interestingly, iron supplementation of IDA mice resulted in higher bacterial burden in organs and shortened survival. Increased transferrin saturation and non-transferrin bound iron in the circulation together with low expression of ferroportin facilitated the access of the pathogen to iron and promoted bacterial growth. Anaemia, independent of iron supplementation, was correlated with reduced neutrophil counts and cytotoxic T cells. With iron supplementation, anaemia additionally correlated with increased splenic levels of the cytokine IL-10, which is suggestive for a weakened immune control to S.Tm infection. Interpretation: Supplementing iron to anaemic mice worsens the clinical course of bacterial infection. This can be traced back to increased iron delivery to bacteria along with an impaired anti-microbial immune response. Our findings may have important implications for iron supplementation strategies in areas with high endemic burden of infections, putting those individuals, who potentially profit most from iron supplementation for anaemia, at the highest risk for infections. Funding: Financial support by the Christian Doppler Laboratory for Iron Metabolism and Anemia Research. Iron deficiency anaemia Salmonella infection Iron supplementation Macrophages Medicine R Medicine (General) David Haschka verfasserin aut Lara Valente de Souza verfasserin aut Piotr Tymoszuk verfasserin aut Markus Seifert verfasserin aut Laura von Raffay verfasserin aut Richard Hilbe verfasserin aut Verena Petzer verfasserin aut Patrizia L Moser verfasserin aut Manfred Nairz verfasserin aut Günter Weiss verfasserin aut In EBioMedicine Elsevier, 2015 71(2021), Seite 103568- (DE-627)802540074 (DE-600)2799017-5 23523964 nnns volume:71 year:2021 pages:103568- https://doi.org/10.1016/j.ebiom.2021.103568 kostenfrei https://doaj.org/article/1d6b2d16a7a84326b7da1c3c21f6d632 kostenfrei http://www.sciencedirect.com/science/article/pii/S2352396421003613 kostenfrei https://doaj.org/toc/2352-3964 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 71 2021 103568-
language	English
source	In EBioMedicine 71(2021), Seite 103568- volume:71 year:2021 pages:103568-
sourceStr	In EBioMedicine 71(2021), Seite 103568- volume:71 year:2021 pages:103568-
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Iron deficiency anaemia Salmonella infection Iron supplementation Macrophages Medicine R Medicine (General)
isfreeaccess_bool	true
container_title	EBioMedicine
authorswithroles_txt_mv	Alexander Hoffmann @@aut@@ David Haschka @@aut@@ Lara Valente de Souza @@aut@@ Piotr Tymoszuk @@aut@@ Markus Seifert @@aut@@ Laura von Raffay @@aut@@ Richard Hilbe @@aut@@ Verena Petzer @@aut@@ Patrizia L Moser @@aut@@ Manfred Nairz @@aut@@ Günter Weiss @@aut@@
publishDateDaySort_date	2021-01-01T00:00:00Z
hierarchy_top_id	802540074
id	DOAJ061717975
language_de	englisch
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callnumber-first	R - Medicine
author	Alexander Hoffmann
spellingShingle	Alexander Hoffmann misc R5-920 misc Iron deficiency anaemia misc Salmonella infection misc Iron supplementation misc Macrophages misc Medicine misc R misc Medicine (General) Baseline iron status and presence of anaemia determine the course of systemic Salmonella infection following oral iron supplementation in mice
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topic_title	R5-920 Baseline iron status and presence of anaemia determine the course of systemic Salmonella infection following oral iron supplementation in mice Iron deficiency anaemia Salmonella infection Iron supplementation Macrophages
topic	misc R5-920 misc Iron deficiency anaemia misc Salmonella infection misc Iron supplementation misc Macrophages misc Medicine misc R misc Medicine (General)
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title	Baseline iron status and presence of anaemia determine the course of systemic Salmonella infection following oral iron supplementation in mice
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title_full	Baseline iron status and presence of anaemia determine the course of systemic Salmonella infection following oral iron supplementation in mice
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author_browse	Alexander Hoffmann David Haschka Lara Valente de Souza Piotr Tymoszuk Markus Seifert Laura von Raffay Richard Hilbe Verena Petzer Patrizia L Moser Manfred Nairz Günter Weiss
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title_sort	baseline iron status and presence of anaemia determine the course of systemic salmonella infection following oral iron supplementation in mice
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title_auth	Baseline iron status and presence of anaemia determine the course of systemic Salmonella infection following oral iron supplementation in mice
abstract	Background: Iron deficiency anaemia (IDA) is a major health concern. However, preventive iron supplementation in regions with high burden of infectious diseases resulted in an increase of infection related morbidity and mortality. Methods: We fed male C57BL/6N mice with either an iron deficient or an iron adequate diet. Next, they received oral iron supplementation or placebo followed by intraperitoneal infection with Salmonella Typhimurium (S.Tm). Findings: We found that mice with IDA had a poorer clinical outcome than mice on an iron adequate diet. Interestingly, iron supplementation of IDA mice resulted in higher bacterial burden in organs and shortened survival. Increased transferrin saturation and non-transferrin bound iron in the circulation together with low expression of ferroportin facilitated the access of the pathogen to iron and promoted bacterial growth. Anaemia, independent of iron supplementation, was correlated with reduced neutrophil counts and cytotoxic T cells. With iron supplementation, anaemia additionally correlated with increased splenic levels of the cytokine IL-10, which is suggestive for a weakened immune control to S.Tm infection. Interpretation: Supplementing iron to anaemic mice worsens the clinical course of bacterial infection. This can be traced back to increased iron delivery to bacteria along with an impaired anti-microbial immune response. Our findings may have important implications for iron supplementation strategies in areas with high endemic burden of infections, putting those individuals, who potentially profit most from iron supplementation for anaemia, at the highest risk for infections. Funding: Financial support by the Christian Doppler Laboratory for Iron Metabolism and Anemia Research.
abstractGer	Background: Iron deficiency anaemia (IDA) is a major health concern. However, preventive iron supplementation in regions with high burden of infectious diseases resulted in an increase of infection related morbidity and mortality. Methods: We fed male C57BL/6N mice with either an iron deficient or an iron adequate diet. Next, they received oral iron supplementation or placebo followed by intraperitoneal infection with Salmonella Typhimurium (S.Tm). Findings: We found that mice with IDA had a poorer clinical outcome than mice on an iron adequate diet. Interestingly, iron supplementation of IDA mice resulted in higher bacterial burden in organs and shortened survival. Increased transferrin saturation and non-transferrin bound iron in the circulation together with low expression of ferroportin facilitated the access of the pathogen to iron and promoted bacterial growth. Anaemia, independent of iron supplementation, was correlated with reduced neutrophil counts and cytotoxic T cells. With iron supplementation, anaemia additionally correlated with increased splenic levels of the cytokine IL-10, which is suggestive for a weakened immune control to S.Tm infection. Interpretation: Supplementing iron to anaemic mice worsens the clinical course of bacterial infection. This can be traced back to increased iron delivery to bacteria along with an impaired anti-microbial immune response. Our findings may have important implications for iron supplementation strategies in areas with high endemic burden of infections, putting those individuals, who potentially profit most from iron supplementation for anaemia, at the highest risk for infections. Funding: Financial support by the Christian Doppler Laboratory for Iron Metabolism and Anemia Research.
abstract_unstemmed	Background: Iron deficiency anaemia (IDA) is a major health concern. However, preventive iron supplementation in regions with high burden of infectious diseases resulted in an increase of infection related morbidity and mortality. Methods: We fed male C57BL/6N mice with either an iron deficient or an iron adequate diet. Next, they received oral iron supplementation or placebo followed by intraperitoneal infection with Salmonella Typhimurium (S.Tm). Findings: We found that mice with IDA had a poorer clinical outcome than mice on an iron adequate diet. Interestingly, iron supplementation of IDA mice resulted in higher bacterial burden in organs and shortened survival. Increased transferrin saturation and non-transferrin bound iron in the circulation together with low expression of ferroportin facilitated the access of the pathogen to iron and promoted bacterial growth. Anaemia, independent of iron supplementation, was correlated with reduced neutrophil counts and cytotoxic T cells. With iron supplementation, anaemia additionally correlated with increased splenic levels of the cytokine IL-10, which is suggestive for a weakened immune control to S.Tm infection. Interpretation: Supplementing iron to anaemic mice worsens the clinical course of bacterial infection. This can be traced back to increased iron delivery to bacteria along with an impaired anti-microbial immune response. Our findings may have important implications for iron supplementation strategies in areas with high endemic burden of infections, putting those individuals, who potentially profit most from iron supplementation for anaemia, at the highest risk for infections. Funding: Financial support by the Christian Doppler Laboratory for Iron Metabolism and Anemia Research.
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title_short	Baseline iron status and presence of anaemia determine the course of systemic Salmonella infection following oral iron supplementation in mice
url	https://doi.org/10.1016/j.ebiom.2021.103568 https://doaj.org/article/1d6b2d16a7a84326b7da1c3c21f6d632 http://www.sciencedirect.com/science/article/pii/S2352396421003613 https://doaj.org/toc/2352-3964
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However, preventive iron supplementation in regions with high burden of infectious diseases resulted in an increase of infection related morbidity and mortality. Methods: We fed male C57BL/6N mice with either an iron deficient or an iron adequate diet. Next, they received oral iron supplementation or placebo followed by intraperitoneal infection with Salmonella Typhimurium (S.Tm). Findings: We found that mice with IDA had a poorer clinical outcome than mice on an iron adequate diet. Interestingly, iron supplementation of IDA mice resulted in higher bacterial burden in organs and shortened survival. Increased transferrin saturation and non-transferrin bound iron in the circulation together with low expression of ferroportin facilitated the access of the pathogen to iron and promoted bacterial growth. Anaemia, independent of iron supplementation, was correlated with reduced neutrophil counts and cytotoxic T cells. With iron supplementation, anaemia additionally correlated with increased splenic levels of the cytokine IL-10, which is suggestive for a weakened immune control to S.Tm infection. Interpretation: Supplementing iron to anaemic mice worsens the clinical course of bacterial infection. This can be traced back to increased iron delivery to bacteria along with an impaired anti-microbial immune response. Our findings may have important implications for iron supplementation strategies in areas with high endemic burden of infections, putting those individuals, who potentially profit most from iron supplementation for anaemia, at the highest risk for infections. 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Baseline iron status and presence of anaemia determine the course of systemic Salmonella infection following oral iron supplementation in mice

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