Antioxidant Defenses in the Human Eye: A Focus on Metallothioneins

The human eye, the highly specialized organ of vision, is greatly influenced by oxidants of endogenous and exogenous origin. Oxidative stress affects all structures of the human eye with special emphasis on the ocular surface, the lens, the retina and its retinal pigment epithelium, which are consid...
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Gespeichert in:

Autor*in:	Ana Álvarez-Barrios [verfasserIn] Lydia Álvarez [verfasserIn] Montserrat García [verfasserIn] Enol Artime [verfasserIn] Rosario Pereiro [verfasserIn] Héctor González-Iglesias [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	eye oxidative stress natural barriers ocular diseases antioxidants metallothioneins

Übergeordnetes Werk:	In: Antioxidants - MDPI AG, 2013, 10(2021), 1, p 89
Übergeordnetes Werk:	volume:10 ; year:2021 ; number:1, p 89

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/antiox10010089

Katalog-ID:	DOAJ061739197

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spelling	10.3390/antiox10010089 doi (DE-627)DOAJ061739197 (DE-599)DOAJ3064ae6bb03a4ffebe35768eace71062 DE-627 ger DE-627 rakwb eng RM1-950 Ana Álvarez-Barrios verfasserin aut Antioxidant Defenses in the Human Eye: A Focus on Metallothioneins 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The human eye, the highly specialized organ of vision, is greatly influenced by oxidants of endogenous and exogenous origin. Oxidative stress affects all structures of the human eye with special emphasis on the ocular surface, the lens, the retina and its retinal pigment epithelium, which are considered natural barriers of antioxidant protection, contributing to the onset and/or progression of eye diseases. These ocular structures contain a complex antioxidant defense system slightly different along the eye depending on cell tissue. In addition to widely studied enzymatic antioxidants, including superoxide dismutase, glutathione peroxidase, catalase, peroxiredoxins and selenoproteins, inter alia, metallothioneins (MTs) are considered antioxidant proteins of growing interest with further cell-mediated functions. This family of cysteine rich and low molecular mass proteins captures and neutralizes free radicals in a redox-dependent mechanism involving zinc binding and release. The state of the art of MTs, including the isoforms classification, the main functions described to date, the Zn-MT redox cycle as antioxidant defense system, and the antioxidant activity of Zn-MTs in the ocular surface, lens, retina and its retinal pigment epithelium, dependent on the number of occupied zinc-binding sites, will be comprehensively reviewed. eye oxidative stress natural barriers ocular diseases antioxidants metallothioneins Therapeutics. Pharmacology Lydia Álvarez verfasserin aut Montserrat García verfasserin aut Enol Artime verfasserin aut Rosario Pereiro verfasserin aut Héctor González-Iglesias verfasserin aut In Antioxidants MDPI AG, 2013 10(2021), 1, p 89 (DE-627)737287578 (DE-600)2704216-9 20763921 nnns volume:10 year:2021 number:1, p 89 https://doi.org/10.3390/antiox10010089 kostenfrei https://doaj.org/article/3064ae6bb03a4ffebe35768eace71062 kostenfrei https://www.mdpi.com/2076-3921/10/1/89 kostenfrei https://doaj.org/toc/2076-3921 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2021 1, p 89
allfields_unstemmed	10.3390/antiox10010089 doi (DE-627)DOAJ061739197 (DE-599)DOAJ3064ae6bb03a4ffebe35768eace71062 DE-627 ger DE-627 rakwb eng RM1-950 Ana Álvarez-Barrios verfasserin aut Antioxidant Defenses in the Human Eye: A Focus on Metallothioneins 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The human eye, the highly specialized organ of vision, is greatly influenced by oxidants of endogenous and exogenous origin. Oxidative stress affects all structures of the human eye with special emphasis on the ocular surface, the lens, the retina and its retinal pigment epithelium, which are considered natural barriers of antioxidant protection, contributing to the onset and/or progression of eye diseases. These ocular structures contain a complex antioxidant defense system slightly different along the eye depending on cell tissue. In addition to widely studied enzymatic antioxidants, including superoxide dismutase, glutathione peroxidase, catalase, peroxiredoxins and selenoproteins, inter alia, metallothioneins (MTs) are considered antioxidant proteins of growing interest with further cell-mediated functions. This family of cysteine rich and low molecular mass proteins captures and neutralizes free radicals in a redox-dependent mechanism involving zinc binding and release. The state of the art of MTs, including the isoforms classification, the main functions described to date, the Zn-MT redox cycle as antioxidant defense system, and the antioxidant activity of Zn-MTs in the ocular surface, lens, retina and its retinal pigment epithelium, dependent on the number of occupied zinc-binding sites, will be comprehensively reviewed. eye oxidative stress natural barriers ocular diseases antioxidants metallothioneins Therapeutics. Pharmacology Lydia Álvarez verfasserin aut Montserrat García verfasserin aut Enol Artime verfasserin aut Rosario Pereiro verfasserin aut Héctor González-Iglesias verfasserin aut In Antioxidants MDPI AG, 2013 10(2021), 1, p 89 (DE-627)737287578 (DE-600)2704216-9 20763921 nnns volume:10 year:2021 number:1, p 89 https://doi.org/10.3390/antiox10010089 kostenfrei https://doaj.org/article/3064ae6bb03a4ffebe35768eace71062 kostenfrei https://www.mdpi.com/2076-3921/10/1/89 kostenfrei https://doaj.org/toc/2076-3921 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2021 1, p 89
allfieldsGer	10.3390/antiox10010089 doi (DE-627)DOAJ061739197 (DE-599)DOAJ3064ae6bb03a4ffebe35768eace71062 DE-627 ger DE-627 rakwb eng RM1-950 Ana Álvarez-Barrios verfasserin aut Antioxidant Defenses in the Human Eye: A Focus on Metallothioneins 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The human eye, the highly specialized organ of vision, is greatly influenced by oxidants of endogenous and exogenous origin. Oxidative stress affects all structures of the human eye with special emphasis on the ocular surface, the lens, the retina and its retinal pigment epithelium, which are considered natural barriers of antioxidant protection, contributing to the onset and/or progression of eye diseases. These ocular structures contain a complex antioxidant defense system slightly different along the eye depending on cell tissue. In addition to widely studied enzymatic antioxidants, including superoxide dismutase, glutathione peroxidase, catalase, peroxiredoxins and selenoproteins, inter alia, metallothioneins (MTs) are considered antioxidant proteins of growing interest with further cell-mediated functions. This family of cysteine rich and low molecular mass proteins captures and neutralizes free radicals in a redox-dependent mechanism involving zinc binding and release. The state of the art of MTs, including the isoforms classification, the main functions described to date, the Zn-MT redox cycle as antioxidant defense system, and the antioxidant activity of Zn-MTs in the ocular surface, lens, retina and its retinal pigment epithelium, dependent on the number of occupied zinc-binding sites, will be comprehensively reviewed. eye oxidative stress natural barriers ocular diseases antioxidants metallothioneins Therapeutics. Pharmacology Lydia Álvarez verfasserin aut Montserrat García verfasserin aut Enol Artime verfasserin aut Rosario Pereiro verfasserin aut Héctor González-Iglesias verfasserin aut In Antioxidants MDPI AG, 2013 10(2021), 1, p 89 (DE-627)737287578 (DE-600)2704216-9 20763921 nnns volume:10 year:2021 number:1, p 89 https://doi.org/10.3390/antiox10010089 kostenfrei https://doaj.org/article/3064ae6bb03a4ffebe35768eace71062 kostenfrei https://www.mdpi.com/2076-3921/10/1/89 kostenfrei https://doaj.org/toc/2076-3921 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2021 1, p 89
allfieldsSound	10.3390/antiox10010089 doi (DE-627)DOAJ061739197 (DE-599)DOAJ3064ae6bb03a4ffebe35768eace71062 DE-627 ger DE-627 rakwb eng RM1-950 Ana Álvarez-Barrios verfasserin aut Antioxidant Defenses in the Human Eye: A Focus on Metallothioneins 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The human eye, the highly specialized organ of vision, is greatly influenced by oxidants of endogenous and exogenous origin. Oxidative stress affects all structures of the human eye with special emphasis on the ocular surface, the lens, the retina and its retinal pigment epithelium, which are considered natural barriers of antioxidant protection, contributing to the onset and/or progression of eye diseases. These ocular structures contain a complex antioxidant defense system slightly different along the eye depending on cell tissue. In addition to widely studied enzymatic antioxidants, including superoxide dismutase, glutathione peroxidase, catalase, peroxiredoxins and selenoproteins, inter alia, metallothioneins (MTs) are considered antioxidant proteins of growing interest with further cell-mediated functions. This family of cysteine rich and low molecular mass proteins captures and neutralizes free radicals in a redox-dependent mechanism involving zinc binding and release. The state of the art of MTs, including the isoforms classification, the main functions described to date, the Zn-MT redox cycle as antioxidant defense system, and the antioxidant activity of Zn-MTs in the ocular surface, lens, retina and its retinal pigment epithelium, dependent on the number of occupied zinc-binding sites, will be comprehensively reviewed. eye oxidative stress natural barriers ocular diseases antioxidants metallothioneins Therapeutics. Pharmacology Lydia Álvarez verfasserin aut Montserrat García verfasserin aut Enol Artime verfasserin aut Rosario Pereiro verfasserin aut Héctor González-Iglesias verfasserin aut In Antioxidants MDPI AG, 2013 10(2021), 1, p 89 (DE-627)737287578 (DE-600)2704216-9 20763921 nnns volume:10 year:2021 number:1, p 89 https://doi.org/10.3390/antiox10010089 kostenfrei https://doaj.org/article/3064ae6bb03a4ffebe35768eace71062 kostenfrei https://www.mdpi.com/2076-3921/10/1/89 kostenfrei https://doaj.org/toc/2076-3921 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2021 1, p 89
language	English
source	In Antioxidants 10(2021), 1, p 89 volume:10 year:2021 number:1, p 89
sourceStr	In Antioxidants 10(2021), 1, p 89 volume:10 year:2021 number:1, p 89
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	eye oxidative stress natural barriers ocular diseases antioxidants metallothioneins Therapeutics. Pharmacology
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container_title	Antioxidants
authorswithroles_txt_mv	Ana Álvarez-Barrios @@aut@@ Lydia Álvarez @@aut@@ Montserrat García @@aut@@ Enol Artime @@aut@@ Rosario Pereiro @@aut@@ Héctor González-Iglesias @@aut@@
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callnumber-first	R - Medicine
author	Ana Álvarez-Barrios
spellingShingle	Ana Álvarez-Barrios misc RM1-950 misc eye misc oxidative stress misc natural barriers misc ocular diseases misc antioxidants misc metallothioneins misc Therapeutics. Pharmacology Antioxidant Defenses in the Human Eye: A Focus on Metallothioneins
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topic_title	RM1-950 Antioxidant Defenses in the Human Eye: A Focus on Metallothioneins eye oxidative stress natural barriers ocular diseases antioxidants metallothioneins
topic	misc RM1-950 misc eye misc oxidative stress misc natural barriers misc ocular diseases misc antioxidants misc metallothioneins misc Therapeutics. Pharmacology
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title_sort	antioxidant defenses in the human eye: a focus on metallothioneins
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title_auth	Antioxidant Defenses in the Human Eye: A Focus on Metallothioneins
abstract	The human eye, the highly specialized organ of vision, is greatly influenced by oxidants of endogenous and exogenous origin. Oxidative stress affects all structures of the human eye with special emphasis on the ocular surface, the lens, the retina and its retinal pigment epithelium, which are considered natural barriers of antioxidant protection, contributing to the onset and/or progression of eye diseases. These ocular structures contain a complex antioxidant defense system slightly different along the eye depending on cell tissue. In addition to widely studied enzymatic antioxidants, including superoxide dismutase, glutathione peroxidase, catalase, peroxiredoxins and selenoproteins, inter alia, metallothioneins (MTs) are considered antioxidant proteins of growing interest with further cell-mediated functions. This family of cysteine rich and low molecular mass proteins captures and neutralizes free radicals in a redox-dependent mechanism involving zinc binding and release. The state of the art of MTs, including the isoforms classification, the main functions described to date, the Zn-MT redox cycle as antioxidant defense system, and the antioxidant activity of Zn-MTs in the ocular surface, lens, retina and its retinal pigment epithelium, dependent on the number of occupied zinc-binding sites, will be comprehensively reviewed.
abstractGer	The human eye, the highly specialized organ of vision, is greatly influenced by oxidants of endogenous and exogenous origin. Oxidative stress affects all structures of the human eye with special emphasis on the ocular surface, the lens, the retina and its retinal pigment epithelium, which are considered natural barriers of antioxidant protection, contributing to the onset and/or progression of eye diseases. These ocular structures contain a complex antioxidant defense system slightly different along the eye depending on cell tissue. In addition to widely studied enzymatic antioxidants, including superoxide dismutase, glutathione peroxidase, catalase, peroxiredoxins and selenoproteins, inter alia, metallothioneins (MTs) are considered antioxidant proteins of growing interest with further cell-mediated functions. This family of cysteine rich and low molecular mass proteins captures and neutralizes free radicals in a redox-dependent mechanism involving zinc binding and release. The state of the art of MTs, including the isoforms classification, the main functions described to date, the Zn-MT redox cycle as antioxidant defense system, and the antioxidant activity of Zn-MTs in the ocular surface, lens, retina and its retinal pigment epithelium, dependent on the number of occupied zinc-binding sites, will be comprehensively reviewed.
abstract_unstemmed	The human eye, the highly specialized organ of vision, is greatly influenced by oxidants of endogenous and exogenous origin. Oxidative stress affects all structures of the human eye with special emphasis on the ocular surface, the lens, the retina and its retinal pigment epithelium, which are considered natural barriers of antioxidant protection, contributing to the onset and/or progression of eye diseases. These ocular structures contain a complex antioxidant defense system slightly different along the eye depending on cell tissue. In addition to widely studied enzymatic antioxidants, including superoxide dismutase, glutathione peroxidase, catalase, peroxiredoxins and selenoproteins, inter alia, metallothioneins (MTs) are considered antioxidant proteins of growing interest with further cell-mediated functions. This family of cysteine rich and low molecular mass proteins captures and neutralizes free radicals in a redox-dependent mechanism involving zinc binding and release. The state of the art of MTs, including the isoforms classification, the main functions described to date, the Zn-MT redox cycle as antioxidant defense system, and the antioxidant activity of Zn-MTs in the ocular surface, lens, retina and its retinal pigment epithelium, dependent on the number of occupied zinc-binding sites, will be comprehensively reviewed.
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title_short	Antioxidant Defenses in the Human Eye: A Focus on Metallothioneins
url	https://doi.org/10.3390/antiox10010089 https://doaj.org/article/3064ae6bb03a4ffebe35768eace71062 https://www.mdpi.com/2076-3921/10/1/89 https://doaj.org/toc/2076-3921
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