The Expression of E6 HPV, P53 and P16ink4a at Well, Moderately, and Poorly Differentiated Cervical Adenocarcinoma
The objective of this study is to analyze the expression of E6 Humanpapilloma virus (HPV), p53, and p16INK4A in cervical adenocarcinoma grade well differentiated (WD), moderately differentiated (MD), and poorly differentiated (PD). A cross sectional study conducted at Department of Anatomic Patholog...
Ausführliche Beschreibung
Autor*in: |
Gondo Mastutik [verfasserIn] Alphania Rahniayu [verfasserIn] Nila Kurniasari [verfasserIn] Anny Setijo Rahaju [verfasserIn] Rahmi Alia [verfasserIn] Sjahjenny Mustokoweni [verfasserIn] |
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Sprache: |
Englisch |
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2021 |
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Übergeordnetes Werk: |
In: Folia Medica Indonesiana - Universitas Airlangga, 2018, 55(2021), 4, Seite 295-300 |
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Übergeordnetes Werk: |
volume:55 ; year:2021 ; number:4 ; pages:295-300 |
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DOI / URN: |
10.20473/fmi.v55i4.24468 |
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Katalog-ID: |
DOAJ061766755 |
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10.20473/fmi.v55i4.24468 doi (DE-627)DOAJ061766755 (DE-599)DOAJ4fca8094d4d14ea1a0585a9dd60e9e47 DE-627 ger DE-627 rakwb eng Gondo Mastutik verfasserin aut The Expression of E6 HPV, P53 and P16ink4a at Well, Moderately, and Poorly Differentiated Cervical Adenocarcinoma 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The objective of this study is to analyze the expression of E6 Humanpapilloma virus (HPV), p53, and p16INK4A in cervical adenocarcinoma grade well differentiated (WD), moderately differentiated (MD), and poorly differentiated (PD). A cross sectional study conducted at Department of Anatomic Pathology, Dr. Soetomo General Academic Hospital Surabaya Indonesia using formalin fix paraffin embedded (FFPE) from cervical normal and cervical adenocarcioma grade WD, MD, and PD. The expression of E6 HPV, p53, and p16INK4A was performed by immunohistochemistry (IHC) staining. Data were analyzed with Kruskal-Wallis and continued with Mann-Withney test. The expression of E6 HPV in the cervical adenocarcinoma showed 35.9% specimens represented negative and 64.1% specimens represented positive. There was no significant difference in the expression of E6 HPV and p53 in cervical adenocarcinoma between grade WD, MD, and PD. The p16INK4A was overexpressed, shown as diffuse appearance in 89.7% of the specimens. There was a significant difference in the expression of p16INK4A between grade WD and MD with PD. In conclusion, some of cervical adecarcinoma were not caused by infection of HPV type 16 or 18 and the expression of p16INK4A might take a role in the developing of malignancy that caused by infection of HPV. grading of cervical adenocarcinoma e6 hpv p53 p16ink4a Medicine R Alphania Rahniayu verfasserin aut Nila Kurniasari verfasserin aut Anny Setijo Rahaju verfasserin aut Rahmi Alia verfasserin aut Sjahjenny Mustokoweni verfasserin aut In Folia Medica Indonesiana Universitas Airlangga, 2018 55(2021), 4, Seite 295-300 (DE-627)633754757 (DE-600)2569109-0 2599056X nnns volume:55 year:2021 number:4 pages:295-300 https://doi.org/10.20473/fmi.v55i4.24468 kostenfrei https://doaj.org/article/4fca8094d4d14ea1a0585a9dd60e9e47 kostenfrei https://e-journal.unair.ac.id/FMI/article/view/24468 kostenfrei https://doaj.org/toc/2355-8393 Journal toc kostenfrei https://doaj.org/toc/2599-056X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_206 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4305 AR 55 2021 4 295-300 |
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10.20473/fmi.v55i4.24468 doi (DE-627)DOAJ061766755 (DE-599)DOAJ4fca8094d4d14ea1a0585a9dd60e9e47 DE-627 ger DE-627 rakwb eng Gondo Mastutik verfasserin aut The Expression of E6 HPV, P53 and P16ink4a at Well, Moderately, and Poorly Differentiated Cervical Adenocarcinoma 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The objective of this study is to analyze the expression of E6 Humanpapilloma virus (HPV), p53, and p16INK4A in cervical adenocarcinoma grade well differentiated (WD), moderately differentiated (MD), and poorly differentiated (PD). A cross sectional study conducted at Department of Anatomic Pathology, Dr. Soetomo General Academic Hospital Surabaya Indonesia using formalin fix paraffin embedded (FFPE) from cervical normal and cervical adenocarcioma grade WD, MD, and PD. The expression of E6 HPV, p53, and p16INK4A was performed by immunohistochemistry (IHC) staining. Data were analyzed with Kruskal-Wallis and continued with Mann-Withney test. The expression of E6 HPV in the cervical adenocarcinoma showed 35.9% specimens represented negative and 64.1% specimens represented positive. There was no significant difference in the expression of E6 HPV and p53 in cervical adenocarcinoma between grade WD, MD, and PD. The p16INK4A was overexpressed, shown as diffuse appearance in 89.7% of the specimens. There was a significant difference in the expression of p16INK4A between grade WD and MD with PD. In conclusion, some of cervical adecarcinoma were not caused by infection of HPV type 16 or 18 and the expression of p16INK4A might take a role in the developing of malignancy that caused by infection of HPV. grading of cervical adenocarcinoma e6 hpv p53 p16ink4a Medicine R Alphania Rahniayu verfasserin aut Nila Kurniasari verfasserin aut Anny Setijo Rahaju verfasserin aut Rahmi Alia verfasserin aut Sjahjenny Mustokoweni verfasserin aut In Folia Medica Indonesiana Universitas Airlangga, 2018 55(2021), 4, Seite 295-300 (DE-627)633754757 (DE-600)2569109-0 2599056X nnns volume:55 year:2021 number:4 pages:295-300 https://doi.org/10.20473/fmi.v55i4.24468 kostenfrei https://doaj.org/article/4fca8094d4d14ea1a0585a9dd60e9e47 kostenfrei https://e-journal.unair.ac.id/FMI/article/view/24468 kostenfrei https://doaj.org/toc/2355-8393 Journal toc kostenfrei https://doaj.org/toc/2599-056X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_206 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4305 AR 55 2021 4 295-300 |
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10.20473/fmi.v55i4.24468 doi (DE-627)DOAJ061766755 (DE-599)DOAJ4fca8094d4d14ea1a0585a9dd60e9e47 DE-627 ger DE-627 rakwb eng Gondo Mastutik verfasserin aut The Expression of E6 HPV, P53 and P16ink4a at Well, Moderately, and Poorly Differentiated Cervical Adenocarcinoma 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The objective of this study is to analyze the expression of E6 Humanpapilloma virus (HPV), p53, and p16INK4A in cervical adenocarcinoma grade well differentiated (WD), moderately differentiated (MD), and poorly differentiated (PD). A cross sectional study conducted at Department of Anatomic Pathology, Dr. Soetomo General Academic Hospital Surabaya Indonesia using formalin fix paraffin embedded (FFPE) from cervical normal and cervical adenocarcioma grade WD, MD, and PD. The expression of E6 HPV, p53, and p16INK4A was performed by immunohistochemistry (IHC) staining. Data were analyzed with Kruskal-Wallis and continued with Mann-Withney test. The expression of E6 HPV in the cervical adenocarcinoma showed 35.9% specimens represented negative and 64.1% specimens represented positive. There was no significant difference in the expression of E6 HPV and p53 in cervical adenocarcinoma between grade WD, MD, and PD. The p16INK4A was overexpressed, shown as diffuse appearance in 89.7% of the specimens. There was a significant difference in the expression of p16INK4A between grade WD and MD with PD. In conclusion, some of cervical adecarcinoma were not caused by infection of HPV type 16 or 18 and the expression of p16INK4A might take a role in the developing of malignancy that caused by infection of HPV. grading of cervical adenocarcinoma e6 hpv p53 p16ink4a Medicine R Alphania Rahniayu verfasserin aut Nila Kurniasari verfasserin aut Anny Setijo Rahaju verfasserin aut Rahmi Alia verfasserin aut Sjahjenny Mustokoweni verfasserin aut In Folia Medica Indonesiana Universitas Airlangga, 2018 55(2021), 4, Seite 295-300 (DE-627)633754757 (DE-600)2569109-0 2599056X nnns volume:55 year:2021 number:4 pages:295-300 https://doi.org/10.20473/fmi.v55i4.24468 kostenfrei https://doaj.org/article/4fca8094d4d14ea1a0585a9dd60e9e47 kostenfrei https://e-journal.unair.ac.id/FMI/article/view/24468 kostenfrei https://doaj.org/toc/2355-8393 Journal toc kostenfrei https://doaj.org/toc/2599-056X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_206 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4305 AR 55 2021 4 295-300 |
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10.20473/fmi.v55i4.24468 doi (DE-627)DOAJ061766755 (DE-599)DOAJ4fca8094d4d14ea1a0585a9dd60e9e47 DE-627 ger DE-627 rakwb eng Gondo Mastutik verfasserin aut The Expression of E6 HPV, P53 and P16ink4a at Well, Moderately, and Poorly Differentiated Cervical Adenocarcinoma 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The objective of this study is to analyze the expression of E6 Humanpapilloma virus (HPV), p53, and p16INK4A in cervical adenocarcinoma grade well differentiated (WD), moderately differentiated (MD), and poorly differentiated (PD). A cross sectional study conducted at Department of Anatomic Pathology, Dr. Soetomo General Academic Hospital Surabaya Indonesia using formalin fix paraffin embedded (FFPE) from cervical normal and cervical adenocarcioma grade WD, MD, and PD. The expression of E6 HPV, p53, and p16INK4A was performed by immunohistochemistry (IHC) staining. Data were analyzed with Kruskal-Wallis and continued with Mann-Withney test. The expression of E6 HPV in the cervical adenocarcinoma showed 35.9% specimens represented negative and 64.1% specimens represented positive. There was no significant difference in the expression of E6 HPV and p53 in cervical adenocarcinoma between grade WD, MD, and PD. The p16INK4A was overexpressed, shown as diffuse appearance in 89.7% of the specimens. There was a significant difference in the expression of p16INK4A between grade WD and MD with PD. In conclusion, some of cervical adecarcinoma were not caused by infection of HPV type 16 or 18 and the expression of p16INK4A might take a role in the developing of malignancy that caused by infection of HPV. grading of cervical adenocarcinoma e6 hpv p53 p16ink4a Medicine R Alphania Rahniayu verfasserin aut Nila Kurniasari verfasserin aut Anny Setijo Rahaju verfasserin aut Rahmi Alia verfasserin aut Sjahjenny Mustokoweni verfasserin aut In Folia Medica Indonesiana Universitas Airlangga, 2018 55(2021), 4, Seite 295-300 (DE-627)633754757 (DE-600)2569109-0 2599056X nnns volume:55 year:2021 number:4 pages:295-300 https://doi.org/10.20473/fmi.v55i4.24468 kostenfrei https://doaj.org/article/4fca8094d4d14ea1a0585a9dd60e9e47 kostenfrei https://e-journal.unair.ac.id/FMI/article/view/24468 kostenfrei https://doaj.org/toc/2355-8393 Journal toc kostenfrei https://doaj.org/toc/2599-056X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_206 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4305 AR 55 2021 4 295-300 |
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10.20473/fmi.v55i4.24468 doi (DE-627)DOAJ061766755 (DE-599)DOAJ4fca8094d4d14ea1a0585a9dd60e9e47 DE-627 ger DE-627 rakwb eng Gondo Mastutik verfasserin aut The Expression of E6 HPV, P53 and P16ink4a at Well, Moderately, and Poorly Differentiated Cervical Adenocarcinoma 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The objective of this study is to analyze the expression of E6 Humanpapilloma virus (HPV), p53, and p16INK4A in cervical adenocarcinoma grade well differentiated (WD), moderately differentiated (MD), and poorly differentiated (PD). A cross sectional study conducted at Department of Anatomic Pathology, Dr. Soetomo General Academic Hospital Surabaya Indonesia using formalin fix paraffin embedded (FFPE) from cervical normal and cervical adenocarcioma grade WD, MD, and PD. The expression of E6 HPV, p53, and p16INK4A was performed by immunohistochemistry (IHC) staining. Data were analyzed with Kruskal-Wallis and continued with Mann-Withney test. The expression of E6 HPV in the cervical adenocarcinoma showed 35.9% specimens represented negative and 64.1% specimens represented positive. There was no significant difference in the expression of E6 HPV and p53 in cervical adenocarcinoma between grade WD, MD, and PD. The p16INK4A was overexpressed, shown as diffuse appearance in 89.7% of the specimens. There was a significant difference in the expression of p16INK4A between grade WD and MD with PD. In conclusion, some of cervical adecarcinoma were not caused by infection of HPV type 16 or 18 and the expression of p16INK4A might take a role in the developing of malignancy that caused by infection of HPV. grading of cervical adenocarcinoma e6 hpv p53 p16ink4a Medicine R Alphania Rahniayu verfasserin aut Nila Kurniasari verfasserin aut Anny Setijo Rahaju verfasserin aut Rahmi Alia verfasserin aut Sjahjenny Mustokoweni verfasserin aut In Folia Medica Indonesiana Universitas Airlangga, 2018 55(2021), 4, Seite 295-300 (DE-627)633754757 (DE-600)2569109-0 2599056X nnns volume:55 year:2021 number:4 pages:295-300 https://doi.org/10.20473/fmi.v55i4.24468 kostenfrei https://doaj.org/article/4fca8094d4d14ea1a0585a9dd60e9e47 kostenfrei https://e-journal.unair.ac.id/FMI/article/view/24468 kostenfrei https://doaj.org/toc/2355-8393 Journal toc kostenfrei https://doaj.org/toc/2599-056X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_206 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4305 AR 55 2021 4 295-300 |
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The Expression of E6 HPV, P53 and P16ink4a at Well, Moderately, and Poorly Differentiated Cervical Adenocarcinoma |
abstract |
The objective of this study is to analyze the expression of E6 Humanpapilloma virus (HPV), p53, and p16INK4A in cervical adenocarcinoma grade well differentiated (WD), moderately differentiated (MD), and poorly differentiated (PD). A cross sectional study conducted at Department of Anatomic Pathology, Dr. Soetomo General Academic Hospital Surabaya Indonesia using formalin fix paraffin embedded (FFPE) from cervical normal and cervical adenocarcioma grade WD, MD, and PD. The expression of E6 HPV, p53, and p16INK4A was performed by immunohistochemistry (IHC) staining. Data were analyzed with Kruskal-Wallis and continued with Mann-Withney test. The expression of E6 HPV in the cervical adenocarcinoma showed 35.9% specimens represented negative and 64.1% specimens represented positive. There was no significant difference in the expression of E6 HPV and p53 in cervical adenocarcinoma between grade WD, MD, and PD. The p16INK4A was overexpressed, shown as diffuse appearance in 89.7% of the specimens. There was a significant difference in the expression of p16INK4A between grade WD and MD with PD. In conclusion, some of cervical adecarcinoma were not caused by infection of HPV type 16 or 18 and the expression of p16INK4A might take a role in the developing of malignancy that caused by infection of HPV. |
abstractGer |
The objective of this study is to analyze the expression of E6 Humanpapilloma virus (HPV), p53, and p16INK4A in cervical adenocarcinoma grade well differentiated (WD), moderately differentiated (MD), and poorly differentiated (PD). A cross sectional study conducted at Department of Anatomic Pathology, Dr. Soetomo General Academic Hospital Surabaya Indonesia using formalin fix paraffin embedded (FFPE) from cervical normal and cervical adenocarcioma grade WD, MD, and PD. The expression of E6 HPV, p53, and p16INK4A was performed by immunohistochemistry (IHC) staining. Data were analyzed with Kruskal-Wallis and continued with Mann-Withney test. The expression of E6 HPV in the cervical adenocarcinoma showed 35.9% specimens represented negative and 64.1% specimens represented positive. There was no significant difference in the expression of E6 HPV and p53 in cervical adenocarcinoma between grade WD, MD, and PD. The p16INK4A was overexpressed, shown as diffuse appearance in 89.7% of the specimens. There was a significant difference in the expression of p16INK4A between grade WD and MD with PD. In conclusion, some of cervical adecarcinoma were not caused by infection of HPV type 16 or 18 and the expression of p16INK4A might take a role in the developing of malignancy that caused by infection of HPV. |
abstract_unstemmed |
The objective of this study is to analyze the expression of E6 Humanpapilloma virus (HPV), p53, and p16INK4A in cervical adenocarcinoma grade well differentiated (WD), moderately differentiated (MD), and poorly differentiated (PD). A cross sectional study conducted at Department of Anatomic Pathology, Dr. Soetomo General Academic Hospital Surabaya Indonesia using formalin fix paraffin embedded (FFPE) from cervical normal and cervical adenocarcioma grade WD, MD, and PD. The expression of E6 HPV, p53, and p16INK4A was performed by immunohistochemistry (IHC) staining. Data were analyzed with Kruskal-Wallis and continued with Mann-Withney test. The expression of E6 HPV in the cervical adenocarcinoma showed 35.9% specimens represented negative and 64.1% specimens represented positive. There was no significant difference in the expression of E6 HPV and p53 in cervical adenocarcinoma between grade WD, MD, and PD. The p16INK4A was overexpressed, shown as diffuse appearance in 89.7% of the specimens. There was a significant difference in the expression of p16INK4A between grade WD and MD with PD. In conclusion, some of cervical adecarcinoma were not caused by infection of HPV type 16 or 18 and the expression of p16INK4A might take a role in the developing of malignancy that caused by infection of HPV. |
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The Expression of E6 HPV, P53 and P16ink4a at Well, Moderately, and Poorly Differentiated Cervical Adenocarcinoma |
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