The Expression of E6 HPV, P53 and P16ink4a at Well, Moderately, and Poorly Differentiated Cervical Adenocarcinoma

The objective of this study is to analyze the expression of E6 Humanpapilloma virus (HPV), p53, and p16INK4A in cervical adenocarcinoma grade well differentiated (WD), moderately differentiated (MD), and poorly differentiated (PD). A cross sectional study conducted at Department of Anatomic Patholog...
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Autor*in:	Gondo Mastutik [verfasserIn] Alphania Rahniayu [verfasserIn] Nila Kurniasari [verfasserIn] Anny Setijo Rahaju [verfasserIn] Rahmi Alia [verfasserIn] Sjahjenny Mustokoweni [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	grading of cervical adenocarcinoma e6 hpv p53 p16ink4a

Übergeordnetes Werk:	In: Folia Medica Indonesiana - Universitas Airlangga, 2018, 55(2021), 4, Seite 295-300
Übergeordnetes Werk:	volume:55 ; year:2021 ; number:4 ; pages:295-300

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.20473/fmi.v55i4.24468

Katalog-ID:	DOAJ061766755

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allfields	10.20473/fmi.v55i4.24468 doi (DE-627)DOAJ061766755 (DE-599)DOAJ4fca8094d4d14ea1a0585a9dd60e9e47 DE-627 ger DE-627 rakwb eng Gondo Mastutik verfasserin aut The Expression of E6 HPV, P53 and P16ink4a at Well, Moderately, and Poorly Differentiated Cervical Adenocarcinoma 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The objective of this study is to analyze the expression of E6 Humanpapilloma virus (HPV), p53, and p16INK4A in cervical adenocarcinoma grade well differentiated (WD), moderately differentiated (MD), and poorly differentiated (PD). A cross sectional study conducted at Department of Anatomic Pathology, Dr. Soetomo General Academic Hospital Surabaya Indonesia using formalin fix paraffin embedded (FFPE) from cervical normal and cervical adenocarcioma grade WD, MD, and PD. The expression of E6 HPV, p53, and p16INK4A was performed by immunohistochemistry (IHC) staining. Data were analyzed with Kruskal-Wallis and continued with Mann-Withney test. The expression of E6 HPV in the cervical adenocarcinoma showed 35.9% specimens represented negative and 64.1% specimens represented positive. There was no significant difference in the expression of E6 HPV and p53 in cervical adenocarcinoma between grade WD, MD, and PD. The p16INK4A was overexpressed, shown as diffuse appearance in 89.7% of the specimens. There was a significant difference in the expression of p16INK4A between grade WD and MD with PD. In conclusion, some of cervical adecarcinoma were not caused by infection of HPV type 16 or 18 and the expression of p16INK4A might take a role in the developing of malignancy that caused by infection of HPV. grading of cervical adenocarcinoma e6 hpv p53 p16ink4a Medicine R Alphania Rahniayu verfasserin aut Nila Kurniasari verfasserin aut Anny Setijo Rahaju verfasserin aut Rahmi Alia verfasserin aut Sjahjenny Mustokoweni verfasserin aut In Folia Medica Indonesiana Universitas Airlangga, 2018 55(2021), 4, Seite 295-300 (DE-627)633754757 (DE-600)2569109-0 2599056X nnns volume:55 year:2021 number:4 pages:295-300 https://doi.org/10.20473/fmi.v55i4.24468 kostenfrei https://doaj.org/article/4fca8094d4d14ea1a0585a9dd60e9e47 kostenfrei https://e-journal.unair.ac.id/FMI/article/view/24468 kostenfrei https://doaj.org/toc/2355-8393 Journal toc kostenfrei https://doaj.org/toc/2599-056X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_206 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4305 AR 55 2021 4 295-300
spelling	10.20473/fmi.v55i4.24468 doi (DE-627)DOAJ061766755 (DE-599)DOAJ4fca8094d4d14ea1a0585a9dd60e9e47 DE-627 ger DE-627 rakwb eng Gondo Mastutik verfasserin aut The Expression of E6 HPV, P53 and P16ink4a at Well, Moderately, and Poorly Differentiated Cervical Adenocarcinoma 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The objective of this study is to analyze the expression of E6 Humanpapilloma virus (HPV), p53, and p16INK4A in cervical adenocarcinoma grade well differentiated (WD), moderately differentiated (MD), and poorly differentiated (PD). A cross sectional study conducted at Department of Anatomic Pathology, Dr. Soetomo General Academic Hospital Surabaya Indonesia using formalin fix paraffin embedded (FFPE) from cervical normal and cervical adenocarcioma grade WD, MD, and PD. The expression of E6 HPV, p53, and p16INK4A was performed by immunohistochemistry (IHC) staining. Data were analyzed with Kruskal-Wallis and continued with Mann-Withney test. The expression of E6 HPV in the cervical adenocarcinoma showed 35.9% specimens represented negative and 64.1% specimens represented positive. There was no significant difference in the expression of E6 HPV and p53 in cervical adenocarcinoma between grade WD, MD, and PD. The p16INK4A was overexpressed, shown as diffuse appearance in 89.7% of the specimens. There was a significant difference in the expression of p16INK4A between grade WD and MD with PD. In conclusion, some of cervical adecarcinoma were not caused by infection of HPV type 16 or 18 and the expression of p16INK4A might take a role in the developing of malignancy that caused by infection of HPV. grading of cervical adenocarcinoma e6 hpv p53 p16ink4a Medicine R Alphania Rahniayu verfasserin aut Nila Kurniasari verfasserin aut Anny Setijo Rahaju verfasserin aut Rahmi Alia verfasserin aut Sjahjenny Mustokoweni verfasserin aut In Folia Medica Indonesiana Universitas Airlangga, 2018 55(2021), 4, Seite 295-300 (DE-627)633754757 (DE-600)2569109-0 2599056X nnns volume:55 year:2021 number:4 pages:295-300 https://doi.org/10.20473/fmi.v55i4.24468 kostenfrei https://doaj.org/article/4fca8094d4d14ea1a0585a9dd60e9e47 kostenfrei https://e-journal.unair.ac.id/FMI/article/view/24468 kostenfrei https://doaj.org/toc/2355-8393 Journal toc kostenfrei https://doaj.org/toc/2599-056X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_206 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4305 AR 55 2021 4 295-300
allfields_unstemmed	10.20473/fmi.v55i4.24468 doi (DE-627)DOAJ061766755 (DE-599)DOAJ4fca8094d4d14ea1a0585a9dd60e9e47 DE-627 ger DE-627 rakwb eng Gondo Mastutik verfasserin aut The Expression of E6 HPV, P53 and P16ink4a at Well, Moderately, and Poorly Differentiated Cervical Adenocarcinoma 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The objective of this study is to analyze the expression of E6 Humanpapilloma virus (HPV), p53, and p16INK4A in cervical adenocarcinoma grade well differentiated (WD), moderately differentiated (MD), and poorly differentiated (PD). A cross sectional study conducted at Department of Anatomic Pathology, Dr. Soetomo General Academic Hospital Surabaya Indonesia using formalin fix paraffin embedded (FFPE) from cervical normal and cervical adenocarcioma grade WD, MD, and PD. The expression of E6 HPV, p53, and p16INK4A was performed by immunohistochemistry (IHC) staining. Data were analyzed with Kruskal-Wallis and continued with Mann-Withney test. The expression of E6 HPV in the cervical adenocarcinoma showed 35.9% specimens represented negative and 64.1% specimens represented positive. There was no significant difference in the expression of E6 HPV and p53 in cervical adenocarcinoma between grade WD, MD, and PD. The p16INK4A was overexpressed, shown as diffuse appearance in 89.7% of the specimens. There was a significant difference in the expression of p16INK4A between grade WD and MD with PD. In conclusion, some of cervical adecarcinoma were not caused by infection of HPV type 16 or 18 and the expression of p16INK4A might take a role in the developing of malignancy that caused by infection of HPV. grading of cervical adenocarcinoma e6 hpv p53 p16ink4a Medicine R Alphania Rahniayu verfasserin aut Nila Kurniasari verfasserin aut Anny Setijo Rahaju verfasserin aut Rahmi Alia verfasserin aut Sjahjenny Mustokoweni verfasserin aut In Folia Medica Indonesiana Universitas Airlangga, 2018 55(2021), 4, Seite 295-300 (DE-627)633754757 (DE-600)2569109-0 2599056X nnns volume:55 year:2021 number:4 pages:295-300 https://doi.org/10.20473/fmi.v55i4.24468 kostenfrei https://doaj.org/article/4fca8094d4d14ea1a0585a9dd60e9e47 kostenfrei https://e-journal.unair.ac.id/FMI/article/view/24468 kostenfrei https://doaj.org/toc/2355-8393 Journal toc kostenfrei https://doaj.org/toc/2599-056X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_206 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4305 AR 55 2021 4 295-300
allfieldsGer	10.20473/fmi.v55i4.24468 doi (DE-627)DOAJ061766755 (DE-599)DOAJ4fca8094d4d14ea1a0585a9dd60e9e47 DE-627 ger DE-627 rakwb eng Gondo Mastutik verfasserin aut The Expression of E6 HPV, P53 and P16ink4a at Well, Moderately, and Poorly Differentiated Cervical Adenocarcinoma 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The objective of this study is to analyze the expression of E6 Humanpapilloma virus (HPV), p53, and p16INK4A in cervical adenocarcinoma grade well differentiated (WD), moderately differentiated (MD), and poorly differentiated (PD). A cross sectional study conducted at Department of Anatomic Pathology, Dr. Soetomo General Academic Hospital Surabaya Indonesia using formalin fix paraffin embedded (FFPE) from cervical normal and cervical adenocarcioma grade WD, MD, and PD. The expression of E6 HPV, p53, and p16INK4A was performed by immunohistochemistry (IHC) staining. Data were analyzed with Kruskal-Wallis and continued with Mann-Withney test. The expression of E6 HPV in the cervical adenocarcinoma showed 35.9% specimens represented negative and 64.1% specimens represented positive. There was no significant difference in the expression of E6 HPV and p53 in cervical adenocarcinoma between grade WD, MD, and PD. The p16INK4A was overexpressed, shown as diffuse appearance in 89.7% of the specimens. There was a significant difference in the expression of p16INK4A between grade WD and MD with PD. In conclusion, some of cervical adecarcinoma were not caused by infection of HPV type 16 or 18 and the expression of p16INK4A might take a role in the developing of malignancy that caused by infection of HPV. grading of cervical adenocarcinoma e6 hpv p53 p16ink4a Medicine R Alphania Rahniayu verfasserin aut Nila Kurniasari verfasserin aut Anny Setijo Rahaju verfasserin aut Rahmi Alia verfasserin aut Sjahjenny Mustokoweni verfasserin aut In Folia Medica Indonesiana Universitas Airlangga, 2018 55(2021), 4, Seite 295-300 (DE-627)633754757 (DE-600)2569109-0 2599056X nnns volume:55 year:2021 number:4 pages:295-300 https://doi.org/10.20473/fmi.v55i4.24468 kostenfrei https://doaj.org/article/4fca8094d4d14ea1a0585a9dd60e9e47 kostenfrei https://e-journal.unair.ac.id/FMI/article/view/24468 kostenfrei https://doaj.org/toc/2355-8393 Journal toc kostenfrei https://doaj.org/toc/2599-056X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_206 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4305 AR 55 2021 4 295-300
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author	Gondo Mastutik
spellingShingle	Gondo Mastutik misc grading of cervical adenocarcinoma misc e6 hpv misc p53 misc p16ink4a misc Medicine misc R The Expression of E6 HPV, P53 and P16ink4a at Well, Moderately, and Poorly Differentiated Cervical Adenocarcinoma
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topic_title	The Expression of E6 HPV, P53 and P16ink4a at Well, Moderately, and Poorly Differentiated Cervical Adenocarcinoma grading of cervical adenocarcinoma e6 hpv p53 p16ink4a
topic	misc grading of cervical adenocarcinoma misc e6 hpv misc p53 misc p16ink4a misc Medicine misc R
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title	The Expression of E6 HPV, P53 and P16ink4a at Well, Moderately, and Poorly Differentiated Cervical Adenocarcinoma
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title_full	The Expression of E6 HPV, P53 and P16ink4a at Well, Moderately, and Poorly Differentiated Cervical Adenocarcinoma
author_sort	Gondo Mastutik
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author_browse	Gondo Mastutik Alphania Rahniayu Nila Kurniasari Anny Setijo Rahaju Rahmi Alia Sjahjenny Mustokoweni
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title_sort	expression of e6 hpv, p53 and p16ink4a at well, moderately, and poorly differentiated cervical adenocarcinoma
title_auth	The Expression of E6 HPV, P53 and P16ink4a at Well, Moderately, and Poorly Differentiated Cervical Adenocarcinoma
abstract	The objective of this study is to analyze the expression of E6 Humanpapilloma virus (HPV), p53, and p16INK4A in cervical adenocarcinoma grade well differentiated (WD), moderately differentiated (MD), and poorly differentiated (PD). A cross sectional study conducted at Department of Anatomic Pathology, Dr. Soetomo General Academic Hospital Surabaya Indonesia using formalin fix paraffin embedded (FFPE) from cervical normal and cervical adenocarcioma grade WD, MD, and PD. The expression of E6 HPV, p53, and p16INK4A was performed by immunohistochemistry (IHC) staining. Data were analyzed with Kruskal-Wallis and continued with Mann-Withney test. The expression of E6 HPV in the cervical adenocarcinoma showed 35.9% specimens represented negative and 64.1% specimens represented positive. There was no significant difference in the expression of E6 HPV and p53 in cervical adenocarcinoma between grade WD, MD, and PD. The p16INK4A was overexpressed, shown as diffuse appearance in 89.7% of the specimens. There was a significant difference in the expression of p16INK4A between grade WD and MD with PD. In conclusion, some of cervical adecarcinoma were not caused by infection of HPV type 16 or 18 and the expression of p16INK4A might take a role in the developing of malignancy that caused by infection of HPV.
abstractGer	The objective of this study is to analyze the expression of E6 Humanpapilloma virus (HPV), p53, and p16INK4A in cervical adenocarcinoma grade well differentiated (WD), moderately differentiated (MD), and poorly differentiated (PD). A cross sectional study conducted at Department of Anatomic Pathology, Dr. Soetomo General Academic Hospital Surabaya Indonesia using formalin fix paraffin embedded (FFPE) from cervical normal and cervical adenocarcioma grade WD, MD, and PD. The expression of E6 HPV, p53, and p16INK4A was performed by immunohistochemistry (IHC) staining. Data were analyzed with Kruskal-Wallis and continued with Mann-Withney test. The expression of E6 HPV in the cervical adenocarcinoma showed 35.9% specimens represented negative and 64.1% specimens represented positive. There was no significant difference in the expression of E6 HPV and p53 in cervical adenocarcinoma between grade WD, MD, and PD. The p16INK4A was overexpressed, shown as diffuse appearance in 89.7% of the specimens. There was a significant difference in the expression of p16INK4A between grade WD and MD with PD. In conclusion, some of cervical adecarcinoma were not caused by infection of HPV type 16 or 18 and the expression of p16INK4A might take a role in the developing of malignancy that caused by infection of HPV.
abstract_unstemmed	The objective of this study is to analyze the expression of E6 Humanpapilloma virus (HPV), p53, and p16INK4A in cervical adenocarcinoma grade well differentiated (WD), moderately differentiated (MD), and poorly differentiated (PD). A cross sectional study conducted at Department of Anatomic Pathology, Dr. Soetomo General Academic Hospital Surabaya Indonesia using formalin fix paraffin embedded (FFPE) from cervical normal and cervical adenocarcioma grade WD, MD, and PD. The expression of E6 HPV, p53, and p16INK4A was performed by immunohistochemistry (IHC) staining. Data were analyzed with Kruskal-Wallis and continued with Mann-Withney test. The expression of E6 HPV in the cervical adenocarcinoma showed 35.9% specimens represented negative and 64.1% specimens represented positive. There was no significant difference in the expression of E6 HPV and p53 in cervical adenocarcinoma between grade WD, MD, and PD. The p16INK4A was overexpressed, shown as diffuse appearance in 89.7% of the specimens. There was a significant difference in the expression of p16INK4A between grade WD and MD with PD. In conclusion, some of cervical adecarcinoma were not caused by infection of HPV type 16 or 18 and the expression of p16INK4A might take a role in the developing of malignancy that caused by infection of HPV.
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title_short	The Expression of E6 HPV, P53 and P16ink4a at Well, Moderately, and Poorly Differentiated Cervical Adenocarcinoma
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