A Mediterranean Dietary Intervention in Female Carriers of BRCA Mutations: Results from an Italian Prospective Randomized Controlled Trial

<i<Background:</i< Women carriers of <i<BRCA1</i</<i<2</i< mutations face a high lifetime risk (penetrance) of developing breast and/or ovarian cancer. Insulin-like growth factor I (IGF-I), body weight and markers of insulin resistance affect BRCA penetrance. We c...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Eleonora Bruno [verfasserIn] Andreina Oliverio [verfasserIn] Angelo Virgilio Paradiso [verfasserIn] Antonella Daniele [verfasserIn] Stefania Tommasi [verfasserIn] Antonio Tufaro [verfasserIn] Daniela Andreina Terribile [verfasserIn] Stefano Magno [verfasserIn] Alessio Filippone [verfasserIn] Elisabetta Venturelli [verfasserIn] Daniele Morelli [verfasserIn] Ivan Baldassari [verfasserIn] Maria Luisa Cravana [verfasserIn] Siranoush Manoukian [verfasserIn] Patrizia Pasanisi [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	randomized controlled trial mediterranean diet insulin-like growth factor I penetrance personalized medicine

Übergeordnetes Werk:	In: Cancers - MDPI AG, 2010, 12(2020), 12, p 3732
Übergeordnetes Werk:	volume:12 ; year:2020 ; number:12, p 3732

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/cancers12123732

Katalog-ID:	DOAJ061961787

Internformat


LEADER	01000caa a22002652 4500
001	DOAJ061961787
003	DE-627
005	20240412205906.0
007	cr uuu---uuuuu
008	230228s2020 xx \|\|\|\|\|o 00\| \|\|eng c
024	7		\|a 10.3390/cancers12123732 \|2 doi
035			\|a (DE-627)DOAJ061961787
035			\|a (DE-599)DOAJ9efaf71774b64c1ca576df0aafed587c
040			\|a DE-627 \|b ger \|c DE-627 \|e rakwb
041			\|a eng
050		0	\|a RC254-282
100	0		\|a Eleonora Bruno \|e verfasserin \|4 aut
245	1	2	\|a A Mediterranean Dietary Intervention in Female Carriers of BRCA Mutations: Results from an Italian Prospective Randomized Controlled Trial
264		1	\|c 2020
336			\|a Text \|b txt \|2 rdacontent
337			\|a Computermedien \|b c \|2 rdamedia
338			\|a Online-Ressource \|b cr \|2 rdacarrier
520			\|a <i<Background:</i< Women carriers of <i<BRCA1</i</<i<2</i< mutations face a high lifetime risk (penetrance) of developing breast and/or ovarian cancer. Insulin-like growth factor I (IGF-I), body weight and markers of insulin resistance affect BRCA penetrance. We conducted a multicenter prospective two-armed (1:1) randomized controlled trial (NCT03066856) to investigate whether a Mediterranean dietary intervention with moderate protein restriction reduces IGF-I and other metabolic modulators of BRCA penetrance. <i<Methods</i<: BRCA carriers, with or without a previous cancer, aged 18–70 years and without metastases were randomly assigned to an active dietary intervention group (IG) or to a control group (CG). The primary endpoint of the intervention was the IGF-I reduction. <i<Results</i<: 416 women (216 in the IG and 200 in the CG) concluded the six-month dietary intervention. The IG showed significantly lowered serum levels of IGF-I (−11.3 ng/mL versus −1.3 ng/mL, <i<p</i< = 0.02), weight (−1.5 Kg versus −0.5 Kg, <i<p</i< < 0.001), waist circumference (−2 cm versus −0.7 cm, <i<p</i< = 0.01), hip circumference (−1.6 cm versus −0.5 cm, <i<p</i< = 0.01), total cholesterol (−10.2 mg/dL versus −3.6 mg/dL, <i<p</i< = 0.04) and triglycerides (−8.7 mg/dL versus + 5.5 mg/dL, <i<p</i< = 0.01) with respect to the CG. <i<Conclusions</i<: A Mediterranean dietary intervention with moderate protein restriction is effective in reducing IGF-I and other potential modulators of BRCA penetrance.
650		4	\|a randomized controlled trial
650		4	\|a <i<BRCA1</i</<i<2</i< mutations
650		4	\|a mediterranean diet
650		4	\|a insulin-like growth factor I
650		4	\|a penetrance
650		4	\|a personalized medicine
653		0	\|a Neoplasms. Tumors. Oncology. Including cancer and carcinogens
700	0		\|a Andreina Oliverio \|e verfasserin \|4 aut
700	0		\|a Angelo Virgilio Paradiso \|e verfasserin \|4 aut
700	0		\|a Antonella Daniele \|e verfasserin \|4 aut
700	0		\|a Stefania Tommasi \|e verfasserin \|4 aut
700	0		\|a Antonio Tufaro \|e verfasserin \|4 aut
700	0		\|a Daniela Andreina Terribile \|e verfasserin \|4 aut
700	0		\|a Stefano Magno \|e verfasserin \|4 aut
700	0		\|a Alessio Filippone \|e verfasserin \|4 aut
700	0		\|a Elisabetta Venturelli \|e verfasserin \|4 aut
700	0		\|a Daniele Morelli \|e verfasserin \|4 aut
700	0		\|a Ivan Baldassari \|e verfasserin \|4 aut
700	0		\|a Maria Luisa Cravana \|e verfasserin \|4 aut
700	0		\|a Siranoush Manoukian \|e verfasserin \|4 aut
700	0		\|a Patrizia Pasanisi \|e verfasserin \|4 aut
773	0	8	\|i In \|t Cancers \|d MDPI AG, 2010 \|g 12(2020), 12, p 3732 \|w (DE-627)614095670 \|w (DE-600)2527080-1 \|x 20726694 \|7 nnns
773	1	8	\|g volume:12 \|g year:2020 \|g number:12, p 3732
856	4	0	\|u https://doi.org/10.3390/cancers12123732 \|z kostenfrei
856	4	0	\|u https://doaj.org/article/9efaf71774b64c1ca576df0aafed587c \|z kostenfrei
856	4	0	\|u https://www.mdpi.com/2072-6694/12/12/3732 \|z kostenfrei
856	4	2	\|u https://doaj.org/toc/2072-6694 \|y Journal toc \|z kostenfrei
912			\|a GBV_USEFLAG_A
912			\|a SYSFLAG_A
912			\|a GBV_DOAJ
912			\|a GBV_ILN_20
912			\|a GBV_ILN_22
912			\|a GBV_ILN_23
912			\|a GBV_ILN_24
912			\|a GBV_ILN_39
912			\|a GBV_ILN_40
912			\|a GBV_ILN_60
912			\|a GBV_ILN_62
912			\|a GBV_ILN_63
912			\|a GBV_ILN_65
912			\|a GBV_ILN_69
912			\|a GBV_ILN_73
912			\|a GBV_ILN_74
912			\|a GBV_ILN_95
912			\|a GBV_ILN_105
912			\|a GBV_ILN_110
912			\|a GBV_ILN_151
912			\|a GBV_ILN_161
912			\|a GBV_ILN_170
912			\|a GBV_ILN_206
912			\|a GBV_ILN_213
912			\|a GBV_ILN_230
912			\|a GBV_ILN_285
912			\|a GBV_ILN_293
912			\|a GBV_ILN_602
912			\|a GBV_ILN_2005
912			\|a GBV_ILN_2009
912			\|a GBV_ILN_2011
912			\|a GBV_ILN_2014
912			\|a GBV_ILN_2055
912			\|a GBV_ILN_2111
912			\|a GBV_ILN_4012
912			\|a GBV_ILN_4037
912			\|a GBV_ILN_4112
912			\|a GBV_ILN_4125
912			\|a GBV_ILN_4126
912			\|a GBV_ILN_4249
912			\|a GBV_ILN_4305
912			\|a GBV_ILN_4306
912			\|a GBV_ILN_4307
912			\|a GBV_ILN_4313
912			\|a GBV_ILN_4322
912			\|a GBV_ILN_4323
912			\|a GBV_ILN_4324
912			\|a GBV_ILN_4325
912			\|a GBV_ILN_4338
912			\|a GBV_ILN_4367
912			\|a GBV_ILN_4700
951			\|a AR
952			\|d 12 \|j 2020 \|e 12, p 3732

Indexfelder

author_variant	e b eb a o ao a v p avp a d ad s t st a t at d a t dat s m sm a f af e v ev d m dm i b ib m l c mlc s m sm p p pp
matchkey_str	article:20726694:2020----::mdtraenitritretoifmlcrirobcmttoseutfoaiainrse
hierarchy_sort_str	2020
callnumber-subject-code	RC
publishDate	2020
allfields	10.3390/cancers12123732 doi (DE-627)DOAJ061961787 (DE-599)DOAJ9efaf71774b64c1ca576df0aafed587c DE-627 ger DE-627 rakwb eng RC254-282 Eleonora Bruno verfasserin aut A Mediterranean Dietary Intervention in Female Carriers of BRCA Mutations: Results from an Italian Prospective Randomized Controlled Trial 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <i<Background:</i< Women carriers of <i<BRCA1</i</<i<2</i< mutations face a high lifetime risk (penetrance) of developing breast and/or ovarian cancer. Insulin-like growth factor I (IGF-I), body weight and markers of insulin resistance affect BRCA penetrance. We conducted a multicenter prospective two-armed (1:1) randomized controlled trial (NCT03066856) to investigate whether a Mediterranean dietary intervention with moderate protein restriction reduces IGF-I and other metabolic modulators of BRCA penetrance. <i<Methods</i<: BRCA carriers, with or without a previous cancer, aged 18–70 years and without metastases were randomly assigned to an active dietary intervention group (IG) or to a control group (CG). The primary endpoint of the intervention was the IGF-I reduction. <i<Results</i<: 416 women (216 in the IG and 200 in the CG) concluded the six-month dietary intervention. The IG showed significantly lowered serum levels of IGF-I (−11.3 ng/mL versus −1.3 ng/mL, <i<p</i< = 0.02), weight (−1.5 Kg versus −0.5 Kg, <i<p</i< < 0.001), waist circumference (−2 cm versus −0.7 cm, <i<p</i< = 0.01), hip circumference (−1.6 cm versus −0.5 cm, <i<p</i< = 0.01), total cholesterol (−10.2 mg/dL versus −3.6 mg/dL, <i<p</i< = 0.04) and triglycerides (−8.7 mg/dL versus + 5.5 mg/dL, <i<p</i< = 0.01) with respect to the CG. <i<Conclusions</i<: A Mediterranean dietary intervention with moderate protein restriction is effective in reducing IGF-I and other potential modulators of BRCA penetrance. randomized controlled trial <i<BRCA1</i</<i<2</i< mutations mediterranean diet insulin-like growth factor I penetrance personalized medicine Neoplasms. Tumors. Oncology. Including cancer and carcinogens Andreina Oliverio verfasserin aut Angelo Virgilio Paradiso verfasserin aut Antonella Daniele verfasserin aut Stefania Tommasi verfasserin aut Antonio Tufaro verfasserin aut Daniela Andreina Terribile verfasserin aut Stefano Magno verfasserin aut Alessio Filippone verfasserin aut Elisabetta Venturelli verfasserin aut Daniele Morelli verfasserin aut Ivan Baldassari verfasserin aut Maria Luisa Cravana verfasserin aut Siranoush Manoukian verfasserin aut Patrizia Pasanisi verfasserin aut In Cancers MDPI AG, 2010 12(2020), 12, p 3732 (DE-627)614095670 (DE-600)2527080-1 20726694 nnns volume:12 year:2020 number:12, p 3732 https://doi.org/10.3390/cancers12123732 kostenfrei https://doaj.org/article/9efaf71774b64c1ca576df0aafed587c kostenfrei https://www.mdpi.com/2072-6694/12/12/3732 kostenfrei https://doaj.org/toc/2072-6694 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2020 12, p 3732
spelling	10.3390/cancers12123732 doi (DE-627)DOAJ061961787 (DE-599)DOAJ9efaf71774b64c1ca576df0aafed587c DE-627 ger DE-627 rakwb eng RC254-282 Eleonora Bruno verfasserin aut A Mediterranean Dietary Intervention in Female Carriers of BRCA Mutations: Results from an Italian Prospective Randomized Controlled Trial 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <i<Background:</i< Women carriers of <i<BRCA1</i</<i<2</i< mutations face a high lifetime risk (penetrance) of developing breast and/or ovarian cancer. Insulin-like growth factor I (IGF-I), body weight and markers of insulin resistance affect BRCA penetrance. We conducted a multicenter prospective two-armed (1:1) randomized controlled trial (NCT03066856) to investigate whether a Mediterranean dietary intervention with moderate protein restriction reduces IGF-I and other metabolic modulators of BRCA penetrance. <i<Methods</i<: BRCA carriers, with or without a previous cancer, aged 18–70 years and without metastases were randomly assigned to an active dietary intervention group (IG) or to a control group (CG). The primary endpoint of the intervention was the IGF-I reduction. <i<Results</i<: 416 women (216 in the IG and 200 in the CG) concluded the six-month dietary intervention. The IG showed significantly lowered serum levels of IGF-I (−11.3 ng/mL versus −1.3 ng/mL, <i<p</i< = 0.02), weight (−1.5 Kg versus −0.5 Kg, <i<p</i< < 0.001), waist circumference (−2 cm versus −0.7 cm, <i<p</i< = 0.01), hip circumference (−1.6 cm versus −0.5 cm, <i<p</i< = 0.01), total cholesterol (−10.2 mg/dL versus −3.6 mg/dL, <i<p</i< = 0.04) and triglycerides (−8.7 mg/dL versus + 5.5 mg/dL, <i<p</i< = 0.01) with respect to the CG. <i<Conclusions</i<: A Mediterranean dietary intervention with moderate protein restriction is effective in reducing IGF-I and other potential modulators of BRCA penetrance. randomized controlled trial <i<BRCA1</i</<i<2</i< mutations mediterranean diet insulin-like growth factor I penetrance personalized medicine Neoplasms. Tumors. Oncology. Including cancer and carcinogens Andreina Oliverio verfasserin aut Angelo Virgilio Paradiso verfasserin aut Antonella Daniele verfasserin aut Stefania Tommasi verfasserin aut Antonio Tufaro verfasserin aut Daniela Andreina Terribile verfasserin aut Stefano Magno verfasserin aut Alessio Filippone verfasserin aut Elisabetta Venturelli verfasserin aut Daniele Morelli verfasserin aut Ivan Baldassari verfasserin aut Maria Luisa Cravana verfasserin aut Siranoush Manoukian verfasserin aut Patrizia Pasanisi verfasserin aut In Cancers MDPI AG, 2010 12(2020), 12, p 3732 (DE-627)614095670 (DE-600)2527080-1 20726694 nnns volume:12 year:2020 number:12, p 3732 https://doi.org/10.3390/cancers12123732 kostenfrei https://doaj.org/article/9efaf71774b64c1ca576df0aafed587c kostenfrei https://www.mdpi.com/2072-6694/12/12/3732 kostenfrei https://doaj.org/toc/2072-6694 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2020 12, p 3732
allfields_unstemmed	10.3390/cancers12123732 doi (DE-627)DOAJ061961787 (DE-599)DOAJ9efaf71774b64c1ca576df0aafed587c DE-627 ger DE-627 rakwb eng RC254-282 Eleonora Bruno verfasserin aut A Mediterranean Dietary Intervention in Female Carriers of BRCA Mutations: Results from an Italian Prospective Randomized Controlled Trial 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <i<Background:</i< Women carriers of <i<BRCA1</i</<i<2</i< mutations face a high lifetime risk (penetrance) of developing breast and/or ovarian cancer. Insulin-like growth factor I (IGF-I), body weight and markers of insulin resistance affect BRCA penetrance. We conducted a multicenter prospective two-armed (1:1) randomized controlled trial (NCT03066856) to investigate whether a Mediterranean dietary intervention with moderate protein restriction reduces IGF-I and other metabolic modulators of BRCA penetrance. <i<Methods</i<: BRCA carriers, with or without a previous cancer, aged 18–70 years and without metastases were randomly assigned to an active dietary intervention group (IG) or to a control group (CG). The primary endpoint of the intervention was the IGF-I reduction. <i<Results</i<: 416 women (216 in the IG and 200 in the CG) concluded the six-month dietary intervention. The IG showed significantly lowered serum levels of IGF-I (−11.3 ng/mL versus −1.3 ng/mL, <i<p</i< = 0.02), weight (−1.5 Kg versus −0.5 Kg, <i<p</i< < 0.001), waist circumference (−2 cm versus −0.7 cm, <i<p</i< = 0.01), hip circumference (−1.6 cm versus −0.5 cm, <i<p</i< = 0.01), total cholesterol (−10.2 mg/dL versus −3.6 mg/dL, <i<p</i< = 0.04) and triglycerides (−8.7 mg/dL versus + 5.5 mg/dL, <i<p</i< = 0.01) with respect to the CG. <i<Conclusions</i<: A Mediterranean dietary intervention with moderate protein restriction is effective in reducing IGF-I and other potential modulators of BRCA penetrance. randomized controlled trial <i<BRCA1</i</<i<2</i< mutations mediterranean diet insulin-like growth factor I penetrance personalized medicine Neoplasms. Tumors. Oncology. Including cancer and carcinogens Andreina Oliverio verfasserin aut Angelo Virgilio Paradiso verfasserin aut Antonella Daniele verfasserin aut Stefania Tommasi verfasserin aut Antonio Tufaro verfasserin aut Daniela Andreina Terribile verfasserin aut Stefano Magno verfasserin aut Alessio Filippone verfasserin aut Elisabetta Venturelli verfasserin aut Daniele Morelli verfasserin aut Ivan Baldassari verfasserin aut Maria Luisa Cravana verfasserin aut Siranoush Manoukian verfasserin aut Patrizia Pasanisi verfasserin aut In Cancers MDPI AG, 2010 12(2020), 12, p 3732 (DE-627)614095670 (DE-600)2527080-1 20726694 nnns volume:12 year:2020 number:12, p 3732 https://doi.org/10.3390/cancers12123732 kostenfrei https://doaj.org/article/9efaf71774b64c1ca576df0aafed587c kostenfrei https://www.mdpi.com/2072-6694/12/12/3732 kostenfrei https://doaj.org/toc/2072-6694 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2020 12, p 3732
allfieldsGer	10.3390/cancers12123732 doi (DE-627)DOAJ061961787 (DE-599)DOAJ9efaf71774b64c1ca576df0aafed587c DE-627 ger DE-627 rakwb eng RC254-282 Eleonora Bruno verfasserin aut A Mediterranean Dietary Intervention in Female Carriers of BRCA Mutations: Results from an Italian Prospective Randomized Controlled Trial 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <i<Background:</i< Women carriers of <i<BRCA1</i</<i<2</i< mutations face a high lifetime risk (penetrance) of developing breast and/or ovarian cancer. Insulin-like growth factor I (IGF-I), body weight and markers of insulin resistance affect BRCA penetrance. We conducted a multicenter prospective two-armed (1:1) randomized controlled trial (NCT03066856) to investigate whether a Mediterranean dietary intervention with moderate protein restriction reduces IGF-I and other metabolic modulators of BRCA penetrance. <i<Methods</i<: BRCA carriers, with or without a previous cancer, aged 18–70 years and without metastases were randomly assigned to an active dietary intervention group (IG) or to a control group (CG). The primary endpoint of the intervention was the IGF-I reduction. <i<Results</i<: 416 women (216 in the IG and 200 in the CG) concluded the six-month dietary intervention. The IG showed significantly lowered serum levels of IGF-I (−11.3 ng/mL versus −1.3 ng/mL, <i<p</i< = 0.02), weight (−1.5 Kg versus −0.5 Kg, <i<p</i< < 0.001), waist circumference (−2 cm versus −0.7 cm, <i<p</i< = 0.01), hip circumference (−1.6 cm versus −0.5 cm, <i<p</i< = 0.01), total cholesterol (−10.2 mg/dL versus −3.6 mg/dL, <i<p</i< = 0.04) and triglycerides (−8.7 mg/dL versus + 5.5 mg/dL, <i<p</i< = 0.01) with respect to the CG. <i<Conclusions</i<: A Mediterranean dietary intervention with moderate protein restriction is effective in reducing IGF-I and other potential modulators of BRCA penetrance. randomized controlled trial <i<BRCA1</i</<i<2</i< mutations mediterranean diet insulin-like growth factor I penetrance personalized medicine Neoplasms. Tumors. Oncology. Including cancer and carcinogens Andreina Oliverio verfasserin aut Angelo Virgilio Paradiso verfasserin aut Antonella Daniele verfasserin aut Stefania Tommasi verfasserin aut Antonio Tufaro verfasserin aut Daniela Andreina Terribile verfasserin aut Stefano Magno verfasserin aut Alessio Filippone verfasserin aut Elisabetta Venturelli verfasserin aut Daniele Morelli verfasserin aut Ivan Baldassari verfasserin aut Maria Luisa Cravana verfasserin aut Siranoush Manoukian verfasserin aut Patrizia Pasanisi verfasserin aut In Cancers MDPI AG, 2010 12(2020), 12, p 3732 (DE-627)614095670 (DE-600)2527080-1 20726694 nnns volume:12 year:2020 number:12, p 3732 https://doi.org/10.3390/cancers12123732 kostenfrei https://doaj.org/article/9efaf71774b64c1ca576df0aafed587c kostenfrei https://www.mdpi.com/2072-6694/12/12/3732 kostenfrei https://doaj.org/toc/2072-6694 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2020 12, p 3732
allfieldsSound	10.3390/cancers12123732 doi (DE-627)DOAJ061961787 (DE-599)DOAJ9efaf71774b64c1ca576df0aafed587c DE-627 ger DE-627 rakwb eng RC254-282 Eleonora Bruno verfasserin aut A Mediterranean Dietary Intervention in Female Carriers of BRCA Mutations: Results from an Italian Prospective Randomized Controlled Trial 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <i<Background:</i< Women carriers of <i<BRCA1</i</<i<2</i< mutations face a high lifetime risk (penetrance) of developing breast and/or ovarian cancer. Insulin-like growth factor I (IGF-I), body weight and markers of insulin resistance affect BRCA penetrance. We conducted a multicenter prospective two-armed (1:1) randomized controlled trial (NCT03066856) to investigate whether a Mediterranean dietary intervention with moderate protein restriction reduces IGF-I and other metabolic modulators of BRCA penetrance. <i<Methods</i<: BRCA carriers, with or without a previous cancer, aged 18–70 years and without metastases were randomly assigned to an active dietary intervention group (IG) or to a control group (CG). The primary endpoint of the intervention was the IGF-I reduction. <i<Results</i<: 416 women (216 in the IG and 200 in the CG) concluded the six-month dietary intervention. The IG showed significantly lowered serum levels of IGF-I (−11.3 ng/mL versus −1.3 ng/mL, <i<p</i< = 0.02), weight (−1.5 Kg versus −0.5 Kg, <i<p</i< < 0.001), waist circumference (−2 cm versus −0.7 cm, <i<p</i< = 0.01), hip circumference (−1.6 cm versus −0.5 cm, <i<p</i< = 0.01), total cholesterol (−10.2 mg/dL versus −3.6 mg/dL, <i<p</i< = 0.04) and triglycerides (−8.7 mg/dL versus + 5.5 mg/dL, <i<p</i< = 0.01) with respect to the CG. <i<Conclusions</i<: A Mediterranean dietary intervention with moderate protein restriction is effective in reducing IGF-I and other potential modulators of BRCA penetrance. randomized controlled trial <i<BRCA1</i</<i<2</i< mutations mediterranean diet insulin-like growth factor I penetrance personalized medicine Neoplasms. Tumors. Oncology. Including cancer and carcinogens Andreina Oliverio verfasserin aut Angelo Virgilio Paradiso verfasserin aut Antonella Daniele verfasserin aut Stefania Tommasi verfasserin aut Antonio Tufaro verfasserin aut Daniela Andreina Terribile verfasserin aut Stefano Magno verfasserin aut Alessio Filippone verfasserin aut Elisabetta Venturelli verfasserin aut Daniele Morelli verfasserin aut Ivan Baldassari verfasserin aut Maria Luisa Cravana verfasserin aut Siranoush Manoukian verfasserin aut Patrizia Pasanisi verfasserin aut In Cancers MDPI AG, 2010 12(2020), 12, p 3732 (DE-627)614095670 (DE-600)2527080-1 20726694 nnns volume:12 year:2020 number:12, p 3732 https://doi.org/10.3390/cancers12123732 kostenfrei https://doaj.org/article/9efaf71774b64c1ca576df0aafed587c kostenfrei https://www.mdpi.com/2072-6694/12/12/3732 kostenfrei https://doaj.org/toc/2072-6694 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2020 12, p 3732
language	English
source	In Cancers 12(2020), 12, p 3732 volume:12 year:2020 number:12, p 3732
sourceStr	In Cancers 12(2020), 12, p 3732 volume:12 year:2020 number:12, p 3732
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	randomized controlled trial <i<BRCA1</i</<i<2</i< mutations mediterranean diet insulin-like growth factor I penetrance personalized medicine Neoplasms. Tumors. Oncology. Including cancer and carcinogens
isfreeaccess_bool	true
container_title	Cancers
authorswithroles_txt_mv	Eleonora Bruno @@aut@@ Andreina Oliverio @@aut@@ Angelo Virgilio Paradiso @@aut@@ Antonella Daniele @@aut@@ Stefania Tommasi @@aut@@ Antonio Tufaro @@aut@@ Daniela Andreina Terribile @@aut@@ Stefano Magno @@aut@@ Alessio Filippone @@aut@@ Elisabetta Venturelli @@aut@@ Daniele Morelli @@aut@@ Ivan Baldassari @@aut@@ Maria Luisa Cravana @@aut@@ Siranoush Manoukian @@aut@@ Patrizia Pasanisi @@aut@@
publishDateDaySort_date	2020-01-01T00:00:00Z
hierarchy_top_id	614095670
id	DOAJ061961787
language_de	englisch
fullrecord	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">DOAJ061961787</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20240412205906.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230228s2020 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.3390/cancers12123732</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)DOAJ061961787</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DOAJ9efaf71774b64c1ca576df0aafed587c</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">RC254-282</subfield></datafield><datafield tag="100" ind1="0" ind2=" "><subfield code="a">Eleonora Bruno</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="2"><subfield code="a">A Mediterranean Dietary Intervention in Female Carriers of BRCA Mutations: Results from an Italian Prospective Randomized Controlled Trial</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2020</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a"><i<Background:</i< Women carriers of <i<BRCA1</i</<i<2</i< mutations face a high lifetime risk (penetrance) of developing breast and/or ovarian cancer. Insulin-like growth factor I (IGF-I), body weight and markers of insulin resistance affect BRCA penetrance. We conducted a multicenter prospective two-armed (1:1) randomized controlled trial (NCT03066856) to investigate whether a Mediterranean dietary intervention with moderate protein restriction reduces IGF-I and other metabolic modulators of BRCA penetrance. <i<Methods</i<: BRCA carriers, with or without a previous cancer, aged 18–70 years and without metastases were randomly assigned to an active dietary intervention group (IG) or to a control group (CG). The primary endpoint of the intervention was the IGF-I reduction. <i<Results</i<: 416 women (216 in the IG and 200 in the CG) concluded the six-month dietary intervention. The IG showed significantly lowered serum levels of IGF-I (−11.3 ng/mL versus −1.3 ng/mL, <i<p</i< = 0.02), weight (−1.5 Kg versus −0.5 Kg, <i<p</i< < 0.001), waist circumference (−2 cm versus −0.7 cm, <i<p</i< = 0.01), hip circumference (−1.6 cm versus −0.5 cm, <i<p</i< = 0.01), total cholesterol (−10.2 mg/dL versus −3.6 mg/dL, <i<p</i< = 0.04) and triglycerides (−8.7 mg/dL versus + 5.5 mg/dL, <i<p</i< = 0.01) with respect to the CG. <i<Conclusions</i<: A Mediterranean dietary intervention with moderate protein restriction is effective in reducing IGF-I and other potential modulators of BRCA penetrance.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">randomized controlled trial</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a"><i<BRCA1</i</<i<2</i< mutations</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">mediterranean diet</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">insulin-like growth factor I</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">penetrance</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">personalized medicine</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Neoplasms. Tumors. Oncology. Including cancer and carcinogens</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Andreina Oliverio</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Angelo Virgilio Paradiso</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Antonella Daniele</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Stefania Tommasi</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Antonio Tufaro</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Daniela Andreina Terribile</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Stefano Magno</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Alessio Filippone</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Elisabetta Venturelli</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Daniele Morelli</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Ivan Baldassari</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Maria Luisa Cravana</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Siranoush Manoukian</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Patrizia Pasanisi</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">In</subfield><subfield code="t">Cancers</subfield><subfield code="d">MDPI AG, 2010</subfield><subfield code="g">12(2020), 12, p 3732</subfield><subfield code="w">(DE-627)614095670</subfield><subfield code="w">(DE-600)2527080-1</subfield><subfield code="x">20726694</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:12</subfield><subfield code="g">year:2020</subfield><subfield code="g">number:12, p 3732</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doi.org/10.3390/cancers12123732</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doaj.org/article/9efaf71774b64c1ca576df0aafed587c</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://www.mdpi.com/2072-6694/12/12/3732</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="u">https://doaj.org/toc/2072-6694</subfield><subfield code="y">Journal toc</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_DOAJ</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_20</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_22</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_23</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_24</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_39</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_40</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_60</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_62</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_63</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_65</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_69</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_73</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_74</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_95</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_105</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_110</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_151</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_161</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_170</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_206</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_213</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_230</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_285</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_293</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_602</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2005</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2009</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2011</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2014</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2055</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2111</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4012</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4037</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4112</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4125</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4126</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4249</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4305</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4306</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4307</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4313</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4322</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4323</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4324</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4325</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4338</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4367</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4700</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">12</subfield><subfield code="j">2020</subfield><subfield code="e">12, p 3732</subfield></datafield></record></collection>
callnumber-first	R - Medicine
author	Eleonora Bruno
spellingShingle	Eleonora Bruno misc RC254-282 misc randomized controlled trial misc <i<BRCA1</i</<i<2</i< mutations misc mediterranean diet misc insulin-like growth factor I misc penetrance misc personalized medicine misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens A Mediterranean Dietary Intervention in Female Carriers of BRCA Mutations: Results from an Italian Prospective Randomized Controlled Trial
authorStr	Eleonora Bruno
ppnlink_with_tag_str_mv	@@773@@(DE-627)614095670
format	electronic Article
delete_txt_mv	keep
author_role	aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut
collection	DOAJ
remote_str	true
callnumber-label	RC254-282
illustrated	Not Illustrated
issn	20726694
topic_title	RC254-282 A Mediterranean Dietary Intervention in Female Carriers of BRCA Mutations: Results from an Italian Prospective Randomized Controlled Trial randomized controlled trial <i<BRCA1</i</<i<2</i< mutations mediterranean diet insulin-like growth factor I penetrance personalized medicine
topic	misc RC254-282 misc randomized controlled trial misc <i<BRCA1</i</<i<2</i< mutations misc mediterranean diet misc insulin-like growth factor I misc penetrance misc personalized medicine misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_unstemmed	misc RC254-282 misc randomized controlled trial misc <i<BRCA1</i</<i<2</i< mutations misc mediterranean diet misc insulin-like growth factor I misc penetrance misc personalized medicine misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_browse	misc RC254-282 misc randomized controlled trial misc <i<BRCA1</i</<i<2</i< mutations misc mediterranean diet misc insulin-like growth factor I misc penetrance misc personalized medicine misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
format_facet	Elektronische Aufsätze Aufsätze Elektronische Ressource
format_main_str_mv	Text Zeitschrift/Artikel
carriertype_str_mv	cr
hierarchy_parent_title	Cancers
hierarchy_parent_id	614095670
hierarchy_top_title	Cancers
isfreeaccess_txt	true
familylinks_str_mv	(DE-627)614095670 (DE-600)2527080-1
title	A Mediterranean Dietary Intervention in Female Carriers of BRCA Mutations: Results from an Italian Prospective Randomized Controlled Trial
ctrlnum	(DE-627)DOAJ061961787 (DE-599)DOAJ9efaf71774b64c1ca576df0aafed587c
title_full	A Mediterranean Dietary Intervention in Female Carriers of BRCA Mutations: Results from an Italian Prospective Randomized Controlled Trial
author_sort	Eleonora Bruno
journal	Cancers
journalStr	Cancers
callnumber-first-code	R
lang_code	eng
isOA_bool	true
recordtype	marc
publishDateSort	2020
contenttype_str_mv	txt
author_browse	Eleonora Bruno Andreina Oliverio Angelo Virgilio Paradiso Antonella Daniele Stefania Tommasi Antonio Tufaro Daniela Andreina Terribile Stefano Magno Alessio Filippone Elisabetta Venturelli Daniele Morelli Ivan Baldassari Maria Luisa Cravana Siranoush Manoukian Patrizia Pasanisi
container_volume	12
class	RC254-282
format_se	Elektronische Aufsätze
author-letter	Eleonora Bruno
doi_str_mv	10.3390/cancers12123732
author2-role	verfasserin
title_sort	mediterranean dietary intervention in female carriers of brca mutations: results from an italian prospective randomized controlled trial
callnumber	RC254-282
title_auth	A Mediterranean Dietary Intervention in Female Carriers of BRCA Mutations: Results from an Italian Prospective Randomized Controlled Trial
abstract	<i<Background:</i< Women carriers of <i<BRCA1</i</<i<2</i< mutations face a high lifetime risk (penetrance) of developing breast and/or ovarian cancer. Insulin-like growth factor I (IGF-I), body weight and markers of insulin resistance affect BRCA penetrance. We conducted a multicenter prospective two-armed (1:1) randomized controlled trial (NCT03066856) to investigate whether a Mediterranean dietary intervention with moderate protein restriction reduces IGF-I and other metabolic modulators of BRCA penetrance. <i<Methods</i<: BRCA carriers, with or without a previous cancer, aged 18–70 years and without metastases were randomly assigned to an active dietary intervention group (IG) or to a control group (CG). The primary endpoint of the intervention was the IGF-I reduction. <i<Results</i<: 416 women (216 in the IG and 200 in the CG) concluded the six-month dietary intervention. The IG showed significantly lowered serum levels of IGF-I (−11.3 ng/mL versus −1.3 ng/mL, <i<p</i< = 0.02), weight (−1.5 Kg versus −0.5 Kg, <i<p</i< < 0.001), waist circumference (−2 cm versus −0.7 cm, <i<p</i< = 0.01), hip circumference (−1.6 cm versus −0.5 cm, <i<p</i< = 0.01), total cholesterol (−10.2 mg/dL versus −3.6 mg/dL, <i<p</i< = 0.04) and triglycerides (−8.7 mg/dL versus + 5.5 mg/dL, <i<p</i< = 0.01) with respect to the CG. <i<Conclusions</i<: A Mediterranean dietary intervention with moderate protein restriction is effective in reducing IGF-I and other potential modulators of BRCA penetrance.
abstractGer	<i<Background:</i< Women carriers of <i<BRCA1</i</<i<2</i< mutations face a high lifetime risk (penetrance) of developing breast and/or ovarian cancer. Insulin-like growth factor I (IGF-I), body weight and markers of insulin resistance affect BRCA penetrance. We conducted a multicenter prospective two-armed (1:1) randomized controlled trial (NCT03066856) to investigate whether a Mediterranean dietary intervention with moderate protein restriction reduces IGF-I and other metabolic modulators of BRCA penetrance. <i<Methods</i<: BRCA carriers, with or without a previous cancer, aged 18–70 years and without metastases were randomly assigned to an active dietary intervention group (IG) or to a control group (CG). The primary endpoint of the intervention was the IGF-I reduction. <i<Results</i<: 416 women (216 in the IG and 200 in the CG) concluded the six-month dietary intervention. The IG showed significantly lowered serum levels of IGF-I (−11.3 ng/mL versus −1.3 ng/mL, <i<p</i< = 0.02), weight (−1.5 Kg versus −0.5 Kg, <i<p</i< < 0.001), waist circumference (−2 cm versus −0.7 cm, <i<p</i< = 0.01), hip circumference (−1.6 cm versus −0.5 cm, <i<p</i< = 0.01), total cholesterol (−10.2 mg/dL versus −3.6 mg/dL, <i<p</i< = 0.04) and triglycerides (−8.7 mg/dL versus + 5.5 mg/dL, <i<p</i< = 0.01) with respect to the CG. <i<Conclusions</i<: A Mediterranean dietary intervention with moderate protein restriction is effective in reducing IGF-I and other potential modulators of BRCA penetrance.
abstract_unstemmed	<i<Background:</i< Women carriers of <i<BRCA1</i</<i<2</i< mutations face a high lifetime risk (penetrance) of developing breast and/or ovarian cancer. Insulin-like growth factor I (IGF-I), body weight and markers of insulin resistance affect BRCA penetrance. We conducted a multicenter prospective two-armed (1:1) randomized controlled trial (NCT03066856) to investigate whether a Mediterranean dietary intervention with moderate protein restriction reduces IGF-I and other metabolic modulators of BRCA penetrance. <i<Methods</i<: BRCA carriers, with or without a previous cancer, aged 18–70 years and without metastases were randomly assigned to an active dietary intervention group (IG) or to a control group (CG). The primary endpoint of the intervention was the IGF-I reduction. <i<Results</i<: 416 women (216 in the IG and 200 in the CG) concluded the six-month dietary intervention. The IG showed significantly lowered serum levels of IGF-I (−11.3 ng/mL versus −1.3 ng/mL, <i<p</i< = 0.02), weight (−1.5 Kg versus −0.5 Kg, <i<p</i< < 0.001), waist circumference (−2 cm versus −0.7 cm, <i<p</i< = 0.01), hip circumference (−1.6 cm versus −0.5 cm, <i<p</i< = 0.01), total cholesterol (−10.2 mg/dL versus −3.6 mg/dL, <i<p</i< = 0.04) and triglycerides (−8.7 mg/dL versus + 5.5 mg/dL, <i<p</i< = 0.01) with respect to the CG. <i<Conclusions</i<: A Mediterranean dietary intervention with moderate protein restriction is effective in reducing IGF-I and other potential modulators of BRCA penetrance.
collection_details	GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700
container_issue	12, p 3732
title_short	A Mediterranean Dietary Intervention in Female Carriers of BRCA Mutations: Results from an Italian Prospective Randomized Controlled Trial
url	https://doi.org/10.3390/cancers12123732 https://doaj.org/article/9efaf71774b64c1ca576df0aafed587c https://www.mdpi.com/2072-6694/12/12/3732 https://doaj.org/toc/2072-6694
remote_bool	true
author2	Andreina Oliverio Angelo Virgilio Paradiso Antonella Daniele Stefania Tommasi Antonio Tufaro Daniela Andreina Terribile Stefano Magno Alessio Filippone Elisabetta Venturelli Daniele Morelli Ivan Baldassari Maria Luisa Cravana Siranoush Manoukian Patrizia Pasanisi
author2Str	Andreina Oliverio Angelo Virgilio Paradiso Antonella Daniele Stefania Tommasi Antonio Tufaro Daniela Andreina Terribile Stefano Magno Alessio Filippone Elisabetta Venturelli Daniele Morelli Ivan Baldassari Maria Luisa Cravana Siranoush Manoukian Patrizia Pasanisi
ppnlink	614095670
callnumber-subject	RC - Internal Medicine
mediatype_str_mv	c
isOA_txt	true
hochschulschrift_bool	false
doi_str	10.3390/cancers12123732
callnumber-a	RC254-282
up_date	2024-07-03T23:37:29.908Z
_version_	1803602991422373888
fullrecord_marcxml	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">DOAJ061961787</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20240412205906.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230228s2020 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.3390/cancers12123732</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)DOAJ061961787</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DOAJ9efaf71774b64c1ca576df0aafed587c</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">RC254-282</subfield></datafield><datafield tag="100" ind1="0" ind2=" "><subfield code="a">Eleonora Bruno</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="2"><subfield code="a">A Mediterranean Dietary Intervention in Female Carriers of BRCA Mutations: Results from an Italian Prospective Randomized Controlled Trial</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2020</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a"><i<Background:</i< Women carriers of <i<BRCA1</i</<i<2</i< mutations face a high lifetime risk (penetrance) of developing breast and/or ovarian cancer. Insulin-like growth factor I (IGF-I), body weight and markers of insulin resistance affect BRCA penetrance. We conducted a multicenter prospective two-armed (1:1) randomized controlled trial (NCT03066856) to investigate whether a Mediterranean dietary intervention with moderate protein restriction reduces IGF-I and other metabolic modulators of BRCA penetrance. <i<Methods</i<: BRCA carriers, with or without a previous cancer, aged 18–70 years and without metastases were randomly assigned to an active dietary intervention group (IG) or to a control group (CG). The primary endpoint of the intervention was the IGF-I reduction. <i<Results</i<: 416 women (216 in the IG and 200 in the CG) concluded the six-month dietary intervention. The IG showed significantly lowered serum levels of IGF-I (−11.3 ng/mL versus −1.3 ng/mL, <i<p</i< = 0.02), weight (−1.5 Kg versus −0.5 Kg, <i<p</i< < 0.001), waist circumference (−2 cm versus −0.7 cm, <i<p</i< = 0.01), hip circumference (−1.6 cm versus −0.5 cm, <i<p</i< = 0.01), total cholesterol (−10.2 mg/dL versus −3.6 mg/dL, <i<p</i< = 0.04) and triglycerides (−8.7 mg/dL versus + 5.5 mg/dL, <i<p</i< = 0.01) with respect to the CG. <i<Conclusions</i<: A Mediterranean dietary intervention with moderate protein restriction is effective in reducing IGF-I and other potential modulators of BRCA penetrance.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">randomized controlled trial</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a"><i<BRCA1</i</<i<2</i< mutations</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">mediterranean diet</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">insulin-like growth factor I</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">penetrance</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">personalized medicine</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Neoplasms. Tumors. Oncology. Including cancer and carcinogens</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Andreina Oliverio</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Angelo Virgilio Paradiso</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Antonella Daniele</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Stefania Tommasi</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Antonio Tufaro</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Daniela Andreina Terribile</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Stefano Magno</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Alessio Filippone</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Elisabetta Venturelli</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Daniele Morelli</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Ivan Baldassari</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Maria Luisa Cravana</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Siranoush Manoukian</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Patrizia Pasanisi</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">In</subfield><subfield code="t">Cancers</subfield><subfield code="d">MDPI AG, 2010</subfield><subfield code="g">12(2020), 12, p 3732</subfield><subfield code="w">(DE-627)614095670</subfield><subfield code="w">(DE-600)2527080-1</subfield><subfield code="x">20726694</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:12</subfield><subfield code="g">year:2020</subfield><subfield code="g">number:12, p 3732</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doi.org/10.3390/cancers12123732</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doaj.org/article/9efaf71774b64c1ca576df0aafed587c</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://www.mdpi.com/2072-6694/12/12/3732</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="u">https://doaj.org/toc/2072-6694</subfield><subfield code="y">Journal toc</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_DOAJ</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_20</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_22</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_23</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_24</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_39</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_40</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_60</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_62</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_63</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_65</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_69</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_73</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_74</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_95</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_105</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_110</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_151</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_161</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_170</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_206</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_213</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_230</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_285</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_293</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_602</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2005</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2009</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2011</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2014</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2055</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2111</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4012</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4037</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4112</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4125</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4126</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4249</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4305</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4306</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4307</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4313</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4322</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4323</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4324</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4325</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4338</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4367</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4700</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">12</subfield><subfield code="j">2020</subfield><subfield code="e">12, p 3732</subfield></datafield></record></collection>
score	7.400876

Nicht das Richtige dabei?

Schreiben Sie uns!

A Mediterranean Dietary Intervention in Female Carriers of BRCA Mutations: Results from an Italian Prospective Randomized Controlled Trial

Nicht das Richtige dabei?

Zugang & Verfügbarkeit

Vorhandene Bände

Nicht das Richtige dabei?