Association of and gene polymorphisms with methotrexate efficacy and toxicity in Chinese Han patients with rheumatoid arthritis

Objective The objective was to explore the association of methylene tetrahydrofolate reductase ( MTHFR ) C667T and A1298C and reduced folate carrier 1 ( RFC-1 ) A80G single nucleotide polymorphisms (SNP) with rheumatoid arthritis (RA) and efficacy and toxicity of methotrexate (MTX) treatment in Chin...
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Autor*in:	Shengli Wang [verfasserIn] Shuguang Zuo [verfasserIn] Zhigang Liu [verfasserIn] Xinying Ji [verfasserIn] Zhenqiang Yao [verfasserIn] Xinchun Wang [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Übergeordnetes Werk:	In: Journal of International Medical Research - SAGE Publishing, 2015, 48(2020)
Übergeordnetes Werk:	volume:48 ; year:2020

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1177/0300060519879588

Katalog-ID:	DOAJ061986518

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520			\|a Objective The objective was to explore the association of methylene tetrahydrofolate reductase ( MTHFR ) C667T and A1298C and reduced folate carrier 1 ( RFC-1 ) A80G single nucleotide polymorphisms (SNP) with rheumatoid arthritis (RA) and efficacy and toxicity of methotrexate (MTX) treatment in Chinese Han patients in Henan, China. Methods Two hundred ninety-six patients with RA were enrolled (cases) and 120 healthy individuals served as controls. The genotypes of MTHFR C667T and A1298C SNP and RFC-1 A80G SNP were detected by restriction fragment length polymorphism-PCR and compared between cases and controls. We analyzed correlations of clinical effect, toxicity, and SNPs after 6 months of MTX treatment. Results We detected no significant differences in MTHFR C677T and A1298C and RFC-1 A80G SNPs between cases and controls. The RFC-1 A80G SNP differed between RA patients with good and poor efficacy after 6 months of MTX, and was an independent factor of MTX efficacy. The MTHFR C677T SNP was differently distributed in the adverse drug reaction (ADR) and non-ADR groups and was an independent factor of MTX toxicity. Conclusions In Chinese Han patients with RA, the MTHFR C667T SNP may correlate with MTX toxicity, whereas the RFC-1 A80G SNP may correlate with MTX efficacy rather than toxicity.
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allfields	10.1177/0300060519879588 doi (DE-627)DOAJ061986518 (DE-599)DOAJ85de94a5d8904a57ba1c26b99bc9ecb3 DE-627 ger DE-627 rakwb eng R5-920 Shengli Wang verfasserin aut Association of and gene polymorphisms with methotrexate efficacy and toxicity in Chinese Han patients with rheumatoid arthritis 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective The objective was to explore the association of methylene tetrahydrofolate reductase ( MTHFR ) C667T and A1298C and reduced folate carrier 1 ( RFC-1 ) A80G single nucleotide polymorphisms (SNP) with rheumatoid arthritis (RA) and efficacy and toxicity of methotrexate (MTX) treatment in Chinese Han patients in Henan, China. Methods Two hundred ninety-six patients with RA were enrolled (cases) and 120 healthy individuals served as controls. The genotypes of MTHFR C667T and A1298C SNP and RFC-1 A80G SNP were detected by restriction fragment length polymorphism-PCR and compared between cases and controls. We analyzed correlations of clinical effect, toxicity, and SNPs after 6 months of MTX treatment. Results We detected no significant differences in MTHFR C677T and A1298C and RFC-1 A80G SNPs between cases and controls. The RFC-1 A80G SNP differed between RA patients with good and poor efficacy after 6 months of MTX, and was an independent factor of MTX efficacy. The MTHFR C677T SNP was differently distributed in the adverse drug reaction (ADR) and non-ADR groups and was an independent factor of MTX toxicity. Conclusions In Chinese Han patients with RA, the MTHFR C667T SNP may correlate with MTX toxicity, whereas the RFC-1 A80G SNP may correlate with MTX efficacy rather than toxicity. Medicine (General) Shuguang Zuo verfasserin aut Zhigang Liu verfasserin aut Xinying Ji verfasserin aut Zhenqiang Yao verfasserin aut Xinchun Wang verfasserin aut In Journal of International Medical Research SAGE Publishing, 2015 48(2020) (DE-627)350260621 (DE-600)2082422-1 14732300 nnns volume:48 year:2020 https://doi.org/10.1177/0300060519879588 kostenfrei https://doaj.org/article/85de94a5d8904a57ba1c26b99bc9ecb3 kostenfrei https://doi.org/10.1177/0300060519879588 kostenfrei https://doaj.org/toc/1473-2300 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_374 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2704 GBV_ILN_2707 GBV_ILN_2889 GBV_ILN_2890 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 48 2020
spelling	10.1177/0300060519879588 doi (DE-627)DOAJ061986518 (DE-599)DOAJ85de94a5d8904a57ba1c26b99bc9ecb3 DE-627 ger DE-627 rakwb eng R5-920 Shengli Wang verfasserin aut Association of and gene polymorphisms with methotrexate efficacy and toxicity in Chinese Han patients with rheumatoid arthritis 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective The objective was to explore the association of methylene tetrahydrofolate reductase ( MTHFR ) C667T and A1298C and reduced folate carrier 1 ( RFC-1 ) A80G single nucleotide polymorphisms (SNP) with rheumatoid arthritis (RA) and efficacy and toxicity of methotrexate (MTX) treatment in Chinese Han patients in Henan, China. Methods Two hundred ninety-six patients with RA were enrolled (cases) and 120 healthy individuals served as controls. The genotypes of MTHFR C667T and A1298C SNP and RFC-1 A80G SNP were detected by restriction fragment length polymorphism-PCR and compared between cases and controls. We analyzed correlations of clinical effect, toxicity, and SNPs after 6 months of MTX treatment. Results We detected no significant differences in MTHFR C677T and A1298C and RFC-1 A80G SNPs between cases and controls. The RFC-1 A80G SNP differed between RA patients with good and poor efficacy after 6 months of MTX, and was an independent factor of MTX efficacy. The MTHFR C677T SNP was differently distributed in the adverse drug reaction (ADR) and non-ADR groups and was an independent factor of MTX toxicity. Conclusions In Chinese Han patients with RA, the MTHFR C667T SNP may correlate with MTX toxicity, whereas the RFC-1 A80G SNP may correlate with MTX efficacy rather than toxicity. Medicine (General) Shuguang Zuo verfasserin aut Zhigang Liu verfasserin aut Xinying Ji verfasserin aut Zhenqiang Yao verfasserin aut Xinchun Wang verfasserin aut In Journal of International Medical Research SAGE Publishing, 2015 48(2020) (DE-627)350260621 (DE-600)2082422-1 14732300 nnns volume:48 year:2020 https://doi.org/10.1177/0300060519879588 kostenfrei https://doaj.org/article/85de94a5d8904a57ba1c26b99bc9ecb3 kostenfrei https://doi.org/10.1177/0300060519879588 kostenfrei https://doaj.org/toc/1473-2300 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_374 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2704 GBV_ILN_2707 GBV_ILN_2889 GBV_ILN_2890 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 48 2020
allfields_unstemmed	10.1177/0300060519879588 doi (DE-627)DOAJ061986518 (DE-599)DOAJ85de94a5d8904a57ba1c26b99bc9ecb3 DE-627 ger DE-627 rakwb eng R5-920 Shengli Wang verfasserin aut Association of and gene polymorphisms with methotrexate efficacy and toxicity in Chinese Han patients with rheumatoid arthritis 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective The objective was to explore the association of methylene tetrahydrofolate reductase ( MTHFR ) C667T and A1298C and reduced folate carrier 1 ( RFC-1 ) A80G single nucleotide polymorphisms (SNP) with rheumatoid arthritis (RA) and efficacy and toxicity of methotrexate (MTX) treatment in Chinese Han patients in Henan, China. Methods Two hundred ninety-six patients with RA were enrolled (cases) and 120 healthy individuals served as controls. The genotypes of MTHFR C667T and A1298C SNP and RFC-1 A80G SNP were detected by restriction fragment length polymorphism-PCR and compared between cases and controls. We analyzed correlations of clinical effect, toxicity, and SNPs after 6 months of MTX treatment. Results We detected no significant differences in MTHFR C677T and A1298C and RFC-1 A80G SNPs between cases and controls. The RFC-1 A80G SNP differed between RA patients with good and poor efficacy after 6 months of MTX, and was an independent factor of MTX efficacy. The MTHFR C677T SNP was differently distributed in the adverse drug reaction (ADR) and non-ADR groups and was an independent factor of MTX toxicity. Conclusions In Chinese Han patients with RA, the MTHFR C667T SNP may correlate with MTX toxicity, whereas the RFC-1 A80G SNP may correlate with MTX efficacy rather than toxicity. Medicine (General) Shuguang Zuo verfasserin aut Zhigang Liu verfasserin aut Xinying Ji verfasserin aut Zhenqiang Yao verfasserin aut Xinchun Wang verfasserin aut In Journal of International Medical Research SAGE Publishing, 2015 48(2020) (DE-627)350260621 (DE-600)2082422-1 14732300 nnns volume:48 year:2020 https://doi.org/10.1177/0300060519879588 kostenfrei https://doaj.org/article/85de94a5d8904a57ba1c26b99bc9ecb3 kostenfrei https://doi.org/10.1177/0300060519879588 kostenfrei https://doaj.org/toc/1473-2300 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_374 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2704 GBV_ILN_2707 GBV_ILN_2889 GBV_ILN_2890 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 48 2020
allfieldsGer	10.1177/0300060519879588 doi (DE-627)DOAJ061986518 (DE-599)DOAJ85de94a5d8904a57ba1c26b99bc9ecb3 DE-627 ger DE-627 rakwb eng R5-920 Shengli Wang verfasserin aut Association of and gene polymorphisms with methotrexate efficacy and toxicity in Chinese Han patients with rheumatoid arthritis 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective The objective was to explore the association of methylene tetrahydrofolate reductase ( MTHFR ) C667T and A1298C and reduced folate carrier 1 ( RFC-1 ) A80G single nucleotide polymorphisms (SNP) with rheumatoid arthritis (RA) and efficacy and toxicity of methotrexate (MTX) treatment in Chinese Han patients in Henan, China. Methods Two hundred ninety-six patients with RA were enrolled (cases) and 120 healthy individuals served as controls. The genotypes of MTHFR C667T and A1298C SNP and RFC-1 A80G SNP were detected by restriction fragment length polymorphism-PCR and compared between cases and controls. We analyzed correlations of clinical effect, toxicity, and SNPs after 6 months of MTX treatment. Results We detected no significant differences in MTHFR C677T and A1298C and RFC-1 A80G SNPs between cases and controls. The RFC-1 A80G SNP differed between RA patients with good and poor efficacy after 6 months of MTX, and was an independent factor of MTX efficacy. The MTHFR C677T SNP was differently distributed in the adverse drug reaction (ADR) and non-ADR groups and was an independent factor of MTX toxicity. Conclusions In Chinese Han patients with RA, the MTHFR C667T SNP may correlate with MTX toxicity, whereas the RFC-1 A80G SNP may correlate with MTX efficacy rather than toxicity. Medicine (General) Shuguang Zuo verfasserin aut Zhigang Liu verfasserin aut Xinying Ji verfasserin aut Zhenqiang Yao verfasserin aut Xinchun Wang verfasserin aut In Journal of International Medical Research SAGE Publishing, 2015 48(2020) (DE-627)350260621 (DE-600)2082422-1 14732300 nnns volume:48 year:2020 https://doi.org/10.1177/0300060519879588 kostenfrei https://doaj.org/article/85de94a5d8904a57ba1c26b99bc9ecb3 kostenfrei https://doi.org/10.1177/0300060519879588 kostenfrei https://doaj.org/toc/1473-2300 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_374 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2704 GBV_ILN_2707 GBV_ILN_2889 GBV_ILN_2890 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 48 2020
allfieldsSound	10.1177/0300060519879588 doi (DE-627)DOAJ061986518 (DE-599)DOAJ85de94a5d8904a57ba1c26b99bc9ecb3 DE-627 ger DE-627 rakwb eng R5-920 Shengli Wang verfasserin aut Association of and gene polymorphisms with methotrexate efficacy and toxicity in Chinese Han patients with rheumatoid arthritis 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective The objective was to explore the association of methylene tetrahydrofolate reductase ( MTHFR ) C667T and A1298C and reduced folate carrier 1 ( RFC-1 ) A80G single nucleotide polymorphisms (SNP) with rheumatoid arthritis (RA) and efficacy and toxicity of methotrexate (MTX) treatment in Chinese Han patients in Henan, China. Methods Two hundred ninety-six patients with RA were enrolled (cases) and 120 healthy individuals served as controls. The genotypes of MTHFR C667T and A1298C SNP and RFC-1 A80G SNP were detected by restriction fragment length polymorphism-PCR and compared between cases and controls. We analyzed correlations of clinical effect, toxicity, and SNPs after 6 months of MTX treatment. Results We detected no significant differences in MTHFR C677T and A1298C and RFC-1 A80G SNPs between cases and controls. The RFC-1 A80G SNP differed between RA patients with good and poor efficacy after 6 months of MTX, and was an independent factor of MTX efficacy. The MTHFR C677T SNP was differently distributed in the adverse drug reaction (ADR) and non-ADR groups and was an independent factor of MTX toxicity. Conclusions In Chinese Han patients with RA, the MTHFR C667T SNP may correlate with MTX toxicity, whereas the RFC-1 A80G SNP may correlate with MTX efficacy rather than toxicity. Medicine (General) Shuguang Zuo verfasserin aut Zhigang Liu verfasserin aut Xinying Ji verfasserin aut Zhenqiang Yao verfasserin aut Xinchun Wang verfasserin aut In Journal of International Medical Research SAGE Publishing, 2015 48(2020) (DE-627)350260621 (DE-600)2082422-1 14732300 nnns volume:48 year:2020 https://doi.org/10.1177/0300060519879588 kostenfrei https://doaj.org/article/85de94a5d8904a57ba1c26b99bc9ecb3 kostenfrei https://doi.org/10.1177/0300060519879588 kostenfrei https://doaj.org/toc/1473-2300 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_374 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2704 GBV_ILN_2707 GBV_ILN_2889 GBV_ILN_2890 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 48 2020
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Methods Two hundred ninety-six patients with RA were enrolled (cases) and 120 healthy individuals served as controls. The genotypes of MTHFR C667T and A1298C SNP and RFC-1 A80G SNP were detected by restriction fragment length polymorphism-PCR and compared between cases and controls. We analyzed correlations of clinical effect, toxicity, and SNPs after 6 months of MTX treatment. Results We detected no significant differences in MTHFR C677T and A1298C and RFC-1 A80G SNPs between cases and controls. The RFC-1 A80G SNP differed between RA patients with good and poor efficacy after 6 months of MTX, and was an independent factor of MTX efficacy. The MTHFR C677T SNP was differently distributed in the adverse drug reaction (ADR) and non-ADR groups and was an independent factor of MTX toxicity. Conclusions In Chinese Han patients with RA, the MTHFR C667T SNP may correlate with MTX toxicity, whereas the RFC-1 A80G SNP may correlate with MTX efficacy rather than toxicity.</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Medicine (General)</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Shuguang Zuo</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Zhigang Liu</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Xinying Ji</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Zhenqiang Yao</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" 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callnumber-first	R - Medicine
author	Shengli Wang
spellingShingle	Shengli Wang misc R5-920 misc Medicine (General) Association of and gene polymorphisms with methotrexate efficacy and toxicity in Chinese Han patients with rheumatoid arthritis
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topic_title	R5-920 Association of and gene polymorphisms with methotrexate efficacy and toxicity in Chinese Han patients with rheumatoid arthritis
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title	Association of and gene polymorphisms with methotrexate efficacy and toxicity in Chinese Han patients with rheumatoid arthritis
ctrlnum	(DE-627)DOAJ061986518 (DE-599)DOAJ85de94a5d8904a57ba1c26b99bc9ecb3
title_full	Association of and gene polymorphisms with methotrexate efficacy and toxicity in Chinese Han patients with rheumatoid arthritis
author_sort	Shengli Wang
journal	Journal of International Medical Research
journalStr	Journal of International Medical Research
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author_browse	Shengli Wang Shuguang Zuo Zhigang Liu Xinying Ji Zhenqiang Yao Xinchun Wang
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author-letter	Shengli Wang
doi_str_mv	10.1177/0300060519879588
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title_sort	association of and gene polymorphisms with methotrexate efficacy and toxicity in chinese han patients with rheumatoid arthritis
callnumber	R5-920
title_auth	Association of and gene polymorphisms with methotrexate efficacy and toxicity in Chinese Han patients with rheumatoid arthritis
abstract	Objective The objective was to explore the association of methylene tetrahydrofolate reductase ( MTHFR ) C667T and A1298C and reduced folate carrier 1 ( RFC-1 ) A80G single nucleotide polymorphisms (SNP) with rheumatoid arthritis (RA) and efficacy and toxicity of methotrexate (MTX) treatment in Chinese Han patients in Henan, China. Methods Two hundred ninety-six patients with RA were enrolled (cases) and 120 healthy individuals served as controls. The genotypes of MTHFR C667T and A1298C SNP and RFC-1 A80G SNP were detected by restriction fragment length polymorphism-PCR and compared between cases and controls. We analyzed correlations of clinical effect, toxicity, and SNPs after 6 months of MTX treatment. Results We detected no significant differences in MTHFR C677T and A1298C and RFC-1 A80G SNPs between cases and controls. The RFC-1 A80G SNP differed between RA patients with good and poor efficacy after 6 months of MTX, and was an independent factor of MTX efficacy. The MTHFR C677T SNP was differently distributed in the adverse drug reaction (ADR) and non-ADR groups and was an independent factor of MTX toxicity. Conclusions In Chinese Han patients with RA, the MTHFR C667T SNP may correlate with MTX toxicity, whereas the RFC-1 A80G SNP may correlate with MTX efficacy rather than toxicity.
abstractGer	Objective The objective was to explore the association of methylene tetrahydrofolate reductase ( MTHFR ) C667T and A1298C and reduced folate carrier 1 ( RFC-1 ) A80G single nucleotide polymorphisms (SNP) with rheumatoid arthritis (RA) and efficacy and toxicity of methotrexate (MTX) treatment in Chinese Han patients in Henan, China. Methods Two hundred ninety-six patients with RA were enrolled (cases) and 120 healthy individuals served as controls. The genotypes of MTHFR C667T and A1298C SNP and RFC-1 A80G SNP were detected by restriction fragment length polymorphism-PCR and compared between cases and controls. We analyzed correlations of clinical effect, toxicity, and SNPs after 6 months of MTX treatment. Results We detected no significant differences in MTHFR C677T and A1298C and RFC-1 A80G SNPs between cases and controls. The RFC-1 A80G SNP differed between RA patients with good and poor efficacy after 6 months of MTX, and was an independent factor of MTX efficacy. The MTHFR C677T SNP was differently distributed in the adverse drug reaction (ADR) and non-ADR groups and was an independent factor of MTX toxicity. Conclusions In Chinese Han patients with RA, the MTHFR C667T SNP may correlate with MTX toxicity, whereas the RFC-1 A80G SNP may correlate with MTX efficacy rather than toxicity.
abstract_unstemmed	Objective The objective was to explore the association of methylene tetrahydrofolate reductase ( MTHFR ) C667T and A1298C and reduced folate carrier 1 ( RFC-1 ) A80G single nucleotide polymorphisms (SNP) with rheumatoid arthritis (RA) and efficacy and toxicity of methotrexate (MTX) treatment in Chinese Han patients in Henan, China. Methods Two hundred ninety-six patients with RA were enrolled (cases) and 120 healthy individuals served as controls. The genotypes of MTHFR C667T and A1298C SNP and RFC-1 A80G SNP were detected by restriction fragment length polymorphism-PCR and compared between cases and controls. We analyzed correlations of clinical effect, toxicity, and SNPs after 6 months of MTX treatment. Results We detected no significant differences in MTHFR C677T and A1298C and RFC-1 A80G SNPs between cases and controls. The RFC-1 A80G SNP differed between RA patients with good and poor efficacy after 6 months of MTX, and was an independent factor of MTX efficacy. The MTHFR C677T SNP was differently distributed in the adverse drug reaction (ADR) and non-ADR groups and was an independent factor of MTX toxicity. Conclusions In Chinese Han patients with RA, the MTHFR C667T SNP may correlate with MTX toxicity, whereas the RFC-1 A80G SNP may correlate with MTX efficacy rather than toxicity.
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title_short	Association of and gene polymorphisms with methotrexate efficacy and toxicity in Chinese Han patients with rheumatoid arthritis
url	https://doi.org/10.1177/0300060519879588 https://doaj.org/article/85de94a5d8904a57ba1c26b99bc9ecb3 https://doaj.org/toc/1473-2300
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author2	Shuguang Zuo Zhigang Liu Xinying Ji Zhenqiang Yao Xinchun Wang
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doi_str	10.1177/0300060519879588
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up_date	2024-07-03T23:44:47.162Z
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Methods Two hundred ninety-six patients with RA were enrolled (cases) and 120 healthy individuals served as controls. The genotypes of MTHFR C667T and A1298C SNP and RFC-1 A80G SNP were detected by restriction fragment length polymorphism-PCR and compared between cases and controls. We analyzed correlations of clinical effect, toxicity, and SNPs after 6 months of MTX treatment. Results We detected no significant differences in MTHFR C677T and A1298C and RFC-1 A80G SNPs between cases and controls. The RFC-1 A80G SNP differed between RA patients with good and poor efficacy after 6 months of MTX, and was an independent factor of MTX efficacy. The MTHFR C677T SNP was differently distributed in the adverse drug reaction (ADR) and non-ADR groups and was an independent factor of MTX toxicity. 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Association of and gene polymorphisms with methotrexate efficacy and toxicity in Chinese Han patients with rheumatoid arthritis

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