Personalized neoantigen pulsed dendritic cell vaccine for advanced lung cancer

Abstract Neoantigens are considered to be ultimate target of tumor immunotherapy due to their high tumor specificity and immunogenicity. Dendritic cell (DCs) vaccines based on neoantigens have exciting effects in treatment of some malignant tumors and are a promising therapeutic modality. Lung cance...
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Autor*in:	Zhenyu Ding [verfasserIn] Qing Li [verfasserIn] Rui Zhang [verfasserIn] Li Xie [verfasserIn] Yang Shu [verfasserIn] Song Gao [verfasserIn] Peipei Wang [verfasserIn] Xiaoqing Su [verfasserIn] Yun Qin [verfasserIn] Yuelan Wang [verfasserIn] Juemin Fang [verfasserIn] Zhongzheng Zhu [verfasserIn] Xuyang Xia [verfasserIn] Guochao Wei [verfasserIn] Hui Wang [verfasserIn] Hong Qian [verfasserIn] Xianling Guo [verfasserIn] Zhibo Gao [verfasserIn] Yu Wang [verfasserIn] Yuquan Wei [verfasserIn] Qing Xu [verfasserIn] Heng Xu [verfasserIn] Li Yang [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Übergeordnetes Werk:	In: Signal Transduction and Targeted Therapy - Nature Publishing Group, 2016, 6(2021), 1, Seite 12
Übergeordnetes Werk:	volume:6 ; year:2021 ; number:1 ; pages:12

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1038/s41392-020-00448-5

Katalog-ID:	DOAJ062024930

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allfields	10.1038/s41392-020-00448-5 doi (DE-627)DOAJ062024930 (DE-599)DOAJc10bd265f05444cdade00bafa7bdcbab DE-627 ger DE-627 rakwb eng QH301-705.5 Zhenyu Ding verfasserin aut Personalized neoantigen pulsed dendritic cell vaccine for advanced lung cancer 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Neoantigens are considered to be ultimate target of tumor immunotherapy due to their high tumor specificity and immunogenicity. Dendritic cell (DCs) vaccines based on neoantigens have exciting effects in treatment of some malignant tumors and are a promising therapeutic modality. Lung cancer is a lethal disease with the highest morbidity and mortality rate in the world. Despite the rapid development of targeted therapy and immune checkpoint inhibitors for lung cancer in recent years, their efficacy is still unsatisfactory overall. Therefore, there is an urgent unmet clinical need for lung cancer treatment. Here, we attempted to treat lung cancer using a personalized neoantigen peptide-pulsed autologous DC vaccine and conducted a single-arm, 2 medical centers, pilot study initiated by the investigator (ChiCTR-ONC-16009100, NCT02956551). The patients enrolled were patients with heavily treated metastatic lung cancer. Candidate neoantigens were derived from whole-exome sequencing and RNA sequencing of fresh biopsy tissues as well as bioinformatics analysis. A total of 12 patients were enrolled in this study. A total of 85 vaccine treatments were administered with a median value of 5 doses/person (range: 3–14 doses/person). In total, 12–30 peptide-based neoantigens were selected for each patient. All treatment-related adverse events were grade 1–2 and there were no delays in dosing due to toxic effects. The objective effectiveness rate was 25%; the disease control rate was 75%; the median progression-free survival was 5.5 months and the median overall survival was 7.9 months. This study provides new evidence for neoantigen vaccine therapy and new therapeutic opportunities for lung cancer treatment. Medicine R Biology (General) Qing Li verfasserin aut Rui Zhang verfasserin aut Li Xie verfasserin aut Yang Shu verfasserin aut Song Gao verfasserin aut Peipei Wang verfasserin aut Xiaoqing Su verfasserin aut Yun Qin verfasserin aut Yuelan Wang verfasserin aut Juemin Fang verfasserin aut Zhongzheng Zhu verfasserin aut Xuyang Xia verfasserin aut Guochao Wei verfasserin aut Hui Wang verfasserin aut Hong Qian verfasserin aut Xianling Guo verfasserin aut Zhibo Gao verfasserin aut Yu Wang verfasserin aut Yuquan Wei verfasserin aut Qing Xu verfasserin aut Heng Xu verfasserin aut Li Yang verfasserin aut In Signal Transduction and Targeted Therapy Nature Publishing Group, 2016 6(2021), 1, Seite 12 (DE-627)881466581 (DE-600)2886872-9 20593635 nnns volume:6 year:2021 number:1 pages:12 https://doi.org/10.1038/s41392-020-00448-5 kostenfrei https://doaj.org/article/c10bd265f05444cdade00bafa7bdcbab kostenfrei https://doi.org/10.1038/s41392-020-00448-5 kostenfrei https://doaj.org/toc/2059-3635 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2021 1 12
spelling	10.1038/s41392-020-00448-5 doi (DE-627)DOAJ062024930 (DE-599)DOAJc10bd265f05444cdade00bafa7bdcbab DE-627 ger DE-627 rakwb eng QH301-705.5 Zhenyu Ding verfasserin aut Personalized neoantigen pulsed dendritic cell vaccine for advanced lung cancer 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Neoantigens are considered to be ultimate target of tumor immunotherapy due to their high tumor specificity and immunogenicity. Dendritic cell (DCs) vaccines based on neoantigens have exciting effects in treatment of some malignant tumors and are a promising therapeutic modality. Lung cancer is a lethal disease with the highest morbidity and mortality rate in the world. Despite the rapid development of targeted therapy and immune checkpoint inhibitors for lung cancer in recent years, their efficacy is still unsatisfactory overall. Therefore, there is an urgent unmet clinical need for lung cancer treatment. Here, we attempted to treat lung cancer using a personalized neoantigen peptide-pulsed autologous DC vaccine and conducted a single-arm, 2 medical centers, pilot study initiated by the investigator (ChiCTR-ONC-16009100, NCT02956551). The patients enrolled were patients with heavily treated metastatic lung cancer. Candidate neoantigens were derived from whole-exome sequencing and RNA sequencing of fresh biopsy tissues as well as bioinformatics analysis. A total of 12 patients were enrolled in this study. A total of 85 vaccine treatments were administered with a median value of 5 doses/person (range: 3–14 doses/person). In total, 12–30 peptide-based neoantigens were selected for each patient. All treatment-related adverse events were grade 1–2 and there were no delays in dosing due to toxic effects. The objective effectiveness rate was 25%; the disease control rate was 75%; the median progression-free survival was 5.5 months and the median overall survival was 7.9 months. This study provides new evidence for neoantigen vaccine therapy and new therapeutic opportunities for lung cancer treatment. Medicine R Biology (General) Qing Li verfasserin aut Rui Zhang verfasserin aut Li Xie verfasserin aut Yang Shu verfasserin aut Song Gao verfasserin aut Peipei Wang verfasserin aut Xiaoqing Su verfasserin aut Yun Qin verfasserin aut Yuelan Wang verfasserin aut Juemin Fang verfasserin aut Zhongzheng Zhu verfasserin aut Xuyang Xia verfasserin aut Guochao Wei verfasserin aut Hui Wang verfasserin aut Hong Qian verfasserin aut Xianling Guo verfasserin aut Zhibo Gao verfasserin aut Yu Wang verfasserin aut Yuquan Wei verfasserin aut Qing Xu verfasserin aut Heng Xu verfasserin aut Li Yang verfasserin aut In Signal Transduction and Targeted Therapy Nature Publishing Group, 2016 6(2021), 1, Seite 12 (DE-627)881466581 (DE-600)2886872-9 20593635 nnns volume:6 year:2021 number:1 pages:12 https://doi.org/10.1038/s41392-020-00448-5 kostenfrei https://doaj.org/article/c10bd265f05444cdade00bafa7bdcbab kostenfrei https://doi.org/10.1038/s41392-020-00448-5 kostenfrei https://doaj.org/toc/2059-3635 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2021 1 12
allfields_unstemmed	10.1038/s41392-020-00448-5 doi (DE-627)DOAJ062024930 (DE-599)DOAJc10bd265f05444cdade00bafa7bdcbab DE-627 ger DE-627 rakwb eng QH301-705.5 Zhenyu Ding verfasserin aut Personalized neoantigen pulsed dendritic cell vaccine for advanced lung cancer 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Neoantigens are considered to be ultimate target of tumor immunotherapy due to their high tumor specificity and immunogenicity. Dendritic cell (DCs) vaccines based on neoantigens have exciting effects in treatment of some malignant tumors and are a promising therapeutic modality. Lung cancer is a lethal disease with the highest morbidity and mortality rate in the world. Despite the rapid development of targeted therapy and immune checkpoint inhibitors for lung cancer in recent years, their efficacy is still unsatisfactory overall. Therefore, there is an urgent unmet clinical need for lung cancer treatment. Here, we attempted to treat lung cancer using a personalized neoantigen peptide-pulsed autologous DC vaccine and conducted a single-arm, 2 medical centers, pilot study initiated by the investigator (ChiCTR-ONC-16009100, NCT02956551). The patients enrolled were patients with heavily treated metastatic lung cancer. Candidate neoantigens were derived from whole-exome sequencing and RNA sequencing of fresh biopsy tissues as well as bioinformatics analysis. A total of 12 patients were enrolled in this study. A total of 85 vaccine treatments were administered with a median value of 5 doses/person (range: 3–14 doses/person). In total, 12–30 peptide-based neoantigens were selected for each patient. All treatment-related adverse events were grade 1–2 and there were no delays in dosing due to toxic effects. The objective effectiveness rate was 25%; the disease control rate was 75%; the median progression-free survival was 5.5 months and the median overall survival was 7.9 months. This study provides new evidence for neoantigen vaccine therapy and new therapeutic opportunities for lung cancer treatment. Medicine R Biology (General) Qing Li verfasserin aut Rui Zhang verfasserin aut Li Xie verfasserin aut Yang Shu verfasserin aut Song Gao verfasserin aut Peipei Wang verfasserin aut Xiaoqing Su verfasserin aut Yun Qin verfasserin aut Yuelan Wang verfasserin aut Juemin Fang verfasserin aut Zhongzheng Zhu verfasserin aut Xuyang Xia verfasserin aut Guochao Wei verfasserin aut Hui Wang verfasserin aut Hong Qian verfasserin aut Xianling Guo verfasserin aut Zhibo Gao verfasserin aut Yu Wang verfasserin aut Yuquan Wei verfasserin aut Qing Xu verfasserin aut Heng Xu verfasserin aut Li Yang verfasserin aut In Signal Transduction and Targeted Therapy Nature Publishing Group, 2016 6(2021), 1, Seite 12 (DE-627)881466581 (DE-600)2886872-9 20593635 nnns volume:6 year:2021 number:1 pages:12 https://doi.org/10.1038/s41392-020-00448-5 kostenfrei https://doaj.org/article/c10bd265f05444cdade00bafa7bdcbab kostenfrei https://doi.org/10.1038/s41392-020-00448-5 kostenfrei https://doaj.org/toc/2059-3635 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2021 1 12
allfieldsGer	10.1038/s41392-020-00448-5 doi (DE-627)DOAJ062024930 (DE-599)DOAJc10bd265f05444cdade00bafa7bdcbab DE-627 ger DE-627 rakwb eng QH301-705.5 Zhenyu Ding verfasserin aut Personalized neoantigen pulsed dendritic cell vaccine for advanced lung cancer 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Neoantigens are considered to be ultimate target of tumor immunotherapy due to their high tumor specificity and immunogenicity. Dendritic cell (DCs) vaccines based on neoantigens have exciting effects in treatment of some malignant tumors and are a promising therapeutic modality. Lung cancer is a lethal disease with the highest morbidity and mortality rate in the world. Despite the rapid development of targeted therapy and immune checkpoint inhibitors for lung cancer in recent years, their efficacy is still unsatisfactory overall. Therefore, there is an urgent unmet clinical need for lung cancer treatment. Here, we attempted to treat lung cancer using a personalized neoantigen peptide-pulsed autologous DC vaccine and conducted a single-arm, 2 medical centers, pilot study initiated by the investigator (ChiCTR-ONC-16009100, NCT02956551). The patients enrolled were patients with heavily treated metastatic lung cancer. Candidate neoantigens were derived from whole-exome sequencing and RNA sequencing of fresh biopsy tissues as well as bioinformatics analysis. A total of 12 patients were enrolled in this study. A total of 85 vaccine treatments were administered with a median value of 5 doses/person (range: 3–14 doses/person). In total, 12–30 peptide-based neoantigens were selected for each patient. All treatment-related adverse events were grade 1–2 and there were no delays in dosing due to toxic effects. The objective effectiveness rate was 25%; the disease control rate was 75%; the median progression-free survival was 5.5 months and the median overall survival was 7.9 months. This study provides new evidence for neoantigen vaccine therapy and new therapeutic opportunities for lung cancer treatment. Medicine R Biology (General) Qing Li verfasserin aut Rui Zhang verfasserin aut Li Xie verfasserin aut Yang Shu verfasserin aut Song Gao verfasserin aut Peipei Wang verfasserin aut Xiaoqing Su verfasserin aut Yun Qin verfasserin aut Yuelan Wang verfasserin aut Juemin Fang verfasserin aut Zhongzheng Zhu verfasserin aut Xuyang Xia verfasserin aut Guochao Wei verfasserin aut Hui Wang verfasserin aut Hong Qian verfasserin aut Xianling Guo verfasserin aut Zhibo Gao verfasserin aut Yu Wang verfasserin aut Yuquan Wei verfasserin aut Qing Xu verfasserin aut Heng Xu verfasserin aut Li Yang verfasserin aut In Signal Transduction and Targeted Therapy Nature Publishing Group, 2016 6(2021), 1, Seite 12 (DE-627)881466581 (DE-600)2886872-9 20593635 nnns volume:6 year:2021 number:1 pages:12 https://doi.org/10.1038/s41392-020-00448-5 kostenfrei https://doaj.org/article/c10bd265f05444cdade00bafa7bdcbab kostenfrei https://doi.org/10.1038/s41392-020-00448-5 kostenfrei https://doaj.org/toc/2059-3635 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2021 1 12
allfieldsSound	10.1038/s41392-020-00448-5 doi (DE-627)DOAJ062024930 (DE-599)DOAJc10bd265f05444cdade00bafa7bdcbab DE-627 ger DE-627 rakwb eng QH301-705.5 Zhenyu Ding verfasserin aut Personalized neoantigen pulsed dendritic cell vaccine for advanced lung cancer 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Neoantigens are considered to be ultimate target of tumor immunotherapy due to their high tumor specificity and immunogenicity. Dendritic cell (DCs) vaccines based on neoantigens have exciting effects in treatment of some malignant tumors and are a promising therapeutic modality. Lung cancer is a lethal disease with the highest morbidity and mortality rate in the world. Despite the rapid development of targeted therapy and immune checkpoint inhibitors for lung cancer in recent years, their efficacy is still unsatisfactory overall. Therefore, there is an urgent unmet clinical need for lung cancer treatment. Here, we attempted to treat lung cancer using a personalized neoantigen peptide-pulsed autologous DC vaccine and conducted a single-arm, 2 medical centers, pilot study initiated by the investigator (ChiCTR-ONC-16009100, NCT02956551). The patients enrolled were patients with heavily treated metastatic lung cancer. Candidate neoantigens were derived from whole-exome sequencing and RNA sequencing of fresh biopsy tissues as well as bioinformatics analysis. A total of 12 patients were enrolled in this study. A total of 85 vaccine treatments were administered with a median value of 5 doses/person (range: 3–14 doses/person). In total, 12–30 peptide-based neoantigens were selected for each patient. All treatment-related adverse events were grade 1–2 and there were no delays in dosing due to toxic effects. The objective effectiveness rate was 25%; the disease control rate was 75%; the median progression-free survival was 5.5 months and the median overall survival was 7.9 months. This study provides new evidence for neoantigen vaccine therapy and new therapeutic opportunities for lung cancer treatment. Medicine R Biology (General) Qing Li verfasserin aut Rui Zhang verfasserin aut Li Xie verfasserin aut Yang Shu verfasserin aut Song Gao verfasserin aut Peipei Wang verfasserin aut Xiaoqing Su verfasserin aut Yun Qin verfasserin aut Yuelan Wang verfasserin aut Juemin Fang verfasserin aut Zhongzheng Zhu verfasserin aut Xuyang Xia verfasserin aut Guochao Wei verfasserin aut Hui Wang verfasserin aut Hong Qian verfasserin aut Xianling Guo verfasserin aut Zhibo Gao verfasserin aut Yu Wang verfasserin aut Yuquan Wei verfasserin aut Qing Xu verfasserin aut Heng Xu verfasserin aut Li Yang verfasserin aut In Signal Transduction and Targeted Therapy Nature Publishing Group, 2016 6(2021), 1, Seite 12 (DE-627)881466581 (DE-600)2886872-9 20593635 nnns volume:6 year:2021 number:1 pages:12 https://doi.org/10.1038/s41392-020-00448-5 kostenfrei https://doaj.org/article/c10bd265f05444cdade00bafa7bdcbab kostenfrei https://doi.org/10.1038/s41392-020-00448-5 kostenfrei https://doaj.org/toc/2059-3635 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2021 1 12
language	English
source	In Signal Transduction and Targeted Therapy 6(2021), 1, Seite 12 volume:6 year:2021 number:1 pages:12
sourceStr	In Signal Transduction and Targeted Therapy 6(2021), 1, Seite 12 volume:6 year:2021 number:1 pages:12
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Medicine R Biology (General)
isfreeaccess_bool	true
container_title	Signal Transduction and Targeted Therapy
authorswithroles_txt_mv	Zhenyu Ding @@aut@@ Qing Li @@aut@@ Rui Zhang @@aut@@ Li Xie @@aut@@ Yang Shu @@aut@@ Song Gao @@aut@@ Peipei Wang @@aut@@ Xiaoqing Su @@aut@@ Yun Qin @@aut@@ Yuelan Wang @@aut@@ Juemin Fang @@aut@@ Zhongzheng Zhu @@aut@@ Xuyang Xia @@aut@@ Guochao Wei @@aut@@ Hui Wang @@aut@@ Hong Qian @@aut@@ Xianling Guo @@aut@@ Zhibo Gao @@aut@@ Yu Wang @@aut@@ Yuquan Wei @@aut@@ Qing Xu @@aut@@ Heng Xu @@aut@@ Li Yang @@aut@@
publishDateDaySort_date	2021-01-01T00:00:00Z
hierarchy_top_id	881466581
id	DOAJ062024930
language_de	englisch
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author	Zhenyu Ding
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topic_title	QH301-705.5 Personalized neoantigen pulsed dendritic cell vaccine for advanced lung cancer
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title	Personalized neoantigen pulsed dendritic cell vaccine for advanced lung cancer
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title_full	Personalized neoantigen pulsed dendritic cell vaccine for advanced lung cancer
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author_browse	Zhenyu Ding Qing Li Rui Zhang Li Xie Yang Shu Song Gao Peipei Wang Xiaoqing Su Yun Qin Yuelan Wang Juemin Fang Zhongzheng Zhu Xuyang Xia Guochao Wei Hui Wang Hong Qian Xianling Guo Zhibo Gao Yu Wang Yuquan Wei Qing Xu Heng Xu Li Yang
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title_sort	personalized neoantigen pulsed dendritic cell vaccine for advanced lung cancer
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title_auth	Personalized neoantigen pulsed dendritic cell vaccine for advanced lung cancer
abstract	Abstract Neoantigens are considered to be ultimate target of tumor immunotherapy due to their high tumor specificity and immunogenicity. Dendritic cell (DCs) vaccines based on neoantigens have exciting effects in treatment of some malignant tumors and are a promising therapeutic modality. Lung cancer is a lethal disease with the highest morbidity and mortality rate in the world. Despite the rapid development of targeted therapy and immune checkpoint inhibitors for lung cancer in recent years, their efficacy is still unsatisfactory overall. Therefore, there is an urgent unmet clinical need for lung cancer treatment. Here, we attempted to treat lung cancer using a personalized neoantigen peptide-pulsed autologous DC vaccine and conducted a single-arm, 2 medical centers, pilot study initiated by the investigator (ChiCTR-ONC-16009100, NCT02956551). The patients enrolled were patients with heavily treated metastatic lung cancer. Candidate neoantigens were derived from whole-exome sequencing and RNA sequencing of fresh biopsy tissues as well as bioinformatics analysis. A total of 12 patients were enrolled in this study. A total of 85 vaccine treatments were administered with a median value of 5 doses/person (range: 3–14 doses/person). In total, 12–30 peptide-based neoantigens were selected for each patient. All treatment-related adverse events were grade 1–2 and there were no delays in dosing due to toxic effects. The objective effectiveness rate was 25%; the disease control rate was 75%; the median progression-free survival was 5.5 months and the median overall survival was 7.9 months. This study provides new evidence for neoantigen vaccine therapy and new therapeutic opportunities for lung cancer treatment.
abstractGer	Abstract Neoantigens are considered to be ultimate target of tumor immunotherapy due to their high tumor specificity and immunogenicity. Dendritic cell (DCs) vaccines based on neoantigens have exciting effects in treatment of some malignant tumors and are a promising therapeutic modality. Lung cancer is a lethal disease with the highest morbidity and mortality rate in the world. Despite the rapid development of targeted therapy and immune checkpoint inhibitors for lung cancer in recent years, their efficacy is still unsatisfactory overall. Therefore, there is an urgent unmet clinical need for lung cancer treatment. Here, we attempted to treat lung cancer using a personalized neoantigen peptide-pulsed autologous DC vaccine and conducted a single-arm, 2 medical centers, pilot study initiated by the investigator (ChiCTR-ONC-16009100, NCT02956551). The patients enrolled were patients with heavily treated metastatic lung cancer. Candidate neoantigens were derived from whole-exome sequencing and RNA sequencing of fresh biopsy tissues as well as bioinformatics analysis. A total of 12 patients were enrolled in this study. A total of 85 vaccine treatments were administered with a median value of 5 doses/person (range: 3–14 doses/person). In total, 12–30 peptide-based neoantigens were selected for each patient. All treatment-related adverse events were grade 1–2 and there were no delays in dosing due to toxic effects. The objective effectiveness rate was 25%; the disease control rate was 75%; the median progression-free survival was 5.5 months and the median overall survival was 7.9 months. This study provides new evidence for neoantigen vaccine therapy and new therapeutic opportunities for lung cancer treatment.
abstract_unstemmed	Abstract Neoantigens are considered to be ultimate target of tumor immunotherapy due to their high tumor specificity and immunogenicity. Dendritic cell (DCs) vaccines based on neoantigens have exciting effects in treatment of some malignant tumors and are a promising therapeutic modality. Lung cancer is a lethal disease with the highest morbidity and mortality rate in the world. Despite the rapid development of targeted therapy and immune checkpoint inhibitors for lung cancer in recent years, their efficacy is still unsatisfactory overall. Therefore, there is an urgent unmet clinical need for lung cancer treatment. Here, we attempted to treat lung cancer using a personalized neoantigen peptide-pulsed autologous DC vaccine and conducted a single-arm, 2 medical centers, pilot study initiated by the investigator (ChiCTR-ONC-16009100, NCT02956551). The patients enrolled were patients with heavily treated metastatic lung cancer. Candidate neoantigens were derived from whole-exome sequencing and RNA sequencing of fresh biopsy tissues as well as bioinformatics analysis. A total of 12 patients were enrolled in this study. A total of 85 vaccine treatments were administered with a median value of 5 doses/person (range: 3–14 doses/person). In total, 12–30 peptide-based neoantigens were selected for each patient. All treatment-related adverse events were grade 1–2 and there were no delays in dosing due to toxic effects. The objective effectiveness rate was 25%; the disease control rate was 75%; the median progression-free survival was 5.5 months and the median overall survival was 7.9 months. This study provides new evidence for neoantigen vaccine therapy and new therapeutic opportunities for lung cancer treatment.
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title_short	Personalized neoantigen pulsed dendritic cell vaccine for advanced lung cancer
url	https://doi.org/10.1038/s41392-020-00448-5 https://doaj.org/article/c10bd265f05444cdade00bafa7bdcbab https://doaj.org/toc/2059-3635
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author2	Qing Li Rui Zhang Li Xie Yang Shu Song Gao Peipei Wang Xiaoqing Su Yun Qin Yuelan Wang Juemin Fang Zhongzheng Zhu Xuyang Xia Guochao Wei Hui Wang Hong Qian Xianling Guo Zhibo Gao Yu Wang Yuquan Wei Qing Xu Heng Xu Li Yang
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score	7.400959

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Personalized neoantigen pulsed dendritic cell vaccine for advanced lung cancer

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