Prevalence of Sleep Disordered Breathing in Patients with Primary Mitral Regurgitation Undergoing Mitral Valve Surgery

Background: Sleep disordered breathing (SDB) is a frequent comorbidity in cardiac disease patients. Nevertheless, the prevalence and relationship between SDB and severe primary mitral regurgitation (PMR) has not been well investigated to date. Methods: A cohort of 121 patients with significant PMR u...
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Autor*in:	Muhammed Gerçek [verfasserIn] Olaf Oldenburg [verfasserIn] Mustafa Gerçek [verfasserIn] Henrik Fox [verfasserIn] Volker Rudolph [verfasserIn] Thomas Puehler [verfasserIn] Hazem Omran [verfasserIn] Lisa Katharina Wolf [verfasserIn] Kavous Hakim-Meibodi [verfasserIn] Andreas M. Zeiher [verfasserIn] Jan Gummert [verfasserIn] Zisis Dimitriadis [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	mitral valve surgery sleep disordered breathing mitral regurgitation

Übergeordnetes Werk:	In: Journal of Clinical Medicine - MDPI AG, 2013, 10(2021), 9, p 2039
Übergeordnetes Werk:	volume:10 ; year:2021 ; number:9, p 2039

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/jcm10092039

Katalog-ID:	DOAJ062056190

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520			\|a Background: Sleep disordered breathing (SDB) is a frequent comorbidity in cardiac disease patients. Nevertheless, the prevalence and relationship between SDB and severe primary mitral regurgitation (PMR) has not been well investigated to date. Methods: A cohort of 121 patients with significant PMR undergoing mitral valve surgery were prospectively enrolled and received a cardiorespiratory single night polygraphy screening using ApneaLink before surgery. Eighty-two of them underwent a follow-up examination including a follow-up single-night sleep study 3 months after surgery. Results: The mean age of patients was 65.3 ± 12.0 years. Sixty patients (49.6%) were female. The mean EuroSCORE II was 2.5 ± 2.4%. Initially, 91 (75.2%) patients presented with SDB, among whom 50.4% (46 patients, 38.0% of total cohort) were classified as moderate to severe. These patients tended to require significantly longer postoperative intensive care and mechanical ventilation. Among the 82 patients who completed follow-up exams, mitral valve surgery led to a significant reduction in relevant SDB (20.7%). The apnea-hypopnea index (from 11/h [4;18] to 4/h [3;14] (<i<p</i< = 0.04)), the oxygenation-desaturation index (from 8/h [3;18] to 5/h [3;12] (<i<p</i< = 0.008)) as well as the saturation time below 90% (from 32 min [13;86] to 18 min [5;36] (<i<p</i< = 0.005)), were all shown to be improved significantly. Conclusion: The prevalence of SDB is very high in patients with severe primary mitral regurgitation and may contribute to postoperative complications and prolonged intensive care. A significantly reduced but still high prevalence of SDB was observed 3 months after mitral valve surgery, highlighting the bidirectional relationship between SDB and heart failure.
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allfields	10.3390/jcm10092039 doi (DE-627)DOAJ062056190 (DE-599)DOAJff73de00e35c4c5ca71a1d444ba8afac DE-627 ger DE-627 rakwb eng Muhammed Gerçek verfasserin aut Prevalence of Sleep Disordered Breathing in Patients with Primary Mitral Regurgitation Undergoing Mitral Valve Surgery 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Sleep disordered breathing (SDB) is a frequent comorbidity in cardiac disease patients. Nevertheless, the prevalence and relationship between SDB and severe primary mitral regurgitation (PMR) has not been well investigated to date. Methods: A cohort of 121 patients with significant PMR undergoing mitral valve surgery were prospectively enrolled and received a cardiorespiratory single night polygraphy screening using ApneaLink before surgery. Eighty-two of them underwent a follow-up examination including a follow-up single-night sleep study 3 months after surgery. Results: The mean age of patients was 65.3 ± 12.0 years. Sixty patients (49.6%) were female. The mean EuroSCORE II was 2.5 ± 2.4%. Initially, 91 (75.2%) patients presented with SDB, among whom 50.4% (46 patients, 38.0% of total cohort) were classified as moderate to severe. These patients tended to require significantly longer postoperative intensive care and mechanical ventilation. Among the 82 patients who completed follow-up exams, mitral valve surgery led to a significant reduction in relevant SDB (20.7%). The apnea-hypopnea index (from 11/h [4;18] to 4/h [3;14] (<i<p</i< = 0.04)), the oxygenation-desaturation index (from 8/h [3;18] to 5/h [3;12] (<i<p</i< = 0.008)) as well as the saturation time below 90% (from 32 min [13;86] to 18 min [5;36] (<i<p</i< = 0.005)), were all shown to be improved significantly. Conclusion: The prevalence of SDB is very high in patients with severe primary mitral regurgitation and may contribute to postoperative complications and prolonged intensive care. A significantly reduced but still high prevalence of SDB was observed 3 months after mitral valve surgery, highlighting the bidirectional relationship between SDB and heart failure. mitral valve surgery sleep disordered breathing mitral regurgitation Medicine R Olaf Oldenburg verfasserin aut Mustafa Gerçek verfasserin aut Henrik Fox verfasserin aut Volker Rudolph verfasserin aut Thomas Puehler verfasserin aut Hazem Omran verfasserin aut Lisa Katharina Wolf verfasserin aut Kavous Hakim-Meibodi verfasserin aut Andreas M. Zeiher verfasserin aut Jan Gummert verfasserin aut Zisis Dimitriadis verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 10(2021), 9, p 2039 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:10 year:2021 number:9, p 2039 https://doi.org/10.3390/jcm10092039 kostenfrei https://doaj.org/article/ff73de00e35c4c5ca71a1d444ba8afac kostenfrei https://www.mdpi.com/2077-0383/10/9/2039 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2021 9, p 2039
spelling	10.3390/jcm10092039 doi (DE-627)DOAJ062056190 (DE-599)DOAJff73de00e35c4c5ca71a1d444ba8afac DE-627 ger DE-627 rakwb eng Muhammed Gerçek verfasserin aut Prevalence of Sleep Disordered Breathing in Patients with Primary Mitral Regurgitation Undergoing Mitral Valve Surgery 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Sleep disordered breathing (SDB) is a frequent comorbidity in cardiac disease patients. Nevertheless, the prevalence and relationship between SDB and severe primary mitral regurgitation (PMR) has not been well investigated to date. Methods: A cohort of 121 patients with significant PMR undergoing mitral valve surgery were prospectively enrolled and received a cardiorespiratory single night polygraphy screening using ApneaLink before surgery. Eighty-two of them underwent a follow-up examination including a follow-up single-night sleep study 3 months after surgery. Results: The mean age of patients was 65.3 ± 12.0 years. Sixty patients (49.6%) were female. The mean EuroSCORE II was 2.5 ± 2.4%. Initially, 91 (75.2%) patients presented with SDB, among whom 50.4% (46 patients, 38.0% of total cohort) were classified as moderate to severe. These patients tended to require significantly longer postoperative intensive care and mechanical ventilation. Among the 82 patients who completed follow-up exams, mitral valve surgery led to a significant reduction in relevant SDB (20.7%). The apnea-hypopnea index (from 11/h [4;18] to 4/h [3;14] (<i<p</i< = 0.04)), the oxygenation-desaturation index (from 8/h [3;18] to 5/h [3;12] (<i<p</i< = 0.008)) as well as the saturation time below 90% (from 32 min [13;86] to 18 min [5;36] (<i<p</i< = 0.005)), were all shown to be improved significantly. Conclusion: The prevalence of SDB is very high in patients with severe primary mitral regurgitation and may contribute to postoperative complications and prolonged intensive care. A significantly reduced but still high prevalence of SDB was observed 3 months after mitral valve surgery, highlighting the bidirectional relationship between SDB and heart failure. mitral valve surgery sleep disordered breathing mitral regurgitation Medicine R Olaf Oldenburg verfasserin aut Mustafa Gerçek verfasserin aut Henrik Fox verfasserin aut Volker Rudolph verfasserin aut Thomas Puehler verfasserin aut Hazem Omran verfasserin aut Lisa Katharina Wolf verfasserin aut Kavous Hakim-Meibodi verfasserin aut Andreas M. Zeiher verfasserin aut Jan Gummert verfasserin aut Zisis Dimitriadis verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 10(2021), 9, p 2039 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:10 year:2021 number:9, p 2039 https://doi.org/10.3390/jcm10092039 kostenfrei https://doaj.org/article/ff73de00e35c4c5ca71a1d444ba8afac kostenfrei https://www.mdpi.com/2077-0383/10/9/2039 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2021 9, p 2039
allfields_unstemmed	10.3390/jcm10092039 doi (DE-627)DOAJ062056190 (DE-599)DOAJff73de00e35c4c5ca71a1d444ba8afac DE-627 ger DE-627 rakwb eng Muhammed Gerçek verfasserin aut Prevalence of Sleep Disordered Breathing in Patients with Primary Mitral Regurgitation Undergoing Mitral Valve Surgery 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Sleep disordered breathing (SDB) is a frequent comorbidity in cardiac disease patients. Nevertheless, the prevalence and relationship between SDB and severe primary mitral regurgitation (PMR) has not been well investigated to date. Methods: A cohort of 121 patients with significant PMR undergoing mitral valve surgery were prospectively enrolled and received a cardiorespiratory single night polygraphy screening using ApneaLink before surgery. Eighty-two of them underwent a follow-up examination including a follow-up single-night sleep study 3 months after surgery. Results: The mean age of patients was 65.3 ± 12.0 years. Sixty patients (49.6%) were female. The mean EuroSCORE II was 2.5 ± 2.4%. Initially, 91 (75.2%) patients presented with SDB, among whom 50.4% (46 patients, 38.0% of total cohort) were classified as moderate to severe. These patients tended to require significantly longer postoperative intensive care and mechanical ventilation. Among the 82 patients who completed follow-up exams, mitral valve surgery led to a significant reduction in relevant SDB (20.7%). The apnea-hypopnea index (from 11/h [4;18] to 4/h [3;14] (<i<p</i< = 0.04)), the oxygenation-desaturation index (from 8/h [3;18] to 5/h [3;12] (<i<p</i< = 0.008)) as well as the saturation time below 90% (from 32 min [13;86] to 18 min [5;36] (<i<p</i< = 0.005)), were all shown to be improved significantly. Conclusion: The prevalence of SDB is very high in patients with severe primary mitral regurgitation and may contribute to postoperative complications and prolonged intensive care. A significantly reduced but still high prevalence of SDB was observed 3 months after mitral valve surgery, highlighting the bidirectional relationship between SDB and heart failure. mitral valve surgery sleep disordered breathing mitral regurgitation Medicine R Olaf Oldenburg verfasserin aut Mustafa Gerçek verfasserin aut Henrik Fox verfasserin aut Volker Rudolph verfasserin aut Thomas Puehler verfasserin aut Hazem Omran verfasserin aut Lisa Katharina Wolf verfasserin aut Kavous Hakim-Meibodi verfasserin aut Andreas M. Zeiher verfasserin aut Jan Gummert verfasserin aut Zisis Dimitriadis verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 10(2021), 9, p 2039 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:10 year:2021 number:9, p 2039 https://doi.org/10.3390/jcm10092039 kostenfrei https://doaj.org/article/ff73de00e35c4c5ca71a1d444ba8afac kostenfrei https://www.mdpi.com/2077-0383/10/9/2039 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2021 9, p 2039
allfieldsGer	10.3390/jcm10092039 doi (DE-627)DOAJ062056190 (DE-599)DOAJff73de00e35c4c5ca71a1d444ba8afac DE-627 ger DE-627 rakwb eng Muhammed Gerçek verfasserin aut Prevalence of Sleep Disordered Breathing in Patients with Primary Mitral Regurgitation Undergoing Mitral Valve Surgery 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Sleep disordered breathing (SDB) is a frequent comorbidity in cardiac disease patients. Nevertheless, the prevalence and relationship between SDB and severe primary mitral regurgitation (PMR) has not been well investigated to date. Methods: A cohort of 121 patients with significant PMR undergoing mitral valve surgery were prospectively enrolled and received a cardiorespiratory single night polygraphy screening using ApneaLink before surgery. Eighty-two of them underwent a follow-up examination including a follow-up single-night sleep study 3 months after surgery. Results: The mean age of patients was 65.3 ± 12.0 years. Sixty patients (49.6%) were female. The mean EuroSCORE II was 2.5 ± 2.4%. Initially, 91 (75.2%) patients presented with SDB, among whom 50.4% (46 patients, 38.0% of total cohort) were classified as moderate to severe. These patients tended to require significantly longer postoperative intensive care and mechanical ventilation. Among the 82 patients who completed follow-up exams, mitral valve surgery led to a significant reduction in relevant SDB (20.7%). The apnea-hypopnea index (from 11/h [4;18] to 4/h [3;14] (<i<p</i< = 0.04)), the oxygenation-desaturation index (from 8/h [3;18] to 5/h [3;12] (<i<p</i< = 0.008)) as well as the saturation time below 90% (from 32 min [13;86] to 18 min [5;36] (<i<p</i< = 0.005)), were all shown to be improved significantly. Conclusion: The prevalence of SDB is very high in patients with severe primary mitral regurgitation and may contribute to postoperative complications and prolonged intensive care. A significantly reduced but still high prevalence of SDB was observed 3 months after mitral valve surgery, highlighting the bidirectional relationship between SDB and heart failure. mitral valve surgery sleep disordered breathing mitral regurgitation Medicine R Olaf Oldenburg verfasserin aut Mustafa Gerçek verfasserin aut Henrik Fox verfasserin aut Volker Rudolph verfasserin aut Thomas Puehler verfasserin aut Hazem Omran verfasserin aut Lisa Katharina Wolf verfasserin aut Kavous Hakim-Meibodi verfasserin aut Andreas M. Zeiher verfasserin aut Jan Gummert verfasserin aut Zisis Dimitriadis verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 10(2021), 9, p 2039 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:10 year:2021 number:9, p 2039 https://doi.org/10.3390/jcm10092039 kostenfrei https://doaj.org/article/ff73de00e35c4c5ca71a1d444ba8afac kostenfrei https://www.mdpi.com/2077-0383/10/9/2039 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2021 9, p 2039
allfieldsSound	10.3390/jcm10092039 doi (DE-627)DOAJ062056190 (DE-599)DOAJff73de00e35c4c5ca71a1d444ba8afac DE-627 ger DE-627 rakwb eng Muhammed Gerçek verfasserin aut Prevalence of Sleep Disordered Breathing in Patients with Primary Mitral Regurgitation Undergoing Mitral Valve Surgery 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Sleep disordered breathing (SDB) is a frequent comorbidity in cardiac disease patients. Nevertheless, the prevalence and relationship between SDB and severe primary mitral regurgitation (PMR) has not been well investigated to date. Methods: A cohort of 121 patients with significant PMR undergoing mitral valve surgery were prospectively enrolled and received a cardiorespiratory single night polygraphy screening using ApneaLink before surgery. Eighty-two of them underwent a follow-up examination including a follow-up single-night sleep study 3 months after surgery. Results: The mean age of patients was 65.3 ± 12.0 years. Sixty patients (49.6%) were female. The mean EuroSCORE II was 2.5 ± 2.4%. Initially, 91 (75.2%) patients presented with SDB, among whom 50.4% (46 patients, 38.0% of total cohort) were classified as moderate to severe. These patients tended to require significantly longer postoperative intensive care and mechanical ventilation. Among the 82 patients who completed follow-up exams, mitral valve surgery led to a significant reduction in relevant SDB (20.7%). The apnea-hypopnea index (from 11/h [4;18] to 4/h [3;14] (<i<p</i< = 0.04)), the oxygenation-desaturation index (from 8/h [3;18] to 5/h [3;12] (<i<p</i< = 0.008)) as well as the saturation time below 90% (from 32 min [13;86] to 18 min [5;36] (<i<p</i< = 0.005)), were all shown to be improved significantly. Conclusion: The prevalence of SDB is very high in patients with severe primary mitral regurgitation and may contribute to postoperative complications and prolonged intensive care. A significantly reduced but still high prevalence of SDB was observed 3 months after mitral valve surgery, highlighting the bidirectional relationship between SDB and heart failure. mitral valve surgery sleep disordered breathing mitral regurgitation Medicine R Olaf Oldenburg verfasserin aut Mustafa Gerçek verfasserin aut Henrik Fox verfasserin aut Volker Rudolph verfasserin aut Thomas Puehler verfasserin aut Hazem Omran verfasserin aut Lisa Katharina Wolf verfasserin aut Kavous Hakim-Meibodi verfasserin aut Andreas M. Zeiher verfasserin aut Jan Gummert verfasserin aut Zisis Dimitriadis verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 10(2021), 9, p 2039 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:10 year:2021 number:9, p 2039 https://doi.org/10.3390/jcm10092039 kostenfrei https://doaj.org/article/ff73de00e35c4c5ca71a1d444ba8afac kostenfrei https://www.mdpi.com/2077-0383/10/9/2039 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2021 9, p 2039
language	English
source	In Journal of Clinical Medicine 10(2021), 9, p 2039 volume:10 year:2021 number:9, p 2039
sourceStr	In Journal of Clinical Medicine 10(2021), 9, p 2039 volume:10 year:2021 number:9, p 2039
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	mitral valve surgery sleep disordered breathing mitral regurgitation Medicine R
isfreeaccess_bool	true
container_title	Journal of Clinical Medicine
authorswithroles_txt_mv	Muhammed Gerçek @@aut@@ Olaf Oldenburg @@aut@@ Mustafa Gerçek @@aut@@ Henrik Fox @@aut@@ Volker Rudolph @@aut@@ Thomas Puehler @@aut@@ Hazem Omran @@aut@@ Lisa Katharina Wolf @@aut@@ Kavous Hakim-Meibodi @@aut@@ Andreas M. Zeiher @@aut@@ Jan Gummert @@aut@@ Zisis Dimitriadis @@aut@@
publishDateDaySort_date	2021-01-01T00:00:00Z
hierarchy_top_id	718632478
id	DOAJ062056190
language_de	englisch
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author	Muhammed Gerçek
spellingShingle	Muhammed Gerçek misc mitral valve surgery misc sleep disordered breathing misc mitral regurgitation misc Medicine misc R Prevalence of Sleep Disordered Breathing in Patients with Primary Mitral Regurgitation Undergoing Mitral Valve Surgery
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topic_title	Prevalence of Sleep Disordered Breathing in Patients with Primary Mitral Regurgitation Undergoing Mitral Valve Surgery mitral valve surgery sleep disordered breathing mitral regurgitation
topic	misc mitral valve surgery misc sleep disordered breathing misc mitral regurgitation misc Medicine misc R
topic_unstemmed	misc mitral valve surgery misc sleep disordered breathing misc mitral regurgitation misc Medicine misc R
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title	Prevalence of Sleep Disordered Breathing in Patients with Primary Mitral Regurgitation Undergoing Mitral Valve Surgery
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title_full	Prevalence of Sleep Disordered Breathing in Patients with Primary Mitral Regurgitation Undergoing Mitral Valve Surgery
author_sort	Muhammed Gerçek
journal	Journal of Clinical Medicine
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author_browse	Muhammed Gerçek Olaf Oldenburg Mustafa Gerçek Henrik Fox Volker Rudolph Thomas Puehler Hazem Omran Lisa Katharina Wolf Kavous Hakim-Meibodi Andreas M. Zeiher Jan Gummert Zisis Dimitriadis
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author-letter	Muhammed Gerçek
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title_sort	prevalence of sleep disordered breathing in patients with primary mitral regurgitation undergoing mitral valve surgery
title_auth	Prevalence of Sleep Disordered Breathing in Patients with Primary Mitral Regurgitation Undergoing Mitral Valve Surgery
abstract	Background: Sleep disordered breathing (SDB) is a frequent comorbidity in cardiac disease patients. Nevertheless, the prevalence and relationship between SDB and severe primary mitral regurgitation (PMR) has not been well investigated to date. Methods: A cohort of 121 patients with significant PMR undergoing mitral valve surgery were prospectively enrolled and received a cardiorespiratory single night polygraphy screening using ApneaLink before surgery. Eighty-two of them underwent a follow-up examination including a follow-up single-night sleep study 3 months after surgery. Results: The mean age of patients was 65.3 ± 12.0 years. Sixty patients (49.6%) were female. The mean EuroSCORE II was 2.5 ± 2.4%. Initially, 91 (75.2%) patients presented with SDB, among whom 50.4% (46 patients, 38.0% of total cohort) were classified as moderate to severe. These patients tended to require significantly longer postoperative intensive care and mechanical ventilation. Among the 82 patients who completed follow-up exams, mitral valve surgery led to a significant reduction in relevant SDB (20.7%). The apnea-hypopnea index (from 11/h [4;18] to 4/h [3;14] (<i<p</i< = 0.04)), the oxygenation-desaturation index (from 8/h [3;18] to 5/h [3;12] (<i<p</i< = 0.008)) as well as the saturation time below 90% (from 32 min [13;86] to 18 min [5;36] (<i<p</i< = 0.005)), were all shown to be improved significantly. Conclusion: The prevalence of SDB is very high in patients with severe primary mitral regurgitation and may contribute to postoperative complications and prolonged intensive care. A significantly reduced but still high prevalence of SDB was observed 3 months after mitral valve surgery, highlighting the bidirectional relationship between SDB and heart failure.
abstractGer	Background: Sleep disordered breathing (SDB) is a frequent comorbidity in cardiac disease patients. Nevertheless, the prevalence and relationship between SDB and severe primary mitral regurgitation (PMR) has not been well investigated to date. Methods: A cohort of 121 patients with significant PMR undergoing mitral valve surgery were prospectively enrolled and received a cardiorespiratory single night polygraphy screening using ApneaLink before surgery. Eighty-two of them underwent a follow-up examination including a follow-up single-night sleep study 3 months after surgery. Results: The mean age of patients was 65.3 ± 12.0 years. Sixty patients (49.6%) were female. The mean EuroSCORE II was 2.5 ± 2.4%. Initially, 91 (75.2%) patients presented with SDB, among whom 50.4% (46 patients, 38.0% of total cohort) were classified as moderate to severe. These patients tended to require significantly longer postoperative intensive care and mechanical ventilation. Among the 82 patients who completed follow-up exams, mitral valve surgery led to a significant reduction in relevant SDB (20.7%). The apnea-hypopnea index (from 11/h [4;18] to 4/h [3;14] (<i<p</i< = 0.04)), the oxygenation-desaturation index (from 8/h [3;18] to 5/h [3;12] (<i<p</i< = 0.008)) as well as the saturation time below 90% (from 32 min [13;86] to 18 min [5;36] (<i<p</i< = 0.005)), were all shown to be improved significantly. Conclusion: The prevalence of SDB is very high in patients with severe primary mitral regurgitation and may contribute to postoperative complications and prolonged intensive care. A significantly reduced but still high prevalence of SDB was observed 3 months after mitral valve surgery, highlighting the bidirectional relationship between SDB and heart failure.
abstract_unstemmed	Background: Sleep disordered breathing (SDB) is a frequent comorbidity in cardiac disease patients. Nevertheless, the prevalence and relationship between SDB and severe primary mitral regurgitation (PMR) has not been well investigated to date. Methods: A cohort of 121 patients with significant PMR undergoing mitral valve surgery were prospectively enrolled and received a cardiorespiratory single night polygraphy screening using ApneaLink before surgery. Eighty-two of them underwent a follow-up examination including a follow-up single-night sleep study 3 months after surgery. Results: The mean age of patients was 65.3 ± 12.0 years. Sixty patients (49.6%) were female. The mean EuroSCORE II was 2.5 ± 2.4%. Initially, 91 (75.2%) patients presented with SDB, among whom 50.4% (46 patients, 38.0% of total cohort) were classified as moderate to severe. These patients tended to require significantly longer postoperative intensive care and mechanical ventilation. Among the 82 patients who completed follow-up exams, mitral valve surgery led to a significant reduction in relevant SDB (20.7%). The apnea-hypopnea index (from 11/h [4;18] to 4/h [3;14] (<i<p</i< = 0.04)), the oxygenation-desaturation index (from 8/h [3;18] to 5/h [3;12] (<i<p</i< = 0.008)) as well as the saturation time below 90% (from 32 min [13;86] to 18 min [5;36] (<i<p</i< = 0.005)), were all shown to be improved significantly. Conclusion: The prevalence of SDB is very high in patients with severe primary mitral regurgitation and may contribute to postoperative complications and prolonged intensive care. A significantly reduced but still high prevalence of SDB was observed 3 months after mitral valve surgery, highlighting the bidirectional relationship between SDB and heart failure.
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title_short	Prevalence of Sleep Disordered Breathing in Patients with Primary Mitral Regurgitation Undergoing Mitral Valve Surgery
url	https://doi.org/10.3390/jcm10092039 https://doaj.org/article/ff73de00e35c4c5ca71a1d444ba8afac https://www.mdpi.com/2077-0383/10/9/2039 https://doaj.org/toc/2077-0383
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