Polymorphisms of the FCN2 Gene 3’UTR Region and Their Clinical Associations in Preterm Newborns

Ficolin-2 is regarded as an important innate immunity factor endowed with both lectin (carbohydrate recognition) qualities and ability to induce complement activation. The aim of this study was to investigate the association of the FCN2 3’-untranslated region (3’UTR) polymorphisms with ficolin-2 exp...
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Autor*in:	Anna S. Świerzko [verfasserIn] Dariusz Jarych [verfasserIn] Gabriela Gajek [verfasserIn] Karolina Chojnacka [verfasserIn] Paulina Kobiela [verfasserIn] Maja Kufelnicka-Babout [verfasserIn] Mateusz Michalski [verfasserIn] Katarzyna Sobczuk [verfasserIn] Agnieszka Szala-Poździej [verfasserIn] Misao Matsushita [verfasserIn] Jan Mazela [verfasserIn] Iwona Domżalska-Popadiuk [verfasserIn] David C. Kilpatrick [verfasserIn] Jarosław Kalinka [verfasserIn] Hideharu Sekine [verfasserIn] Maciej Cedzyński [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	3’UTR ficolin-2 FCN2 newborn prematurity

Übergeordnetes Werk:	In: Frontiers in Immunology - Frontiers Media S.A., 2011, 12(2021)
Übergeordnetes Werk:	volume:12 ; year:2021

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fimmu.2021.741140

Katalog-ID:	DOAJ062188763

Internformat


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100	0		\|a Anna S. Świerzko \|e verfasserin \|4 aut
245	1	0	\|a Polymorphisms of the FCN2 Gene 3’UTR Region and Their Clinical Associations in Preterm Newborns
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520			\|a Ficolin-2 is regarded as an important innate immunity factor endowed with both lectin (carbohydrate recognition) qualities and ability to induce complement activation. The aim of this study was to investigate the association of the FCN2 3’-untranslated region (3’UTR) polymorphisms with ficolin-2 expression and perinatal complications in preterm neonates. The sequencing analysis allowed us to identify six 3’UTR polymorphisms with minor allele frequency (MAF) >1%: rs4521835, rs73664188, rs11103564, rs11103565, rs6537958 and rs6537959. Except for rs4521835, all adhered to Hardy-Weinberg expectations. Moreover, rs6537958 and rs6537959 were shown to be in perfect linkage disequilibrium (LD) with nine other genetic polymorphisms: rs7040372, rs7046516, rs747422, rs7847431, rs6537957, rs6537960, rs6537962, rs11462298 and rs7860507 together stretched on a distance of 1242 bp and very high LD with rs11103565. The 3’UTR region was shown to bind nuclear extract proteins. The polymorphisms at rs4521835 and rs73664188 were found to influence serum ficolin-2 concentration significantly. All polymorphisms identified create (together with exon 8 polymorphism, rs7851696) two haplotype blocks. Among 49 diplotypes (D1-D49) created from rs7851696 (G>T), rs4521835 (T>G), rs73664188 (T>C), rs11103564 (T>C), rs11103565 (G>A) and rs6537959 (T>A), twenty two occurred with frequency >1%. Two diplotypes: D13 (GTTTGT/GGTCGT) and D10 (GTTTGT/GGTCGA), were significantly more frequent among preterm neonates with early onset of infection and pneumonia, compared with newborns with no infectious complications (OR 2.69 and 2.81, respectively; both p<0.05). The minor (C) allele at rs73664188 was associated with an increased risk of very low (≤1500 g) birthweight (OR=1.95, p=0.042) but was associated with the opposite effect at rs11103564 (OR=0.11, p=0.005).
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700	0		\|a Gabriela Gajek \|e verfasserin \|4 aut
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700	0		\|a Paulina Kobiela \|e verfasserin \|4 aut
700	0		\|a Maja Kufelnicka-Babout \|e verfasserin \|4 aut
700	0		\|a Mateusz Michalski \|e verfasserin \|4 aut
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700	0		\|a Agnieszka Szala-Poździej \|e verfasserin \|4 aut
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700	0		\|a Jan Mazela \|e verfasserin \|4 aut
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700	0		\|a Hideharu Sekine \|e verfasserin \|4 aut
700	0		\|a Maciej Cedzyński \|e verfasserin \|4 aut
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912			\|a GBV_ILN_4112
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912			\|a GBV_ILN_4126
912			\|a GBV_ILN_4249
912			\|a GBV_ILN_4305
912			\|a GBV_ILN_4306
912			\|a GBV_ILN_4307
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912			\|a GBV_ILN_4323
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912			\|a GBV_ILN_4367
912			\|a GBV_ILN_4700
951			\|a AR
952			\|d 12 \|j 2021

Indexfelder

author_variant	a s ś asś d j dj g g gg k c kc p k pk m k b mkb m m mm k s ks a s p asp m m mm j m jm i d p idp d c k dck j k jk h s hs m c mc
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callnumber-subject-code	RC
publishDate	2021
allfields	10.3389/fimmu.2021.741140 doi (DE-627)DOAJ062188763 (DE-599)DOAJ0aa3694819ae4ea8bb98554a02850b12 DE-627 ger DE-627 rakwb eng RC581-607 Anna S. Świerzko verfasserin aut Polymorphisms of the FCN2 Gene 3’UTR Region and Their Clinical Associations in Preterm Newborns 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Ficolin-2 is regarded as an important innate immunity factor endowed with both lectin (carbohydrate recognition) qualities and ability to induce complement activation. The aim of this study was to investigate the association of the FCN2 3’-untranslated region (3’UTR) polymorphisms with ficolin-2 expression and perinatal complications in preterm neonates. The sequencing analysis allowed us to identify six 3’UTR polymorphisms with minor allele frequency (MAF) >1%: rs4521835, rs73664188, rs11103564, rs11103565, rs6537958 and rs6537959. Except for rs4521835, all adhered to Hardy-Weinberg expectations. Moreover, rs6537958 and rs6537959 were shown to be in perfect linkage disequilibrium (LD) with nine other genetic polymorphisms: rs7040372, rs7046516, rs747422, rs7847431, rs6537957, rs6537960, rs6537962, rs11462298 and rs7860507 together stretched on a distance of 1242 bp and very high LD with rs11103565. The 3’UTR region was shown to bind nuclear extract proteins. The polymorphisms at rs4521835 and rs73664188 were found to influence serum ficolin-2 concentration significantly. All polymorphisms identified create (together with exon 8 polymorphism, rs7851696) two haplotype blocks. Among 49 diplotypes (D1-D49) created from rs7851696 (G>T), rs4521835 (T>G), rs73664188 (T>C), rs11103564 (T>C), rs11103565 (G>A) and rs6537959 (T>A), twenty two occurred with frequency >1%. Two diplotypes: D13 (GTTTGT/GGTCGT) and D10 (GTTTGT/GGTCGA), were significantly more frequent among preterm neonates with early onset of infection and pneumonia, compared with newborns with no infectious complications (OR 2.69 and 2.81, respectively; both p<0.05). The minor (C) allele at rs73664188 was associated with an increased risk of very low (≤1500 g) birthweight (OR=1.95, p=0.042) but was associated with the opposite effect at rs11103564 (OR=0.11, p=0.005). 3’UTR ficolin-2 FCN2 newborn prematurity Immunologic diseases. Allergy Dariusz Jarych verfasserin aut Gabriela Gajek verfasserin aut Karolina Chojnacka verfasserin aut Paulina Kobiela verfasserin aut Maja Kufelnicka-Babout verfasserin aut Mateusz Michalski verfasserin aut Katarzyna Sobczuk verfasserin aut Agnieszka Szala-Poździej verfasserin aut Misao Matsushita verfasserin aut Jan Mazela verfasserin aut Iwona Domżalska-Popadiuk verfasserin aut David C. Kilpatrick verfasserin aut Jarosław Kalinka verfasserin aut Hideharu Sekine verfasserin aut Maciej Cedzyński verfasserin aut In Frontiers in Immunology Frontiers Media S.A., 2011 12(2021) (DE-627)657998354 (DE-600)2606827-8 16643224 nnns volume:12 year:2021 https://doi.org/10.3389/fimmu.2021.741140 kostenfrei https://doaj.org/article/0aa3694819ae4ea8bb98554a02850b12 kostenfrei https://www.frontiersin.org/articles/10.3389/fimmu.2021.741140/full kostenfrei https://doaj.org/toc/1664-3224 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2021
spelling	10.3389/fimmu.2021.741140 doi (DE-627)DOAJ062188763 (DE-599)DOAJ0aa3694819ae4ea8bb98554a02850b12 DE-627 ger DE-627 rakwb eng RC581-607 Anna S. Świerzko verfasserin aut Polymorphisms of the FCN2 Gene 3’UTR Region and Their Clinical Associations in Preterm Newborns 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Ficolin-2 is regarded as an important innate immunity factor endowed with both lectin (carbohydrate recognition) qualities and ability to induce complement activation. The aim of this study was to investigate the association of the FCN2 3’-untranslated region (3’UTR) polymorphisms with ficolin-2 expression and perinatal complications in preterm neonates. The sequencing analysis allowed us to identify six 3’UTR polymorphisms with minor allele frequency (MAF) >1%: rs4521835, rs73664188, rs11103564, rs11103565, rs6537958 and rs6537959. Except for rs4521835, all adhered to Hardy-Weinberg expectations. Moreover, rs6537958 and rs6537959 were shown to be in perfect linkage disequilibrium (LD) with nine other genetic polymorphisms: rs7040372, rs7046516, rs747422, rs7847431, rs6537957, rs6537960, rs6537962, rs11462298 and rs7860507 together stretched on a distance of 1242 bp and very high LD with rs11103565. The 3’UTR region was shown to bind nuclear extract proteins. The polymorphisms at rs4521835 and rs73664188 were found to influence serum ficolin-2 concentration significantly. All polymorphisms identified create (together with exon 8 polymorphism, rs7851696) two haplotype blocks. Among 49 diplotypes (D1-D49) created from rs7851696 (G>T), rs4521835 (T>G), rs73664188 (T>C), rs11103564 (T>C), rs11103565 (G>A) and rs6537959 (T>A), twenty two occurred with frequency >1%. Two diplotypes: D13 (GTTTGT/GGTCGT) and D10 (GTTTGT/GGTCGA), were significantly more frequent among preterm neonates with early onset of infection and pneumonia, compared with newborns with no infectious complications (OR 2.69 and 2.81, respectively; both p<0.05). The minor (C) allele at rs73664188 was associated with an increased risk of very low (≤1500 g) birthweight (OR=1.95, p=0.042) but was associated with the opposite effect at rs11103564 (OR=0.11, p=0.005). 3’UTR ficolin-2 FCN2 newborn prematurity Immunologic diseases. Allergy Dariusz Jarych verfasserin aut Gabriela Gajek verfasserin aut Karolina Chojnacka verfasserin aut Paulina Kobiela verfasserin aut Maja Kufelnicka-Babout verfasserin aut Mateusz Michalski verfasserin aut Katarzyna Sobczuk verfasserin aut Agnieszka Szala-Poździej verfasserin aut Misao Matsushita verfasserin aut Jan Mazela verfasserin aut Iwona Domżalska-Popadiuk verfasserin aut David C. Kilpatrick verfasserin aut Jarosław Kalinka verfasserin aut Hideharu Sekine verfasserin aut Maciej Cedzyński verfasserin aut In Frontiers in Immunology Frontiers Media S.A., 2011 12(2021) (DE-627)657998354 (DE-600)2606827-8 16643224 nnns volume:12 year:2021 https://doi.org/10.3389/fimmu.2021.741140 kostenfrei https://doaj.org/article/0aa3694819ae4ea8bb98554a02850b12 kostenfrei https://www.frontiersin.org/articles/10.3389/fimmu.2021.741140/full kostenfrei https://doaj.org/toc/1664-3224 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2021
allfields_unstemmed	10.3389/fimmu.2021.741140 doi (DE-627)DOAJ062188763 (DE-599)DOAJ0aa3694819ae4ea8bb98554a02850b12 DE-627 ger DE-627 rakwb eng RC581-607 Anna S. Świerzko verfasserin aut Polymorphisms of the FCN2 Gene 3’UTR Region and Their Clinical Associations in Preterm Newborns 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Ficolin-2 is regarded as an important innate immunity factor endowed with both lectin (carbohydrate recognition) qualities and ability to induce complement activation. The aim of this study was to investigate the association of the FCN2 3’-untranslated region (3’UTR) polymorphisms with ficolin-2 expression and perinatal complications in preterm neonates. The sequencing analysis allowed us to identify six 3’UTR polymorphisms with minor allele frequency (MAF) >1%: rs4521835, rs73664188, rs11103564, rs11103565, rs6537958 and rs6537959. Except for rs4521835, all adhered to Hardy-Weinberg expectations. Moreover, rs6537958 and rs6537959 were shown to be in perfect linkage disequilibrium (LD) with nine other genetic polymorphisms: rs7040372, rs7046516, rs747422, rs7847431, rs6537957, rs6537960, rs6537962, rs11462298 and rs7860507 together stretched on a distance of 1242 bp and very high LD with rs11103565. The 3’UTR region was shown to bind nuclear extract proteins. The polymorphisms at rs4521835 and rs73664188 were found to influence serum ficolin-2 concentration significantly. All polymorphisms identified create (together with exon 8 polymorphism, rs7851696) two haplotype blocks. Among 49 diplotypes (D1-D49) created from rs7851696 (G>T), rs4521835 (T>G), rs73664188 (T>C), rs11103564 (T>C), rs11103565 (G>A) and rs6537959 (T>A), twenty two occurred with frequency >1%. Two diplotypes: D13 (GTTTGT/GGTCGT) and D10 (GTTTGT/GGTCGA), were significantly more frequent among preterm neonates with early onset of infection and pneumonia, compared with newborns with no infectious complications (OR 2.69 and 2.81, respectively; both p<0.05). The minor (C) allele at rs73664188 was associated with an increased risk of very low (≤1500 g) birthweight (OR=1.95, p=0.042) but was associated with the opposite effect at rs11103564 (OR=0.11, p=0.005). 3’UTR ficolin-2 FCN2 newborn prematurity Immunologic diseases. Allergy Dariusz Jarych verfasserin aut Gabriela Gajek verfasserin aut Karolina Chojnacka verfasserin aut Paulina Kobiela verfasserin aut Maja Kufelnicka-Babout verfasserin aut Mateusz Michalski verfasserin aut Katarzyna Sobczuk verfasserin aut Agnieszka Szala-Poździej verfasserin aut Misao Matsushita verfasserin aut Jan Mazela verfasserin aut Iwona Domżalska-Popadiuk verfasserin aut David C. Kilpatrick verfasserin aut Jarosław Kalinka verfasserin aut Hideharu Sekine verfasserin aut Maciej Cedzyński verfasserin aut In Frontiers in Immunology Frontiers Media S.A., 2011 12(2021) (DE-627)657998354 (DE-600)2606827-8 16643224 nnns volume:12 year:2021 https://doi.org/10.3389/fimmu.2021.741140 kostenfrei https://doaj.org/article/0aa3694819ae4ea8bb98554a02850b12 kostenfrei https://www.frontiersin.org/articles/10.3389/fimmu.2021.741140/full kostenfrei https://doaj.org/toc/1664-3224 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2021
allfieldsGer	10.3389/fimmu.2021.741140 doi (DE-627)DOAJ062188763 (DE-599)DOAJ0aa3694819ae4ea8bb98554a02850b12 DE-627 ger DE-627 rakwb eng RC581-607 Anna S. Świerzko verfasserin aut Polymorphisms of the FCN2 Gene 3’UTR Region and Their Clinical Associations in Preterm Newborns 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Ficolin-2 is regarded as an important innate immunity factor endowed with both lectin (carbohydrate recognition) qualities and ability to induce complement activation. The aim of this study was to investigate the association of the FCN2 3’-untranslated region (3’UTR) polymorphisms with ficolin-2 expression and perinatal complications in preterm neonates. The sequencing analysis allowed us to identify six 3’UTR polymorphisms with minor allele frequency (MAF) >1%: rs4521835, rs73664188, rs11103564, rs11103565, rs6537958 and rs6537959. Except for rs4521835, all adhered to Hardy-Weinberg expectations. Moreover, rs6537958 and rs6537959 were shown to be in perfect linkage disequilibrium (LD) with nine other genetic polymorphisms: rs7040372, rs7046516, rs747422, rs7847431, rs6537957, rs6537960, rs6537962, rs11462298 and rs7860507 together stretched on a distance of 1242 bp and very high LD with rs11103565. The 3’UTR region was shown to bind nuclear extract proteins. The polymorphisms at rs4521835 and rs73664188 were found to influence serum ficolin-2 concentration significantly. All polymorphisms identified create (together with exon 8 polymorphism, rs7851696) two haplotype blocks. Among 49 diplotypes (D1-D49) created from rs7851696 (G>T), rs4521835 (T>G), rs73664188 (T>C), rs11103564 (T>C), rs11103565 (G>A) and rs6537959 (T>A), twenty two occurred with frequency >1%. Two diplotypes: D13 (GTTTGT/GGTCGT) and D10 (GTTTGT/GGTCGA), were significantly more frequent among preterm neonates with early onset of infection and pneumonia, compared with newborns with no infectious complications (OR 2.69 and 2.81, respectively; both p<0.05). The minor (C) allele at rs73664188 was associated with an increased risk of very low (≤1500 g) birthweight (OR=1.95, p=0.042) but was associated with the opposite effect at rs11103564 (OR=0.11, p=0.005). 3’UTR ficolin-2 FCN2 newborn prematurity Immunologic diseases. Allergy Dariusz Jarych verfasserin aut Gabriela Gajek verfasserin aut Karolina Chojnacka verfasserin aut Paulina Kobiela verfasserin aut Maja Kufelnicka-Babout verfasserin aut Mateusz Michalski verfasserin aut Katarzyna Sobczuk verfasserin aut Agnieszka Szala-Poździej verfasserin aut Misao Matsushita verfasserin aut Jan Mazela verfasserin aut Iwona Domżalska-Popadiuk verfasserin aut David C. Kilpatrick verfasserin aut Jarosław Kalinka verfasserin aut Hideharu Sekine verfasserin aut Maciej Cedzyński verfasserin aut In Frontiers in Immunology Frontiers Media S.A., 2011 12(2021) (DE-627)657998354 (DE-600)2606827-8 16643224 nnns volume:12 year:2021 https://doi.org/10.3389/fimmu.2021.741140 kostenfrei https://doaj.org/article/0aa3694819ae4ea8bb98554a02850b12 kostenfrei https://www.frontiersin.org/articles/10.3389/fimmu.2021.741140/full kostenfrei https://doaj.org/toc/1664-3224 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2021
allfieldsSound	10.3389/fimmu.2021.741140 doi (DE-627)DOAJ062188763 (DE-599)DOAJ0aa3694819ae4ea8bb98554a02850b12 DE-627 ger DE-627 rakwb eng RC581-607 Anna S. Świerzko verfasserin aut Polymorphisms of the FCN2 Gene 3’UTR Region and Their Clinical Associations in Preterm Newborns 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Ficolin-2 is regarded as an important innate immunity factor endowed with both lectin (carbohydrate recognition) qualities and ability to induce complement activation. The aim of this study was to investigate the association of the FCN2 3’-untranslated region (3’UTR) polymorphisms with ficolin-2 expression and perinatal complications in preterm neonates. The sequencing analysis allowed us to identify six 3’UTR polymorphisms with minor allele frequency (MAF) >1%: rs4521835, rs73664188, rs11103564, rs11103565, rs6537958 and rs6537959. Except for rs4521835, all adhered to Hardy-Weinberg expectations. Moreover, rs6537958 and rs6537959 were shown to be in perfect linkage disequilibrium (LD) with nine other genetic polymorphisms: rs7040372, rs7046516, rs747422, rs7847431, rs6537957, rs6537960, rs6537962, rs11462298 and rs7860507 together stretched on a distance of 1242 bp and very high LD with rs11103565. The 3’UTR region was shown to bind nuclear extract proteins. The polymorphisms at rs4521835 and rs73664188 were found to influence serum ficolin-2 concentration significantly. All polymorphisms identified create (together with exon 8 polymorphism, rs7851696) two haplotype blocks. Among 49 diplotypes (D1-D49) created from rs7851696 (G>T), rs4521835 (T>G), rs73664188 (T>C), rs11103564 (T>C), rs11103565 (G>A) and rs6537959 (T>A), twenty two occurred with frequency >1%. Two diplotypes: D13 (GTTTGT/GGTCGT) and D10 (GTTTGT/GGTCGA), were significantly more frequent among preterm neonates with early onset of infection and pneumonia, compared with newborns with no infectious complications (OR 2.69 and 2.81, respectively; both p<0.05). The minor (C) allele at rs73664188 was associated with an increased risk of very low (≤1500 g) birthweight (OR=1.95, p=0.042) but was associated with the opposite effect at rs11103564 (OR=0.11, p=0.005). 3’UTR ficolin-2 FCN2 newborn prematurity Immunologic diseases. Allergy Dariusz Jarych verfasserin aut Gabriela Gajek verfasserin aut Karolina Chojnacka verfasserin aut Paulina Kobiela verfasserin aut Maja Kufelnicka-Babout verfasserin aut Mateusz Michalski verfasserin aut Katarzyna Sobczuk verfasserin aut Agnieszka Szala-Poździej verfasserin aut Misao Matsushita verfasserin aut Jan Mazela verfasserin aut Iwona Domżalska-Popadiuk verfasserin aut David C. Kilpatrick verfasserin aut Jarosław Kalinka verfasserin aut Hideharu Sekine verfasserin aut Maciej Cedzyński verfasserin aut In Frontiers in Immunology Frontiers Media S.A., 2011 12(2021) (DE-627)657998354 (DE-600)2606827-8 16643224 nnns volume:12 year:2021 https://doi.org/10.3389/fimmu.2021.741140 kostenfrei https://doaj.org/article/0aa3694819ae4ea8bb98554a02850b12 kostenfrei https://www.frontiersin.org/articles/10.3389/fimmu.2021.741140/full kostenfrei https://doaj.org/toc/1664-3224 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2021
language	English
source	In Frontiers in Immunology 12(2021) volume:12 year:2021
sourceStr	In Frontiers in Immunology 12(2021) volume:12 year:2021
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	3’UTR ficolin-2 FCN2 newborn prematurity Immunologic diseases. Allergy
isfreeaccess_bool	true
container_title	Frontiers in Immunology
authorswithroles_txt_mv	Anna S. Świerzko @@aut@@ Dariusz Jarych @@aut@@ Gabriela Gajek @@aut@@ Karolina Chojnacka @@aut@@ Paulina Kobiela @@aut@@ Maja Kufelnicka-Babout @@aut@@ Mateusz Michalski @@aut@@ Katarzyna Sobczuk @@aut@@ Agnieszka Szala-Poździej @@aut@@ Misao Matsushita @@aut@@ Jan Mazela @@aut@@ Iwona Domżalska-Popadiuk @@aut@@ David C. Kilpatrick @@aut@@ Jarosław Kalinka @@aut@@ Hideharu Sekine @@aut@@ Maciej Cedzyński @@aut@@
publishDateDaySort_date	2021-01-01T00:00:00Z
hierarchy_top_id	657998354
id	DOAJ062188763
language_de	englisch
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callnumber-first	R - Medicine
author	Anna S. Świerzko
spellingShingle	Anna S. Świerzko misc RC581-607 misc 3’UTR misc ficolin-2 misc FCN2 misc newborn misc prematurity misc Immunologic diseases. Allergy Polymorphisms of the FCN2 Gene 3’UTR Region and Their Clinical Associations in Preterm Newborns
authorStr	Anna S. Świerzko
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topic_title	RC581-607 Polymorphisms of the FCN2 Gene 3’UTR Region and Their Clinical Associations in Preterm Newborns 3’UTR ficolin-2 FCN2 newborn prematurity
topic	misc RC581-607 misc 3’UTR misc ficolin-2 misc FCN2 misc newborn misc prematurity misc Immunologic diseases. Allergy
topic_unstemmed	misc RC581-607 misc 3’UTR misc ficolin-2 misc FCN2 misc newborn misc prematurity misc Immunologic diseases. Allergy
topic_browse	misc RC581-607 misc 3’UTR misc ficolin-2 misc FCN2 misc newborn misc prematurity misc Immunologic diseases. Allergy
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title	Polymorphisms of the FCN2 Gene 3’UTR Region and Their Clinical Associations in Preterm Newborns
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title_full	Polymorphisms of the FCN2 Gene 3’UTR Region and Their Clinical Associations in Preterm Newborns
author_sort	Anna S. Świerzko
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author_browse	Anna S. Świerzko Dariusz Jarych Gabriela Gajek Karolina Chojnacka Paulina Kobiela Maja Kufelnicka-Babout Mateusz Michalski Katarzyna Sobczuk Agnieszka Szala-Poździej Misao Matsushita Jan Mazela Iwona Domżalska-Popadiuk David C. Kilpatrick Jarosław Kalinka Hideharu Sekine Maciej Cedzyński
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author-letter	Anna S. Świerzko
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title_sort	polymorphisms of the fcn2 gene 3’utr region and their clinical associations in preterm newborns
callnumber	RC581-607
title_auth	Polymorphisms of the FCN2 Gene 3’UTR Region and Their Clinical Associations in Preterm Newborns
abstract	Ficolin-2 is regarded as an important innate immunity factor endowed with both lectin (carbohydrate recognition) qualities and ability to induce complement activation. The aim of this study was to investigate the association of the FCN2 3’-untranslated region (3’UTR) polymorphisms with ficolin-2 expression and perinatal complications in preterm neonates. The sequencing analysis allowed us to identify six 3’UTR polymorphisms with minor allele frequency (MAF) >1%: rs4521835, rs73664188, rs11103564, rs11103565, rs6537958 and rs6537959. Except for rs4521835, all adhered to Hardy-Weinberg expectations. Moreover, rs6537958 and rs6537959 were shown to be in perfect linkage disequilibrium (LD) with nine other genetic polymorphisms: rs7040372, rs7046516, rs747422, rs7847431, rs6537957, rs6537960, rs6537962, rs11462298 and rs7860507 together stretched on a distance of 1242 bp and very high LD with rs11103565. The 3’UTR region was shown to bind nuclear extract proteins. The polymorphisms at rs4521835 and rs73664188 were found to influence serum ficolin-2 concentration significantly. All polymorphisms identified create (together with exon 8 polymorphism, rs7851696) two haplotype blocks. Among 49 diplotypes (D1-D49) created from rs7851696 (G>T), rs4521835 (T>G), rs73664188 (T>C), rs11103564 (T>C), rs11103565 (G>A) and rs6537959 (T>A), twenty two occurred with frequency >1%. Two diplotypes: D13 (GTTTGT/GGTCGT) and D10 (GTTTGT/GGTCGA), were significantly more frequent among preterm neonates with early onset of infection and pneumonia, compared with newborns with no infectious complications (OR 2.69 and 2.81, respectively; both p<0.05). The minor (C) allele at rs73664188 was associated with an increased risk of very low (≤1500 g) birthweight (OR=1.95, p=0.042) but was associated with the opposite effect at rs11103564 (OR=0.11, p=0.005).
abstractGer	Ficolin-2 is regarded as an important innate immunity factor endowed with both lectin (carbohydrate recognition) qualities and ability to induce complement activation. The aim of this study was to investigate the association of the FCN2 3’-untranslated region (3’UTR) polymorphisms with ficolin-2 expression and perinatal complications in preterm neonates. The sequencing analysis allowed us to identify six 3’UTR polymorphisms with minor allele frequency (MAF) >1%: rs4521835, rs73664188, rs11103564, rs11103565, rs6537958 and rs6537959. Except for rs4521835, all adhered to Hardy-Weinberg expectations. Moreover, rs6537958 and rs6537959 were shown to be in perfect linkage disequilibrium (LD) with nine other genetic polymorphisms: rs7040372, rs7046516, rs747422, rs7847431, rs6537957, rs6537960, rs6537962, rs11462298 and rs7860507 together stretched on a distance of 1242 bp and very high LD with rs11103565. The 3’UTR region was shown to bind nuclear extract proteins. The polymorphisms at rs4521835 and rs73664188 were found to influence serum ficolin-2 concentration significantly. All polymorphisms identified create (together with exon 8 polymorphism, rs7851696) two haplotype blocks. Among 49 diplotypes (D1-D49) created from rs7851696 (G>T), rs4521835 (T>G), rs73664188 (T>C), rs11103564 (T>C), rs11103565 (G>A) and rs6537959 (T>A), twenty two occurred with frequency >1%. Two diplotypes: D13 (GTTTGT/GGTCGT) and D10 (GTTTGT/GGTCGA), were significantly more frequent among preterm neonates with early onset of infection and pneumonia, compared with newborns with no infectious complications (OR 2.69 and 2.81, respectively; both p<0.05). The minor (C) allele at rs73664188 was associated with an increased risk of very low (≤1500 g) birthweight (OR=1.95, p=0.042) but was associated with the opposite effect at rs11103564 (OR=0.11, p=0.005).
abstract_unstemmed	Ficolin-2 is regarded as an important innate immunity factor endowed with both lectin (carbohydrate recognition) qualities and ability to induce complement activation. The aim of this study was to investigate the association of the FCN2 3’-untranslated region (3’UTR) polymorphisms with ficolin-2 expression and perinatal complications in preterm neonates. The sequencing analysis allowed us to identify six 3’UTR polymorphisms with minor allele frequency (MAF) >1%: rs4521835, rs73664188, rs11103564, rs11103565, rs6537958 and rs6537959. Except for rs4521835, all adhered to Hardy-Weinberg expectations. Moreover, rs6537958 and rs6537959 were shown to be in perfect linkage disequilibrium (LD) with nine other genetic polymorphisms: rs7040372, rs7046516, rs747422, rs7847431, rs6537957, rs6537960, rs6537962, rs11462298 and rs7860507 together stretched on a distance of 1242 bp and very high LD with rs11103565. The 3’UTR region was shown to bind nuclear extract proteins. The polymorphisms at rs4521835 and rs73664188 were found to influence serum ficolin-2 concentration significantly. All polymorphisms identified create (together with exon 8 polymorphism, rs7851696) two haplotype blocks. Among 49 diplotypes (D1-D49) created from rs7851696 (G>T), rs4521835 (T>G), rs73664188 (T>C), rs11103564 (T>C), rs11103565 (G>A) and rs6537959 (T>A), twenty two occurred with frequency >1%. Two diplotypes: D13 (GTTTGT/GGTCGT) and D10 (GTTTGT/GGTCGA), were significantly more frequent among preterm neonates with early onset of infection and pneumonia, compared with newborns with no infectious complications (OR 2.69 and 2.81, respectively; both p<0.05). The minor (C) allele at rs73664188 was associated with an increased risk of very low (≤1500 g) birthweight (OR=1.95, p=0.042) but was associated with the opposite effect at rs11103564 (OR=0.11, p=0.005).
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title_short	Polymorphisms of the FCN2 Gene 3’UTR Region and Their Clinical Associations in Preterm Newborns
url	https://doi.org/10.3389/fimmu.2021.741140 https://doaj.org/article/0aa3694819ae4ea8bb98554a02850b12 https://www.frontiersin.org/articles/10.3389/fimmu.2021.741140/full https://doaj.org/toc/1664-3224
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Świerzko</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Polymorphisms of the FCN2 Gene 3’UTR Region and Their Clinical Associations in Preterm Newborns</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2021</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Ficolin-2 is regarded as an important innate immunity factor endowed with both lectin (carbohydrate recognition) qualities and ability to induce complement activation. The aim of this study was to investigate the association of the FCN2 3’-untranslated region (3’UTR) polymorphisms with ficolin-2 expression and perinatal complications in preterm neonates. The sequencing analysis allowed us to identify six 3’UTR polymorphisms with minor allele frequency (MAF) &gt;1%: rs4521835, rs73664188, rs11103564, rs11103565, rs6537958 and rs6537959. Except for rs4521835, all adhered to Hardy-Weinberg expectations. Moreover, rs6537958 and rs6537959 were shown to be in perfect linkage disequilibrium (LD) with nine other genetic polymorphisms: rs7040372, rs7046516, rs747422, rs7847431, rs6537957, rs6537960, rs6537962, rs11462298 and rs7860507 together stretched on a distance of 1242 bp and very high LD with rs11103565. The 3’UTR region was shown to bind nuclear extract proteins. The polymorphisms at rs4521835 and rs73664188 were found to influence serum ficolin-2 concentration significantly. All polymorphisms identified create (together with exon 8 polymorphism, rs7851696) two haplotype blocks. Among 49 diplotypes (D1-D49) created from rs7851696 (G&gt;T), rs4521835 (T&gt;G), rs73664188 (T&gt;C), rs11103564 (T&gt;C), rs11103565 (G&gt;A) and rs6537959 (T&gt;A), twenty two occurred with frequency &gt;1%. Two diplotypes: D13 (GTTTGT/GGTCGT) and D10 (GTTTGT/GGTCGA), were significantly more frequent among preterm neonates with early onset of infection and pneumonia, compared with newborns with no infectious complications (OR 2.69 and 2.81, respectively; both p&lt;0.05). The minor (C) allele at rs73664188 was associated with an increased risk of very low (≤1500 g) birthweight (OR=1.95, p=0.042) but was associated with the opposite effect at rs11103564 (OR=0.11, p=0.005).</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">3’UTR</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">ficolin-2</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">FCN2</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">newborn</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">prematurity</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Immunologic diseases. 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Polymorphisms of the FCN2 Gene 3’UTR Region and Their Clinical Associations in Preterm Newborns

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