Influencing factors for the 90-day prognosis of patients with HBV-related acute-on-chronic liver failure
ObjectiveTo investigate the risk factors for short-term prognosis in patients with HBV-related acute-on-chronic liver failure (ACLF). MethodsA retrospective analysis was performed for the clinical data of 119 patients with HBV-related ACLF who were admitted to Mengchao Hepatobiliary Hospital of Fuji...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
ZHANG Dongqing [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Chinesisch |
| Erschienen: |
2021 |
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| Übergeordnetes Werk: |
In: Linchuang Gandanbing Zazhi - Editorial Department of Journal of Clinical Hepatology, 2017, 37(2021), 10, Seite 2316-2319 |
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| Übergeordnetes Werk: |
volume:37 ; year:2021 ; number:10 ; pages:2316-2319 |
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DOAJ062206133 |
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| 520 | |a ObjectiveTo investigate the risk factors for short-term prognosis in patients with HBV-related acute-on-chronic liver failure (ACLF). MethodsA retrospective analysis was performed for the clinical data of 119 patients with HBV-related ACLF who were admitted to Mengchao Hepatobiliary Hospital of Fujian Medical University from October 2019 to October 2020, and according to their survival status on day 90, they were divided into death group and survival group. The patients were given antiviral therapy with entecavir or tenofovir. Related clinical data were collected, including alanine aminotransferase (ALT), aspartate aminotransferase, cholinesterase (ChE), albumin (Alb), cholesterol, alpha-fetoprotein, and HBV DNA at baseline, as well as the incidence rate of important complications. Model for End-Stage Liver Disease (MELD) score was also calculated. The t-test or the Mann-Whitney U test was used for comparison of continuous data between two groups, and the chi-squared test was used for comparison of categorical data between two groups; a logistic regression analysis was used to investigate the influencing factors for the 90-day prognosis of patients with HBV-related ACLF and establish a new predictive model; the receiver operating characteristic (ROC) curve was used to evaluate the diagnostic efficiency of the new model in predicting the prognosis of HBV-related ACLF. ResultsOf all patients, 33 died within 90 days, resulting in a mortality rate of 27.7%. There were significant differences between the survival group and the death group in age, ALT, Alb, ChE, MELD score, and incidence rates of hepatic encephalopathy, primary peritonitis, and hepatorenal syndrome (all P＜0.05). The logistic regression analysis showed that baseline hepatic encephalopathy (odds ratio ［OR］=10.404, 95% confidence interval ［CI］: 2.522-42.926, P=0.001), serum Alb at baseline (OR=0.853, 95%CI: 0.764-0.952, P=0.005), and MELD score at baseline (OR=1.143, 95%CI: 1.036-1.261, P=0008) were independent predictive factors for the short-term prognosis of patients with HBV-related ACLF. A new predictive model was established based on the combination of these three indices, and the ROC curve analysis showed that this new model had an area under the curve of 0.833, while MELD score had an area under the ROC curve of 0.672. ConclusionAs for the evaluation of the 90-day prognosis of patients with HBV-related ACLF, the new prognostic model established based on hepatic encephalopathy, Alb, and MELD score has a better predictive value than MELD score alone. | ||
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(DE-627)DOAJ062206133 (DE-599)DOAJa2c9b49388c74c7db33af2d1fb703768 DE-627 ger DE-627 rakwb chi RC799-869 ZHANG Dongqing verfasserin aut Influencing factors for the 90-day prognosis of patients with HBV-related acute-on-chronic liver failure 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier ObjectiveTo investigate the risk factors for short-term prognosis in patients with HBV-related acute-on-chronic liver failure (ACLF). MethodsA retrospective analysis was performed for the clinical data of 119 patients with HBV-related ACLF who were admitted to Mengchao Hepatobiliary Hospital of Fujian Medical University from October 2019 to October 2020, and according to their survival status on day 90, they were divided into death group and survival group. The patients were given antiviral therapy with entecavir or tenofovir. Related clinical data were collected, including alanine aminotransferase (ALT), aspartate aminotransferase, cholinesterase (ChE), albumin (Alb), cholesterol, alpha-fetoprotein, and HBV DNA at baseline, as well as the incidence rate of important complications. Model for End-Stage Liver Disease (MELD) score was also calculated. The t-test or the Mann-Whitney U test was used for comparison of continuous data between two groups, and the chi-squared test was used for comparison of categorical data between two groups; a logistic regression analysis was used to investigate the influencing factors for the 90-day prognosis of patients with HBV-related ACLF and establish a new predictive model; the receiver operating characteristic (ROC) curve was used to evaluate the diagnostic efficiency of the new model in predicting the prognosis of HBV-related ACLF. ResultsOf all patients, 33 died within 90 days, resulting in a mortality rate of 27.7%. There were significant differences between the survival group and the death group in age, ALT, Alb, ChE, MELD score, and incidence rates of hepatic encephalopathy, primary peritonitis, and hepatorenal syndrome (all P＜0.05). The logistic regression analysis showed that baseline hepatic encephalopathy (odds ratio ［OR］=10.404, 95% confidence interval ［CI］: 2.522-42.926, P=0.001), serum Alb at baseline (OR=0.853, 95%CI: 0.764-0.952, P=0.005), and MELD score at baseline (OR=1.143, 95%CI: 1.036-1.261, P=0008) were independent predictive factors for the short-term prognosis of patients with HBV-related ACLF. A new predictive model was established based on the combination of these three indices, and the ROC curve analysis showed that this new model had an area under the curve of 0.833, while MELD score had an area under the ROC curve of 0.672. ConclusionAs for the evaluation of the 90-day prognosis of patients with HBV-related ACLF, the new prognostic model established based on hepatic encephalopathy, Alb, and MELD score has a better predictive value than MELD score alone. Diseases of the digestive system. Gastroenterology In Linchuang Gandanbing Zazhi Editorial Department of Journal of Clinical Hepatology, 2017 37(2021), 10, Seite 2316-2319 (DE-627)591509873 (DE-600)2477443-1 10015256 nnns volume:37 year:2021 number:10 pages:2316-2319 https://doaj.org/article/a2c9b49388c74c7db33af2d1fb703768 kostenfrei http://www.lcgdbzz.org/cn/article/doi/10.3969/j.issn.1001-5256.2021.10.011 kostenfrei https://doaj.org/toc/1001-5256 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_39 GBV_ILN_206 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 37 2021 10 2316-2319 |
| spelling |
(DE-627)DOAJ062206133 (DE-599)DOAJa2c9b49388c74c7db33af2d1fb703768 DE-627 ger DE-627 rakwb chi RC799-869 ZHANG Dongqing verfasserin aut Influencing factors for the 90-day prognosis of patients with HBV-related acute-on-chronic liver failure 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier ObjectiveTo investigate the risk factors for short-term prognosis in patients with HBV-related acute-on-chronic liver failure (ACLF). MethodsA retrospective analysis was performed for the clinical data of 119 patients with HBV-related ACLF who were admitted to Mengchao Hepatobiliary Hospital of Fujian Medical University from October 2019 to October 2020, and according to their survival status on day 90, they were divided into death group and survival group. The patients were given antiviral therapy with entecavir or tenofovir. Related clinical data were collected, including alanine aminotransferase (ALT), aspartate aminotransferase, cholinesterase (ChE), albumin (Alb), cholesterol, alpha-fetoprotein, and HBV DNA at baseline, as well as the incidence rate of important complications. Model for End-Stage Liver Disease (MELD) score was also calculated. The t-test or the Mann-Whitney U test was used for comparison of continuous data between two groups, and the chi-squared test was used for comparison of categorical data between two groups; a logistic regression analysis was used to investigate the influencing factors for the 90-day prognosis of patients with HBV-related ACLF and establish a new predictive model; the receiver operating characteristic (ROC) curve was used to evaluate the diagnostic efficiency of the new model in predicting the prognosis of HBV-related ACLF. ResultsOf all patients, 33 died within 90 days, resulting in a mortality rate of 27.7%. There were significant differences between the survival group and the death group in age, ALT, Alb, ChE, MELD score, and incidence rates of hepatic encephalopathy, primary peritonitis, and hepatorenal syndrome (all P＜0.05). The logistic regression analysis showed that baseline hepatic encephalopathy (odds ratio ［OR］=10.404, 95% confidence interval ［CI］: 2.522-42.926, P=0.001), serum Alb at baseline (OR=0.853, 95%CI: 0.764-0.952, P=0.005), and MELD score at baseline (OR=1.143, 95%CI: 1.036-1.261, P=0008) were independent predictive factors for the short-term prognosis of patients with HBV-related ACLF. A new predictive model was established based on the combination of these three indices, and the ROC curve analysis showed that this new model had an area under the curve of 0.833, while MELD score had an area under the ROC curve of 0.672. ConclusionAs for the evaluation of the 90-day prognosis of patients with HBV-related ACLF, the new prognostic model established based on hepatic encephalopathy, Alb, and MELD score has a better predictive value than MELD score alone. Diseases of the digestive system. Gastroenterology In Linchuang Gandanbing Zazhi Editorial Department of Journal of Clinical Hepatology, 2017 37(2021), 10, Seite 2316-2319 (DE-627)591509873 (DE-600)2477443-1 10015256 nnns volume:37 year:2021 number:10 pages:2316-2319 https://doaj.org/article/a2c9b49388c74c7db33af2d1fb703768 kostenfrei http://www.lcgdbzz.org/cn/article/doi/10.3969/j.issn.1001-5256.2021.10.011 kostenfrei https://doaj.org/toc/1001-5256 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_39 GBV_ILN_206 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 37 2021 10 2316-2319 |
| allfields_unstemmed |
(DE-627)DOAJ062206133 (DE-599)DOAJa2c9b49388c74c7db33af2d1fb703768 DE-627 ger DE-627 rakwb chi RC799-869 ZHANG Dongqing verfasserin aut Influencing factors for the 90-day prognosis of patients with HBV-related acute-on-chronic liver failure 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier ObjectiveTo investigate the risk factors for short-term prognosis in patients with HBV-related acute-on-chronic liver failure (ACLF). MethodsA retrospective analysis was performed for the clinical data of 119 patients with HBV-related ACLF who were admitted to Mengchao Hepatobiliary Hospital of Fujian Medical University from October 2019 to October 2020, and according to their survival status on day 90, they were divided into death group and survival group. The patients were given antiviral therapy with entecavir or tenofovir. Related clinical data were collected, including alanine aminotransferase (ALT), aspartate aminotransferase, cholinesterase (ChE), albumin (Alb), cholesterol, alpha-fetoprotein, and HBV DNA at baseline, as well as the incidence rate of important complications. Model for End-Stage Liver Disease (MELD) score was also calculated. The t-test or the Mann-Whitney U test was used for comparison of continuous data between two groups, and the chi-squared test was used for comparison of categorical data between two groups; a logistic regression analysis was used to investigate the influencing factors for the 90-day prognosis of patients with HBV-related ACLF and establish a new predictive model; the receiver operating characteristic (ROC) curve was used to evaluate the diagnostic efficiency of the new model in predicting the prognosis of HBV-related ACLF. ResultsOf all patients, 33 died within 90 days, resulting in a mortality rate of 27.7%. There were significant differences between the survival group and the death group in age, ALT, Alb, ChE, MELD score, and incidence rates of hepatic encephalopathy, primary peritonitis, and hepatorenal syndrome (all P＜0.05). The logistic regression analysis showed that baseline hepatic encephalopathy (odds ratio ［OR］=10.404, 95% confidence interval ［CI］: 2.522-42.926, P=0.001), serum Alb at baseline (OR=0.853, 95%CI: 0.764-0.952, P=0.005), and MELD score at baseline (OR=1.143, 95%CI: 1.036-1.261, P=0008) were independent predictive factors for the short-term prognosis of patients with HBV-related ACLF. A new predictive model was established based on the combination of these three indices, and the ROC curve analysis showed that this new model had an area under the curve of 0.833, while MELD score had an area under the ROC curve of 0.672. ConclusionAs for the evaluation of the 90-day prognosis of patients with HBV-related ACLF, the new prognostic model established based on hepatic encephalopathy, Alb, and MELD score has a better predictive value than MELD score alone. Diseases of the digestive system. Gastroenterology In Linchuang Gandanbing Zazhi Editorial Department of Journal of Clinical Hepatology, 2017 37(2021), 10, Seite 2316-2319 (DE-627)591509873 (DE-600)2477443-1 10015256 nnns volume:37 year:2021 number:10 pages:2316-2319 https://doaj.org/article/a2c9b49388c74c7db33af2d1fb703768 kostenfrei http://www.lcgdbzz.org/cn/article/doi/10.3969/j.issn.1001-5256.2021.10.011 kostenfrei https://doaj.org/toc/1001-5256 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_39 GBV_ILN_206 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 37 2021 10 2316-2319 |
| allfieldsGer |
(DE-627)DOAJ062206133 (DE-599)DOAJa2c9b49388c74c7db33af2d1fb703768 DE-627 ger DE-627 rakwb chi RC799-869 ZHANG Dongqing verfasserin aut Influencing factors for the 90-day prognosis of patients with HBV-related acute-on-chronic liver failure 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier ObjectiveTo investigate the risk factors for short-term prognosis in patients with HBV-related acute-on-chronic liver failure (ACLF). MethodsA retrospective analysis was performed for the clinical data of 119 patients with HBV-related ACLF who were admitted to Mengchao Hepatobiliary Hospital of Fujian Medical University from October 2019 to October 2020, and according to their survival status on day 90, they were divided into death group and survival group. The patients were given antiviral therapy with entecavir or tenofovir. Related clinical data were collected, including alanine aminotransferase (ALT), aspartate aminotransferase, cholinesterase (ChE), albumin (Alb), cholesterol, alpha-fetoprotein, and HBV DNA at baseline, as well as the incidence rate of important complications. Model for End-Stage Liver Disease (MELD) score was also calculated. The t-test or the Mann-Whitney U test was used for comparison of continuous data between two groups, and the chi-squared test was used for comparison of categorical data between two groups; a logistic regression analysis was used to investigate the influencing factors for the 90-day prognosis of patients with HBV-related ACLF and establish a new predictive model; the receiver operating characteristic (ROC) curve was used to evaluate the diagnostic efficiency of the new model in predicting the prognosis of HBV-related ACLF. ResultsOf all patients, 33 died within 90 days, resulting in a mortality rate of 27.7%. There were significant differences between the survival group and the death group in age, ALT, Alb, ChE, MELD score, and incidence rates of hepatic encephalopathy, primary peritonitis, and hepatorenal syndrome (all P＜0.05). The logistic regression analysis showed that baseline hepatic encephalopathy (odds ratio ［OR］=10.404, 95% confidence interval ［CI］: 2.522-42.926, P=0.001), serum Alb at baseline (OR=0.853, 95%CI: 0.764-0.952, P=0.005), and MELD score at baseline (OR=1.143, 95%CI: 1.036-1.261, P=0008) were independent predictive factors for the short-term prognosis of patients with HBV-related ACLF. A new predictive model was established based on the combination of these three indices, and the ROC curve analysis showed that this new model had an area under the curve of 0.833, while MELD score had an area under the ROC curve of 0.672. ConclusionAs for the evaluation of the 90-day prognosis of patients with HBV-related ACLF, the new prognostic model established based on hepatic encephalopathy, Alb, and MELD score has a better predictive value than MELD score alone. Diseases of the digestive system. Gastroenterology In Linchuang Gandanbing Zazhi Editorial Department of Journal of Clinical Hepatology, 2017 37(2021), 10, Seite 2316-2319 (DE-627)591509873 (DE-600)2477443-1 10015256 nnns volume:37 year:2021 number:10 pages:2316-2319 https://doaj.org/article/a2c9b49388c74c7db33af2d1fb703768 kostenfrei http://www.lcgdbzz.org/cn/article/doi/10.3969/j.issn.1001-5256.2021.10.011 kostenfrei https://doaj.org/toc/1001-5256 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_39 GBV_ILN_206 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 37 2021 10 2316-2319 |
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(DE-627)DOAJ062206133 (DE-599)DOAJa2c9b49388c74c7db33af2d1fb703768 DE-627 ger DE-627 rakwb chi RC799-869 ZHANG Dongqing verfasserin aut Influencing factors for the 90-day prognosis of patients with HBV-related acute-on-chronic liver failure 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier ObjectiveTo investigate the risk factors for short-term prognosis in patients with HBV-related acute-on-chronic liver failure (ACLF). MethodsA retrospective analysis was performed for the clinical data of 119 patients with HBV-related ACLF who were admitted to Mengchao Hepatobiliary Hospital of Fujian Medical University from October 2019 to October 2020, and according to their survival status on day 90, they were divided into death group and survival group. The patients were given antiviral therapy with entecavir or tenofovir. Related clinical data were collected, including alanine aminotransferase (ALT), aspartate aminotransferase, cholinesterase (ChE), albumin (Alb), cholesterol, alpha-fetoprotein, and HBV DNA at baseline, as well as the incidence rate of important complications. Model for End-Stage Liver Disease (MELD) score was also calculated. The t-test or the Mann-Whitney U test was used for comparison of continuous data between two groups, and the chi-squared test was used for comparison of categorical data between two groups; a logistic regression analysis was used to investigate the influencing factors for the 90-day prognosis of patients with HBV-related ACLF and establish a new predictive model; the receiver operating characteristic (ROC) curve was used to evaluate the diagnostic efficiency of the new model in predicting the prognosis of HBV-related ACLF. ResultsOf all patients, 33 died within 90 days, resulting in a mortality rate of 27.7%. There were significant differences between the survival group and the death group in age, ALT, Alb, ChE, MELD score, and incidence rates of hepatic encephalopathy, primary peritonitis, and hepatorenal syndrome (all P＜0.05). The logistic regression analysis showed that baseline hepatic encephalopathy (odds ratio ［OR］=10.404, 95% confidence interval ［CI］: 2.522-42.926, P=0.001), serum Alb at baseline (OR=0.853, 95%CI: 0.764-0.952, P=0.005), and MELD score at baseline (OR=1.143, 95%CI: 1.036-1.261, P=0008) were independent predictive factors for the short-term prognosis of patients with HBV-related ACLF. A new predictive model was established based on the combination of these three indices, and the ROC curve analysis showed that this new model had an area under the curve of 0.833, while MELD score had an area under the ROC curve of 0.672. ConclusionAs for the evaluation of the 90-day prognosis of patients with HBV-related ACLF, the new prognostic model established based on hepatic encephalopathy, Alb, and MELD score has a better predictive value than MELD score alone. Diseases of the digestive system. Gastroenterology In Linchuang Gandanbing Zazhi Editorial Department of Journal of Clinical Hepatology, 2017 37(2021), 10, Seite 2316-2319 (DE-627)591509873 (DE-600)2477443-1 10015256 nnns volume:37 year:2021 number:10 pages:2316-2319 https://doaj.org/article/a2c9b49388c74c7db33af2d1fb703768 kostenfrei http://www.lcgdbzz.org/cn/article/doi/10.3969/j.issn.1001-5256.2021.10.011 kostenfrei https://doaj.org/toc/1001-5256 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_39 GBV_ILN_206 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 37 2021 10 2316-2319 |
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The t-test or the Mann-Whitney U test was used for comparison of continuous data between two groups, and the chi-squared test was used for comparison of categorical data between two groups; a logistic regression analysis was used to investigate the influencing factors for the 90-day prognosis of patients with HBV-related ACLF and establish a new predictive model; the receiver operating characteristic (ROC) curve was used to evaluate the diagnostic efficiency of the new model in predicting the prognosis of HBV-related ACLF. ResultsOf all patients, 33 died within 90 days, resulting in a mortality rate of 27.7%. There were significant differences between the survival group and the death group in age, ALT, Alb, ChE, MELD score, and incidence rates of hepatic encephalopathy, primary peritonitis, and hepatorenal syndrome (all P＜0.05). 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Influencing factors for the 90-day prognosis of patients with HBV-related acute-on-chronic liver failure |
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ObjectiveTo investigate the risk factors for short-term prognosis in patients with HBV-related acute-on-chronic liver failure (ACLF). MethodsA retrospective analysis was performed for the clinical data of 119 patients with HBV-related ACLF who were admitted to Mengchao Hepatobiliary Hospital of Fujian Medical University from October 2019 to October 2020, and according to their survival status on day 90, they were divided into death group and survival group. The patients were given antiviral therapy with entecavir or tenofovir. Related clinical data were collected, including alanine aminotransferase (ALT), aspartate aminotransferase, cholinesterase (ChE), albumin (Alb), cholesterol, alpha-fetoprotein, and HBV DNA at baseline, as well as the incidence rate of important complications. Model for End-Stage Liver Disease (MELD) score was also calculated. The t-test or the Mann-Whitney U test was used for comparison of continuous data between two groups, and the chi-squared test was used for comparison of categorical data between two groups; a logistic regression analysis was used to investigate the influencing factors for the 90-day prognosis of patients with HBV-related ACLF and establish a new predictive model; the receiver operating characteristic (ROC) curve was used to evaluate the diagnostic efficiency of the new model in predicting the prognosis of HBV-related ACLF. ResultsOf all patients, 33 died within 90 days, resulting in a mortality rate of 27.7%. There were significant differences between the survival group and the death group in age, ALT, Alb, ChE, MELD score, and incidence rates of hepatic encephalopathy, primary peritonitis, and hepatorenal syndrome (all P＜0.05). The logistic regression analysis showed that baseline hepatic encephalopathy (odds ratio ［OR］=10.404, 95% confidence interval ［CI］: 2.522-42.926, P=0.001), serum Alb at baseline (OR=0.853, 95%CI: 0.764-0.952, P=0.005), and MELD score at baseline (OR=1.143, 95%CI: 1.036-1.261, P=0008) were independent predictive factors for the short-term prognosis of patients with HBV-related ACLF. A new predictive model was established based on the combination of these three indices, and the ROC curve analysis showed that this new model had an area under the curve of 0.833, while MELD score had an area under the ROC curve of 0.672. ConclusionAs for the evaluation of the 90-day prognosis of patients with HBV-related ACLF, the new prognostic model established based on hepatic encephalopathy, Alb, and MELD score has a better predictive value than MELD score alone. |
| abstractGer |
ObjectiveTo investigate the risk factors for short-term prognosis in patients with HBV-related acute-on-chronic liver failure (ACLF). MethodsA retrospective analysis was performed for the clinical data of 119 patients with HBV-related ACLF who were admitted to Mengchao Hepatobiliary Hospital of Fujian Medical University from October 2019 to October 2020, and according to their survival status on day 90, they were divided into death group and survival group. The patients were given antiviral therapy with entecavir or tenofovir. Related clinical data were collected, including alanine aminotransferase (ALT), aspartate aminotransferase, cholinesterase (ChE), albumin (Alb), cholesterol, alpha-fetoprotein, and HBV DNA at baseline, as well as the incidence rate of important complications. Model for End-Stage Liver Disease (MELD) score was also calculated. The t-test or the Mann-Whitney U test was used for comparison of continuous data between two groups, and the chi-squared test was used for comparison of categorical data between two groups; a logistic regression analysis was used to investigate the influencing factors for the 90-day prognosis of patients with HBV-related ACLF and establish a new predictive model; the receiver operating characteristic (ROC) curve was used to evaluate the diagnostic efficiency of the new model in predicting the prognosis of HBV-related ACLF. ResultsOf all patients, 33 died within 90 days, resulting in a mortality rate of 27.7%. There were significant differences between the survival group and the death group in age, ALT, Alb, ChE, MELD score, and incidence rates of hepatic encephalopathy, primary peritonitis, and hepatorenal syndrome (all P＜0.05). The logistic regression analysis showed that baseline hepatic encephalopathy (odds ratio ［OR］=10.404, 95% confidence interval ［CI］: 2.522-42.926, P=0.001), serum Alb at baseline (OR=0.853, 95%CI: 0.764-0.952, P=0.005), and MELD score at baseline (OR=1.143, 95%CI: 1.036-1.261, P=0008) were independent predictive factors for the short-term prognosis of patients with HBV-related ACLF. A new predictive model was established based on the combination of these three indices, and the ROC curve analysis showed that this new model had an area under the curve of 0.833, while MELD score had an area under the ROC curve of 0.672. ConclusionAs for the evaluation of the 90-day prognosis of patients with HBV-related ACLF, the new prognostic model established based on hepatic encephalopathy, Alb, and MELD score has a better predictive value than MELD score alone. |
| abstract_unstemmed |
ObjectiveTo investigate the risk factors for short-term prognosis in patients with HBV-related acute-on-chronic liver failure (ACLF). MethodsA retrospective analysis was performed for the clinical data of 119 patients with HBV-related ACLF who were admitted to Mengchao Hepatobiliary Hospital of Fujian Medical University from October 2019 to October 2020, and according to their survival status on day 90, they were divided into death group and survival group. The patients were given antiviral therapy with entecavir or tenofovir. Related clinical data were collected, including alanine aminotransferase (ALT), aspartate aminotransferase, cholinesterase (ChE), albumin (Alb), cholesterol, alpha-fetoprotein, and HBV DNA at baseline, as well as the incidence rate of important complications. Model for End-Stage Liver Disease (MELD) score was also calculated. The t-test or the Mann-Whitney U test was used for comparison of continuous data between two groups, and the chi-squared test was used for comparison of categorical data between two groups; a logistic regression analysis was used to investigate the influencing factors for the 90-day prognosis of patients with HBV-related ACLF and establish a new predictive model; the receiver operating characteristic (ROC) curve was used to evaluate the diagnostic efficiency of the new model in predicting the prognosis of HBV-related ACLF. ResultsOf all patients, 33 died within 90 days, resulting in a mortality rate of 27.7%. There were significant differences between the survival group and the death group in age, ALT, Alb, ChE, MELD score, and incidence rates of hepatic encephalopathy, primary peritonitis, and hepatorenal syndrome (all P＜0.05). The logistic regression analysis showed that baseline hepatic encephalopathy (odds ratio ［OR］=10.404, 95% confidence interval ［CI］: 2.522-42.926, P=0.001), serum Alb at baseline (OR=0.853, 95%CI: 0.764-0.952, P=0.005), and MELD score at baseline (OR=1.143, 95%CI: 1.036-1.261, P=0008) were independent predictive factors for the short-term prognosis of patients with HBV-related ACLF. A new predictive model was established based on the combination of these three indices, and the ROC curve analysis showed that this new model had an area under the curve of 0.833, while MELD score had an area under the ROC curve of 0.672. ConclusionAs for the evaluation of the 90-day prognosis of patients with HBV-related ACLF, the new prognostic model established based on hepatic encephalopathy, Alb, and MELD score has a better predictive value than MELD score alone. |
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Influencing factors for the 90-day prognosis of patients with HBV-related acute-on-chronic liver failure |
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https://doaj.org/article/a2c9b49388c74c7db33af2d1fb703768 http://www.lcgdbzz.org/cn/article/doi/10.3969/j.issn.1001-5256.2021.10.011 https://doaj.org/toc/1001-5256 |
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