Hormonal regulation of adrenal microvillar channel formation

This study examined the in vivo relationship between expression of the HDL receptor scavenger receptor class B (SR-BI) and corresponding structural changes in the rat adrenocortical cell microvillar compartment. Using hormonal stimulation and withdrawal protocols, we were able to manipulate adrenal...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Salman Azhar [verfasserIn] Ann Nomoto [verfasserIn] Eve Reaven [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2002

Schlagwörter:	SR-BI HDL steroid hormone ACTH corticosterone cholesterol

Übergeordnetes Werk:	In: Journal of Lipid Research - Elsevier, 2021, 43(2002), 6, Seite 861-871
Übergeordnetes Werk:	volume:43 ; year:2002 ; number:6 ; pages:861-871

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1016/S0022-2275(20)30459-4

Katalog-ID:	DOAJ062247735

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language	English
source	In Journal of Lipid Research 43(2002), 6, Seite 861-871 volume:43 year:2002 number:6 pages:861-871
sourceStr	In Journal of Lipid Research 43(2002), 6, Seite 861-871 volume:43 year:2002 number:6 pages:861-871
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	SR-BI HDL steroid hormone ACTH corticosterone cholesterol Biochemistry
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container_title	Journal of Lipid Research
authorswithroles_txt_mv	Salman Azhar @@aut@@ Ann Nomoto @@aut@@ Eve Reaven @@aut@@
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callnumber-first	Q - Science
author	Salman Azhar
spellingShingle	Salman Azhar misc QD415-436 misc SR-BI misc HDL misc steroid hormone misc ACTH misc corticosterone misc cholesterol misc Biochemistry Hormonal regulation of adrenal microvillar channel formation
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topic_title	QD415-436 Hormonal regulation of adrenal microvillar channel formation SR-BI HDL steroid hormone ACTH corticosterone cholesterol
topic	misc QD415-436 misc SR-BI misc HDL misc steroid hormone misc ACTH misc corticosterone misc cholesterol misc Biochemistry
topic_unstemmed	misc QD415-436 misc SR-BI misc HDL misc steroid hormone misc ACTH misc corticosterone misc cholesterol misc Biochemistry
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title	Hormonal regulation of adrenal microvillar channel formation
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title_sort	hormonal regulation of adrenal microvillar channel formation
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title_auth	Hormonal regulation of adrenal microvillar channel formation
abstract	This study examined the in vivo relationship between expression of the HDL receptor scavenger receptor class B (SR-BI) and corresponding structural changes in the rat adrenocortical cell microvillar compartment. Using hormonal stimulation and withdrawal protocols, we were able to manipulate adrenal SR-BI levels and carry out qualitative and quantitative measurements correlating SR-BI expression with microvillar mass and microvillar channel formation. Young male rats were used as controls or treated with adrenocorticotropin hormone (ACTH) (24 h), 17α-ethinyl estradiol (17α-E2) (5 days), or dexamethasone (DEX) (24 h). Quantitative Western blot analysis and immunocytochemistry indicated that ACTH and 17α-E2 treatment greatly increased SR-BI expression in the adrenal (especially in the microvillar compartment of adrenocortical cells), whereas DEX treatment led to a decrease of SR-BI by all measurements. At the same time, striking ultrastructural changes occurred in the adrenocortical cell microvillar compartment: e.g., microvillar area and microvillar channel formation and complexity dramatically increased (compared with control values) after ACTH or 17α-E2 treatment, whereas the same values declined after DEX treatment.These measurements illustrate the exceptional flexibility and responsiveness of the microvillar compartment to hormonal stimuli, and suggest that regulation of SR-BI expression and structural configuration of the surface of steroidogenic cells goes hand in hand.
abstractGer	This study examined the in vivo relationship between expression of the HDL receptor scavenger receptor class B (SR-BI) and corresponding structural changes in the rat adrenocortical cell microvillar compartment. Using hormonal stimulation and withdrawal protocols, we were able to manipulate adrenal SR-BI levels and carry out qualitative and quantitative measurements correlating SR-BI expression with microvillar mass and microvillar channel formation. Young male rats were used as controls or treated with adrenocorticotropin hormone (ACTH) (24 h), 17α-ethinyl estradiol (17α-E2) (5 days), or dexamethasone (DEX) (24 h). Quantitative Western blot analysis and immunocytochemistry indicated that ACTH and 17α-E2 treatment greatly increased SR-BI expression in the adrenal (especially in the microvillar compartment of adrenocortical cells), whereas DEX treatment led to a decrease of SR-BI by all measurements. At the same time, striking ultrastructural changes occurred in the adrenocortical cell microvillar compartment: e.g., microvillar area and microvillar channel formation and complexity dramatically increased (compared with control values) after ACTH or 17α-E2 treatment, whereas the same values declined after DEX treatment.These measurements illustrate the exceptional flexibility and responsiveness of the microvillar compartment to hormonal stimuli, and suggest that regulation of SR-BI expression and structural configuration of the surface of steroidogenic cells goes hand in hand.
abstract_unstemmed	This study examined the in vivo relationship between expression of the HDL receptor scavenger receptor class B (SR-BI) and corresponding structural changes in the rat adrenocortical cell microvillar compartment. Using hormonal stimulation and withdrawal protocols, we were able to manipulate adrenal SR-BI levels and carry out qualitative and quantitative measurements correlating SR-BI expression with microvillar mass and microvillar channel formation. Young male rats were used as controls or treated with adrenocorticotropin hormone (ACTH) (24 h), 17α-ethinyl estradiol (17α-E2) (5 days), or dexamethasone (DEX) (24 h). Quantitative Western blot analysis and immunocytochemistry indicated that ACTH and 17α-E2 treatment greatly increased SR-BI expression in the adrenal (especially in the microvillar compartment of adrenocortical cells), whereas DEX treatment led to a decrease of SR-BI by all measurements. At the same time, striking ultrastructural changes occurred in the adrenocortical cell microvillar compartment: e.g., microvillar area and microvillar channel formation and complexity dramatically increased (compared with control values) after ACTH or 17α-E2 treatment, whereas the same values declined after DEX treatment.These measurements illustrate the exceptional flexibility and responsiveness of the microvillar compartment to hormonal stimuli, and suggest that regulation of SR-BI expression and structural configuration of the surface of steroidogenic cells goes hand in hand.
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title_short	Hormonal regulation of adrenal microvillar channel formation
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