Apolipoprotein composition of HDL in cholesteryl ester transfer protein deficiency

Our purpose was to compare HDL subpopulations, as determined by nondenaturing two-dimensional gel electrophoresis followed by immunoblotting for apolipoprotein A-I (apoA-I), apoA-II, apoA-IV, apoCs, and apoE in heterozygous, compound heterozygous, and homozygous subjects for cholesteryl ester transf...
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Autor*in:	Bela F. Asztalos [verfasserIn] Katalin V. Horvath [verfasserIn] Kouji Kajinami [verfasserIn] Chorthip Nartsupha [verfasserIn] Caitlin E. Cox [verfasserIn] Marcelo Batista [verfasserIn] Ernst J. Schaefer [verfasserIn] Akihiro Inazu [verfasserIn] Hiroshi Mabuchi [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2004

Schlagwörter:	lipoproteins high density lipoprotein subpopulations reverse cholesterol transport

Übergeordnetes Werk:	In: Journal of Lipid Research - Elsevier, 2021, 45(2004), 3, Seite 448-455
Übergeordnetes Werk:	volume:45 ; year:2004 ; number:3 ; pages:448-455

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1194/jlr.M300198-JLR200

Katalog-ID:	DOAJ062421387

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allfields	10.1194/jlr.M300198-JLR200 doi (DE-627)DOAJ062421387 (DE-599)DOAJ0b89bf1b86ad433b9acedb018602b86e DE-627 ger DE-627 rakwb eng QD415-436 Bela F. Asztalos verfasserin aut Apolipoprotein composition of HDL in cholesteryl ester transfer protein deficiency 2004 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Our purpose was to compare HDL subpopulations, as determined by nondenaturing two-dimensional gel electrophoresis followed by immunoblotting for apolipoprotein A-I (apoA-I), apoA-II, apoA-IV, apoCs, and apoE in heterozygous, compound heterozygous, and homozygous subjects for cholesteryl ester transfer protein (CETP) deficiency and controls. Heterozygotes, compound heterozygotes, and homozygotes had CETP masses that were 30, 63, and more than 90% lower and HDL-cholesterol values that were 64, 168, and 203% higher than those in controls, respectively. Heterozygotes had ∼50% lower preβ-1 and more than 2-fold higher levels of α-1 and preα-1 particles than controls. Three of the five heterozygotes' α-1 particles also contained apoA-II, which was not seen in controls. Compound heterozygotes and homozygotes had very large particles not observed in controls and heterozygotes. These particles contained apoA-I, apoA-II, apoCs, and apoE. However, these subjects did not have decreased preβ-1 levels.Our data indicate that CETP deficiency results in the formation of very large HDL particles containing all of the major HDL apolipoproteins except for apoA-IV. We hypothesize that the HDL subpopulation profile of heterozygous CETP-deficient patients, especially those with high levels of α-1 containing apoA-I but no apoA-II, represent an improved anti-atherogenic state, although this might not be the case for compound heterozygotes and homozygotes with very large, undifferentiated HDL particles. lipoproteins high density lipoprotein subpopulations reverse cholesterol transport Biochemistry Katalin V. Horvath verfasserin aut Kouji Kajinami verfasserin aut Chorthip Nartsupha verfasserin aut Caitlin E. Cox verfasserin aut Marcelo Batista verfasserin aut Ernst J. Schaefer verfasserin aut Akihiro Inazu verfasserin aut Hiroshi Mabuchi verfasserin aut In Journal of Lipid Research Elsevier, 2021 45(2004), 3, Seite 448-455 (DE-627)26601593X (DE-600)1466675-3 15397262 nnns volume:45 year:2004 number:3 pages:448-455 https://doi.org/10.1194/jlr.M300198-JLR200 kostenfrei https://doaj.org/article/0b89bf1b86ad433b9acedb018602b86e kostenfrei http://www.sciencedirect.com/science/article/pii/S0022227520318721 kostenfrei https://doaj.org/toc/0022-2275 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_252 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2006 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 45 2004 3 448-455
spelling	10.1194/jlr.M300198-JLR200 doi (DE-627)DOAJ062421387 (DE-599)DOAJ0b89bf1b86ad433b9acedb018602b86e DE-627 ger DE-627 rakwb eng QD415-436 Bela F. Asztalos verfasserin aut Apolipoprotein composition of HDL in cholesteryl ester transfer protein deficiency 2004 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Our purpose was to compare HDL subpopulations, as determined by nondenaturing two-dimensional gel electrophoresis followed by immunoblotting for apolipoprotein A-I (apoA-I), apoA-II, apoA-IV, apoCs, and apoE in heterozygous, compound heterozygous, and homozygous subjects for cholesteryl ester transfer protein (CETP) deficiency and controls. Heterozygotes, compound heterozygotes, and homozygotes had CETP masses that were 30, 63, and more than 90% lower and HDL-cholesterol values that were 64, 168, and 203% higher than those in controls, respectively. Heterozygotes had ∼50% lower preβ-1 and more than 2-fold higher levels of α-1 and preα-1 particles than controls. Three of the five heterozygotes' α-1 particles also contained apoA-II, which was not seen in controls. Compound heterozygotes and homozygotes had very large particles not observed in controls and heterozygotes. These particles contained apoA-I, apoA-II, apoCs, and apoE. However, these subjects did not have decreased preβ-1 levels.Our data indicate that CETP deficiency results in the formation of very large HDL particles containing all of the major HDL apolipoproteins except for apoA-IV. We hypothesize that the HDL subpopulation profile of heterozygous CETP-deficient patients, especially those with high levels of α-1 containing apoA-I but no apoA-II, represent an improved anti-atherogenic state, although this might not be the case for compound heterozygotes and homozygotes with very large, undifferentiated HDL particles. lipoproteins high density lipoprotein subpopulations reverse cholesterol transport Biochemistry Katalin V. Horvath verfasserin aut Kouji Kajinami verfasserin aut Chorthip Nartsupha verfasserin aut Caitlin E. Cox verfasserin aut Marcelo Batista verfasserin aut Ernst J. Schaefer verfasserin aut Akihiro Inazu verfasserin aut Hiroshi Mabuchi verfasserin aut In Journal of Lipid Research Elsevier, 2021 45(2004), 3, Seite 448-455 (DE-627)26601593X (DE-600)1466675-3 15397262 nnns volume:45 year:2004 number:3 pages:448-455 https://doi.org/10.1194/jlr.M300198-JLR200 kostenfrei https://doaj.org/article/0b89bf1b86ad433b9acedb018602b86e kostenfrei http://www.sciencedirect.com/science/article/pii/S0022227520318721 kostenfrei https://doaj.org/toc/0022-2275 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_252 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2006 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 45 2004 3 448-455
allfields_unstemmed	10.1194/jlr.M300198-JLR200 doi (DE-627)DOAJ062421387 (DE-599)DOAJ0b89bf1b86ad433b9acedb018602b86e DE-627 ger DE-627 rakwb eng QD415-436 Bela F. Asztalos verfasserin aut Apolipoprotein composition of HDL in cholesteryl ester transfer protein deficiency 2004 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Our purpose was to compare HDL subpopulations, as determined by nondenaturing two-dimensional gel electrophoresis followed by immunoblotting for apolipoprotein A-I (apoA-I), apoA-II, apoA-IV, apoCs, and apoE in heterozygous, compound heterozygous, and homozygous subjects for cholesteryl ester transfer protein (CETP) deficiency and controls. Heterozygotes, compound heterozygotes, and homozygotes had CETP masses that were 30, 63, and more than 90% lower and HDL-cholesterol values that were 64, 168, and 203% higher than those in controls, respectively. Heterozygotes had ∼50% lower preβ-1 and more than 2-fold higher levels of α-1 and preα-1 particles than controls. Three of the five heterozygotes' α-1 particles also contained apoA-II, which was not seen in controls. Compound heterozygotes and homozygotes had very large particles not observed in controls and heterozygotes. These particles contained apoA-I, apoA-II, apoCs, and apoE. However, these subjects did not have decreased preβ-1 levels.Our data indicate that CETP deficiency results in the formation of very large HDL particles containing all of the major HDL apolipoproteins except for apoA-IV. We hypothesize that the HDL subpopulation profile of heterozygous CETP-deficient patients, especially those with high levels of α-1 containing apoA-I but no apoA-II, represent an improved anti-atherogenic state, although this might not be the case for compound heterozygotes and homozygotes with very large, undifferentiated HDL particles. lipoproteins high density lipoprotein subpopulations reverse cholesterol transport Biochemistry Katalin V. Horvath verfasserin aut Kouji Kajinami verfasserin aut Chorthip Nartsupha verfasserin aut Caitlin E. Cox verfasserin aut Marcelo Batista verfasserin aut Ernst J. Schaefer verfasserin aut Akihiro Inazu verfasserin aut Hiroshi Mabuchi verfasserin aut In Journal of Lipid Research Elsevier, 2021 45(2004), 3, Seite 448-455 (DE-627)26601593X (DE-600)1466675-3 15397262 nnns volume:45 year:2004 number:3 pages:448-455 https://doi.org/10.1194/jlr.M300198-JLR200 kostenfrei https://doaj.org/article/0b89bf1b86ad433b9acedb018602b86e kostenfrei http://www.sciencedirect.com/science/article/pii/S0022227520318721 kostenfrei https://doaj.org/toc/0022-2275 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_252 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2006 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 45 2004 3 448-455
allfieldsGer	10.1194/jlr.M300198-JLR200 doi (DE-627)DOAJ062421387 (DE-599)DOAJ0b89bf1b86ad433b9acedb018602b86e DE-627 ger DE-627 rakwb eng QD415-436 Bela F. Asztalos verfasserin aut Apolipoprotein composition of HDL in cholesteryl ester transfer protein deficiency 2004 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Our purpose was to compare HDL subpopulations, as determined by nondenaturing two-dimensional gel electrophoresis followed by immunoblotting for apolipoprotein A-I (apoA-I), apoA-II, apoA-IV, apoCs, and apoE in heterozygous, compound heterozygous, and homozygous subjects for cholesteryl ester transfer protein (CETP) deficiency and controls. Heterozygotes, compound heterozygotes, and homozygotes had CETP masses that were 30, 63, and more than 90% lower and HDL-cholesterol values that were 64, 168, and 203% higher than those in controls, respectively. Heterozygotes had ∼50% lower preβ-1 and more than 2-fold higher levels of α-1 and preα-1 particles than controls. Three of the five heterozygotes' α-1 particles also contained apoA-II, which was not seen in controls. Compound heterozygotes and homozygotes had very large particles not observed in controls and heterozygotes. These particles contained apoA-I, apoA-II, apoCs, and apoE. However, these subjects did not have decreased preβ-1 levels.Our data indicate that CETP deficiency results in the formation of very large HDL particles containing all of the major HDL apolipoproteins except for apoA-IV. We hypothesize that the HDL subpopulation profile of heterozygous CETP-deficient patients, especially those with high levels of α-1 containing apoA-I but no apoA-II, represent an improved anti-atherogenic state, although this might not be the case for compound heterozygotes and homozygotes with very large, undifferentiated HDL particles. lipoproteins high density lipoprotein subpopulations reverse cholesterol transport Biochemistry Katalin V. Horvath verfasserin aut Kouji Kajinami verfasserin aut Chorthip Nartsupha verfasserin aut Caitlin E. Cox verfasserin aut Marcelo Batista verfasserin aut Ernst J. Schaefer verfasserin aut Akihiro Inazu verfasserin aut Hiroshi Mabuchi verfasserin aut In Journal of Lipid Research Elsevier, 2021 45(2004), 3, Seite 448-455 (DE-627)26601593X (DE-600)1466675-3 15397262 nnns volume:45 year:2004 number:3 pages:448-455 https://doi.org/10.1194/jlr.M300198-JLR200 kostenfrei https://doaj.org/article/0b89bf1b86ad433b9acedb018602b86e kostenfrei http://www.sciencedirect.com/science/article/pii/S0022227520318721 kostenfrei https://doaj.org/toc/0022-2275 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_252 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2006 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 45 2004 3 448-455
allfieldsSound	10.1194/jlr.M300198-JLR200 doi (DE-627)DOAJ062421387 (DE-599)DOAJ0b89bf1b86ad433b9acedb018602b86e DE-627 ger DE-627 rakwb eng QD415-436 Bela F. Asztalos verfasserin aut Apolipoprotein composition of HDL in cholesteryl ester transfer protein deficiency 2004 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Our purpose was to compare HDL subpopulations, as determined by nondenaturing two-dimensional gel electrophoresis followed by immunoblotting for apolipoprotein A-I (apoA-I), apoA-II, apoA-IV, apoCs, and apoE in heterozygous, compound heterozygous, and homozygous subjects for cholesteryl ester transfer protein (CETP) deficiency and controls. Heterozygotes, compound heterozygotes, and homozygotes had CETP masses that were 30, 63, and more than 90% lower and HDL-cholesterol values that were 64, 168, and 203% higher than those in controls, respectively. Heterozygotes had ∼50% lower preβ-1 and more than 2-fold higher levels of α-1 and preα-1 particles than controls. Three of the five heterozygotes' α-1 particles also contained apoA-II, which was not seen in controls. Compound heterozygotes and homozygotes had very large particles not observed in controls and heterozygotes. These particles contained apoA-I, apoA-II, apoCs, and apoE. However, these subjects did not have decreased preβ-1 levels.Our data indicate that CETP deficiency results in the formation of very large HDL particles containing all of the major HDL apolipoproteins except for apoA-IV. We hypothesize that the HDL subpopulation profile of heterozygous CETP-deficient patients, especially those with high levels of α-1 containing apoA-I but no apoA-II, represent an improved anti-atherogenic state, although this might not be the case for compound heterozygotes and homozygotes with very large, undifferentiated HDL particles. lipoproteins high density lipoprotein subpopulations reverse cholesterol transport Biochemistry Katalin V. Horvath verfasserin aut Kouji Kajinami verfasserin aut Chorthip Nartsupha verfasserin aut Caitlin E. Cox verfasserin aut Marcelo Batista verfasserin aut Ernst J. Schaefer verfasserin aut Akihiro Inazu verfasserin aut Hiroshi Mabuchi verfasserin aut In Journal of Lipid Research Elsevier, 2021 45(2004), 3, Seite 448-455 (DE-627)26601593X (DE-600)1466675-3 15397262 nnns volume:45 year:2004 number:3 pages:448-455 https://doi.org/10.1194/jlr.M300198-JLR200 kostenfrei https://doaj.org/article/0b89bf1b86ad433b9acedb018602b86e kostenfrei http://www.sciencedirect.com/science/article/pii/S0022227520318721 kostenfrei https://doaj.org/toc/0022-2275 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_252 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2006 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 45 2004 3 448-455
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source	In Journal of Lipid Research 45(2004), 3, Seite 448-455 volume:45 year:2004 number:3 pages:448-455
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callnumber-first	Q - Science
author	Bela F. Asztalos
spellingShingle	Bela F. Asztalos misc QD415-436 misc lipoproteins misc high density lipoprotein subpopulations misc reverse cholesterol transport misc Biochemistry Apolipoprotein composition of HDL in cholesteryl ester transfer protein deficiency
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topic_title	QD415-436 Apolipoprotein composition of HDL in cholesteryl ester transfer protein deficiency lipoproteins high density lipoprotein subpopulations reverse cholesterol transport
topic	misc QD415-436 misc lipoproteins misc high density lipoprotein subpopulations misc reverse cholesterol transport misc Biochemistry
topic_unstemmed	misc QD415-436 misc lipoproteins misc high density lipoprotein subpopulations misc reverse cholesterol transport misc Biochemistry
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title	Apolipoprotein composition of HDL in cholesteryl ester transfer protein deficiency
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title_full	Apolipoprotein composition of HDL in cholesteryl ester transfer protein deficiency
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author_browse	Bela F. Asztalos Katalin V. Horvath Kouji Kajinami Chorthip Nartsupha Caitlin E. Cox Marcelo Batista Ernst J. Schaefer Akihiro Inazu Hiroshi Mabuchi
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title_sort	apolipoprotein composition of hdl in cholesteryl ester transfer protein deficiency
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title_auth	Apolipoprotein composition of HDL in cholesteryl ester transfer protein deficiency
abstract	Our purpose was to compare HDL subpopulations, as determined by nondenaturing two-dimensional gel electrophoresis followed by immunoblotting for apolipoprotein A-I (apoA-I), apoA-II, apoA-IV, apoCs, and apoE in heterozygous, compound heterozygous, and homozygous subjects for cholesteryl ester transfer protein (CETP) deficiency and controls. Heterozygotes, compound heterozygotes, and homozygotes had CETP masses that were 30, 63, and more than 90% lower and HDL-cholesterol values that were 64, 168, and 203% higher than those in controls, respectively. Heterozygotes had ∼50% lower preβ-1 and more than 2-fold higher levels of α-1 and preα-1 particles than controls. Three of the five heterozygotes' α-1 particles also contained apoA-II, which was not seen in controls. Compound heterozygotes and homozygotes had very large particles not observed in controls and heterozygotes. These particles contained apoA-I, apoA-II, apoCs, and apoE. However, these subjects did not have decreased preβ-1 levels.Our data indicate that CETP deficiency results in the formation of very large HDL particles containing all of the major HDL apolipoproteins except for apoA-IV. We hypothesize that the HDL subpopulation profile of heterozygous CETP-deficient patients, especially those with high levels of α-1 containing apoA-I but no apoA-II, represent an improved anti-atherogenic state, although this might not be the case for compound heterozygotes and homozygotes with very large, undifferentiated HDL particles.
abstractGer	Our purpose was to compare HDL subpopulations, as determined by nondenaturing two-dimensional gel electrophoresis followed by immunoblotting for apolipoprotein A-I (apoA-I), apoA-II, apoA-IV, apoCs, and apoE in heterozygous, compound heterozygous, and homozygous subjects for cholesteryl ester transfer protein (CETP) deficiency and controls. Heterozygotes, compound heterozygotes, and homozygotes had CETP masses that were 30, 63, and more than 90% lower and HDL-cholesterol values that were 64, 168, and 203% higher than those in controls, respectively. Heterozygotes had ∼50% lower preβ-1 and more than 2-fold higher levels of α-1 and preα-1 particles than controls. Three of the five heterozygotes' α-1 particles also contained apoA-II, which was not seen in controls. Compound heterozygotes and homozygotes had very large particles not observed in controls and heterozygotes. These particles contained apoA-I, apoA-II, apoCs, and apoE. However, these subjects did not have decreased preβ-1 levels.Our data indicate that CETP deficiency results in the formation of very large HDL particles containing all of the major HDL apolipoproteins except for apoA-IV. We hypothesize that the HDL subpopulation profile of heterozygous CETP-deficient patients, especially those with high levels of α-1 containing apoA-I but no apoA-II, represent an improved anti-atherogenic state, although this might not be the case for compound heterozygotes and homozygotes with very large, undifferentiated HDL particles.
abstract_unstemmed	Our purpose was to compare HDL subpopulations, as determined by nondenaturing two-dimensional gel electrophoresis followed by immunoblotting for apolipoprotein A-I (apoA-I), apoA-II, apoA-IV, apoCs, and apoE in heterozygous, compound heterozygous, and homozygous subjects for cholesteryl ester transfer protein (CETP) deficiency and controls. Heterozygotes, compound heterozygotes, and homozygotes had CETP masses that were 30, 63, and more than 90% lower and HDL-cholesterol values that were 64, 168, and 203% higher than those in controls, respectively. Heterozygotes had ∼50% lower preβ-1 and more than 2-fold higher levels of α-1 and preα-1 particles than controls. Three of the five heterozygotes' α-1 particles also contained apoA-II, which was not seen in controls. Compound heterozygotes and homozygotes had very large particles not observed in controls and heterozygotes. These particles contained apoA-I, apoA-II, apoCs, and apoE. However, these subjects did not have decreased preβ-1 levels.Our data indicate that CETP deficiency results in the formation of very large HDL particles containing all of the major HDL apolipoproteins except for apoA-IV. We hypothesize that the HDL subpopulation profile of heterozygous CETP-deficient patients, especially those with high levels of α-1 containing apoA-I but no apoA-II, represent an improved anti-atherogenic state, although this might not be the case for compound heterozygotes and homozygotes with very large, undifferentiated HDL particles.
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title_short	Apolipoprotein composition of HDL in cholesteryl ester transfer protein deficiency
url	https://doi.org/10.1194/jlr.M300198-JLR200 https://doaj.org/article/0b89bf1b86ad433b9acedb018602b86e http://www.sciencedirect.com/science/article/pii/S0022227520318721 https://doaj.org/toc/0022-2275
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Heterozygotes, compound heterozygotes, and homozygotes had CETP masses that were 30, 63, and more than 90% lower and HDL-cholesterol values that were 64, 168, and 203% higher than those in controls, respectively. Heterozygotes had ∼50% lower preβ-1 and more than 2-fold higher levels of α-1 and preα-1 particles than controls. Three of the five heterozygotes' α-1 particles also contained apoA-II, which was not seen in controls. Compound heterozygotes and homozygotes had very large particles not observed in controls and heterozygotes. These particles contained apoA-I, apoA-II, apoCs, and apoE. However, these subjects did not have decreased preβ-1 levels.Our data indicate that CETP deficiency results in the formation of very large HDL particles containing all of the major HDL apolipoproteins except for apoA-IV. We hypothesize that the HDL subpopulation profile of heterozygous CETP-deficient patients, especially those with high levels of α-1 containing apoA-I but no apoA-II, represent an improved anti-atherogenic state, although this might not be the case for compound heterozygotes and homozygotes with very large, undifferentiated HDL particles.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">lipoproteins</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">high density lipoprotein subpopulations</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">reverse cholesterol transport</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Biochemistry</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Katalin V. Horvath</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Kouji Kajinami</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Chorthip Nartsupha</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Caitlin E. Cox</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Marcelo Batista</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Ernst J. 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Apolipoprotein composition of HDL in cholesteryl ester transfer protein deficiency

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