The Rapid Antigen Detection Test for SARS-CoV-2 Underestimates the Identification of COVID-19 Positive Cases and Compromises the Diagnosis of the SARS-CoV-2 (K417N/T, E484K, and N501Y) Variants

Timely detection of severe acute respiratory syndrome due to coronavirus 2 (SARS-CoV-2) by reverse transcription quantitative polymerase chain reaction (RT-qPCR) has been the gold- strategy for identifying positive cases during the current pandemic. However, faster and less expensive methodologies a...
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Autor*in:	Carlos Barrera-Avalos [verfasserIn] Roberto Luraschi [verfasserIn] Eva Vallejos-Vidal [verfasserIn] Andrea Mella-Torres [verfasserIn] Felipe Hernández [verfasserIn] Maximiliano Figueroa [verfasserIn] Claudia Rioseco [verfasserIn] Daniel Valdés [verfasserIn] Mónica Imarai [verfasserIn] Claudio Acuña-Castillo [verfasserIn] Felipe E. Reyes-López [verfasserIn] Ana María Sandino [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	rapid antigen test SARS-CoV-2 detection COVID-19 diagnosis COVID-19 false negative rapid test for COVID-19 diagnosis pandemic control strategies

Übergeordnetes Werk:	In: Frontiers in Public Health - Frontiers Media S.A., 2013, 9(2022)
Übergeordnetes Werk:	volume:9 ; year:2022

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fpubh.2021.780801

Katalog-ID:	DOAJ062468723

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spelling	10.3389/fpubh.2021.780801 doi (DE-627)DOAJ062468723 (DE-599)DOAJb35ea9af0c814efdbf4f724cfd5e4fb9 DE-627 ger DE-627 rakwb eng RA1-1270 Carlos Barrera-Avalos verfasserin aut The Rapid Antigen Detection Test for SARS-CoV-2 Underestimates the Identification of COVID-19 Positive Cases and Compromises the Diagnosis of the SARS-CoV-2 (K417N/T, E484K, and N501Y) Variants 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Timely detection of severe acute respiratory syndrome due to coronavirus 2 (SARS-CoV-2) by reverse transcription quantitative polymerase chain reaction (RT-qPCR) has been the gold- strategy for identifying positive cases during the current pandemic. However, faster and less expensive methodologies are also applied for the massive diagnosis of COVID-19. In this way, the rapid antigen test (RAT) is widely used. However, it is necessary to evaluate its detection efficiency considering the current pandemic context with the circulation of new viral variants. In this study, we evaluated the sensitivity and specificity of RAT (SD BIOSENSOR, South Korea), widely used for testing and SARS-CoV-2 diagnosis in Santiago of Chile. The RAT showed a 90% (amplification range of 20 ≤ Cq <25) and 10% (amplification range of 25 ≤ Cq <30) of positive SARS-CoV-2 cases identified previously by RT-qPCR. Importantly, a 0% detection was obtained for samples within a Cq value>30. In SARS-CoV-2 variant detection, RAT had a 42.8% detection sensitivity in samples with RT-qPCR amplification range 20 ≤ Cq <25 containing the single nucleotide polymorphisms (SNP) K417N/T, N501Y and E484K, associated with beta or gamma SARS-CoV-2 variants. This study alerts for the special attention that must be paid for the use of RAT at a massive diagnosis level, especially in the current scenario of appearance of several new SARS-CoV-2 variants which could generate false negatives and the compromise of possible viral outbreaks. rapid antigen test SARS-CoV-2 detection COVID-19 diagnosis COVID-19 false negative rapid test for COVID-19 diagnosis pandemic control strategies Public aspects of medicine Roberto Luraschi verfasserin aut Eva Vallejos-Vidal verfasserin aut Eva Vallejos-Vidal verfasserin aut Andrea Mella-Torres verfasserin aut Felipe Hernández verfasserin aut Maximiliano Figueroa verfasserin aut Claudia Rioseco verfasserin aut Daniel Valdés verfasserin aut Daniel Valdés verfasserin aut Mónica Imarai verfasserin aut Mónica Imarai verfasserin aut Claudio Acuña-Castillo verfasserin aut Claudio Acuña-Castillo verfasserin aut Felipe E. Reyes-López verfasserin aut Felipe E. Reyes-López verfasserin aut Felipe E. Reyes-López verfasserin aut Ana María Sandino verfasserin aut Ana María Sandino verfasserin aut In Frontiers in Public Health Frontiers Media S.A., 2013 9(2022) (DE-627)742224589 (DE-600)2711781-9 22962565 nnns volume:9 year:2022 https://doi.org/10.3389/fpubh.2021.780801 kostenfrei https://doaj.org/article/b35ea9af0c814efdbf4f724cfd5e4fb9 kostenfrei https://www.frontiersin.org/articles/10.3389/fpubh.2021.780801/full kostenfrei https://doaj.org/toc/2296-2565 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2022
allfields_unstemmed	10.3389/fpubh.2021.780801 doi (DE-627)DOAJ062468723 (DE-599)DOAJb35ea9af0c814efdbf4f724cfd5e4fb9 DE-627 ger DE-627 rakwb eng RA1-1270 Carlos Barrera-Avalos verfasserin aut The Rapid Antigen Detection Test for SARS-CoV-2 Underestimates the Identification of COVID-19 Positive Cases and Compromises the Diagnosis of the SARS-CoV-2 (K417N/T, E484K, and N501Y) Variants 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Timely detection of severe acute respiratory syndrome due to coronavirus 2 (SARS-CoV-2) by reverse transcription quantitative polymerase chain reaction (RT-qPCR) has been the gold- strategy for identifying positive cases during the current pandemic. However, faster and less expensive methodologies are also applied for the massive diagnosis of COVID-19. In this way, the rapid antigen test (RAT) is widely used. However, it is necessary to evaluate its detection efficiency considering the current pandemic context with the circulation of new viral variants. In this study, we evaluated the sensitivity and specificity of RAT (SD BIOSENSOR, South Korea), widely used for testing and SARS-CoV-2 diagnosis in Santiago of Chile. The RAT showed a 90% (amplification range of 20 ≤ Cq <25) and 10% (amplification range of 25 ≤ Cq <30) of positive SARS-CoV-2 cases identified previously by RT-qPCR. Importantly, a 0% detection was obtained for samples within a Cq value>30. In SARS-CoV-2 variant detection, RAT had a 42.8% detection sensitivity in samples with RT-qPCR amplification range 20 ≤ Cq <25 containing the single nucleotide polymorphisms (SNP) K417N/T, N501Y and E484K, associated with beta or gamma SARS-CoV-2 variants. This study alerts for the special attention that must be paid for the use of RAT at a massive diagnosis level, especially in the current scenario of appearance of several new SARS-CoV-2 variants which could generate false negatives and the compromise of possible viral outbreaks. rapid antigen test SARS-CoV-2 detection COVID-19 diagnosis COVID-19 false negative rapid test for COVID-19 diagnosis pandemic control strategies Public aspects of medicine Roberto Luraschi verfasserin aut Eva Vallejos-Vidal verfasserin aut Eva Vallejos-Vidal verfasserin aut Andrea Mella-Torres verfasserin aut Felipe Hernández verfasserin aut Maximiliano Figueroa verfasserin aut Claudia Rioseco verfasserin aut Daniel Valdés verfasserin aut Daniel Valdés verfasserin aut Mónica Imarai verfasserin aut Mónica Imarai verfasserin aut Claudio Acuña-Castillo verfasserin aut Claudio Acuña-Castillo verfasserin aut Felipe E. Reyes-López verfasserin aut Felipe E. Reyes-López verfasserin aut Felipe E. Reyes-López verfasserin aut Ana María Sandino verfasserin aut Ana María Sandino verfasserin aut In Frontiers in Public Health Frontiers Media S.A., 2013 9(2022) (DE-627)742224589 (DE-600)2711781-9 22962565 nnns volume:9 year:2022 https://doi.org/10.3389/fpubh.2021.780801 kostenfrei https://doaj.org/article/b35ea9af0c814efdbf4f724cfd5e4fb9 kostenfrei https://www.frontiersin.org/articles/10.3389/fpubh.2021.780801/full kostenfrei https://doaj.org/toc/2296-2565 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2022
allfieldsGer	10.3389/fpubh.2021.780801 doi (DE-627)DOAJ062468723 (DE-599)DOAJb35ea9af0c814efdbf4f724cfd5e4fb9 DE-627 ger DE-627 rakwb eng RA1-1270 Carlos Barrera-Avalos verfasserin aut The Rapid Antigen Detection Test for SARS-CoV-2 Underestimates the Identification of COVID-19 Positive Cases and Compromises the Diagnosis of the SARS-CoV-2 (K417N/T, E484K, and N501Y) Variants 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Timely detection of severe acute respiratory syndrome due to coronavirus 2 (SARS-CoV-2) by reverse transcription quantitative polymerase chain reaction (RT-qPCR) has been the gold- strategy for identifying positive cases during the current pandemic. However, faster and less expensive methodologies are also applied for the massive diagnosis of COVID-19. In this way, the rapid antigen test (RAT) is widely used. However, it is necessary to evaluate its detection efficiency considering the current pandemic context with the circulation of new viral variants. In this study, we evaluated the sensitivity and specificity of RAT (SD BIOSENSOR, South Korea), widely used for testing and SARS-CoV-2 diagnosis in Santiago of Chile. The RAT showed a 90% (amplification range of 20 ≤ Cq <25) and 10% (amplification range of 25 ≤ Cq <30) of positive SARS-CoV-2 cases identified previously by RT-qPCR. Importantly, a 0% detection was obtained for samples within a Cq value>30. In SARS-CoV-2 variant detection, RAT had a 42.8% detection sensitivity in samples with RT-qPCR amplification range 20 ≤ Cq <25 containing the single nucleotide polymorphisms (SNP) K417N/T, N501Y and E484K, associated with beta or gamma SARS-CoV-2 variants. This study alerts for the special attention that must be paid for the use of RAT at a massive diagnosis level, especially in the current scenario of appearance of several new SARS-CoV-2 variants which could generate false negatives and the compromise of possible viral outbreaks. rapid antigen test SARS-CoV-2 detection COVID-19 diagnosis COVID-19 false negative rapid test for COVID-19 diagnosis pandemic control strategies Public aspects of medicine Roberto Luraschi verfasserin aut Eva Vallejos-Vidal verfasserin aut Eva Vallejos-Vidal verfasserin aut Andrea Mella-Torres verfasserin aut Felipe Hernández verfasserin aut Maximiliano Figueroa verfasserin aut Claudia Rioseco verfasserin aut Daniel Valdés verfasserin aut Daniel Valdés verfasserin aut Mónica Imarai verfasserin aut Mónica Imarai verfasserin aut Claudio Acuña-Castillo verfasserin aut Claudio Acuña-Castillo verfasserin aut Felipe E. Reyes-López verfasserin aut Felipe E. Reyes-López verfasserin aut Felipe E. Reyes-López verfasserin aut Ana María Sandino verfasserin aut Ana María Sandino verfasserin aut In Frontiers in Public Health Frontiers Media S.A., 2013 9(2022) (DE-627)742224589 (DE-600)2711781-9 22962565 nnns volume:9 year:2022 https://doi.org/10.3389/fpubh.2021.780801 kostenfrei https://doaj.org/article/b35ea9af0c814efdbf4f724cfd5e4fb9 kostenfrei https://www.frontiersin.org/articles/10.3389/fpubh.2021.780801/full kostenfrei https://doaj.org/toc/2296-2565 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2022
allfieldsSound	10.3389/fpubh.2021.780801 doi (DE-627)DOAJ062468723 (DE-599)DOAJb35ea9af0c814efdbf4f724cfd5e4fb9 DE-627 ger DE-627 rakwb eng RA1-1270 Carlos Barrera-Avalos verfasserin aut The Rapid Antigen Detection Test for SARS-CoV-2 Underestimates the Identification of COVID-19 Positive Cases and Compromises the Diagnosis of the SARS-CoV-2 (K417N/T, E484K, and N501Y) Variants 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Timely detection of severe acute respiratory syndrome due to coronavirus 2 (SARS-CoV-2) by reverse transcription quantitative polymerase chain reaction (RT-qPCR) has been the gold- strategy for identifying positive cases during the current pandemic. However, faster and less expensive methodologies are also applied for the massive diagnosis of COVID-19. In this way, the rapid antigen test (RAT) is widely used. However, it is necessary to evaluate its detection efficiency considering the current pandemic context with the circulation of new viral variants. In this study, we evaluated the sensitivity and specificity of RAT (SD BIOSENSOR, South Korea), widely used for testing and SARS-CoV-2 diagnosis in Santiago of Chile. The RAT showed a 90% (amplification range of 20 ≤ Cq <25) and 10% (amplification range of 25 ≤ Cq <30) of positive SARS-CoV-2 cases identified previously by RT-qPCR. Importantly, a 0% detection was obtained for samples within a Cq value>30. In SARS-CoV-2 variant detection, RAT had a 42.8% detection sensitivity in samples with RT-qPCR amplification range 20 ≤ Cq <25 containing the single nucleotide polymorphisms (SNP) K417N/T, N501Y and E484K, associated with beta or gamma SARS-CoV-2 variants. This study alerts for the special attention that must be paid for the use of RAT at a massive diagnosis level, especially in the current scenario of appearance of several new SARS-CoV-2 variants which could generate false negatives and the compromise of possible viral outbreaks. rapid antigen test SARS-CoV-2 detection COVID-19 diagnosis COVID-19 false negative rapid test for COVID-19 diagnosis pandemic control strategies Public aspects of medicine Roberto Luraschi verfasserin aut Eva Vallejos-Vidal verfasserin aut Eva Vallejos-Vidal verfasserin aut Andrea Mella-Torres verfasserin aut Felipe Hernández verfasserin aut Maximiliano Figueroa verfasserin aut Claudia Rioseco verfasserin aut Daniel Valdés verfasserin aut Daniel Valdés verfasserin aut Mónica Imarai verfasserin aut Mónica Imarai verfasserin aut Claudio Acuña-Castillo verfasserin aut Claudio Acuña-Castillo verfasserin aut Felipe E. Reyes-López verfasserin aut Felipe E. Reyes-López verfasserin aut Felipe E. Reyes-López verfasserin aut Ana María Sandino verfasserin aut Ana María Sandino verfasserin aut In Frontiers in Public Health Frontiers Media S.A., 2013 9(2022) (DE-627)742224589 (DE-600)2711781-9 22962565 nnns volume:9 year:2022 https://doi.org/10.3389/fpubh.2021.780801 kostenfrei https://doaj.org/article/b35ea9af0c814efdbf4f724cfd5e4fb9 kostenfrei https://www.frontiersin.org/articles/10.3389/fpubh.2021.780801/full kostenfrei https://doaj.org/toc/2296-2565 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2022
language	English
source	In Frontiers in Public Health 9(2022) volume:9 year:2022
sourceStr	In Frontiers in Public Health 9(2022) volume:9 year:2022
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	rapid antigen test SARS-CoV-2 detection COVID-19 diagnosis COVID-19 false negative rapid test for COVID-19 diagnosis pandemic control strategies Public aspects of medicine
isfreeaccess_bool	true
container_title	Frontiers in Public Health
authorswithroles_txt_mv	Carlos Barrera-Avalos @@aut@@ Roberto Luraschi @@aut@@ Eva Vallejos-Vidal @@aut@@ Andrea Mella-Torres @@aut@@ Felipe Hernández @@aut@@ Maximiliano Figueroa @@aut@@ Claudia Rioseco @@aut@@ Daniel Valdés @@aut@@ Mónica Imarai @@aut@@ Claudio Acuña-Castillo @@aut@@ Felipe E. Reyes-López @@aut@@ Ana María Sandino @@aut@@
publishDateDaySort_date	2022-01-01T00:00:00Z
hierarchy_top_id	742224589
id	DOAJ062468723
language_de	englisch
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callnumber-first	R - Medicine
author	Carlos Barrera-Avalos
spellingShingle	Carlos Barrera-Avalos misc RA1-1270 misc rapid antigen test misc SARS-CoV-2 detection misc COVID-19 diagnosis misc COVID-19 false negative rapid test for COVID-19 diagnosis misc pandemic control strategies misc Public aspects of medicine The Rapid Antigen Detection Test for SARS-CoV-2 Underestimates the Identification of COVID-19 Positive Cases and Compromises the Diagnosis of the SARS-CoV-2 (K417N/T, E484K, and N501Y) Variants
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topic_title	RA1-1270 The Rapid Antigen Detection Test for SARS-CoV-2 Underestimates the Identification of COVID-19 Positive Cases and Compromises the Diagnosis of the SARS-CoV-2 (K417N/T, E484K, and N501Y) Variants rapid antigen test SARS-CoV-2 detection COVID-19 diagnosis COVID-19 false negative rapid test for COVID-19 diagnosis pandemic control strategies
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title	The Rapid Antigen Detection Test for SARS-CoV-2 Underestimates the Identification of COVID-19 Positive Cases and Compromises the Diagnosis of the SARS-CoV-2 (K417N/T, E484K, and N501Y) Variants
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title_full	The Rapid Antigen Detection Test for SARS-CoV-2 Underestimates the Identification of COVID-19 Positive Cases and Compromises the Diagnosis of the SARS-CoV-2 (K417N/T, E484K, and N501Y) Variants
author_sort	Carlos Barrera-Avalos
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author_browse	Carlos Barrera-Avalos Roberto Luraschi Eva Vallejos-Vidal Andrea Mella-Torres Felipe Hernández Maximiliano Figueroa Claudia Rioseco Daniel Valdés Mónica Imarai Claudio Acuña-Castillo Felipe E. Reyes-López Ana María Sandino
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title_sort	rapid antigen detection test for sars-cov-2 underestimates the identification of covid-19 positive cases and compromises the diagnosis of the sars-cov-2 (k417n/t, e484k, and n501y) variants
callnumber	RA1-1270
title_auth	The Rapid Antigen Detection Test for SARS-CoV-2 Underestimates the Identification of COVID-19 Positive Cases and Compromises the Diagnosis of the SARS-CoV-2 (K417N/T, E484K, and N501Y) Variants
abstract	Timely detection of severe acute respiratory syndrome due to coronavirus 2 (SARS-CoV-2) by reverse transcription quantitative polymerase chain reaction (RT-qPCR) has been the gold- strategy for identifying positive cases during the current pandemic. However, faster and less expensive methodologies are also applied for the massive diagnosis of COVID-19. In this way, the rapid antigen test (RAT) is widely used. However, it is necessary to evaluate its detection efficiency considering the current pandemic context with the circulation of new viral variants. In this study, we evaluated the sensitivity and specificity of RAT (SD BIOSENSOR, South Korea), widely used for testing and SARS-CoV-2 diagnosis in Santiago of Chile. The RAT showed a 90% (amplification range of 20 ≤ Cq <25) and 10% (amplification range of 25 ≤ Cq <30) of positive SARS-CoV-2 cases identified previously by RT-qPCR. Importantly, a 0% detection was obtained for samples within a Cq value>30. In SARS-CoV-2 variant detection, RAT had a 42.8% detection sensitivity in samples with RT-qPCR amplification range 20 ≤ Cq <25 containing the single nucleotide polymorphisms (SNP) K417N/T, N501Y and E484K, associated with beta or gamma SARS-CoV-2 variants. This study alerts for the special attention that must be paid for the use of RAT at a massive diagnosis level, especially in the current scenario of appearance of several new SARS-CoV-2 variants which could generate false negatives and the compromise of possible viral outbreaks.
abstractGer	Timely detection of severe acute respiratory syndrome due to coronavirus 2 (SARS-CoV-2) by reverse transcription quantitative polymerase chain reaction (RT-qPCR) has been the gold- strategy for identifying positive cases during the current pandemic. However, faster and less expensive methodologies are also applied for the massive diagnosis of COVID-19. In this way, the rapid antigen test (RAT) is widely used. However, it is necessary to evaluate its detection efficiency considering the current pandemic context with the circulation of new viral variants. In this study, we evaluated the sensitivity and specificity of RAT (SD BIOSENSOR, South Korea), widely used for testing and SARS-CoV-2 diagnosis in Santiago of Chile. The RAT showed a 90% (amplification range of 20 ≤ Cq <25) and 10% (amplification range of 25 ≤ Cq <30) of positive SARS-CoV-2 cases identified previously by RT-qPCR. Importantly, a 0% detection was obtained for samples within a Cq value>30. In SARS-CoV-2 variant detection, RAT had a 42.8% detection sensitivity in samples with RT-qPCR amplification range 20 ≤ Cq <25 containing the single nucleotide polymorphisms (SNP) K417N/T, N501Y and E484K, associated with beta or gamma SARS-CoV-2 variants. This study alerts for the special attention that must be paid for the use of RAT at a massive diagnosis level, especially in the current scenario of appearance of several new SARS-CoV-2 variants which could generate false negatives and the compromise of possible viral outbreaks.
abstract_unstemmed	Timely detection of severe acute respiratory syndrome due to coronavirus 2 (SARS-CoV-2) by reverse transcription quantitative polymerase chain reaction (RT-qPCR) has been the gold- strategy for identifying positive cases during the current pandemic. However, faster and less expensive methodologies are also applied for the massive diagnosis of COVID-19. In this way, the rapid antigen test (RAT) is widely used. However, it is necessary to evaluate its detection efficiency considering the current pandemic context with the circulation of new viral variants. In this study, we evaluated the sensitivity and specificity of RAT (SD BIOSENSOR, South Korea), widely used for testing and SARS-CoV-2 diagnosis in Santiago of Chile. The RAT showed a 90% (amplification range of 20 ≤ Cq <25) and 10% (amplification range of 25 ≤ Cq <30) of positive SARS-CoV-2 cases identified previously by RT-qPCR. Importantly, a 0% detection was obtained for samples within a Cq value>30. In SARS-CoV-2 variant detection, RAT had a 42.8% detection sensitivity in samples with RT-qPCR amplification range 20 ≤ Cq <25 containing the single nucleotide polymorphisms (SNP) K417N/T, N501Y and E484K, associated with beta or gamma SARS-CoV-2 variants. This study alerts for the special attention that must be paid for the use of RAT at a massive diagnosis level, especially in the current scenario of appearance of several new SARS-CoV-2 variants which could generate false negatives and the compromise of possible viral outbreaks.
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title_short	The Rapid Antigen Detection Test for SARS-CoV-2 Underestimates the Identification of COVID-19 Positive Cases and Compromises the Diagnosis of the SARS-CoV-2 (K417N/T, E484K, and N501Y) Variants
url	https://doi.org/10.3389/fpubh.2021.780801 https://doaj.org/article/b35ea9af0c814efdbf4f724cfd5e4fb9 https://www.frontiersin.org/articles/10.3389/fpubh.2021.780801/full https://doaj.org/toc/2296-2565
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author2	Roberto Luraschi Eva Vallejos-Vidal Andrea Mella-Torres Felipe Hernández Maximiliano Figueroa Claudia Rioseco Daniel Valdés Mónica Imarai Claudio Acuña-Castillo Felipe E. Reyes-López Ana María Sandino
author2Str	Roberto Luraschi Eva Vallejos-Vidal Andrea Mella-Torres Felipe Hernández Maximiliano Figueroa Claudia Rioseco Daniel Valdés Mónica Imarai Claudio Acuña-Castillo Felipe E. Reyes-López Ana María Sandino
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up_date	2024-07-04T01:46:48.995Z
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The Rapid Antigen Detection Test for SARS-CoV-2 Underestimates the Identification of COVID-19 Positive Cases and Compromises the Diagnosis of the SARS-CoV-2 (K417N/T, E484K, and N501Y) Variants

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