External Validation of Surrogate Indices of Fatty Liver in the General Population: The Bagnacavallo Study

We externally validated the fatty liver index (FLI), the lipid accumulation product (LAP), the hepatic steatosis index (HSI), and the Zhejiang University index (ZJU) for the diagnosis of fatty liver (FL) and non-alcoholic fatty liver disease (NAFLD) in the general population. The validation was perf...
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Autor*in:	Francesco Giuseppe Foschi [verfasserIn] Fabio Conti [verfasserIn] Marco Domenicali [verfasserIn] Pierluigi Giacomoni [verfasserIn] Alberto Borghi [verfasserIn] Vittoria Bevilacqua [verfasserIn] Lucia Napoli [verfasserIn] Dante Berardinelli [verfasserIn] Mattia Altini [verfasserIn] Alessandro Cucchetti [verfasserIn] Giorgio Ercolani [verfasserIn] Andrea Casadei-Gardini [verfasserIn] Stefano Bellentani [verfasserIn] Amalia Gastaldelli [verfasserIn] Claudio Tiribelli [verfasserIn] Giorgio Bedogni [verfasserIn] Bagnacavallo Study Group [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	cross-sectional study diagnostic techniques and procedures validation study fatty liver non-alcoholic fatty liver disease

Übergeordnetes Werk:	In: Journal of Clinical Medicine - MDPI AG, 2013, 10(2021), 3, p 520
Übergeordnetes Werk:	volume:10 ; year:2021 ; number:3, p 520

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/jcm10030520

Katalog-ID:	DOAJ062533304

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allfields	10.3390/jcm10030520 doi (DE-627)DOAJ062533304 (DE-599)DOAJ7069f46212d94b73a1113e65e5ce7c25 DE-627 ger DE-627 rakwb eng Francesco Giuseppe Foschi verfasserin aut External Validation of Surrogate Indices of Fatty Liver in the General Population: The Bagnacavallo Study 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier We externally validated the fatty liver index (FLI), the lipid accumulation product (LAP), the hepatic steatosis index (HSI), and the Zhejiang University index (ZJU) for the diagnosis of fatty liver (FL) and non-alcoholic fatty liver disease (NAFLD) in the general population. The validation was performed on 2159 citizens of the town of Bagnacavallo (Ravenna, Italy). Calibration was evaluated by calculating the calibration slope and intercept and by inspecting calibration plots; discrimination was evaluated using the c-statistic. The average calibration slope was 1 and the average intercept was 0 for all combinations of outcomes and indices. For the diagnosis of FL, the c-statistic was 0.85 for FLI, 0.83 for ZJU, 0.82 for HSI, and 0.80 for LAP; for the diagnosis of NAFLD, the c-statistic was 0.77 for FLI, 0.76 for ZJU, 0.75 for HSI, and 0.74 for LAP. All indices were strongly correlated with each other. In conclusion, FLI, LAP, HSI, and ZJU perform similarly well to diagnose FL and NAFLD in the Bagnacavallo population, even if FLI has a small advantage as discrimination is concerned. cross-sectional study diagnostic techniques and procedures validation study fatty liver non-alcoholic fatty liver disease Medicine R Fabio Conti verfasserin aut Marco Domenicali verfasserin aut Pierluigi Giacomoni verfasserin aut Alberto Borghi verfasserin aut Vittoria Bevilacqua verfasserin aut Lucia Napoli verfasserin aut Dante Berardinelli verfasserin aut Mattia Altini verfasserin aut Alessandro Cucchetti verfasserin aut Giorgio Ercolani verfasserin aut Andrea Casadei-Gardini verfasserin aut Stefano Bellentani verfasserin aut Amalia Gastaldelli verfasserin aut Claudio Tiribelli verfasserin aut Giorgio Bedogni verfasserin aut Bagnacavallo Study Group verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 10(2021), 3, p 520 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:10 year:2021 number:3, p 520 https://doi.org/10.3390/jcm10030520 kostenfrei https://doaj.org/article/7069f46212d94b73a1113e65e5ce7c25 kostenfrei https://www.mdpi.com/2077-0383/10/3/520 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2021 3, p 520
spelling	10.3390/jcm10030520 doi (DE-627)DOAJ062533304 (DE-599)DOAJ7069f46212d94b73a1113e65e5ce7c25 DE-627 ger DE-627 rakwb eng Francesco Giuseppe Foschi verfasserin aut External Validation of Surrogate Indices of Fatty Liver in the General Population: The Bagnacavallo Study 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier We externally validated the fatty liver index (FLI), the lipid accumulation product (LAP), the hepatic steatosis index (HSI), and the Zhejiang University index (ZJU) for the diagnosis of fatty liver (FL) and non-alcoholic fatty liver disease (NAFLD) in the general population. The validation was performed on 2159 citizens of the town of Bagnacavallo (Ravenna, Italy). Calibration was evaluated by calculating the calibration slope and intercept and by inspecting calibration plots; discrimination was evaluated using the c-statistic. The average calibration slope was 1 and the average intercept was 0 for all combinations of outcomes and indices. For the diagnosis of FL, the c-statistic was 0.85 for FLI, 0.83 for ZJU, 0.82 for HSI, and 0.80 for LAP; for the diagnosis of NAFLD, the c-statistic was 0.77 for FLI, 0.76 for ZJU, 0.75 for HSI, and 0.74 for LAP. All indices were strongly correlated with each other. In conclusion, FLI, LAP, HSI, and ZJU perform similarly well to diagnose FL and NAFLD in the Bagnacavallo population, even if FLI has a small advantage as discrimination is concerned. cross-sectional study diagnostic techniques and procedures validation study fatty liver non-alcoholic fatty liver disease Medicine R Fabio Conti verfasserin aut Marco Domenicali verfasserin aut Pierluigi Giacomoni verfasserin aut Alberto Borghi verfasserin aut Vittoria Bevilacqua verfasserin aut Lucia Napoli verfasserin aut Dante Berardinelli verfasserin aut Mattia Altini verfasserin aut Alessandro Cucchetti verfasserin aut Giorgio Ercolani verfasserin aut Andrea Casadei-Gardini verfasserin aut Stefano Bellentani verfasserin aut Amalia Gastaldelli verfasserin aut Claudio Tiribelli verfasserin aut Giorgio Bedogni verfasserin aut Bagnacavallo Study Group verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 10(2021), 3, p 520 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:10 year:2021 number:3, p 520 https://doi.org/10.3390/jcm10030520 kostenfrei https://doaj.org/article/7069f46212d94b73a1113e65e5ce7c25 kostenfrei https://www.mdpi.com/2077-0383/10/3/520 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2021 3, p 520
allfields_unstemmed	10.3390/jcm10030520 doi (DE-627)DOAJ062533304 (DE-599)DOAJ7069f46212d94b73a1113e65e5ce7c25 DE-627 ger DE-627 rakwb eng Francesco Giuseppe Foschi verfasserin aut External Validation of Surrogate Indices of Fatty Liver in the General Population: The Bagnacavallo Study 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier We externally validated the fatty liver index (FLI), the lipid accumulation product (LAP), the hepatic steatosis index (HSI), and the Zhejiang University index (ZJU) for the diagnosis of fatty liver (FL) and non-alcoholic fatty liver disease (NAFLD) in the general population. The validation was performed on 2159 citizens of the town of Bagnacavallo (Ravenna, Italy). Calibration was evaluated by calculating the calibration slope and intercept and by inspecting calibration plots; discrimination was evaluated using the c-statistic. The average calibration slope was 1 and the average intercept was 0 for all combinations of outcomes and indices. For the diagnosis of FL, the c-statistic was 0.85 for FLI, 0.83 for ZJU, 0.82 for HSI, and 0.80 for LAP; for the diagnosis of NAFLD, the c-statistic was 0.77 for FLI, 0.76 for ZJU, 0.75 for HSI, and 0.74 for LAP. All indices were strongly correlated with each other. In conclusion, FLI, LAP, HSI, and ZJU perform similarly well to diagnose FL and NAFLD in the Bagnacavallo population, even if FLI has a small advantage as discrimination is concerned. cross-sectional study diagnostic techniques and procedures validation study fatty liver non-alcoholic fatty liver disease Medicine R Fabio Conti verfasserin aut Marco Domenicali verfasserin aut Pierluigi Giacomoni verfasserin aut Alberto Borghi verfasserin aut Vittoria Bevilacqua verfasserin aut Lucia Napoli verfasserin aut Dante Berardinelli verfasserin aut Mattia Altini verfasserin aut Alessandro Cucchetti verfasserin aut Giorgio Ercolani verfasserin aut Andrea Casadei-Gardini verfasserin aut Stefano Bellentani verfasserin aut Amalia Gastaldelli verfasserin aut Claudio Tiribelli verfasserin aut Giorgio Bedogni verfasserin aut Bagnacavallo Study Group verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 10(2021), 3, p 520 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:10 year:2021 number:3, p 520 https://doi.org/10.3390/jcm10030520 kostenfrei https://doaj.org/article/7069f46212d94b73a1113e65e5ce7c25 kostenfrei https://www.mdpi.com/2077-0383/10/3/520 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2021 3, p 520
allfieldsGer	10.3390/jcm10030520 doi (DE-627)DOAJ062533304 (DE-599)DOAJ7069f46212d94b73a1113e65e5ce7c25 DE-627 ger DE-627 rakwb eng Francesco Giuseppe Foschi verfasserin aut External Validation of Surrogate Indices of Fatty Liver in the General Population: The Bagnacavallo Study 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier We externally validated the fatty liver index (FLI), the lipid accumulation product (LAP), the hepatic steatosis index (HSI), and the Zhejiang University index (ZJU) for the diagnosis of fatty liver (FL) and non-alcoholic fatty liver disease (NAFLD) in the general population. The validation was performed on 2159 citizens of the town of Bagnacavallo (Ravenna, Italy). Calibration was evaluated by calculating the calibration slope and intercept and by inspecting calibration plots; discrimination was evaluated using the c-statistic. The average calibration slope was 1 and the average intercept was 0 for all combinations of outcomes and indices. For the diagnosis of FL, the c-statistic was 0.85 for FLI, 0.83 for ZJU, 0.82 for HSI, and 0.80 for LAP; for the diagnosis of NAFLD, the c-statistic was 0.77 for FLI, 0.76 for ZJU, 0.75 for HSI, and 0.74 for LAP. All indices were strongly correlated with each other. In conclusion, FLI, LAP, HSI, and ZJU perform similarly well to diagnose FL and NAFLD in the Bagnacavallo population, even if FLI has a small advantage as discrimination is concerned. cross-sectional study diagnostic techniques and procedures validation study fatty liver non-alcoholic fatty liver disease Medicine R Fabio Conti verfasserin aut Marco Domenicali verfasserin aut Pierluigi Giacomoni verfasserin aut Alberto Borghi verfasserin aut Vittoria Bevilacqua verfasserin aut Lucia Napoli verfasserin aut Dante Berardinelli verfasserin aut Mattia Altini verfasserin aut Alessandro Cucchetti verfasserin aut Giorgio Ercolani verfasserin aut Andrea Casadei-Gardini verfasserin aut Stefano Bellentani verfasserin aut Amalia Gastaldelli verfasserin aut Claudio Tiribelli verfasserin aut Giorgio Bedogni verfasserin aut Bagnacavallo Study Group verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 10(2021), 3, p 520 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:10 year:2021 number:3, p 520 https://doi.org/10.3390/jcm10030520 kostenfrei https://doaj.org/article/7069f46212d94b73a1113e65e5ce7c25 kostenfrei https://www.mdpi.com/2077-0383/10/3/520 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2021 3, p 520
allfieldsSound	10.3390/jcm10030520 doi (DE-627)DOAJ062533304 (DE-599)DOAJ7069f46212d94b73a1113e65e5ce7c25 DE-627 ger DE-627 rakwb eng Francesco Giuseppe Foschi verfasserin aut External Validation of Surrogate Indices of Fatty Liver in the General Population: The Bagnacavallo Study 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier We externally validated the fatty liver index (FLI), the lipid accumulation product (LAP), the hepatic steatosis index (HSI), and the Zhejiang University index (ZJU) for the diagnosis of fatty liver (FL) and non-alcoholic fatty liver disease (NAFLD) in the general population. The validation was performed on 2159 citizens of the town of Bagnacavallo (Ravenna, Italy). Calibration was evaluated by calculating the calibration slope and intercept and by inspecting calibration plots; discrimination was evaluated using the c-statistic. The average calibration slope was 1 and the average intercept was 0 for all combinations of outcomes and indices. For the diagnosis of FL, the c-statistic was 0.85 for FLI, 0.83 for ZJU, 0.82 for HSI, and 0.80 for LAP; for the diagnosis of NAFLD, the c-statistic was 0.77 for FLI, 0.76 for ZJU, 0.75 for HSI, and 0.74 for LAP. All indices were strongly correlated with each other. In conclusion, FLI, LAP, HSI, and ZJU perform similarly well to diagnose FL and NAFLD in the Bagnacavallo population, even if FLI has a small advantage as discrimination is concerned. cross-sectional study diagnostic techniques and procedures validation study fatty liver non-alcoholic fatty liver disease Medicine R Fabio Conti verfasserin aut Marco Domenicali verfasserin aut Pierluigi Giacomoni verfasserin aut Alberto Borghi verfasserin aut Vittoria Bevilacqua verfasserin aut Lucia Napoli verfasserin aut Dante Berardinelli verfasserin aut Mattia Altini verfasserin aut Alessandro Cucchetti verfasserin aut Giorgio Ercolani verfasserin aut Andrea Casadei-Gardini verfasserin aut Stefano Bellentani verfasserin aut Amalia Gastaldelli verfasserin aut Claudio Tiribelli verfasserin aut Giorgio Bedogni verfasserin aut Bagnacavallo Study Group verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 10(2021), 3, p 520 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:10 year:2021 number:3, p 520 https://doi.org/10.3390/jcm10030520 kostenfrei https://doaj.org/article/7069f46212d94b73a1113e65e5ce7c25 kostenfrei https://www.mdpi.com/2077-0383/10/3/520 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2021 3, p 520
language	English
source	In Journal of Clinical Medicine 10(2021), 3, p 520 volume:10 year:2021 number:3, p 520
sourceStr	In Journal of Clinical Medicine 10(2021), 3, p 520 volume:10 year:2021 number:3, p 520
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	cross-sectional study diagnostic techniques and procedures validation study fatty liver non-alcoholic fatty liver disease Medicine R
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container_title	Journal of Clinical Medicine
authorswithroles_txt_mv	Francesco Giuseppe Foschi @@aut@@ Fabio Conti @@aut@@ Marco Domenicali @@aut@@ Pierluigi Giacomoni @@aut@@ Alberto Borghi @@aut@@ Vittoria Bevilacqua @@aut@@ Lucia Napoli @@aut@@ Dante Berardinelli @@aut@@ Mattia Altini @@aut@@ Alessandro Cucchetti @@aut@@ Giorgio Ercolani @@aut@@ Andrea Casadei-Gardini @@aut@@ Stefano Bellentani @@aut@@ Amalia Gastaldelli @@aut@@ Claudio Tiribelli @@aut@@ Giorgio Bedogni @@aut@@ Bagnacavallo Study Group @@aut@@
publishDateDaySort_date	2021-01-01T00:00:00Z
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language_de	englisch
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author	Francesco Giuseppe Foschi
spellingShingle	Francesco Giuseppe Foschi misc cross-sectional study misc diagnostic techniques and procedures misc validation study misc fatty liver misc non-alcoholic fatty liver disease misc Medicine misc R External Validation of Surrogate Indices of Fatty Liver in the General Population: The Bagnacavallo Study
authorStr	Francesco Giuseppe Foschi
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topic_title	External Validation of Surrogate Indices of Fatty Liver in the General Population: The Bagnacavallo Study cross-sectional study diagnostic techniques and procedures validation study fatty liver non-alcoholic fatty liver disease
topic	misc cross-sectional study misc diagnostic techniques and procedures misc validation study misc fatty liver misc non-alcoholic fatty liver disease misc Medicine misc R
topic_unstemmed	misc cross-sectional study misc diagnostic techniques and procedures misc validation study misc fatty liver misc non-alcoholic fatty liver disease misc Medicine misc R
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title	External Validation of Surrogate Indices of Fatty Liver in the General Population: The Bagnacavallo Study
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title_full	External Validation of Surrogate Indices of Fatty Liver in the General Population: The Bagnacavallo Study
author_sort	Francesco Giuseppe Foschi
journal	Journal of Clinical Medicine
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author_browse	Francesco Giuseppe Foschi Fabio Conti Marco Domenicali Pierluigi Giacomoni Alberto Borghi Vittoria Bevilacqua Lucia Napoli Dante Berardinelli Mattia Altini Alessandro Cucchetti Giorgio Ercolani Andrea Casadei-Gardini Stefano Bellentani Amalia Gastaldelli Claudio Tiribelli Giorgio Bedogni Bagnacavallo Study Group
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author-letter	Francesco Giuseppe Foschi
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title_sort	external validation of surrogate indices of fatty liver in the general population: the bagnacavallo study
title_auth	External Validation of Surrogate Indices of Fatty Liver in the General Population: The Bagnacavallo Study
abstract	We externally validated the fatty liver index (FLI), the lipid accumulation product (LAP), the hepatic steatosis index (HSI), and the Zhejiang University index (ZJU) for the diagnosis of fatty liver (FL) and non-alcoholic fatty liver disease (NAFLD) in the general population. The validation was performed on 2159 citizens of the town of Bagnacavallo (Ravenna, Italy). Calibration was evaluated by calculating the calibration slope and intercept and by inspecting calibration plots; discrimination was evaluated using the c-statistic. The average calibration slope was 1 and the average intercept was 0 for all combinations of outcomes and indices. For the diagnosis of FL, the c-statistic was 0.85 for FLI, 0.83 for ZJU, 0.82 for HSI, and 0.80 for LAP; for the diagnosis of NAFLD, the c-statistic was 0.77 for FLI, 0.76 for ZJU, 0.75 for HSI, and 0.74 for LAP. All indices were strongly correlated with each other. In conclusion, FLI, LAP, HSI, and ZJU perform similarly well to diagnose FL and NAFLD in the Bagnacavallo population, even if FLI has a small advantage as discrimination is concerned.
abstractGer	We externally validated the fatty liver index (FLI), the lipid accumulation product (LAP), the hepatic steatosis index (HSI), and the Zhejiang University index (ZJU) for the diagnosis of fatty liver (FL) and non-alcoholic fatty liver disease (NAFLD) in the general population. The validation was performed on 2159 citizens of the town of Bagnacavallo (Ravenna, Italy). Calibration was evaluated by calculating the calibration slope and intercept and by inspecting calibration plots; discrimination was evaluated using the c-statistic. The average calibration slope was 1 and the average intercept was 0 for all combinations of outcomes and indices. For the diagnosis of FL, the c-statistic was 0.85 for FLI, 0.83 for ZJU, 0.82 for HSI, and 0.80 for LAP; for the diagnosis of NAFLD, the c-statistic was 0.77 for FLI, 0.76 for ZJU, 0.75 for HSI, and 0.74 for LAP. All indices were strongly correlated with each other. In conclusion, FLI, LAP, HSI, and ZJU perform similarly well to diagnose FL and NAFLD in the Bagnacavallo population, even if FLI has a small advantage as discrimination is concerned.
abstract_unstemmed	We externally validated the fatty liver index (FLI), the lipid accumulation product (LAP), the hepatic steatosis index (HSI), and the Zhejiang University index (ZJU) for the diagnosis of fatty liver (FL) and non-alcoholic fatty liver disease (NAFLD) in the general population. The validation was performed on 2159 citizens of the town of Bagnacavallo (Ravenna, Italy). Calibration was evaluated by calculating the calibration slope and intercept and by inspecting calibration plots; discrimination was evaluated using the c-statistic. The average calibration slope was 1 and the average intercept was 0 for all combinations of outcomes and indices. For the diagnosis of FL, the c-statistic was 0.85 for FLI, 0.83 for ZJU, 0.82 for HSI, and 0.80 for LAP; for the diagnosis of NAFLD, the c-statistic was 0.77 for FLI, 0.76 for ZJU, 0.75 for HSI, and 0.74 for LAP. All indices were strongly correlated with each other. In conclusion, FLI, LAP, HSI, and ZJU perform similarly well to diagnose FL and NAFLD in the Bagnacavallo population, even if FLI has a small advantage as discrimination is concerned.
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title_short	External Validation of Surrogate Indices of Fatty Liver in the General Population: The Bagnacavallo Study
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author2	Fabio Conti Marco Domenicali Pierluigi Giacomoni Alberto Borghi Vittoria Bevilacqua Lucia Napoli Dante Berardinelli Mattia Altini Alessandro Cucchetti Giorgio Ercolani Andrea Casadei-Gardini Stefano Bellentani Amalia Gastaldelli Claudio Tiribelli Giorgio Bedogni Bagnacavallo Study Group
author2Str	Fabio Conti Marco Domenicali Pierluigi Giacomoni Alberto Borghi Vittoria Bevilacqua Lucia Napoli Dante Berardinelli Mattia Altini Alessandro Cucchetti Giorgio Ercolani Andrea Casadei-Gardini Stefano Bellentani Amalia Gastaldelli Claudio Tiribelli Giorgio Bedogni Bagnacavallo Study Group
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up_date	2024-07-04T02:00:51.317Z
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External Validation of Surrogate Indices of Fatty Liver in the General Population: The Bagnacavallo Study

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Vorhandene Bände

Nicht das Richtige dabei?