Mutation Profile Variability in the Primary Tumor and Multiple Pulmonary Metastases of Clear Cell Renal Cell Carcinoma. A Review of the Literature and Analysis of Four Metastatic Cases

(1) Background: There are limited data concerning inter-tumoral and inter-metastatic heterogeneity in clear cell renal cell carcinoma (CCRCC). The aim of our study was to review published data and to examine mutation profile variability in primary and multiple pulmonary metastases (PMs) in our cohor...
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Autor*in:	Kristyna Prochazkova [verfasserIn] Nikola Ptakova [verfasserIn] Reza Alaghehbandan [verfasserIn] Sean R. Williamson [verfasserIn] Tomáš Vaněček [verfasserIn] Josef Vodicka [verfasserIn] Vladislav Treska [verfasserIn] Joanna Rogala [verfasserIn] Kristyna Pivovarcikova [verfasserIn] Kvetoslava Michalova [verfasserIn] Maryna Slisarenko [verfasserIn] Milan Hora [verfasserIn] Michal Michal [verfasserIn] Ondrej Hes [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	clear cell renal cell carcinoma intra-tumoral heterogeneity inter-tumoral heterogeneity inter-metastatic heterogeneity

Übergeordnetes Werk:	In: Cancers - MDPI AG, 2010, 13(2021), 23, p 5906
Übergeordnetes Werk:	volume:13 ; year:2021 ; number:23, p 5906

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/cancers13235906

Katalog-ID:	DOAJ062653288

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authorswithroles_txt_mv	Kristyna Prochazkova @@aut@@ Nikola Ptakova @@aut@@ Reza Alaghehbandan @@aut@@ Sean R. Williamson @@aut@@ Tomáš Vaněček @@aut@@ Josef Vodicka @@aut@@ Vladislav Treska @@aut@@ Joanna Rogala @@aut@@ Kristyna Pivovarcikova @@aut@@ Kvetoslava Michalova @@aut@@ Maryna Slisarenko @@aut@@ Milan Hora @@aut@@ Michal Michal @@aut@@ Ondrej Hes @@aut@@
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callnumber-first	R - Medicine
author	Kristyna Prochazkova
spellingShingle	Kristyna Prochazkova misc RC254-282 misc clear cell renal cell carcinoma misc intra-tumoral heterogeneity misc inter-tumoral heterogeneity misc inter-metastatic heterogeneity misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens Mutation Profile Variability in the Primary Tumor and Multiple Pulmonary Metastases of Clear Cell Renal Cell Carcinoma. A Review of the Literature and Analysis of Four Metastatic Cases
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topic_title	RC254-282 Mutation Profile Variability in the Primary Tumor and Multiple Pulmonary Metastases of Clear Cell Renal Cell Carcinoma. A Review of the Literature and Analysis of Four Metastatic Cases clear cell renal cell carcinoma intra-tumoral heterogeneity inter-tumoral heterogeneity inter-metastatic heterogeneity
topic	misc RC254-282 misc clear cell renal cell carcinoma misc intra-tumoral heterogeneity misc inter-tumoral heterogeneity misc inter-metastatic heterogeneity misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_unstemmed	misc RC254-282 misc clear cell renal cell carcinoma misc intra-tumoral heterogeneity misc inter-tumoral heterogeneity misc inter-metastatic heterogeneity misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_browse	misc RC254-282 misc clear cell renal cell carcinoma misc intra-tumoral heterogeneity misc inter-tumoral heterogeneity misc inter-metastatic heterogeneity misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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title	Mutation Profile Variability in the Primary Tumor and Multiple Pulmonary Metastases of Clear Cell Renal Cell Carcinoma. A Review of the Literature and Analysis of Four Metastatic Cases
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title_full	Mutation Profile Variability in the Primary Tumor and Multiple Pulmonary Metastases of Clear Cell Renal Cell Carcinoma. A Review of the Literature and Analysis of Four Metastatic Cases
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author_browse	Kristyna Prochazkova Nikola Ptakova Reza Alaghehbandan Sean R. Williamson Tomáš Vaněček Josef Vodicka Vladislav Treska Joanna Rogala Kristyna Pivovarcikova Kvetoslava Michalova Maryna Slisarenko Milan Hora Michal Michal Ondrej Hes
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title_sort	mutation profile variability in the primary tumor and multiple pulmonary metastases of clear cell renal cell carcinoma. a review of the literature and analysis of four metastatic cases
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title_auth	Mutation Profile Variability in the Primary Tumor and Multiple Pulmonary Metastases of Clear Cell Renal Cell Carcinoma. A Review of the Literature and Analysis of Four Metastatic Cases
abstract	(1) Background: There are limited data concerning inter-tumoral and inter-metastatic heterogeneity in clear cell renal cell carcinoma (CCRCC). The aim of our study was to review published data and to examine mutation profile variability in primary and multiple pulmonary metastases (PMs) in our cohort of four patients with metastatic CCRCC. (2) Methods: Four patients were enrolled in this study. The clinical characteristics, types of surgeries, histopathologic results, immunohistochemical and genetic evaluations of corresponding primary tumor and PMs, and follow-up data were recorded. (3) Results: In our series, the most commonly mutated genes were those in the canonically dysregulated VHL pathway, which were detected in both primary tumors and corresponding metastasis. There were genetic profile differences between primary and metastatic tumors, as well as among particular metastases in one patient. (4) Conclusions: CCRCC shows heterogeneity between the primary tumor and its metastasis. Such mutational changes may be responsible for suboptimal treatment outcomes in targeted therapy settings.
abstractGer	(1) Background: There are limited data concerning inter-tumoral and inter-metastatic heterogeneity in clear cell renal cell carcinoma (CCRCC). The aim of our study was to review published data and to examine mutation profile variability in primary and multiple pulmonary metastases (PMs) in our cohort of four patients with metastatic CCRCC. (2) Methods: Four patients were enrolled in this study. The clinical characteristics, types of surgeries, histopathologic results, immunohistochemical and genetic evaluations of corresponding primary tumor and PMs, and follow-up data were recorded. (3) Results: In our series, the most commonly mutated genes were those in the canonically dysregulated VHL pathway, which were detected in both primary tumors and corresponding metastasis. There were genetic profile differences between primary and metastatic tumors, as well as among particular metastases in one patient. (4) Conclusions: CCRCC shows heterogeneity between the primary tumor and its metastasis. Such mutational changes may be responsible for suboptimal treatment outcomes in targeted therapy settings.
abstract_unstemmed	(1) Background: There are limited data concerning inter-tumoral and inter-metastatic heterogeneity in clear cell renal cell carcinoma (CCRCC). The aim of our study was to review published data and to examine mutation profile variability in primary and multiple pulmonary metastases (PMs) in our cohort of four patients with metastatic CCRCC. (2) Methods: Four patients were enrolled in this study. The clinical characteristics, types of surgeries, histopathologic results, immunohistochemical and genetic evaluations of corresponding primary tumor and PMs, and follow-up data were recorded. (3) Results: In our series, the most commonly mutated genes were those in the canonically dysregulated VHL pathway, which were detected in both primary tumors and corresponding metastasis. There were genetic profile differences between primary and metastatic tumors, as well as among particular metastases in one patient. (4) Conclusions: CCRCC shows heterogeneity between the primary tumor and its metastasis. Such mutational changes may be responsible for suboptimal treatment outcomes in targeted therapy settings.
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title_short	Mutation Profile Variability in the Primary Tumor and Multiple Pulmonary Metastases of Clear Cell Renal Cell Carcinoma. A Review of the Literature and Analysis of Four Metastatic Cases
url	https://doi.org/10.3390/cancers13235906 https://doaj.org/article/6d53cc0568374d84a1b86244537ae9de https://www.mdpi.com/2072-6694/13/23/5906 https://doaj.org/toc/2072-6694
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author2	Nikola Ptakova Reza Alaghehbandan Sean R. Williamson Tomáš Vaněček Josef Vodicka Vladislav Treska Joanna Rogala Kristyna Pivovarcikova Kvetoslava Michalova Maryna Slisarenko Milan Hora Michal Michal Ondrej Hes
author2Str	Nikola Ptakova Reza Alaghehbandan Sean R. Williamson Tomáš Vaněček Josef Vodicka Vladislav Treska Joanna Rogala Kristyna Pivovarcikova Kvetoslava Michalova Maryna Slisarenko Milan Hora Michal Michal Ondrej Hes
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Mutation Profile Variability in the Primary Tumor and Multiple Pulmonary Metastases of Clear Cell Renal Cell Carcinoma. A Review of the Literature and Analysis of Four Metastatic Cases

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