Scientific Opinion about the Guidance of the Chemical Regulation Directorate (UK) on how aged sorption studies for pesticides should be conducted, analysed and used in regulatory assessments
Abstract The EFSA Panel on Plant Protection Products and their Residues reviewed the guidance on how aged sorption studies for pesticides should be conducted, analysed and used in regulatory assessment. The inclusion of aged sorption is a higher tier in the groundwater leaching assessment. The Panel...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
EFSA Panel on Plant Protection Products and their Residues (PPR) [verfasserIn] Colin Ockleford [verfasserIn] Antonio F Hernandez‐Jerez [verfasserIn] Susanne Hougaard Bennekou [verfasserIn] Michael Klein [verfasserIn] Thomas Paulien Adriaanse [verfasserIn] Philippe Berny [verfasserIn] Theodorus Brock [verfasserIn] Sabine Duquesne [verfasserIn] Sandro Grilli [verfasserIn] Thomas Kuhl [verfasserIn] Ryszard Laskowski [verfasserIn] Kyriaki Machera [verfasserIn] Olavi Pelkonen [verfasserIn] Silvia Pieper [verfasserIn] Michael Stemmer [verfasserIn] Ingvar Sundh [verfasserIn] Ivana Teodorovic [verfasserIn] Chris J Topping [verfasserIn] Gerrit Wolterink [verfasserIn] Robert H Smith [verfasserIn] Anne Louise Gimsing [verfasserIn] Roy Kasteel [verfasserIn] Arnaud Boivin [verfasserIn] Ton van der Linden [verfasserIn] Jose Oriol Magrans [verfasserIn] Mark Egsmose [verfasserIn] Aaldrik Tiktak [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2018 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
In: EFSA Journal - Wiley, 2018, 16(2018), 8, Seite n/a-n/a |
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| Übergeordnetes Werk: |
volume:16 ; year:2018 ; number:8 ; pages:n/a-n/a |
| Links: |
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| DOI / URN: |
10.2903/j.efsa.2018.5382 |
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| Katalog-ID: |
DOAJ062809482 |
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| 520 | |a Abstract The EFSA Panel on Plant Protection Products and their Residues reviewed the guidance on how aged sorption studies for pesticides should be conducted, analysed and used in regulatory assessment. The inclusion of aged sorption is a higher tier in the groundwater leaching assessment. The Panel based its review on a test with three substances taken from a data set provided by the European Crop Protection Association. Particular points of attention were the quality of the data provided, the proposed fitting procedure of aged sorption experiments and the proposed method for combining results obtained from aged sorption studies and lower‐tier studies on degradation and adsorption. Aged sorption was a relevant process in all cases studied. The test revealed that the guidance could generally be well applied and resulted in robust and plausible results. The Panel considers the guidance suitable for use in the groundwater leaching assessment after the recommendations in this Scientific Opinion have been implemented, with the exception of the use of field data to derive aged sorption parameters. The Panel noted that the draft guidance could only be used by experienced users because there is no software tool that fully supports the work flow in the guidance document. It is therefore recommended that a user‐friendly software tool be developed. Aged sorption lowered the predicted concentration in groundwater. However, because aged sorption experiments may be conducted in different soils than lower‐tier degradation and adsorption experiments, it cannot be guaranteed that the higher tier predicts lower concentrations than the lower tier, while lower tiers should be more conservative than higher tiers. To mitigate this problem, the Panel recommends using all available higher‐ and lower‐tier data in the leaching assessment. The Panel further recommends that aged sorption parameters for metabolites be derived only from metabolite‐dosed studies. The formation fraction can be derived from parent‐dosed degradation studies, provided that the parent and metabolite are fitted with the best‐fit model, which is the double first‐order in parallel model in the case of aged sorption. | ||
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| 650 | 4 | |a aged sorption | |
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| 650 | 4 | |a leaching | |
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| 653 | 0 | |a Nutrition. Foods and food supply | |
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| 700 | 0 | |a Antonio F Hernandez‐Jerez |e verfasserin |4 aut | |
| 700 | 0 | |a Susanne Hougaard Bennekou |e verfasserin |4 aut | |
| 700 | 0 | |a Michael Klein |e verfasserin |4 aut | |
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10.2903/j.efsa.2018.5382 doi (DE-627)DOAJ062809482 (DE-599)DOAJ47a83fff67374f81be4fb5e31b7fa0cd DE-627 ger DE-627 rakwb eng TX341-641 TP1-1185 EFSA Panel on Plant Protection Products and their Residues (PPR) verfasserin aut Scientific Opinion about the Guidance of the Chemical Regulation Directorate (UK) on how aged sorption studies for pesticides should be conducted, analysed and used in regulatory assessments 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The EFSA Panel on Plant Protection Products and their Residues reviewed the guidance on how aged sorption studies for pesticides should be conducted, analysed and used in regulatory assessment. The inclusion of aged sorption is a higher tier in the groundwater leaching assessment. The Panel based its review on a test with three substances taken from a data set provided by the European Crop Protection Association. Particular points of attention were the quality of the data provided, the proposed fitting procedure of aged sorption experiments and the proposed method for combining results obtained from aged sorption studies and lower‐tier studies on degradation and adsorption. Aged sorption was a relevant process in all cases studied. The test revealed that the guidance could generally be well applied and resulted in robust and plausible results. The Panel considers the guidance suitable for use in the groundwater leaching assessment after the recommendations in this Scientific Opinion have been implemented, with the exception of the use of field data to derive aged sorption parameters. The Panel noted that the draft guidance could only be used by experienced users because there is no software tool that fully supports the work flow in the guidance document. It is therefore recommended that a user‐friendly software tool be developed. Aged sorption lowered the predicted concentration in groundwater. However, because aged sorption experiments may be conducted in different soils than lower‐tier degradation and adsorption experiments, it cannot be guaranteed that the higher tier predicts lower concentrations than the lower tier, while lower tiers should be more conservative than higher tiers. To mitigate this problem, the Panel recommends using all available higher‐ and lower‐tier data in the leaching assessment. The Panel further recommends that aged sorption parameters for metabolites be derived only from metabolite‐dosed studies. The formation fraction can be derived from parent‐dosed degradation studies, provided that the parent and metabolite are fitted with the best‐fit model, which is the double first‐order in parallel model in the case of aged sorption. plant protection products aged sorption guidance modelling leaching review Nutrition. Foods and food supply Chemical technology Colin Ockleford verfasserin aut Antonio F Hernandez‐Jerez verfasserin aut Susanne Hougaard Bennekou verfasserin aut Michael Klein verfasserin aut Thomas Paulien Adriaanse verfasserin aut Philippe Berny verfasserin aut Theodorus Brock verfasserin aut Sabine Duquesne verfasserin aut Sandro Grilli verfasserin aut Thomas Kuhl verfasserin aut Ryszard Laskowski verfasserin aut Kyriaki Machera verfasserin aut Olavi Pelkonen verfasserin aut Silvia Pieper verfasserin aut Michael Stemmer verfasserin aut Ingvar Sundh verfasserin aut Ivana Teodorovic verfasserin aut Chris J Topping verfasserin aut Gerrit Wolterink verfasserin aut Robert H Smith verfasserin aut Anne Louise Gimsing verfasserin aut Roy Kasteel verfasserin aut Arnaud Boivin verfasserin aut Ton van der Linden verfasserin aut Jose Oriol Magrans verfasserin aut Mark Egsmose verfasserin aut Aaldrik Tiktak verfasserin aut In EFSA Journal Wiley, 2018 16(2018), 8, Seite n/a-n/a (DE-627)618834982 (DE-600)2540248-1 18314732 nnns volume:16 year:2018 number:8 pages:n/a-n/a https://doi.org/10.2903/j.efsa.2018.5382 kostenfrei https://doaj.org/article/47a83fff67374f81be4fb5e31b7fa0cd kostenfrei https://doi.org/10.2903/j.efsa.2018.5382 kostenfrei https://doaj.org/toc/1831-4732 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_235 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 16 2018 8 n/a-n/a |
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10.2903/j.efsa.2018.5382 doi (DE-627)DOAJ062809482 (DE-599)DOAJ47a83fff67374f81be4fb5e31b7fa0cd DE-627 ger DE-627 rakwb eng TX341-641 TP1-1185 EFSA Panel on Plant Protection Products and their Residues (PPR) verfasserin aut Scientific Opinion about the Guidance of the Chemical Regulation Directorate (UK) on how aged sorption studies for pesticides should be conducted, analysed and used in regulatory assessments 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The EFSA Panel on Plant Protection Products and their Residues reviewed the guidance on how aged sorption studies for pesticides should be conducted, analysed and used in regulatory assessment. The inclusion of aged sorption is a higher tier in the groundwater leaching assessment. The Panel based its review on a test with three substances taken from a data set provided by the European Crop Protection Association. Particular points of attention were the quality of the data provided, the proposed fitting procedure of aged sorption experiments and the proposed method for combining results obtained from aged sorption studies and lower‐tier studies on degradation and adsorption. Aged sorption was a relevant process in all cases studied. The test revealed that the guidance could generally be well applied and resulted in robust and plausible results. The Panel considers the guidance suitable for use in the groundwater leaching assessment after the recommendations in this Scientific Opinion have been implemented, with the exception of the use of field data to derive aged sorption parameters. The Panel noted that the draft guidance could only be used by experienced users because there is no software tool that fully supports the work flow in the guidance document. It is therefore recommended that a user‐friendly software tool be developed. Aged sorption lowered the predicted concentration in groundwater. However, because aged sorption experiments may be conducted in different soils than lower‐tier degradation and adsorption experiments, it cannot be guaranteed that the higher tier predicts lower concentrations than the lower tier, while lower tiers should be more conservative than higher tiers. To mitigate this problem, the Panel recommends using all available higher‐ and lower‐tier data in the leaching assessment. The Panel further recommends that aged sorption parameters for metabolites be derived only from metabolite‐dosed studies. The formation fraction can be derived from parent‐dosed degradation studies, provided that the parent and metabolite are fitted with the best‐fit model, which is the double first‐order in parallel model in the case of aged sorption. plant protection products aged sorption guidance modelling leaching review Nutrition. Foods and food supply Chemical technology Colin Ockleford verfasserin aut Antonio F Hernandez‐Jerez verfasserin aut Susanne Hougaard Bennekou verfasserin aut Michael Klein verfasserin aut Thomas Paulien Adriaanse verfasserin aut Philippe Berny verfasserin aut Theodorus Brock verfasserin aut Sabine Duquesne verfasserin aut Sandro Grilli verfasserin aut Thomas Kuhl verfasserin aut Ryszard Laskowski verfasserin aut Kyriaki Machera verfasserin aut Olavi Pelkonen verfasserin aut Silvia Pieper verfasserin aut Michael Stemmer verfasserin aut Ingvar Sundh verfasserin aut Ivana Teodorovic verfasserin aut Chris J Topping verfasserin aut Gerrit Wolterink verfasserin aut Robert H Smith verfasserin aut Anne Louise Gimsing verfasserin aut Roy Kasteel verfasserin aut Arnaud Boivin verfasserin aut Ton van der Linden verfasserin aut Jose Oriol Magrans verfasserin aut Mark Egsmose verfasserin aut Aaldrik Tiktak verfasserin aut In EFSA Journal Wiley, 2018 16(2018), 8, Seite n/a-n/a (DE-627)618834982 (DE-600)2540248-1 18314732 nnns volume:16 year:2018 number:8 pages:n/a-n/a https://doi.org/10.2903/j.efsa.2018.5382 kostenfrei https://doaj.org/article/47a83fff67374f81be4fb5e31b7fa0cd kostenfrei https://doi.org/10.2903/j.efsa.2018.5382 kostenfrei https://doaj.org/toc/1831-4732 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_235 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 16 2018 8 n/a-n/a |
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10.2903/j.efsa.2018.5382 doi (DE-627)DOAJ062809482 (DE-599)DOAJ47a83fff67374f81be4fb5e31b7fa0cd DE-627 ger DE-627 rakwb eng TX341-641 TP1-1185 EFSA Panel on Plant Protection Products and their Residues (PPR) verfasserin aut Scientific Opinion about the Guidance of the Chemical Regulation Directorate (UK) on how aged sorption studies for pesticides should be conducted, analysed and used in regulatory assessments 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The EFSA Panel on Plant Protection Products and their Residues reviewed the guidance on how aged sorption studies for pesticides should be conducted, analysed and used in regulatory assessment. The inclusion of aged sorption is a higher tier in the groundwater leaching assessment. The Panel based its review on a test with three substances taken from a data set provided by the European Crop Protection Association. Particular points of attention were the quality of the data provided, the proposed fitting procedure of aged sorption experiments and the proposed method for combining results obtained from aged sorption studies and lower‐tier studies on degradation and adsorption. Aged sorption was a relevant process in all cases studied. The test revealed that the guidance could generally be well applied and resulted in robust and plausible results. The Panel considers the guidance suitable for use in the groundwater leaching assessment after the recommendations in this Scientific Opinion have been implemented, with the exception of the use of field data to derive aged sorption parameters. The Panel noted that the draft guidance could only be used by experienced users because there is no software tool that fully supports the work flow in the guidance document. It is therefore recommended that a user‐friendly software tool be developed. Aged sorption lowered the predicted concentration in groundwater. However, because aged sorption experiments may be conducted in different soils than lower‐tier degradation and adsorption experiments, it cannot be guaranteed that the higher tier predicts lower concentrations than the lower tier, while lower tiers should be more conservative than higher tiers. To mitigate this problem, the Panel recommends using all available higher‐ and lower‐tier data in the leaching assessment. The Panel further recommends that aged sorption parameters for metabolites be derived only from metabolite‐dosed studies. The formation fraction can be derived from parent‐dosed degradation studies, provided that the parent and metabolite are fitted with the best‐fit model, which is the double first‐order in parallel model in the case of aged sorption. plant protection products aged sorption guidance modelling leaching review Nutrition. Foods and food supply Chemical technology Colin Ockleford verfasserin aut Antonio F Hernandez‐Jerez verfasserin aut Susanne Hougaard Bennekou verfasserin aut Michael Klein verfasserin aut Thomas Paulien Adriaanse verfasserin aut Philippe Berny verfasserin aut Theodorus Brock verfasserin aut Sabine Duquesne verfasserin aut Sandro Grilli verfasserin aut Thomas Kuhl verfasserin aut Ryszard Laskowski verfasserin aut Kyriaki Machera verfasserin aut Olavi Pelkonen verfasserin aut Silvia Pieper verfasserin aut Michael Stemmer verfasserin aut Ingvar Sundh verfasserin aut Ivana Teodorovic verfasserin aut Chris J Topping verfasserin aut Gerrit Wolterink verfasserin aut Robert H Smith verfasserin aut Anne Louise Gimsing verfasserin aut Roy Kasteel verfasserin aut Arnaud Boivin verfasserin aut Ton van der Linden verfasserin aut Jose Oriol Magrans verfasserin aut Mark Egsmose verfasserin aut Aaldrik Tiktak verfasserin aut In EFSA Journal Wiley, 2018 16(2018), 8, Seite n/a-n/a (DE-627)618834982 (DE-600)2540248-1 18314732 nnns volume:16 year:2018 number:8 pages:n/a-n/a https://doi.org/10.2903/j.efsa.2018.5382 kostenfrei https://doaj.org/article/47a83fff67374f81be4fb5e31b7fa0cd kostenfrei https://doi.org/10.2903/j.efsa.2018.5382 kostenfrei https://doaj.org/toc/1831-4732 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_235 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 16 2018 8 n/a-n/a |
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10.2903/j.efsa.2018.5382 doi (DE-627)DOAJ062809482 (DE-599)DOAJ47a83fff67374f81be4fb5e31b7fa0cd DE-627 ger DE-627 rakwb eng TX341-641 TP1-1185 EFSA Panel on Plant Protection Products and their Residues (PPR) verfasserin aut Scientific Opinion about the Guidance of the Chemical Regulation Directorate (UK) on how aged sorption studies for pesticides should be conducted, analysed and used in regulatory assessments 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The EFSA Panel on Plant Protection Products and their Residues reviewed the guidance on how aged sorption studies for pesticides should be conducted, analysed and used in regulatory assessment. The inclusion of aged sorption is a higher tier in the groundwater leaching assessment. The Panel based its review on a test with three substances taken from a data set provided by the European Crop Protection Association. Particular points of attention were the quality of the data provided, the proposed fitting procedure of aged sorption experiments and the proposed method for combining results obtained from aged sorption studies and lower‐tier studies on degradation and adsorption. Aged sorption was a relevant process in all cases studied. The test revealed that the guidance could generally be well applied and resulted in robust and plausible results. The Panel considers the guidance suitable for use in the groundwater leaching assessment after the recommendations in this Scientific Opinion have been implemented, with the exception of the use of field data to derive aged sorption parameters. The Panel noted that the draft guidance could only be used by experienced users because there is no software tool that fully supports the work flow in the guidance document. It is therefore recommended that a user‐friendly software tool be developed. Aged sorption lowered the predicted concentration in groundwater. However, because aged sorption experiments may be conducted in different soils than lower‐tier degradation and adsorption experiments, it cannot be guaranteed that the higher tier predicts lower concentrations than the lower tier, while lower tiers should be more conservative than higher tiers. To mitigate this problem, the Panel recommends using all available higher‐ and lower‐tier data in the leaching assessment. The Panel further recommends that aged sorption parameters for metabolites be derived only from metabolite‐dosed studies. The formation fraction can be derived from parent‐dosed degradation studies, provided that the parent and metabolite are fitted with the best‐fit model, which is the double first‐order in parallel model in the case of aged sorption. plant protection products aged sorption guidance modelling leaching review Nutrition. Foods and food supply Chemical technology Colin Ockleford verfasserin aut Antonio F Hernandez‐Jerez verfasserin aut Susanne Hougaard Bennekou verfasserin aut Michael Klein verfasserin aut Thomas Paulien Adriaanse verfasserin aut Philippe Berny verfasserin aut Theodorus Brock verfasserin aut Sabine Duquesne verfasserin aut Sandro Grilli verfasserin aut Thomas Kuhl verfasserin aut Ryszard Laskowski verfasserin aut Kyriaki Machera verfasserin aut Olavi Pelkonen verfasserin aut Silvia Pieper verfasserin aut Michael Stemmer verfasserin aut Ingvar Sundh verfasserin aut Ivana Teodorovic verfasserin aut Chris J Topping verfasserin aut Gerrit Wolterink verfasserin aut Robert H Smith verfasserin aut Anne Louise Gimsing verfasserin aut Roy Kasteel verfasserin aut Arnaud Boivin verfasserin aut Ton van der Linden verfasserin aut Jose Oriol Magrans verfasserin aut Mark Egsmose verfasserin aut Aaldrik Tiktak verfasserin aut In EFSA Journal Wiley, 2018 16(2018), 8, Seite n/a-n/a (DE-627)618834982 (DE-600)2540248-1 18314732 nnns volume:16 year:2018 number:8 pages:n/a-n/a https://doi.org/10.2903/j.efsa.2018.5382 kostenfrei https://doaj.org/article/47a83fff67374f81be4fb5e31b7fa0cd kostenfrei https://doi.org/10.2903/j.efsa.2018.5382 kostenfrei https://doaj.org/toc/1831-4732 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_235 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 16 2018 8 n/a-n/a |
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10.2903/j.efsa.2018.5382 doi (DE-627)DOAJ062809482 (DE-599)DOAJ47a83fff67374f81be4fb5e31b7fa0cd DE-627 ger DE-627 rakwb eng TX341-641 TP1-1185 EFSA Panel on Plant Protection Products and their Residues (PPR) verfasserin aut Scientific Opinion about the Guidance of the Chemical Regulation Directorate (UK) on how aged sorption studies for pesticides should be conducted, analysed and used in regulatory assessments 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The EFSA Panel on Plant Protection Products and their Residues reviewed the guidance on how aged sorption studies for pesticides should be conducted, analysed and used in regulatory assessment. The inclusion of aged sorption is a higher tier in the groundwater leaching assessment. The Panel based its review on a test with three substances taken from a data set provided by the European Crop Protection Association. Particular points of attention were the quality of the data provided, the proposed fitting procedure of aged sorption experiments and the proposed method for combining results obtained from aged sorption studies and lower‐tier studies on degradation and adsorption. Aged sorption was a relevant process in all cases studied. The test revealed that the guidance could generally be well applied and resulted in robust and plausible results. The Panel considers the guidance suitable for use in the groundwater leaching assessment after the recommendations in this Scientific Opinion have been implemented, with the exception of the use of field data to derive aged sorption parameters. The Panel noted that the draft guidance could only be used by experienced users because there is no software tool that fully supports the work flow in the guidance document. It is therefore recommended that a user‐friendly software tool be developed. Aged sorption lowered the predicted concentration in groundwater. However, because aged sorption experiments may be conducted in different soils than lower‐tier degradation and adsorption experiments, it cannot be guaranteed that the higher tier predicts lower concentrations than the lower tier, while lower tiers should be more conservative than higher tiers. To mitigate this problem, the Panel recommends using all available higher‐ and lower‐tier data in the leaching assessment. The Panel further recommends that aged sorption parameters for metabolites be derived only from metabolite‐dosed studies. The formation fraction can be derived from parent‐dosed degradation studies, provided that the parent and metabolite are fitted with the best‐fit model, which is the double first‐order in parallel model in the case of aged sorption. plant protection products aged sorption guidance modelling leaching review Nutrition. Foods and food supply Chemical technology Colin Ockleford verfasserin aut Antonio F Hernandez‐Jerez verfasserin aut Susanne Hougaard Bennekou verfasserin aut Michael Klein verfasserin aut Thomas Paulien Adriaanse verfasserin aut Philippe Berny verfasserin aut Theodorus Brock verfasserin aut Sabine Duquesne verfasserin aut Sandro Grilli verfasserin aut Thomas Kuhl verfasserin aut Ryszard Laskowski verfasserin aut Kyriaki Machera verfasserin aut Olavi Pelkonen verfasserin aut Silvia Pieper verfasserin aut Michael Stemmer verfasserin aut Ingvar Sundh verfasserin aut Ivana Teodorovic verfasserin aut Chris J Topping verfasserin aut Gerrit Wolterink verfasserin aut Robert H Smith verfasserin aut Anne Louise Gimsing verfasserin aut Roy Kasteel verfasserin aut Arnaud Boivin verfasserin aut Ton van der Linden verfasserin aut Jose Oriol Magrans verfasserin aut Mark Egsmose verfasserin aut Aaldrik Tiktak verfasserin aut In EFSA Journal Wiley, 2018 16(2018), 8, Seite n/a-n/a (DE-627)618834982 (DE-600)2540248-1 18314732 nnns volume:16 year:2018 number:8 pages:n/a-n/a https://doi.org/10.2903/j.efsa.2018.5382 kostenfrei https://doaj.org/article/47a83fff67374f81be4fb5e31b7fa0cd kostenfrei https://doi.org/10.2903/j.efsa.2018.5382 kostenfrei https://doaj.org/toc/1831-4732 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_235 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 16 2018 8 n/a-n/a |
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EFSA Panel on Plant Protection Products and their Residues (PPR) @@aut@@ Colin Ockleford @@aut@@ Antonio F Hernandez‐Jerez @@aut@@ Susanne Hougaard Bennekou @@aut@@ Michael Klein @@aut@@ Thomas Paulien Adriaanse @@aut@@ Philippe Berny @@aut@@ Theodorus Brock @@aut@@ Sabine Duquesne @@aut@@ Sandro Grilli @@aut@@ Thomas Kuhl @@aut@@ Ryszard Laskowski @@aut@@ Kyriaki Machera @@aut@@ Olavi Pelkonen @@aut@@ Silvia Pieper @@aut@@ Michael Stemmer @@aut@@ Ingvar Sundh @@aut@@ Ivana Teodorovic @@aut@@ Chris J Topping @@aut@@ Gerrit Wolterink @@aut@@ Robert H Smith @@aut@@ Anne Louise Gimsing @@aut@@ Roy Kasteel @@aut@@ Arnaud Boivin @@aut@@ Ton van der Linden @@aut@@ Jose Oriol Magrans @@aut@@ Mark Egsmose @@aut@@ Aaldrik Tiktak @@aut@@ |
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The inclusion of aged sorption is a higher tier in the groundwater leaching assessment. The Panel based its review on a test with three substances taken from a data set provided by the European Crop Protection Association. Particular points of attention were the quality of the data provided, the proposed fitting procedure of aged sorption experiments and the proposed method for combining results obtained from aged sorption studies and lower‐tier studies on degradation and adsorption. Aged sorption was a relevant process in all cases studied. The test revealed that the guidance could generally be well applied and resulted in robust and plausible results. The Panel considers the guidance suitable for use in the groundwater leaching assessment after the recommendations in this Scientific Opinion have been implemented, with the exception of the use of field data to derive aged sorption parameters. The Panel noted that the draft guidance could only be used by experienced users because there is no software tool that fully supports the work flow in the guidance document. It is therefore recommended that a user‐friendly software tool be developed. Aged sorption lowered the predicted concentration in groundwater. However, because aged sorption experiments may be conducted in different soils than lower‐tier degradation and adsorption experiments, it cannot be guaranteed that the higher tier predicts lower concentrations than the lower tier, while lower tiers should be more conservative than higher tiers. To mitigate this problem, the Panel recommends using all available higher‐ and lower‐tier data in the leaching assessment. The Panel further recommends that aged sorption parameters for metabolites be derived only from metabolite‐dosed studies. 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EFSA Panel on Plant Protection Products and their Residues (PPR) Colin Ockleford Antonio F Hernandez‐Jerez Susanne Hougaard Bennekou Michael Klein Thomas Paulien Adriaanse Philippe Berny Theodorus Brock Sabine Duquesne Sandro Grilli Thomas Kuhl Ryszard Laskowski Kyriaki Machera Olavi Pelkonen Silvia Pieper Michael Stemmer Ingvar Sundh Ivana Teodorovic Chris J Topping Gerrit Wolterink Robert H Smith Anne Louise Gimsing Roy Kasteel Arnaud Boivin Ton van der Linden Jose Oriol Magrans Mark Egsmose Aaldrik Tiktak |
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scientific opinion about the guidance of the chemical regulation directorate (uk) on how aged sorption studies for pesticides should be conducted, analysed and used in regulatory assessments |
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Scientific Opinion about the Guidance of the Chemical Regulation Directorate (UK) on how aged sorption studies for pesticides should be conducted, analysed and used in regulatory assessments |
| abstract |
Abstract The EFSA Panel on Plant Protection Products and their Residues reviewed the guidance on how aged sorption studies for pesticides should be conducted, analysed and used in regulatory assessment. The inclusion of aged sorption is a higher tier in the groundwater leaching assessment. The Panel based its review on a test with three substances taken from a data set provided by the European Crop Protection Association. Particular points of attention were the quality of the data provided, the proposed fitting procedure of aged sorption experiments and the proposed method for combining results obtained from aged sorption studies and lower‐tier studies on degradation and adsorption. Aged sorption was a relevant process in all cases studied. The test revealed that the guidance could generally be well applied and resulted in robust and plausible results. The Panel considers the guidance suitable for use in the groundwater leaching assessment after the recommendations in this Scientific Opinion have been implemented, with the exception of the use of field data to derive aged sorption parameters. The Panel noted that the draft guidance could only be used by experienced users because there is no software tool that fully supports the work flow in the guidance document. It is therefore recommended that a user‐friendly software tool be developed. Aged sorption lowered the predicted concentration in groundwater. However, because aged sorption experiments may be conducted in different soils than lower‐tier degradation and adsorption experiments, it cannot be guaranteed that the higher tier predicts lower concentrations than the lower tier, while lower tiers should be more conservative than higher tiers. To mitigate this problem, the Panel recommends using all available higher‐ and lower‐tier data in the leaching assessment. The Panel further recommends that aged sorption parameters for metabolites be derived only from metabolite‐dosed studies. The formation fraction can be derived from parent‐dosed degradation studies, provided that the parent and metabolite are fitted with the best‐fit model, which is the double first‐order in parallel model in the case of aged sorption. |
| abstractGer |
Abstract The EFSA Panel on Plant Protection Products and their Residues reviewed the guidance on how aged sorption studies for pesticides should be conducted, analysed and used in regulatory assessment. The inclusion of aged sorption is a higher tier in the groundwater leaching assessment. The Panel based its review on a test with three substances taken from a data set provided by the European Crop Protection Association. Particular points of attention were the quality of the data provided, the proposed fitting procedure of aged sorption experiments and the proposed method for combining results obtained from aged sorption studies and lower‐tier studies on degradation and adsorption. Aged sorption was a relevant process in all cases studied. The test revealed that the guidance could generally be well applied and resulted in robust and plausible results. The Panel considers the guidance suitable for use in the groundwater leaching assessment after the recommendations in this Scientific Opinion have been implemented, with the exception of the use of field data to derive aged sorption parameters. The Panel noted that the draft guidance could only be used by experienced users because there is no software tool that fully supports the work flow in the guidance document. It is therefore recommended that a user‐friendly software tool be developed. Aged sorption lowered the predicted concentration in groundwater. However, because aged sorption experiments may be conducted in different soils than lower‐tier degradation and adsorption experiments, it cannot be guaranteed that the higher tier predicts lower concentrations than the lower tier, while lower tiers should be more conservative than higher tiers. To mitigate this problem, the Panel recommends using all available higher‐ and lower‐tier data in the leaching assessment. The Panel further recommends that aged sorption parameters for metabolites be derived only from metabolite‐dosed studies. The formation fraction can be derived from parent‐dosed degradation studies, provided that the parent and metabolite are fitted with the best‐fit model, which is the double first‐order in parallel model in the case of aged sorption. |
| abstract_unstemmed |
Abstract The EFSA Panel on Plant Protection Products and their Residues reviewed the guidance on how aged sorption studies for pesticides should be conducted, analysed and used in regulatory assessment. The inclusion of aged sorption is a higher tier in the groundwater leaching assessment. The Panel based its review on a test with three substances taken from a data set provided by the European Crop Protection Association. Particular points of attention were the quality of the data provided, the proposed fitting procedure of aged sorption experiments and the proposed method for combining results obtained from aged sorption studies and lower‐tier studies on degradation and adsorption. Aged sorption was a relevant process in all cases studied. The test revealed that the guidance could generally be well applied and resulted in robust and plausible results. The Panel considers the guidance suitable for use in the groundwater leaching assessment after the recommendations in this Scientific Opinion have been implemented, with the exception of the use of field data to derive aged sorption parameters. The Panel noted that the draft guidance could only be used by experienced users because there is no software tool that fully supports the work flow in the guidance document. It is therefore recommended that a user‐friendly software tool be developed. Aged sorption lowered the predicted concentration in groundwater. However, because aged sorption experiments may be conducted in different soils than lower‐tier degradation and adsorption experiments, it cannot be guaranteed that the higher tier predicts lower concentrations than the lower tier, while lower tiers should be more conservative than higher tiers. To mitigate this problem, the Panel recommends using all available higher‐ and lower‐tier data in the leaching assessment. The Panel further recommends that aged sorption parameters for metabolites be derived only from metabolite‐dosed studies. The formation fraction can be derived from parent‐dosed degradation studies, provided that the parent and metabolite are fitted with the best‐fit model, which is the double first‐order in parallel model in the case of aged sorption. |
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Scientific Opinion about the Guidance of the Chemical Regulation Directorate (UK) on how aged sorption studies for pesticides should be conducted, analysed and used in regulatory assessments |
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https://doi.org/10.2903/j.efsa.2018.5382 https://doaj.org/article/47a83fff67374f81be4fb5e31b7fa0cd https://doaj.org/toc/1831-4732 |
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Colin Ockleford Antonio F Hernandez‐Jerez Susanne Hougaard Bennekou Michael Klein Thomas Paulien Adriaanse Philippe Berny Theodorus Brock Sabine Duquesne Sandro Grilli Thomas Kuhl Ryszard Laskowski Kyriaki Machera Olavi Pelkonen Silvia Pieper Michael Stemmer Ingvar Sundh Ivana Teodorovic Chris J Topping Gerrit Wolterink Robert H Smith Anne Louise Gimsing Roy Kasteel Arnaud Boivin Ton van der Linden Jose Oriol Magrans Mark Egsmose Aaldrik Tiktak |
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Colin Ockleford Antonio F Hernandez‐Jerez Susanne Hougaard Bennekou Michael Klein Thomas Paulien Adriaanse Philippe Berny Theodorus Brock Sabine Duquesne Sandro Grilli Thomas Kuhl Ryszard Laskowski Kyriaki Machera Olavi Pelkonen Silvia Pieper Michael Stemmer Ingvar Sundh Ivana Teodorovic Chris J Topping Gerrit Wolterink Robert H Smith Anne Louise Gimsing Roy Kasteel Arnaud Boivin Ton van der Linden Jose Oriol Magrans Mark Egsmose Aaldrik Tiktak |
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10.2903/j.efsa.2018.5382 |
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2024-07-03T14:10:20.280Z |
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| score |
7.398526 |