Repurposing the yellow fever vaccine for intratumoral immunotherapy

Abstract Live 17D is widely used as a prophylactic vaccine strain for yellow fever virus that induces potent neutralizing humoral and cellular immunity against the wild‐type pathogen. 17D replicates and kills mouse and human tumor cell lines but not non‐transformed human cells. Intratumoral injectio...
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Autor*in:	Maria Angela Aznar [verfasserIn] Carmen Molina [verfasserIn] Alvaro Teijeira [verfasserIn] Inmaculada Rodriguez [verfasserIn] Arantza Azpilikueta [verfasserIn] Saray Garasa [verfasserIn] Alfonso R Sanchez‐Paulete [verfasserIn] Luna Cordeiro [verfasserIn] Iñaki Etxeberria [verfasserIn] Maite Alvarez [verfasserIn] Sergio Rius‐Rocabert [verfasserIn] Estanislao Nistal‐Villan [verfasserIn] Pedro Berraondo [verfasserIn] Ignacio Melero [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	17D cancer immunotherapy intratumoral administration virotherapy yellow fever vaccine

Übergeordnetes Werk:	In: EMBO Molecular Medicine - Wiley, 2012, 12(2020), 1, Seite n/a-n/a
Übergeordnetes Werk:	volume:12 ; year:2020 ; number:1 ; pages:n/a-n/a

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.15252/emmm.201910375

Katalog-ID:	DOAJ062817507

Internformat


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520			\|a Abstract Live 17D is widely used as a prophylactic vaccine strain for yellow fever virus that induces potent neutralizing humoral and cellular immunity against the wild‐type pathogen. 17D replicates and kills mouse and human tumor cell lines but not non‐transformed human cells. Intratumoral injections with viable 17D markedly delay transplanted tumor progression in a CD8 T‐cell‐dependent manner. In mice bearing bilateral tumors in which only one is intratumorally injected, contralateral therapeutic effects are observed consistent with more prominent CD8 T‐cell infiltrates and a treatment‐related reduction of Tregs. Additive efficacy effects were observed upon co‐treatment with intratumoral 17D and systemic anti‐CD137 and anti‐PD‐1 immunostimulatory monoclonal antibodies. Importantly, when mice were preimmunized with 17D, intratumoral 17D treatment achieved better local and distant antitumor immunity. Such beneficial effects of prevaccination are in part explained by the potentiation of CD4 and CD8 T‐cell infiltration in the treated tumor. The repurposed use of a GMP‐grade vaccine to be given via the intratumoral route in prevaccinated patients constitutes a clinically feasible and safe immunotherapy approach.
650		4	\|a 17D
650		4	\|a cancer immunotherapy
650		4	\|a intratumoral administration
650		4	\|a virotherapy
650		4	\|a yellow fever vaccine
653		0	\|a Medicine (General)
653		0	\|a Genetics
700	0		\|a Carmen Molina \|e verfasserin \|4 aut
700	0		\|a Alvaro Teijeira \|e verfasserin \|4 aut
700	0		\|a Inmaculada Rodriguez \|e verfasserin \|4 aut
700	0		\|a Arantza Azpilikueta \|e verfasserin \|4 aut
700	0		\|a Saray Garasa \|e verfasserin \|4 aut
700	0		\|a Alfonso R Sanchez‐Paulete \|e verfasserin \|4 aut
700	0		\|a Luna Cordeiro \|e verfasserin \|4 aut
700	0		\|a Iñaki Etxeberria \|e verfasserin \|4 aut
700	0		\|a Maite Alvarez \|e verfasserin \|4 aut
700	0		\|a Sergio Rius‐Rocabert \|e verfasserin \|4 aut
700	0		\|a Estanislao Nistal‐Villan \|e verfasserin \|4 aut
700	0		\|a Pedro Berraondo \|e verfasserin \|4 aut
700	0		\|a Ignacio Melero \|e verfasserin \|4 aut
773	0	8	\|i In \|t EMBO Molecular Medicine \|d Wiley, 2012 \|g 12(2020), 1, Seite n/a-n/a \|w (DE-627)594772761 \|w (DE-600)2485479-7 \|x 17574684 \|7 nnns
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912			\|a GBV_ILN_22
912			\|a GBV_ILN_23
912			\|a GBV_ILN_24
912			\|a GBV_ILN_31
912			\|a GBV_ILN_39
912			\|a GBV_ILN_40
912			\|a GBV_ILN_60
912			\|a GBV_ILN_62
912			\|a GBV_ILN_63
912			\|a GBV_ILN_65
912			\|a GBV_ILN_69
912			\|a GBV_ILN_73
912			\|a GBV_ILN_74
912			\|a GBV_ILN_95
912			\|a GBV_ILN_105
912			\|a GBV_ILN_110
912			\|a GBV_ILN_151
912			\|a GBV_ILN_161
912			\|a GBV_ILN_170
912			\|a GBV_ILN_171
912			\|a GBV_ILN_206
912			\|a GBV_ILN_213
912			\|a GBV_ILN_224
912			\|a GBV_ILN_230
912			\|a GBV_ILN_285
912			\|a GBV_ILN_293
912			\|a GBV_ILN_602
912			\|a GBV_ILN_636
912			\|a GBV_ILN_2004
912			\|a GBV_ILN_2005
912			\|a GBV_ILN_2006
912			\|a GBV_ILN_2007
912			\|a GBV_ILN_2010
912			\|a GBV_ILN_2011
912			\|a GBV_ILN_2014
912			\|a GBV_ILN_2026
912			\|a GBV_ILN_2027
912			\|a GBV_ILN_2034
912			\|a GBV_ILN_2037
912			\|a GBV_ILN_2038
912			\|a GBV_ILN_2044
912			\|a GBV_ILN_2048
912			\|a GBV_ILN_2049
912			\|a GBV_ILN_2050
912			\|a GBV_ILN_2055
912			\|a GBV_ILN_2056
912			\|a GBV_ILN_2057
912			\|a GBV_ILN_2059
912			\|a GBV_ILN_2061
912			\|a GBV_ILN_2064
912			\|a GBV_ILN_2068
912			\|a GBV_ILN_2088
912			\|a GBV_ILN_2106
912			\|a GBV_ILN_2108
912			\|a GBV_ILN_2110
912			\|a GBV_ILN_2111
912			\|a GBV_ILN_2118
912			\|a GBV_ILN_2122
912			\|a GBV_ILN_2143
912			\|a GBV_ILN_2144
912			\|a GBV_ILN_2147
912			\|a GBV_ILN_2148
912			\|a GBV_ILN_2152
912			\|a GBV_ILN_2153
912			\|a GBV_ILN_2232
912			\|a GBV_ILN_2470
912			\|a GBV_ILN_2507
912			\|a GBV_ILN_2522
912			\|a GBV_ILN_4012
912			\|a GBV_ILN_4035
912			\|a GBV_ILN_4037
912			\|a GBV_ILN_4046
912			\|a GBV_ILN_4112
912			\|a GBV_ILN_4125
912			\|a GBV_ILN_4126
912			\|a GBV_ILN_4242
912			\|a GBV_ILN_4249
912			\|a GBV_ILN_4251
912			\|a GBV_ILN_4305
912			\|a GBV_ILN_4306
912			\|a GBV_ILN_4307
912			\|a GBV_ILN_4313
912			\|a GBV_ILN_4322
912			\|a GBV_ILN_4323
912			\|a GBV_ILN_4324
912			\|a GBV_ILN_4325
912			\|a GBV_ILN_4326
912			\|a GBV_ILN_4333
912			\|a GBV_ILN_4334
912			\|a GBV_ILN_4335
912			\|a GBV_ILN_4336
912			\|a GBV_ILN_4338
912			\|a GBV_ILN_4367
912			\|a GBV_ILN_4700
951			\|a AR
952			\|d 12 \|j 2020 \|e 1 \|h n/a-n/a

Indexfelder

author_variant	m a a maa c m cm a t at i r ir a a aa s g sg a r s ars l c lc i e ie m a ma s r sr e n en p b pb i m im
matchkey_str	article:17574684:2020----::eupsnteelweevcieoitauo
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publishDate	2020
allfields	10.15252/emmm.201910375 doi (DE-627)DOAJ062817507 (DE-599)DOAJ58b62ba6eecb4d9393146a5ae7f34429 DE-627 ger DE-627 rakwb eng R5-920 QH426-470 Maria Angela Aznar verfasserin aut Repurposing the yellow fever vaccine for intratumoral immunotherapy 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Live 17D is widely used as a prophylactic vaccine strain for yellow fever virus that induces potent neutralizing humoral and cellular immunity against the wild‐type pathogen. 17D replicates and kills mouse and human tumor cell lines but not non‐transformed human cells. Intratumoral injections with viable 17D markedly delay transplanted tumor progression in a CD8 T‐cell‐dependent manner. In mice bearing bilateral tumors in which only one is intratumorally injected, contralateral therapeutic effects are observed consistent with more prominent CD8 T‐cell infiltrates and a treatment‐related reduction of Tregs. Additive efficacy effects were observed upon co‐treatment with intratumoral 17D and systemic anti‐CD137 and anti‐PD‐1 immunostimulatory monoclonal antibodies. Importantly, when mice were preimmunized with 17D, intratumoral 17D treatment achieved better local and distant antitumor immunity. Such beneficial effects of prevaccination are in part explained by the potentiation of CD4 and CD8 T‐cell infiltration in the treated tumor. The repurposed use of a GMP‐grade vaccine to be given via the intratumoral route in prevaccinated patients constitutes a clinically feasible and safe immunotherapy approach. 17D cancer immunotherapy intratumoral administration virotherapy yellow fever vaccine Medicine (General) Genetics Carmen Molina verfasserin aut Alvaro Teijeira verfasserin aut Inmaculada Rodriguez verfasserin aut Arantza Azpilikueta verfasserin aut Saray Garasa verfasserin aut Alfonso R Sanchez‐Paulete verfasserin aut Luna Cordeiro verfasserin aut Iñaki Etxeberria verfasserin aut Maite Alvarez verfasserin aut Sergio Rius‐Rocabert verfasserin aut Estanislao Nistal‐Villan verfasserin aut Pedro Berraondo verfasserin aut Ignacio Melero verfasserin aut In EMBO Molecular Medicine Wiley, 2012 12(2020), 1, Seite n/a-n/a (DE-627)594772761 (DE-600)2485479-7 17574684 nnns volume:12 year:2020 number:1 pages:n/a-n/a https://doi.org/10.15252/emmm.201910375 kostenfrei https://doaj.org/article/58b62ba6eecb4d9393146a5ae7f34429 kostenfrei https://doi.org/10.15252/emmm.201910375 kostenfrei https://doaj.org/toc/1757-4676 Journal toc kostenfrei https://doaj.org/toc/1757-4684 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2020 1 n/a-n/a
spelling	10.15252/emmm.201910375 doi (DE-627)DOAJ062817507 (DE-599)DOAJ58b62ba6eecb4d9393146a5ae7f34429 DE-627 ger DE-627 rakwb eng R5-920 QH426-470 Maria Angela Aznar verfasserin aut Repurposing the yellow fever vaccine for intratumoral immunotherapy 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Live 17D is widely used as a prophylactic vaccine strain for yellow fever virus that induces potent neutralizing humoral and cellular immunity against the wild‐type pathogen. 17D replicates and kills mouse and human tumor cell lines but not non‐transformed human cells. Intratumoral injections with viable 17D markedly delay transplanted tumor progression in a CD8 T‐cell‐dependent manner. In mice bearing bilateral tumors in which only one is intratumorally injected, contralateral therapeutic effects are observed consistent with more prominent CD8 T‐cell infiltrates and a treatment‐related reduction of Tregs. Additive efficacy effects were observed upon co‐treatment with intratumoral 17D and systemic anti‐CD137 and anti‐PD‐1 immunostimulatory monoclonal antibodies. Importantly, when mice were preimmunized with 17D, intratumoral 17D treatment achieved better local and distant antitumor immunity. Such beneficial effects of prevaccination are in part explained by the potentiation of CD4 and CD8 T‐cell infiltration in the treated tumor. The repurposed use of a GMP‐grade vaccine to be given via the intratumoral route in prevaccinated patients constitutes a clinically feasible and safe immunotherapy approach. 17D cancer immunotherapy intratumoral administration virotherapy yellow fever vaccine Medicine (General) Genetics Carmen Molina verfasserin aut Alvaro Teijeira verfasserin aut Inmaculada Rodriguez verfasserin aut Arantza Azpilikueta verfasserin aut Saray Garasa verfasserin aut Alfonso R Sanchez‐Paulete verfasserin aut Luna Cordeiro verfasserin aut Iñaki Etxeberria verfasserin aut Maite Alvarez verfasserin aut Sergio Rius‐Rocabert verfasserin aut Estanislao Nistal‐Villan verfasserin aut Pedro Berraondo verfasserin aut Ignacio Melero verfasserin aut In EMBO Molecular Medicine Wiley, 2012 12(2020), 1, Seite n/a-n/a (DE-627)594772761 (DE-600)2485479-7 17574684 nnns volume:12 year:2020 number:1 pages:n/a-n/a https://doi.org/10.15252/emmm.201910375 kostenfrei https://doaj.org/article/58b62ba6eecb4d9393146a5ae7f34429 kostenfrei https://doi.org/10.15252/emmm.201910375 kostenfrei https://doaj.org/toc/1757-4676 Journal toc kostenfrei https://doaj.org/toc/1757-4684 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2020 1 n/a-n/a
allfields_unstemmed	10.15252/emmm.201910375 doi (DE-627)DOAJ062817507 (DE-599)DOAJ58b62ba6eecb4d9393146a5ae7f34429 DE-627 ger DE-627 rakwb eng R5-920 QH426-470 Maria Angela Aznar verfasserin aut Repurposing the yellow fever vaccine for intratumoral immunotherapy 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Live 17D is widely used as a prophylactic vaccine strain for yellow fever virus that induces potent neutralizing humoral and cellular immunity against the wild‐type pathogen. 17D replicates and kills mouse and human tumor cell lines but not non‐transformed human cells. Intratumoral injections with viable 17D markedly delay transplanted tumor progression in a CD8 T‐cell‐dependent manner. In mice bearing bilateral tumors in which only one is intratumorally injected, contralateral therapeutic effects are observed consistent with more prominent CD8 T‐cell infiltrates and a treatment‐related reduction of Tregs. Additive efficacy effects were observed upon co‐treatment with intratumoral 17D and systemic anti‐CD137 and anti‐PD‐1 immunostimulatory monoclonal antibodies. Importantly, when mice were preimmunized with 17D, intratumoral 17D treatment achieved better local and distant antitumor immunity. Such beneficial effects of prevaccination are in part explained by the potentiation of CD4 and CD8 T‐cell infiltration in the treated tumor. The repurposed use of a GMP‐grade vaccine to be given via the intratumoral route in prevaccinated patients constitutes a clinically feasible and safe immunotherapy approach. 17D cancer immunotherapy intratumoral administration virotherapy yellow fever vaccine Medicine (General) Genetics Carmen Molina verfasserin aut Alvaro Teijeira verfasserin aut Inmaculada Rodriguez verfasserin aut Arantza Azpilikueta verfasserin aut Saray Garasa verfasserin aut Alfonso R Sanchez‐Paulete verfasserin aut Luna Cordeiro verfasserin aut Iñaki Etxeberria verfasserin aut Maite Alvarez verfasserin aut Sergio Rius‐Rocabert verfasserin aut Estanislao Nistal‐Villan verfasserin aut Pedro Berraondo verfasserin aut Ignacio Melero verfasserin aut In EMBO Molecular Medicine Wiley, 2012 12(2020), 1, Seite n/a-n/a (DE-627)594772761 (DE-600)2485479-7 17574684 nnns volume:12 year:2020 number:1 pages:n/a-n/a https://doi.org/10.15252/emmm.201910375 kostenfrei https://doaj.org/article/58b62ba6eecb4d9393146a5ae7f34429 kostenfrei https://doi.org/10.15252/emmm.201910375 kostenfrei https://doaj.org/toc/1757-4676 Journal toc kostenfrei https://doaj.org/toc/1757-4684 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2020 1 n/a-n/a
allfieldsGer	10.15252/emmm.201910375 doi (DE-627)DOAJ062817507 (DE-599)DOAJ58b62ba6eecb4d9393146a5ae7f34429 DE-627 ger DE-627 rakwb eng R5-920 QH426-470 Maria Angela Aznar verfasserin aut Repurposing the yellow fever vaccine for intratumoral immunotherapy 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Live 17D is widely used as a prophylactic vaccine strain for yellow fever virus that induces potent neutralizing humoral and cellular immunity against the wild‐type pathogen. 17D replicates and kills mouse and human tumor cell lines but not non‐transformed human cells. Intratumoral injections with viable 17D markedly delay transplanted tumor progression in a CD8 T‐cell‐dependent manner. In mice bearing bilateral tumors in which only one is intratumorally injected, contralateral therapeutic effects are observed consistent with more prominent CD8 T‐cell infiltrates and a treatment‐related reduction of Tregs. Additive efficacy effects were observed upon co‐treatment with intratumoral 17D and systemic anti‐CD137 and anti‐PD‐1 immunostimulatory monoclonal antibodies. Importantly, when mice were preimmunized with 17D, intratumoral 17D treatment achieved better local and distant antitumor immunity. Such beneficial effects of prevaccination are in part explained by the potentiation of CD4 and CD8 T‐cell infiltration in the treated tumor. The repurposed use of a GMP‐grade vaccine to be given via the intratumoral route in prevaccinated patients constitutes a clinically feasible and safe immunotherapy approach. 17D cancer immunotherapy intratumoral administration virotherapy yellow fever vaccine Medicine (General) Genetics Carmen Molina verfasserin aut Alvaro Teijeira verfasserin aut Inmaculada Rodriguez verfasserin aut Arantza Azpilikueta verfasserin aut Saray Garasa verfasserin aut Alfonso R Sanchez‐Paulete verfasserin aut Luna Cordeiro verfasserin aut Iñaki Etxeberria verfasserin aut Maite Alvarez verfasserin aut Sergio Rius‐Rocabert verfasserin aut Estanislao Nistal‐Villan verfasserin aut Pedro Berraondo verfasserin aut Ignacio Melero verfasserin aut In EMBO Molecular Medicine Wiley, 2012 12(2020), 1, Seite n/a-n/a (DE-627)594772761 (DE-600)2485479-7 17574684 nnns volume:12 year:2020 number:1 pages:n/a-n/a https://doi.org/10.15252/emmm.201910375 kostenfrei https://doaj.org/article/58b62ba6eecb4d9393146a5ae7f34429 kostenfrei https://doi.org/10.15252/emmm.201910375 kostenfrei https://doaj.org/toc/1757-4676 Journal toc kostenfrei https://doaj.org/toc/1757-4684 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2020 1 n/a-n/a
allfieldsSound	10.15252/emmm.201910375 doi (DE-627)DOAJ062817507 (DE-599)DOAJ58b62ba6eecb4d9393146a5ae7f34429 DE-627 ger DE-627 rakwb eng R5-920 QH426-470 Maria Angela Aznar verfasserin aut Repurposing the yellow fever vaccine for intratumoral immunotherapy 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Live 17D is widely used as a prophylactic vaccine strain for yellow fever virus that induces potent neutralizing humoral and cellular immunity against the wild‐type pathogen. 17D replicates and kills mouse and human tumor cell lines but not non‐transformed human cells. Intratumoral injections with viable 17D markedly delay transplanted tumor progression in a CD8 T‐cell‐dependent manner. In mice bearing bilateral tumors in which only one is intratumorally injected, contralateral therapeutic effects are observed consistent with more prominent CD8 T‐cell infiltrates and a treatment‐related reduction of Tregs. Additive efficacy effects were observed upon co‐treatment with intratumoral 17D and systemic anti‐CD137 and anti‐PD‐1 immunostimulatory monoclonal antibodies. Importantly, when mice were preimmunized with 17D, intratumoral 17D treatment achieved better local and distant antitumor immunity. Such beneficial effects of prevaccination are in part explained by the potentiation of CD4 and CD8 T‐cell infiltration in the treated tumor. The repurposed use of a GMP‐grade vaccine to be given via the intratumoral route in prevaccinated patients constitutes a clinically feasible and safe immunotherapy approach. 17D cancer immunotherapy intratumoral administration virotherapy yellow fever vaccine Medicine (General) Genetics Carmen Molina verfasserin aut Alvaro Teijeira verfasserin aut Inmaculada Rodriguez verfasserin aut Arantza Azpilikueta verfasserin aut Saray Garasa verfasserin aut Alfonso R Sanchez‐Paulete verfasserin aut Luna Cordeiro verfasserin aut Iñaki Etxeberria verfasserin aut Maite Alvarez verfasserin aut Sergio Rius‐Rocabert verfasserin aut Estanislao Nistal‐Villan verfasserin aut Pedro Berraondo verfasserin aut Ignacio Melero verfasserin aut In EMBO Molecular Medicine Wiley, 2012 12(2020), 1, Seite n/a-n/a (DE-627)594772761 (DE-600)2485479-7 17574684 nnns volume:12 year:2020 number:1 pages:n/a-n/a https://doi.org/10.15252/emmm.201910375 kostenfrei https://doaj.org/article/58b62ba6eecb4d9393146a5ae7f34429 kostenfrei https://doi.org/10.15252/emmm.201910375 kostenfrei https://doaj.org/toc/1757-4676 Journal toc kostenfrei https://doaj.org/toc/1757-4684 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2020 1 n/a-n/a
language	English
source	In EMBO Molecular Medicine 12(2020), 1, Seite n/a-n/a volume:12 year:2020 number:1 pages:n/a-n/a
sourceStr	In EMBO Molecular Medicine 12(2020), 1, Seite n/a-n/a volume:12 year:2020 number:1 pages:n/a-n/a
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	17D cancer immunotherapy intratumoral administration virotherapy yellow fever vaccine Medicine (General) Genetics
isfreeaccess_bool	true
container_title	EMBO Molecular Medicine
authorswithroles_txt_mv	Maria Angela Aznar @@aut@@ Carmen Molina @@aut@@ Alvaro Teijeira @@aut@@ Inmaculada Rodriguez @@aut@@ Arantza Azpilikueta @@aut@@ Saray Garasa @@aut@@ Alfonso R Sanchez‐Paulete @@aut@@ Luna Cordeiro @@aut@@ Iñaki Etxeberria @@aut@@ Maite Alvarez @@aut@@ Sergio Rius‐Rocabert @@aut@@ Estanislao Nistal‐Villan @@aut@@ Pedro Berraondo @@aut@@ Ignacio Melero @@aut@@
publishDateDaySort_date	2020-01-01T00:00:00Z
hierarchy_top_id	594772761
id	DOAJ062817507
language_de	englisch
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callnumber-first	R - Medicine
author	Maria Angela Aznar
spellingShingle	Maria Angela Aznar misc R5-920 misc QH426-470 misc 17D misc cancer immunotherapy misc intratumoral administration misc virotherapy misc yellow fever vaccine misc Medicine (General) misc Genetics Repurposing the yellow fever vaccine for intratumoral immunotherapy
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topic_title	R5-920 QH426-470 Repurposing the yellow fever vaccine for intratumoral immunotherapy 17D cancer immunotherapy intratumoral administration virotherapy yellow fever vaccine
topic	misc R5-920 misc QH426-470 misc 17D misc cancer immunotherapy misc intratumoral administration misc virotherapy misc yellow fever vaccine misc Medicine (General) misc Genetics
topic_unstemmed	misc R5-920 misc QH426-470 misc 17D misc cancer immunotherapy misc intratumoral administration misc virotherapy misc yellow fever vaccine misc Medicine (General) misc Genetics
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title	Repurposing the yellow fever vaccine for intratumoral immunotherapy
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title_full	Repurposing the yellow fever vaccine for intratumoral immunotherapy
author_sort	Maria Angela Aznar
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author_browse	Maria Angela Aznar Carmen Molina Alvaro Teijeira Inmaculada Rodriguez Arantza Azpilikueta Saray Garasa Alfonso R Sanchez‐Paulete Luna Cordeiro Iñaki Etxeberria Maite Alvarez Sergio Rius‐Rocabert Estanislao Nistal‐Villan Pedro Berraondo Ignacio Melero
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title_sort	repurposing the yellow fever vaccine for intratumoral immunotherapy
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title_auth	Repurposing the yellow fever vaccine for intratumoral immunotherapy
abstract	Abstract Live 17D is widely used as a prophylactic vaccine strain for yellow fever virus that induces potent neutralizing humoral and cellular immunity against the wild‐type pathogen. 17D replicates and kills mouse and human tumor cell lines but not non‐transformed human cells. Intratumoral injections with viable 17D markedly delay transplanted tumor progression in a CD8 T‐cell‐dependent manner. In mice bearing bilateral tumors in which only one is intratumorally injected, contralateral therapeutic effects are observed consistent with more prominent CD8 T‐cell infiltrates and a treatment‐related reduction of Tregs. Additive efficacy effects were observed upon co‐treatment with intratumoral 17D and systemic anti‐CD137 and anti‐PD‐1 immunostimulatory monoclonal antibodies. Importantly, when mice were preimmunized with 17D, intratumoral 17D treatment achieved better local and distant antitumor immunity. Such beneficial effects of prevaccination are in part explained by the potentiation of CD4 and CD8 T‐cell infiltration in the treated tumor. The repurposed use of a GMP‐grade vaccine to be given via the intratumoral route in prevaccinated patients constitutes a clinically feasible and safe immunotherapy approach.
abstractGer	Abstract Live 17D is widely used as a prophylactic vaccine strain for yellow fever virus that induces potent neutralizing humoral and cellular immunity against the wild‐type pathogen. 17D replicates and kills mouse and human tumor cell lines but not non‐transformed human cells. Intratumoral injections with viable 17D markedly delay transplanted tumor progression in a CD8 T‐cell‐dependent manner. In mice bearing bilateral tumors in which only one is intratumorally injected, contralateral therapeutic effects are observed consistent with more prominent CD8 T‐cell infiltrates and a treatment‐related reduction of Tregs. Additive efficacy effects were observed upon co‐treatment with intratumoral 17D and systemic anti‐CD137 and anti‐PD‐1 immunostimulatory monoclonal antibodies. Importantly, when mice were preimmunized with 17D, intratumoral 17D treatment achieved better local and distant antitumor immunity. Such beneficial effects of prevaccination are in part explained by the potentiation of CD4 and CD8 T‐cell infiltration in the treated tumor. The repurposed use of a GMP‐grade vaccine to be given via the intratumoral route in prevaccinated patients constitutes a clinically feasible and safe immunotherapy approach.
abstract_unstemmed	Abstract Live 17D is widely used as a prophylactic vaccine strain for yellow fever virus that induces potent neutralizing humoral and cellular immunity against the wild‐type pathogen. 17D replicates and kills mouse and human tumor cell lines but not non‐transformed human cells. Intratumoral injections with viable 17D markedly delay transplanted tumor progression in a CD8 T‐cell‐dependent manner. In mice bearing bilateral tumors in which only one is intratumorally injected, contralateral therapeutic effects are observed consistent with more prominent CD8 T‐cell infiltrates and a treatment‐related reduction of Tregs. Additive efficacy effects were observed upon co‐treatment with intratumoral 17D and systemic anti‐CD137 and anti‐PD‐1 immunostimulatory monoclonal antibodies. Importantly, when mice were preimmunized with 17D, intratumoral 17D treatment achieved better local and distant antitumor immunity. Such beneficial effects of prevaccination are in part explained by the potentiation of CD4 and CD8 T‐cell infiltration in the treated tumor. The repurposed use of a GMP‐grade vaccine to be given via the intratumoral route in prevaccinated patients constitutes a clinically feasible and safe immunotherapy approach.
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title_short	Repurposing the yellow fever vaccine for intratumoral immunotherapy
url	https://doi.org/10.15252/emmm.201910375 https://doaj.org/article/58b62ba6eecb4d9393146a5ae7f34429 https://doaj.org/toc/1757-4676 https://doaj.org/toc/1757-4684
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up_date	2024-07-03T14:13:11.111Z
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Repurposing the yellow fever vaccine for intratumoral immunotherapy

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