Actin Dynamics at the T Cell Synapse as Revealed by Immune-Related Actinopathies

The actin cytoskeleton is composed of dynamic filament networks that build adaptable local architectures to sustain nearly all cellular activities in response to a myriad of stimuli. Although the function of numerous players that tune actin remodeling is known, the coordinated molecular orchestratio...
Ausführliche Beschreibung

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Autor*in:	Loïc Dupré [verfasserIn] Kaan Boztug [verfasserIn] Laurène Pfajfer [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	T lymphocytes immune-related actinopathies actin cytoskeleton remodeling immunological synapse actin binding proteins primary immunodeficiencies

Übergeordnetes Werk:	In: Frontiers in Cell and Developmental Biology - Frontiers Media S.A., 2014, 9(2021)
Übergeordnetes Werk:	volume:9 ; year:2021

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fcell.2021.665519

Katalog-ID:	DOAJ062839225

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520			\|a The actin cytoskeleton is composed of dynamic filament networks that build adaptable local architectures to sustain nearly all cellular activities in response to a myriad of stimuli. Although the function of numerous players that tune actin remodeling is known, the coordinated molecular orchestration of the actin cytoskeleton to guide cellular decisions is still ill defined. T lymphocytes provide a prototypical example of how a complex program of actin cytoskeleton remodeling sustains the spatio-temporal control of key cellular activities, namely antigen scanning and sensing, as well as polarized delivery of effector molecules, via the immunological synapse. We here review the unique knowledge on actin dynamics at the T lymphocyte synapse gained through the study of primary immunodeficiences caused by mutations in genes encoding actin regulatory proteins. Beyond the specific roles of individual actin remodelers, we further develop the view that these operate in a coordinated manner and are an integral part of multiple signaling pathways in T lymphocytes.
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spelling	10.3389/fcell.2021.665519 doi (DE-627)DOAJ062839225 (DE-599)DOAJ1de6c0fbceb4471caa8f023dbf4ace06 DE-627 ger DE-627 rakwb eng QH301-705.5 Loïc Dupré verfasserin aut Actin Dynamics at the T Cell Synapse as Revealed by Immune-Related Actinopathies 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The actin cytoskeleton is composed of dynamic filament networks that build adaptable local architectures to sustain nearly all cellular activities in response to a myriad of stimuli. Although the function of numerous players that tune actin remodeling is known, the coordinated molecular orchestration of the actin cytoskeleton to guide cellular decisions is still ill defined. T lymphocytes provide a prototypical example of how a complex program of actin cytoskeleton remodeling sustains the spatio-temporal control of key cellular activities, namely antigen scanning and sensing, as well as polarized delivery of effector molecules, via the immunological synapse. We here review the unique knowledge on actin dynamics at the T lymphocyte synapse gained through the study of primary immunodeficiences caused by mutations in genes encoding actin regulatory proteins. Beyond the specific roles of individual actin remodelers, we further develop the view that these operate in a coordinated manner and are an integral part of multiple signaling pathways in T lymphocytes. T lymphocytes immune-related actinopathies actin cytoskeleton remodeling immunological synapse actin binding proteins primary immunodeficiencies Biology (General) Loïc Dupré verfasserin aut Loïc Dupré verfasserin aut Kaan Boztug verfasserin aut Kaan Boztug verfasserin aut Kaan Boztug verfasserin aut Kaan Boztug verfasserin aut Kaan Boztug verfasserin aut Laurène Pfajfer verfasserin aut Laurène Pfajfer verfasserin aut Laurène Pfajfer verfasserin aut Laurène Pfajfer verfasserin aut In Frontiers in Cell and Developmental Biology Frontiers Media S.A., 2014 9(2021) (DE-627)770398138 (DE-600)2737824-X 2296634X nnns volume:9 year:2021 https://doi.org/10.3389/fcell.2021.665519 kostenfrei https://doaj.org/article/1de6c0fbceb4471caa8f023dbf4ace06 kostenfrei https://www.frontiersin.org/articles/10.3389/fcell.2021.665519/full kostenfrei https://doaj.org/toc/2296-634X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2021
allfields_unstemmed	10.3389/fcell.2021.665519 doi (DE-627)DOAJ062839225 (DE-599)DOAJ1de6c0fbceb4471caa8f023dbf4ace06 DE-627 ger DE-627 rakwb eng QH301-705.5 Loïc Dupré verfasserin aut Actin Dynamics at the T Cell Synapse as Revealed by Immune-Related Actinopathies 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The actin cytoskeleton is composed of dynamic filament networks that build adaptable local architectures to sustain nearly all cellular activities in response to a myriad of stimuli. Although the function of numerous players that tune actin remodeling is known, the coordinated molecular orchestration of the actin cytoskeleton to guide cellular decisions is still ill defined. T lymphocytes provide a prototypical example of how a complex program of actin cytoskeleton remodeling sustains the spatio-temporal control of key cellular activities, namely antigen scanning and sensing, as well as polarized delivery of effector molecules, via the immunological synapse. We here review the unique knowledge on actin dynamics at the T lymphocyte synapse gained through the study of primary immunodeficiences caused by mutations in genes encoding actin regulatory proteins. Beyond the specific roles of individual actin remodelers, we further develop the view that these operate in a coordinated manner and are an integral part of multiple signaling pathways in T lymphocytes. T lymphocytes immune-related actinopathies actin cytoskeleton remodeling immunological synapse actin binding proteins primary immunodeficiencies Biology (General) Loïc Dupré verfasserin aut Loïc Dupré verfasserin aut Kaan Boztug verfasserin aut Kaan Boztug verfasserin aut Kaan Boztug verfasserin aut Kaan Boztug verfasserin aut Kaan Boztug verfasserin aut Laurène Pfajfer verfasserin aut Laurène Pfajfer verfasserin aut Laurène Pfajfer verfasserin aut Laurène Pfajfer verfasserin aut In Frontiers in Cell and Developmental Biology Frontiers Media S.A., 2014 9(2021) (DE-627)770398138 (DE-600)2737824-X 2296634X nnns volume:9 year:2021 https://doi.org/10.3389/fcell.2021.665519 kostenfrei https://doaj.org/article/1de6c0fbceb4471caa8f023dbf4ace06 kostenfrei https://www.frontiersin.org/articles/10.3389/fcell.2021.665519/full kostenfrei https://doaj.org/toc/2296-634X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2021
allfieldsGer	10.3389/fcell.2021.665519 doi (DE-627)DOAJ062839225 (DE-599)DOAJ1de6c0fbceb4471caa8f023dbf4ace06 DE-627 ger DE-627 rakwb eng QH301-705.5 Loïc Dupré verfasserin aut Actin Dynamics at the T Cell Synapse as Revealed by Immune-Related Actinopathies 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The actin cytoskeleton is composed of dynamic filament networks that build adaptable local architectures to sustain nearly all cellular activities in response to a myriad of stimuli. Although the function of numerous players that tune actin remodeling is known, the coordinated molecular orchestration of the actin cytoskeleton to guide cellular decisions is still ill defined. T lymphocytes provide a prototypical example of how a complex program of actin cytoskeleton remodeling sustains the spatio-temporal control of key cellular activities, namely antigen scanning and sensing, as well as polarized delivery of effector molecules, via the immunological synapse. We here review the unique knowledge on actin dynamics at the T lymphocyte synapse gained through the study of primary immunodeficiences caused by mutations in genes encoding actin regulatory proteins. Beyond the specific roles of individual actin remodelers, we further develop the view that these operate in a coordinated manner and are an integral part of multiple signaling pathways in T lymphocytes. T lymphocytes immune-related actinopathies actin cytoskeleton remodeling immunological synapse actin binding proteins primary immunodeficiencies Biology (General) Loïc Dupré verfasserin aut Loïc Dupré verfasserin aut Kaan Boztug verfasserin aut Kaan Boztug verfasserin aut Kaan Boztug verfasserin aut Kaan Boztug verfasserin aut Kaan Boztug verfasserin aut Laurène Pfajfer verfasserin aut Laurène Pfajfer verfasserin aut Laurène Pfajfer verfasserin aut Laurène Pfajfer verfasserin aut In Frontiers in Cell and Developmental Biology Frontiers Media S.A., 2014 9(2021) (DE-627)770398138 (DE-600)2737824-X 2296634X nnns volume:9 year:2021 https://doi.org/10.3389/fcell.2021.665519 kostenfrei https://doaj.org/article/1de6c0fbceb4471caa8f023dbf4ace06 kostenfrei https://www.frontiersin.org/articles/10.3389/fcell.2021.665519/full kostenfrei https://doaj.org/toc/2296-634X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2021
allfieldsSound	10.3389/fcell.2021.665519 doi (DE-627)DOAJ062839225 (DE-599)DOAJ1de6c0fbceb4471caa8f023dbf4ace06 DE-627 ger DE-627 rakwb eng QH301-705.5 Loïc Dupré verfasserin aut Actin Dynamics at the T Cell Synapse as Revealed by Immune-Related Actinopathies 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The actin cytoskeleton is composed of dynamic filament networks that build adaptable local architectures to sustain nearly all cellular activities in response to a myriad of stimuli. Although the function of numerous players that tune actin remodeling is known, the coordinated molecular orchestration of the actin cytoskeleton to guide cellular decisions is still ill defined. T lymphocytes provide a prototypical example of how a complex program of actin cytoskeleton remodeling sustains the spatio-temporal control of key cellular activities, namely antigen scanning and sensing, as well as polarized delivery of effector molecules, via the immunological synapse. We here review the unique knowledge on actin dynamics at the T lymphocyte synapse gained through the study of primary immunodeficiences caused by mutations in genes encoding actin regulatory proteins. Beyond the specific roles of individual actin remodelers, we further develop the view that these operate in a coordinated manner and are an integral part of multiple signaling pathways in T lymphocytes. T lymphocytes immune-related actinopathies actin cytoskeleton remodeling immunological synapse actin binding proteins primary immunodeficiencies Biology (General) Loïc Dupré verfasserin aut Loïc Dupré verfasserin aut Kaan Boztug verfasserin aut Kaan Boztug verfasserin aut Kaan Boztug verfasserin aut Kaan Boztug verfasserin aut Kaan Boztug verfasserin aut Laurène Pfajfer verfasserin aut Laurène Pfajfer verfasserin aut Laurène Pfajfer verfasserin aut Laurène Pfajfer verfasserin aut In Frontiers in Cell and Developmental Biology Frontiers Media S.A., 2014 9(2021) (DE-627)770398138 (DE-600)2737824-X 2296634X nnns volume:9 year:2021 https://doi.org/10.3389/fcell.2021.665519 kostenfrei https://doaj.org/article/1de6c0fbceb4471caa8f023dbf4ace06 kostenfrei https://www.frontiersin.org/articles/10.3389/fcell.2021.665519/full kostenfrei https://doaj.org/toc/2296-634X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2021
language	English
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authorswithroles_txt_mv	Loïc Dupré @@aut@@ Kaan Boztug @@aut@@ Laurène Pfajfer @@aut@@
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author	Loïc Dupré
spellingShingle	Loïc Dupré misc QH301-705.5 misc T lymphocytes misc immune-related actinopathies misc actin cytoskeleton remodeling misc immunological synapse misc actin binding proteins misc primary immunodeficiencies misc Biology (General) Actin Dynamics at the T Cell Synapse as Revealed by Immune-Related Actinopathies
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topic_title	QH301-705.5 Actin Dynamics at the T Cell Synapse as Revealed by Immune-Related Actinopathies T lymphocytes immune-related actinopathies actin cytoskeleton remodeling immunological synapse actin binding proteins primary immunodeficiencies
topic	misc QH301-705.5 misc T lymphocytes misc immune-related actinopathies misc actin cytoskeleton remodeling misc immunological synapse misc actin binding proteins misc primary immunodeficiencies misc Biology (General)
topic_unstemmed	misc QH301-705.5 misc T lymphocytes misc immune-related actinopathies misc actin cytoskeleton remodeling misc immunological synapse misc actin binding proteins misc primary immunodeficiencies misc Biology (General)
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title	Actin Dynamics at the T Cell Synapse as Revealed by Immune-Related Actinopathies
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title_full	Actin Dynamics at the T Cell Synapse as Revealed by Immune-Related Actinopathies
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title_sort	actin dynamics at the t cell synapse as revealed by immune-related actinopathies
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title_auth	Actin Dynamics at the T Cell Synapse as Revealed by Immune-Related Actinopathies
abstract	The actin cytoskeleton is composed of dynamic filament networks that build adaptable local architectures to sustain nearly all cellular activities in response to a myriad of stimuli. Although the function of numerous players that tune actin remodeling is known, the coordinated molecular orchestration of the actin cytoskeleton to guide cellular decisions is still ill defined. T lymphocytes provide a prototypical example of how a complex program of actin cytoskeleton remodeling sustains the spatio-temporal control of key cellular activities, namely antigen scanning and sensing, as well as polarized delivery of effector molecules, via the immunological synapse. We here review the unique knowledge on actin dynamics at the T lymphocyte synapse gained through the study of primary immunodeficiences caused by mutations in genes encoding actin regulatory proteins. Beyond the specific roles of individual actin remodelers, we further develop the view that these operate in a coordinated manner and are an integral part of multiple signaling pathways in T lymphocytes.
abstractGer	The actin cytoskeleton is composed of dynamic filament networks that build adaptable local architectures to sustain nearly all cellular activities in response to a myriad of stimuli. Although the function of numerous players that tune actin remodeling is known, the coordinated molecular orchestration of the actin cytoskeleton to guide cellular decisions is still ill defined. T lymphocytes provide a prototypical example of how a complex program of actin cytoskeleton remodeling sustains the spatio-temporal control of key cellular activities, namely antigen scanning and sensing, as well as polarized delivery of effector molecules, via the immunological synapse. We here review the unique knowledge on actin dynamics at the T lymphocyte synapse gained through the study of primary immunodeficiences caused by mutations in genes encoding actin regulatory proteins. Beyond the specific roles of individual actin remodelers, we further develop the view that these operate in a coordinated manner and are an integral part of multiple signaling pathways in T lymphocytes.
abstract_unstemmed	The actin cytoskeleton is composed of dynamic filament networks that build adaptable local architectures to sustain nearly all cellular activities in response to a myriad of stimuli. Although the function of numerous players that tune actin remodeling is known, the coordinated molecular orchestration of the actin cytoskeleton to guide cellular decisions is still ill defined. T lymphocytes provide a prototypical example of how a complex program of actin cytoskeleton remodeling sustains the spatio-temporal control of key cellular activities, namely antigen scanning and sensing, as well as polarized delivery of effector molecules, via the immunological synapse. We here review the unique knowledge on actin dynamics at the T lymphocyte synapse gained through the study of primary immunodeficiences caused by mutations in genes encoding actin regulatory proteins. Beyond the specific roles of individual actin remodelers, we further develop the view that these operate in a coordinated manner and are an integral part of multiple signaling pathways in T lymphocytes.
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title_short	Actin Dynamics at the T Cell Synapse as Revealed by Immune-Related Actinopathies
url	https://doi.org/10.3389/fcell.2021.665519 https://doaj.org/article/1de6c0fbceb4471caa8f023dbf4ace06 https://www.frontiersin.org/articles/10.3389/fcell.2021.665519/full https://doaj.org/toc/2296-634X
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