Characterizing preclinical sub‐phenotypic models of acute respiratory distress syndrome: An experimental ovine study

Abstract The acute respiratory distress syndrome (ARDS) describes a heterogenous population of patients with acute severe respiratory failure. However, contemporary advances have begun to identify distinct sub‐phenotypes that exist within its broader envelope. These sub‐phenotypes have varied outcom...
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Autor*in:	Jonathan E. Millar [verfasserIn] Karin Wildi [verfasserIn] Nicole Bartnikowski [verfasserIn] Mahe Bouquet [verfasserIn] Kieran Hyslop [verfasserIn] Margaret R. Passmore [verfasserIn] Katrina K. Ki [verfasserIn] Louise E. See Hoe [verfasserIn] Nchafatso G. Obonyo [verfasserIn] Lucile Neyton [verfasserIn] Sanne Pedersen [verfasserIn] Sacha Rozencwajg [verfasserIn] J. Kenneth Baillie [verfasserIn] Gianluigi Li Bassi [verfasserIn] Jacky Y. Suen [verfasserIn] Daniel F. McAuley [verfasserIn] John F. Fraser [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	acute respiratory distress syndrome animal models phenotype

Übergeordnetes Werk:	In: Physiological Reports - Wiley, 2013, 9(2021), 19, Seite n/a-n/a
Übergeordnetes Werk:	volume:9 ; year:2021 ; number:19 ; pages:n/a-n/a

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.14814/phy2.15048

Katalog-ID:	DOAJ062891448

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520			\|a Abstract The acute respiratory distress syndrome (ARDS) describes a heterogenous population of patients with acute severe respiratory failure. However, contemporary advances have begun to identify distinct sub‐phenotypes that exist within its broader envelope. These sub‐phenotypes have varied outcomes and respond differently to several previously studied interventions. A more precise understanding of their pathobiology and an ability to prospectively identify them, may allow for the development of precision therapies in ARDS. Historically, animal models have played a key role in translational research, although few studies have so far assessed either the ability of animal models to replicate these sub‐phenotypes or investigated the presence of sub‐phenotypes within animal models. Here, in three ovine models of ARDS, using combinations of oleic acid and intravenous, or intratracheal lipopolysaccharide, we investigated the presence of sub‐phenotypes which qualitatively resemble those found in clinical cohorts. Principal Component Analysis and partitional clustering identified two clusters, differentiated by markers of shock, inflammation, and lung injury. This study provides a first exploration of ARDS phenotypes in preclinical models and suggests a methodology for investigating this phenomenon in future studies.
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allfields	10.14814/phy2.15048 doi (DE-627)DOAJ062891448 (DE-599)DOAJ5a9d244998f440a69fa7df490739404c DE-627 ger DE-627 rakwb eng QP1-981 Jonathan E. Millar verfasserin aut Characterizing preclinical sub‐phenotypic models of acute respiratory distress syndrome: An experimental ovine study 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The acute respiratory distress syndrome (ARDS) describes a heterogenous population of patients with acute severe respiratory failure. However, contemporary advances have begun to identify distinct sub‐phenotypes that exist within its broader envelope. These sub‐phenotypes have varied outcomes and respond differently to several previously studied interventions. A more precise understanding of their pathobiology and an ability to prospectively identify them, may allow for the development of precision therapies in ARDS. Historically, animal models have played a key role in translational research, although few studies have so far assessed either the ability of animal models to replicate these sub‐phenotypes or investigated the presence of sub‐phenotypes within animal models. Here, in three ovine models of ARDS, using combinations of oleic acid and intravenous, or intratracheal lipopolysaccharide, we investigated the presence of sub‐phenotypes which qualitatively resemble those found in clinical cohorts. Principal Component Analysis and partitional clustering identified two clusters, differentiated by markers of shock, inflammation, and lung injury. This study provides a first exploration of ARDS phenotypes in preclinical models and suggests a methodology for investigating this phenomenon in future studies. acute respiratory distress syndrome animal models phenotype Physiology Karin Wildi verfasserin aut Nicole Bartnikowski verfasserin aut Mahe Bouquet verfasserin aut Kieran Hyslop verfasserin aut Margaret R. Passmore verfasserin aut Katrina K. Ki verfasserin aut Louise E. See Hoe verfasserin aut Nchafatso G. Obonyo verfasserin aut Lucile Neyton verfasserin aut Sanne Pedersen verfasserin aut Sacha Rozencwajg verfasserin aut J. Kenneth Baillie verfasserin aut Gianluigi Li Bassi verfasserin aut Jacky Y. Suen verfasserin aut Daniel F. McAuley verfasserin aut John F. Fraser verfasserin aut In Physiological Reports Wiley, 2013 9(2021), 19, Seite n/a-n/a (DE-627)75243649X (DE-600)2724325-4 2051817X nnns volume:9 year:2021 number:19 pages:n/a-n/a https://doi.org/10.14814/phy2.15048 kostenfrei https://doaj.org/article/5a9d244998f440a69fa7df490739404c kostenfrei https://doi.org/10.14814/phy2.15048 kostenfrei https://doaj.org/toc/2051-817X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2021 19 n/a-n/a
spelling	10.14814/phy2.15048 doi (DE-627)DOAJ062891448 (DE-599)DOAJ5a9d244998f440a69fa7df490739404c DE-627 ger DE-627 rakwb eng QP1-981 Jonathan E. Millar verfasserin aut Characterizing preclinical sub‐phenotypic models of acute respiratory distress syndrome: An experimental ovine study 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The acute respiratory distress syndrome (ARDS) describes a heterogenous population of patients with acute severe respiratory failure. However, contemporary advances have begun to identify distinct sub‐phenotypes that exist within its broader envelope. These sub‐phenotypes have varied outcomes and respond differently to several previously studied interventions. A more precise understanding of their pathobiology and an ability to prospectively identify them, may allow for the development of precision therapies in ARDS. Historically, animal models have played a key role in translational research, although few studies have so far assessed either the ability of animal models to replicate these sub‐phenotypes or investigated the presence of sub‐phenotypes within animal models. Here, in three ovine models of ARDS, using combinations of oleic acid and intravenous, or intratracheal lipopolysaccharide, we investigated the presence of sub‐phenotypes which qualitatively resemble those found in clinical cohorts. Principal Component Analysis and partitional clustering identified two clusters, differentiated by markers of shock, inflammation, and lung injury. This study provides a first exploration of ARDS phenotypes in preclinical models and suggests a methodology for investigating this phenomenon in future studies. acute respiratory distress syndrome animal models phenotype Physiology Karin Wildi verfasserin aut Nicole Bartnikowski verfasserin aut Mahe Bouquet verfasserin aut Kieran Hyslop verfasserin aut Margaret R. Passmore verfasserin aut Katrina K. Ki verfasserin aut Louise E. See Hoe verfasserin aut Nchafatso G. Obonyo verfasserin aut Lucile Neyton verfasserin aut Sanne Pedersen verfasserin aut Sacha Rozencwajg verfasserin aut J. Kenneth Baillie verfasserin aut Gianluigi Li Bassi verfasserin aut Jacky Y. Suen verfasserin aut Daniel F. McAuley verfasserin aut John F. Fraser verfasserin aut In Physiological Reports Wiley, 2013 9(2021), 19, Seite n/a-n/a (DE-627)75243649X (DE-600)2724325-4 2051817X nnns volume:9 year:2021 number:19 pages:n/a-n/a https://doi.org/10.14814/phy2.15048 kostenfrei https://doaj.org/article/5a9d244998f440a69fa7df490739404c kostenfrei https://doi.org/10.14814/phy2.15048 kostenfrei https://doaj.org/toc/2051-817X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2021 19 n/a-n/a
allfields_unstemmed	10.14814/phy2.15048 doi (DE-627)DOAJ062891448 (DE-599)DOAJ5a9d244998f440a69fa7df490739404c DE-627 ger DE-627 rakwb eng QP1-981 Jonathan E. Millar verfasserin aut Characterizing preclinical sub‐phenotypic models of acute respiratory distress syndrome: An experimental ovine study 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The acute respiratory distress syndrome (ARDS) describes a heterogenous population of patients with acute severe respiratory failure. However, contemporary advances have begun to identify distinct sub‐phenotypes that exist within its broader envelope. These sub‐phenotypes have varied outcomes and respond differently to several previously studied interventions. A more precise understanding of their pathobiology and an ability to prospectively identify them, may allow for the development of precision therapies in ARDS. Historically, animal models have played a key role in translational research, although few studies have so far assessed either the ability of animal models to replicate these sub‐phenotypes or investigated the presence of sub‐phenotypes within animal models. Here, in three ovine models of ARDS, using combinations of oleic acid and intravenous, or intratracheal lipopolysaccharide, we investigated the presence of sub‐phenotypes which qualitatively resemble those found in clinical cohorts. Principal Component Analysis and partitional clustering identified two clusters, differentiated by markers of shock, inflammation, and lung injury. This study provides a first exploration of ARDS phenotypes in preclinical models and suggests a methodology for investigating this phenomenon in future studies. acute respiratory distress syndrome animal models phenotype Physiology Karin Wildi verfasserin aut Nicole Bartnikowski verfasserin aut Mahe Bouquet verfasserin aut Kieran Hyslop verfasserin aut Margaret R. Passmore verfasserin aut Katrina K. Ki verfasserin aut Louise E. See Hoe verfasserin aut Nchafatso G. Obonyo verfasserin aut Lucile Neyton verfasserin aut Sanne Pedersen verfasserin aut Sacha Rozencwajg verfasserin aut J. Kenneth Baillie verfasserin aut Gianluigi Li Bassi verfasserin aut Jacky Y. Suen verfasserin aut Daniel F. McAuley verfasserin aut John F. Fraser verfasserin aut In Physiological Reports Wiley, 2013 9(2021), 19, Seite n/a-n/a (DE-627)75243649X (DE-600)2724325-4 2051817X nnns volume:9 year:2021 number:19 pages:n/a-n/a https://doi.org/10.14814/phy2.15048 kostenfrei https://doaj.org/article/5a9d244998f440a69fa7df490739404c kostenfrei https://doi.org/10.14814/phy2.15048 kostenfrei https://doaj.org/toc/2051-817X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2021 19 n/a-n/a
allfieldsGer	10.14814/phy2.15048 doi (DE-627)DOAJ062891448 (DE-599)DOAJ5a9d244998f440a69fa7df490739404c DE-627 ger DE-627 rakwb eng QP1-981 Jonathan E. Millar verfasserin aut Characterizing preclinical sub‐phenotypic models of acute respiratory distress syndrome: An experimental ovine study 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The acute respiratory distress syndrome (ARDS) describes a heterogenous population of patients with acute severe respiratory failure. However, contemporary advances have begun to identify distinct sub‐phenotypes that exist within its broader envelope. These sub‐phenotypes have varied outcomes and respond differently to several previously studied interventions. A more precise understanding of their pathobiology and an ability to prospectively identify them, may allow for the development of precision therapies in ARDS. Historically, animal models have played a key role in translational research, although few studies have so far assessed either the ability of animal models to replicate these sub‐phenotypes or investigated the presence of sub‐phenotypes within animal models. Here, in three ovine models of ARDS, using combinations of oleic acid and intravenous, or intratracheal lipopolysaccharide, we investigated the presence of sub‐phenotypes which qualitatively resemble those found in clinical cohorts. Principal Component Analysis and partitional clustering identified two clusters, differentiated by markers of shock, inflammation, and lung injury. This study provides a first exploration of ARDS phenotypes in preclinical models and suggests a methodology for investigating this phenomenon in future studies. acute respiratory distress syndrome animal models phenotype Physiology Karin Wildi verfasserin aut Nicole Bartnikowski verfasserin aut Mahe Bouquet verfasserin aut Kieran Hyslop verfasserin aut Margaret R. Passmore verfasserin aut Katrina K. Ki verfasserin aut Louise E. See Hoe verfasserin aut Nchafatso G. Obonyo verfasserin aut Lucile Neyton verfasserin aut Sanne Pedersen verfasserin aut Sacha Rozencwajg verfasserin aut J. Kenneth Baillie verfasserin aut Gianluigi Li Bassi verfasserin aut Jacky Y. Suen verfasserin aut Daniel F. McAuley verfasserin aut John F. Fraser verfasserin aut In Physiological Reports Wiley, 2013 9(2021), 19, Seite n/a-n/a (DE-627)75243649X (DE-600)2724325-4 2051817X nnns volume:9 year:2021 number:19 pages:n/a-n/a https://doi.org/10.14814/phy2.15048 kostenfrei https://doaj.org/article/5a9d244998f440a69fa7df490739404c kostenfrei https://doi.org/10.14814/phy2.15048 kostenfrei https://doaj.org/toc/2051-817X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2021 19 n/a-n/a
allfieldsSound	10.14814/phy2.15048 doi (DE-627)DOAJ062891448 (DE-599)DOAJ5a9d244998f440a69fa7df490739404c DE-627 ger DE-627 rakwb eng QP1-981 Jonathan E. Millar verfasserin aut Characterizing preclinical sub‐phenotypic models of acute respiratory distress syndrome: An experimental ovine study 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The acute respiratory distress syndrome (ARDS) describes a heterogenous population of patients with acute severe respiratory failure. However, contemporary advances have begun to identify distinct sub‐phenotypes that exist within its broader envelope. These sub‐phenotypes have varied outcomes and respond differently to several previously studied interventions. A more precise understanding of their pathobiology and an ability to prospectively identify them, may allow for the development of precision therapies in ARDS. Historically, animal models have played a key role in translational research, although few studies have so far assessed either the ability of animal models to replicate these sub‐phenotypes or investigated the presence of sub‐phenotypes within animal models. Here, in three ovine models of ARDS, using combinations of oleic acid and intravenous, or intratracheal lipopolysaccharide, we investigated the presence of sub‐phenotypes which qualitatively resemble those found in clinical cohorts. Principal Component Analysis and partitional clustering identified two clusters, differentiated by markers of shock, inflammation, and lung injury. This study provides a first exploration of ARDS phenotypes in preclinical models and suggests a methodology for investigating this phenomenon in future studies. acute respiratory distress syndrome animal models phenotype Physiology Karin Wildi verfasserin aut Nicole Bartnikowski verfasserin aut Mahe Bouquet verfasserin aut Kieran Hyslop verfasserin aut Margaret R. Passmore verfasserin aut Katrina K. Ki verfasserin aut Louise E. See Hoe verfasserin aut Nchafatso G. Obonyo verfasserin aut Lucile Neyton verfasserin aut Sanne Pedersen verfasserin aut Sacha Rozencwajg verfasserin aut J. Kenneth Baillie verfasserin aut Gianluigi Li Bassi verfasserin aut Jacky Y. Suen verfasserin aut Daniel F. McAuley verfasserin aut John F. Fraser verfasserin aut In Physiological Reports Wiley, 2013 9(2021), 19, Seite n/a-n/a (DE-627)75243649X (DE-600)2724325-4 2051817X nnns volume:9 year:2021 number:19 pages:n/a-n/a https://doi.org/10.14814/phy2.15048 kostenfrei https://doaj.org/article/5a9d244998f440a69fa7df490739404c kostenfrei https://doi.org/10.14814/phy2.15048 kostenfrei https://doaj.org/toc/2051-817X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2021 19 n/a-n/a
language	English
source	In Physiological Reports 9(2021), 19, Seite n/a-n/a volume:9 year:2021 number:19 pages:n/a-n/a
sourceStr	In Physiological Reports 9(2021), 19, Seite n/a-n/a volume:9 year:2021 number:19 pages:n/a-n/a
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	acute respiratory distress syndrome animal models phenotype Physiology
isfreeaccess_bool	true
container_title	Physiological Reports
authorswithroles_txt_mv	Jonathan E. Millar @@aut@@ Karin Wildi @@aut@@ Nicole Bartnikowski @@aut@@ Mahe Bouquet @@aut@@ Kieran Hyslop @@aut@@ Margaret R. Passmore @@aut@@ Katrina K. Ki @@aut@@ Louise E. See Hoe @@aut@@ Nchafatso G. Obonyo @@aut@@ Lucile Neyton @@aut@@ Sanne Pedersen @@aut@@ Sacha Rozencwajg @@aut@@ J. Kenneth Baillie @@aut@@ Gianluigi Li Bassi @@aut@@ Jacky Y. Suen @@aut@@ Daniel F. McAuley @@aut@@ John F. Fraser @@aut@@
publishDateDaySort_date	2021-01-01T00:00:00Z
hierarchy_top_id	75243649X
id	DOAJ062891448
language_de	englisch
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Millar</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Characterizing preclinical sub‐phenotypic models of acute respiratory distress syndrome: An experimental ovine study</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2021</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Abstract The acute respiratory distress syndrome (ARDS) describes a heterogenous population of patients with acute severe respiratory failure. 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Principal Component Analysis and partitional clustering identified two clusters, differentiated by markers of shock, inflammation, and lung injury. 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author	Jonathan E. Millar
spellingShingle	Jonathan E. Millar misc QP1-981 misc acute respiratory distress syndrome misc animal misc models misc phenotype misc Physiology Characterizing preclinical sub‐phenotypic models of acute respiratory distress syndrome: An experimental ovine study
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topic_title	QP1-981 Characterizing preclinical sub‐phenotypic models of acute respiratory distress syndrome: An experimental ovine study acute respiratory distress syndrome animal models phenotype
topic	misc QP1-981 misc acute respiratory distress syndrome misc animal misc models misc phenotype misc Physiology
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title	Characterizing preclinical sub‐phenotypic models of acute respiratory distress syndrome: An experimental ovine study
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title_full	Characterizing preclinical sub‐phenotypic models of acute respiratory distress syndrome: An experimental ovine study
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author_browse	Jonathan E. Millar Karin Wildi Nicole Bartnikowski Mahe Bouquet Kieran Hyslop Margaret R. Passmore Katrina K. Ki Louise E. See Hoe Nchafatso G. Obonyo Lucile Neyton Sanne Pedersen Sacha Rozencwajg J. Kenneth Baillie Gianluigi Li Bassi Jacky Y. Suen Daniel F. McAuley John F. Fraser
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title_sort	characterizing preclinical sub‐phenotypic models of acute respiratory distress syndrome: an experimental ovine study
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title_auth	Characterizing preclinical sub‐phenotypic models of acute respiratory distress syndrome: An experimental ovine study
abstract	Abstract The acute respiratory distress syndrome (ARDS) describes a heterogenous population of patients with acute severe respiratory failure. However, contemporary advances have begun to identify distinct sub‐phenotypes that exist within its broader envelope. These sub‐phenotypes have varied outcomes and respond differently to several previously studied interventions. A more precise understanding of their pathobiology and an ability to prospectively identify them, may allow for the development of precision therapies in ARDS. Historically, animal models have played a key role in translational research, although few studies have so far assessed either the ability of animal models to replicate these sub‐phenotypes or investigated the presence of sub‐phenotypes within animal models. Here, in three ovine models of ARDS, using combinations of oleic acid and intravenous, or intratracheal lipopolysaccharide, we investigated the presence of sub‐phenotypes which qualitatively resemble those found in clinical cohorts. Principal Component Analysis and partitional clustering identified two clusters, differentiated by markers of shock, inflammation, and lung injury. This study provides a first exploration of ARDS phenotypes in preclinical models and suggests a methodology for investigating this phenomenon in future studies.
abstractGer	Abstract The acute respiratory distress syndrome (ARDS) describes a heterogenous population of patients with acute severe respiratory failure. However, contemporary advances have begun to identify distinct sub‐phenotypes that exist within its broader envelope. These sub‐phenotypes have varied outcomes and respond differently to several previously studied interventions. A more precise understanding of their pathobiology and an ability to prospectively identify them, may allow for the development of precision therapies in ARDS. Historically, animal models have played a key role in translational research, although few studies have so far assessed either the ability of animal models to replicate these sub‐phenotypes or investigated the presence of sub‐phenotypes within animal models. Here, in three ovine models of ARDS, using combinations of oleic acid and intravenous, or intratracheal lipopolysaccharide, we investigated the presence of sub‐phenotypes which qualitatively resemble those found in clinical cohorts. Principal Component Analysis and partitional clustering identified two clusters, differentiated by markers of shock, inflammation, and lung injury. This study provides a first exploration of ARDS phenotypes in preclinical models and suggests a methodology for investigating this phenomenon in future studies.
abstract_unstemmed	Abstract The acute respiratory distress syndrome (ARDS) describes a heterogenous population of patients with acute severe respiratory failure. However, contemporary advances have begun to identify distinct sub‐phenotypes that exist within its broader envelope. These sub‐phenotypes have varied outcomes and respond differently to several previously studied interventions. A more precise understanding of their pathobiology and an ability to prospectively identify them, may allow for the development of precision therapies in ARDS. Historically, animal models have played a key role in translational research, although few studies have so far assessed either the ability of animal models to replicate these sub‐phenotypes or investigated the presence of sub‐phenotypes within animal models. Here, in three ovine models of ARDS, using combinations of oleic acid and intravenous, or intratracheal lipopolysaccharide, we investigated the presence of sub‐phenotypes which qualitatively resemble those found in clinical cohorts. Principal Component Analysis and partitional clustering identified two clusters, differentiated by markers of shock, inflammation, and lung injury. This study provides a first exploration of ARDS phenotypes in preclinical models and suggests a methodology for investigating this phenomenon in future studies.
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title_short	Characterizing preclinical sub‐phenotypic models of acute respiratory distress syndrome: An experimental ovine study
url	https://doi.org/10.14814/phy2.15048 https://doaj.org/article/5a9d244998f440a69fa7df490739404c https://doaj.org/toc/2051-817X
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Millar</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Characterizing preclinical sub‐phenotypic models of acute respiratory distress syndrome: An experimental ovine study</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2021</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Abstract The acute respiratory distress syndrome (ARDS) describes a heterogenous population of patients with acute severe respiratory failure. However, contemporary advances have begun to identify distinct sub‐phenotypes that exist within its broader envelope. These sub‐phenotypes have varied outcomes and respond differently to several previously studied interventions. A more precise understanding of their pathobiology and an ability to prospectively identify them, may allow for the development of precision therapies in ARDS. Historically, animal models have played a key role in translational research, although few studies have so far assessed either the ability of animal models to replicate these sub‐phenotypes or investigated the presence of sub‐phenotypes within animal models. Here, in three ovine models of ARDS, using combinations of oleic acid and intravenous, or intratracheal lipopolysaccharide, we investigated the presence of sub‐phenotypes which qualitatively resemble those found in clinical cohorts. Principal Component Analysis and partitional clustering identified two clusters, differentiated by markers of shock, inflammation, and lung injury. 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Passmore</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Katrina K. Ki</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Louise E. See Hoe</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Nchafatso G. 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Characterizing preclinical sub‐phenotypic models of acute respiratory distress syndrome: An experimental ovine study

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