Sterols in the small intestine of the rat, guinea pig, and rabbit

The sterol content and composition of the small intestinal mucosa has been studied in the rat, guinea pig, and rabbit. In the three species, noncholesterol sterols formed a large proportion of the total sterol content. In the rat, the contribution due to plant sterols was much smaller than in the gu...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	NEIL McINTYRE [verfasserIn] KATHARINA KIRSCH [verfasserIn] J.C. ORR [verfasserIn] K.J. ISSELBACHER [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	1971

Schlagwörter:	cholesterol lathosterol plant sterols mucosal sterols luminal sterols sterol absorption

Übergeordnetes Werk:	In: Journal of Lipid Research - Elsevier, 2021, 12(1971), 3, Seite 336-346
Übergeordnetes Werk:	volume:12 ; year:1971 ; number:3 ; pages:336-346

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1016/S0022-2275(20)39515-8

Katalog-ID:	DOAJ062958968

Internformat


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520			\|a The sterol content and composition of the small intestinal mucosa has been studied in the rat, guinea pig, and rabbit. In the three species, noncholesterol sterols formed a large proportion of the total sterol content. In the rat, the contribution due to plant sterols was much smaller than in the guinea pig and rabbit, but in all three species the amount of campesterol present seemed disproportionately large compared with β-sitosterol. These observations are presented as evidence that the intestinal mucosa is able to discriminate in its uptake of sterols from the lumen. The presence of plant sterol at all levels of the intestine makes it clear that luminal sterols can be taken up throughout the small bowel, but the data suggest that the upper intestine is the major site of sterol uptake.In the rat, the sterol composition of the intraluminal contents was also studied after its separation by ultracentrifugation into an aqueous (or micellar) phase and a sediment. Examination of the content and composition of the intraluminal sterols at different levels of the intestine provided support for the idea that the major site of cholesterol absorption was in the upper small intestine. The major part of the intraluminal sterol was found in the sediment; precipitation did not, however, render sterols unavailable for absorption and the micellar sterols reflected closely the pattern found in the corresponding sediment.Lathosterol was present in the lumen at all levels of the small intestine. Evidence is presented that the small intestine was not a major source of this material, which was probably derived from skin. Despite the presence of lathosterol in the intestinal lumen, it would appear that, at least in the rat, mucosal lathosterol is derived largely from local synthesis.
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allfields	10.1016/S0022-2275(20)39515-8 doi (DE-627)DOAJ062958968 (DE-599)DOAJ6f4195a191ca4f6b84f309d5079b3de8 DE-627 ger DE-627 rakwb eng QD415-436 NEIL McINTYRE verfasserin aut Sterols in the small intestine of the rat, guinea pig, and rabbit 1971 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The sterol content and composition of the small intestinal mucosa has been studied in the rat, guinea pig, and rabbit. In the three species, noncholesterol sterols formed a large proportion of the total sterol content. In the rat, the contribution due to plant sterols was much smaller than in the guinea pig and rabbit, but in all three species the amount of campesterol present seemed disproportionately large compared with β-sitosterol. These observations are presented as evidence that the intestinal mucosa is able to discriminate in its uptake of sterols from the lumen. The presence of plant sterol at all levels of the intestine makes it clear that luminal sterols can be taken up throughout the small bowel, but the data suggest that the upper intestine is the major site of sterol uptake.In the rat, the sterol composition of the intraluminal contents was also studied after its separation by ultracentrifugation into an aqueous (or micellar) phase and a sediment. Examination of the content and composition of the intraluminal sterols at different levels of the intestine provided support for the idea that the major site of cholesterol absorption was in the upper small intestine. The major part of the intraluminal sterol was found in the sediment; precipitation did not, however, render sterols unavailable for absorption and the micellar sterols reflected closely the pattern found in the corresponding sediment.Lathosterol was present in the lumen at all levels of the small intestine. Evidence is presented that the small intestine was not a major source of this material, which was probably derived from skin. Despite the presence of lathosterol in the intestinal lumen, it would appear that, at least in the rat, mucosal lathosterol is derived largely from local synthesis. cholesterol lathosterol plant sterols mucosal sterols luminal sterols sterol absorption Biochemistry KATHARINA KIRSCH verfasserin aut J.C. ORR verfasserin aut K.J. ISSELBACHER verfasserin aut In Journal of Lipid Research Elsevier, 2021 12(1971), 3, Seite 336-346 (DE-627)26601593X (DE-600)1466675-3 15397262 nnns volume:12 year:1971 number:3 pages:336-346 https://doi.org/10.1016/S0022-2275(20)39515-8 kostenfrei https://doaj.org/article/6f4195a191ca4f6b84f309d5079b3de8 kostenfrei http://www.sciencedirect.com/science/article/pii/S0022227520395158 kostenfrei https://doaj.org/toc/0022-2275 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_252 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2006 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 1971 3 336-346
spelling	10.1016/S0022-2275(20)39515-8 doi (DE-627)DOAJ062958968 (DE-599)DOAJ6f4195a191ca4f6b84f309d5079b3de8 DE-627 ger DE-627 rakwb eng QD415-436 NEIL McINTYRE verfasserin aut Sterols in the small intestine of the rat, guinea pig, and rabbit 1971 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The sterol content and composition of the small intestinal mucosa has been studied in the rat, guinea pig, and rabbit. In the three species, noncholesterol sterols formed a large proportion of the total sterol content. In the rat, the contribution due to plant sterols was much smaller than in the guinea pig and rabbit, but in all three species the amount of campesterol present seemed disproportionately large compared with β-sitosterol. These observations are presented as evidence that the intestinal mucosa is able to discriminate in its uptake of sterols from the lumen. The presence of plant sterol at all levels of the intestine makes it clear that luminal sterols can be taken up throughout the small bowel, but the data suggest that the upper intestine is the major site of sterol uptake.In the rat, the sterol composition of the intraluminal contents was also studied after its separation by ultracentrifugation into an aqueous (or micellar) phase and a sediment. Examination of the content and composition of the intraluminal sterols at different levels of the intestine provided support for the idea that the major site of cholesterol absorption was in the upper small intestine. The major part of the intraluminal sterol was found in the sediment; precipitation did not, however, render sterols unavailable for absorption and the micellar sterols reflected closely the pattern found in the corresponding sediment.Lathosterol was present in the lumen at all levels of the small intestine. Evidence is presented that the small intestine was not a major source of this material, which was probably derived from skin. Despite the presence of lathosterol in the intestinal lumen, it would appear that, at least in the rat, mucosal lathosterol is derived largely from local synthesis. cholesterol lathosterol plant sterols mucosal sterols luminal sterols sterol absorption Biochemistry KATHARINA KIRSCH verfasserin aut J.C. ORR verfasserin aut K.J. ISSELBACHER verfasserin aut In Journal of Lipid Research Elsevier, 2021 12(1971), 3, Seite 336-346 (DE-627)26601593X (DE-600)1466675-3 15397262 nnns volume:12 year:1971 number:3 pages:336-346 https://doi.org/10.1016/S0022-2275(20)39515-8 kostenfrei https://doaj.org/article/6f4195a191ca4f6b84f309d5079b3de8 kostenfrei http://www.sciencedirect.com/science/article/pii/S0022227520395158 kostenfrei https://doaj.org/toc/0022-2275 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_252 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2006 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 1971 3 336-346
allfields_unstemmed	10.1016/S0022-2275(20)39515-8 doi (DE-627)DOAJ062958968 (DE-599)DOAJ6f4195a191ca4f6b84f309d5079b3de8 DE-627 ger DE-627 rakwb eng QD415-436 NEIL McINTYRE verfasserin aut Sterols in the small intestine of the rat, guinea pig, and rabbit 1971 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The sterol content and composition of the small intestinal mucosa has been studied in the rat, guinea pig, and rabbit. In the three species, noncholesterol sterols formed a large proportion of the total sterol content. In the rat, the contribution due to plant sterols was much smaller than in the guinea pig and rabbit, but in all three species the amount of campesterol present seemed disproportionately large compared with β-sitosterol. These observations are presented as evidence that the intestinal mucosa is able to discriminate in its uptake of sterols from the lumen. The presence of plant sterol at all levels of the intestine makes it clear that luminal sterols can be taken up throughout the small bowel, but the data suggest that the upper intestine is the major site of sterol uptake.In the rat, the sterol composition of the intraluminal contents was also studied after its separation by ultracentrifugation into an aqueous (or micellar) phase and a sediment. Examination of the content and composition of the intraluminal sterols at different levels of the intestine provided support for the idea that the major site of cholesterol absorption was in the upper small intestine. The major part of the intraluminal sterol was found in the sediment; precipitation did not, however, render sterols unavailable for absorption and the micellar sterols reflected closely the pattern found in the corresponding sediment.Lathosterol was present in the lumen at all levels of the small intestine. Evidence is presented that the small intestine was not a major source of this material, which was probably derived from skin. Despite the presence of lathosterol in the intestinal lumen, it would appear that, at least in the rat, mucosal lathosterol is derived largely from local synthesis. cholesterol lathosterol plant sterols mucosal sterols luminal sterols sterol absorption Biochemistry KATHARINA KIRSCH verfasserin aut J.C. ORR verfasserin aut K.J. ISSELBACHER verfasserin aut In Journal of Lipid Research Elsevier, 2021 12(1971), 3, Seite 336-346 (DE-627)26601593X (DE-600)1466675-3 15397262 nnns volume:12 year:1971 number:3 pages:336-346 https://doi.org/10.1016/S0022-2275(20)39515-8 kostenfrei https://doaj.org/article/6f4195a191ca4f6b84f309d5079b3de8 kostenfrei http://www.sciencedirect.com/science/article/pii/S0022227520395158 kostenfrei https://doaj.org/toc/0022-2275 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_252 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2006 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 1971 3 336-346
allfieldsGer	10.1016/S0022-2275(20)39515-8 doi (DE-627)DOAJ062958968 (DE-599)DOAJ6f4195a191ca4f6b84f309d5079b3de8 DE-627 ger DE-627 rakwb eng QD415-436 NEIL McINTYRE verfasserin aut Sterols in the small intestine of the rat, guinea pig, and rabbit 1971 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The sterol content and composition of the small intestinal mucosa has been studied in the rat, guinea pig, and rabbit. In the three species, noncholesterol sterols formed a large proportion of the total sterol content. In the rat, the contribution due to plant sterols was much smaller than in the guinea pig and rabbit, but in all three species the amount of campesterol present seemed disproportionately large compared with β-sitosterol. These observations are presented as evidence that the intestinal mucosa is able to discriminate in its uptake of sterols from the lumen. The presence of plant sterol at all levels of the intestine makes it clear that luminal sterols can be taken up throughout the small bowel, but the data suggest that the upper intestine is the major site of sterol uptake.In the rat, the sterol composition of the intraluminal contents was also studied after its separation by ultracentrifugation into an aqueous (or micellar) phase and a sediment. Examination of the content and composition of the intraluminal sterols at different levels of the intestine provided support for the idea that the major site of cholesterol absorption was in the upper small intestine. The major part of the intraluminal sterol was found in the sediment; precipitation did not, however, render sterols unavailable for absorption and the micellar sterols reflected closely the pattern found in the corresponding sediment.Lathosterol was present in the lumen at all levels of the small intestine. Evidence is presented that the small intestine was not a major source of this material, which was probably derived from skin. Despite the presence of lathosterol in the intestinal lumen, it would appear that, at least in the rat, mucosal lathosterol is derived largely from local synthesis. cholesterol lathosterol plant sterols mucosal sterols luminal sterols sterol absorption Biochemistry KATHARINA KIRSCH verfasserin aut J.C. ORR verfasserin aut K.J. ISSELBACHER verfasserin aut In Journal of Lipid Research Elsevier, 2021 12(1971), 3, Seite 336-346 (DE-627)26601593X (DE-600)1466675-3 15397262 nnns volume:12 year:1971 number:3 pages:336-346 https://doi.org/10.1016/S0022-2275(20)39515-8 kostenfrei https://doaj.org/article/6f4195a191ca4f6b84f309d5079b3de8 kostenfrei http://www.sciencedirect.com/science/article/pii/S0022227520395158 kostenfrei https://doaj.org/toc/0022-2275 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_252 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2006 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 1971 3 336-346
allfieldsSound	10.1016/S0022-2275(20)39515-8 doi (DE-627)DOAJ062958968 (DE-599)DOAJ6f4195a191ca4f6b84f309d5079b3de8 DE-627 ger DE-627 rakwb eng QD415-436 NEIL McINTYRE verfasserin aut Sterols in the small intestine of the rat, guinea pig, and rabbit 1971 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The sterol content and composition of the small intestinal mucosa has been studied in the rat, guinea pig, and rabbit. In the three species, noncholesterol sterols formed a large proportion of the total sterol content. In the rat, the contribution due to plant sterols was much smaller than in the guinea pig and rabbit, but in all three species the amount of campesterol present seemed disproportionately large compared with β-sitosterol. These observations are presented as evidence that the intestinal mucosa is able to discriminate in its uptake of sterols from the lumen. The presence of plant sterol at all levels of the intestine makes it clear that luminal sterols can be taken up throughout the small bowel, but the data suggest that the upper intestine is the major site of sterol uptake.In the rat, the sterol composition of the intraluminal contents was also studied after its separation by ultracentrifugation into an aqueous (or micellar) phase and a sediment. Examination of the content and composition of the intraluminal sterols at different levels of the intestine provided support for the idea that the major site of cholesterol absorption was in the upper small intestine. The major part of the intraluminal sterol was found in the sediment; precipitation did not, however, render sterols unavailable for absorption and the micellar sterols reflected closely the pattern found in the corresponding sediment.Lathosterol was present in the lumen at all levels of the small intestine. Evidence is presented that the small intestine was not a major source of this material, which was probably derived from skin. Despite the presence of lathosterol in the intestinal lumen, it would appear that, at least in the rat, mucosal lathosterol is derived largely from local synthesis. cholesterol lathosterol plant sterols mucosal sterols luminal sterols sterol absorption Biochemistry KATHARINA KIRSCH verfasserin aut J.C. ORR verfasserin aut K.J. ISSELBACHER verfasserin aut In Journal of Lipid Research Elsevier, 2021 12(1971), 3, Seite 336-346 (DE-627)26601593X (DE-600)1466675-3 15397262 nnns volume:12 year:1971 number:3 pages:336-346 https://doi.org/10.1016/S0022-2275(20)39515-8 kostenfrei https://doaj.org/article/6f4195a191ca4f6b84f309d5079b3de8 kostenfrei http://www.sciencedirect.com/science/article/pii/S0022227520395158 kostenfrei https://doaj.org/toc/0022-2275 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_252 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2006 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 1971 3 336-346
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callnumber-first	Q - Science
author	NEIL McINTYRE
spellingShingle	NEIL McINTYRE misc QD415-436 misc cholesterol misc lathosterol misc plant sterols misc mucosal sterols misc luminal sterols misc sterol absorption misc Biochemistry Sterols in the small intestine of the rat, guinea pig, and rabbit
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topic_title	QD415-436 Sterols in the small intestine of the rat, guinea pig, and rabbit cholesterol lathosterol plant sterols mucosal sterols luminal sterols sterol absorption
topic	misc QD415-436 misc cholesterol misc lathosterol misc plant sterols misc mucosal sterols misc luminal sterols misc sterol absorption misc Biochemistry
topic_unstemmed	misc QD415-436 misc cholesterol misc lathosterol misc plant sterols misc mucosal sterols misc luminal sterols misc sterol absorption misc Biochemistry
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title	Sterols in the small intestine of the rat, guinea pig, and rabbit
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title_sort	sterols in the small intestine of the rat, guinea pig, and rabbit
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title_auth	Sterols in the small intestine of the rat, guinea pig, and rabbit
abstract	The sterol content and composition of the small intestinal mucosa has been studied in the rat, guinea pig, and rabbit. In the three species, noncholesterol sterols formed a large proportion of the total sterol content. In the rat, the contribution due to plant sterols was much smaller than in the guinea pig and rabbit, but in all three species the amount of campesterol present seemed disproportionately large compared with β-sitosterol. These observations are presented as evidence that the intestinal mucosa is able to discriminate in its uptake of sterols from the lumen. The presence of plant sterol at all levels of the intestine makes it clear that luminal sterols can be taken up throughout the small bowel, but the data suggest that the upper intestine is the major site of sterol uptake.In the rat, the sterol composition of the intraluminal contents was also studied after its separation by ultracentrifugation into an aqueous (or micellar) phase and a sediment. Examination of the content and composition of the intraluminal sterols at different levels of the intestine provided support for the idea that the major site of cholesterol absorption was in the upper small intestine. The major part of the intraluminal sterol was found in the sediment; precipitation did not, however, render sterols unavailable for absorption and the micellar sterols reflected closely the pattern found in the corresponding sediment.Lathosterol was present in the lumen at all levels of the small intestine. Evidence is presented that the small intestine was not a major source of this material, which was probably derived from skin. Despite the presence of lathosterol in the intestinal lumen, it would appear that, at least in the rat, mucosal lathosterol is derived largely from local synthesis.
abstractGer	The sterol content and composition of the small intestinal mucosa has been studied in the rat, guinea pig, and rabbit. In the three species, noncholesterol sterols formed a large proportion of the total sterol content. In the rat, the contribution due to plant sterols was much smaller than in the guinea pig and rabbit, but in all three species the amount of campesterol present seemed disproportionately large compared with β-sitosterol. These observations are presented as evidence that the intestinal mucosa is able to discriminate in its uptake of sterols from the lumen. The presence of plant sterol at all levels of the intestine makes it clear that luminal sterols can be taken up throughout the small bowel, but the data suggest that the upper intestine is the major site of sterol uptake.In the rat, the sterol composition of the intraluminal contents was also studied after its separation by ultracentrifugation into an aqueous (or micellar) phase and a sediment. Examination of the content and composition of the intraluminal sterols at different levels of the intestine provided support for the idea that the major site of cholesterol absorption was in the upper small intestine. The major part of the intraluminal sterol was found in the sediment; precipitation did not, however, render sterols unavailable for absorption and the micellar sterols reflected closely the pattern found in the corresponding sediment.Lathosterol was present in the lumen at all levels of the small intestine. Evidence is presented that the small intestine was not a major source of this material, which was probably derived from skin. Despite the presence of lathosterol in the intestinal lumen, it would appear that, at least in the rat, mucosal lathosterol is derived largely from local synthesis.
abstract_unstemmed	The sterol content and composition of the small intestinal mucosa has been studied in the rat, guinea pig, and rabbit. In the three species, noncholesterol sterols formed a large proportion of the total sterol content. In the rat, the contribution due to plant sterols was much smaller than in the guinea pig and rabbit, but in all three species the amount of campesterol present seemed disproportionately large compared with β-sitosterol. These observations are presented as evidence that the intestinal mucosa is able to discriminate in its uptake of sterols from the lumen. The presence of plant sterol at all levels of the intestine makes it clear that luminal sterols can be taken up throughout the small bowel, but the data suggest that the upper intestine is the major site of sterol uptake.In the rat, the sterol composition of the intraluminal contents was also studied after its separation by ultracentrifugation into an aqueous (or micellar) phase and a sediment. Examination of the content and composition of the intraluminal sterols at different levels of the intestine provided support for the idea that the major site of cholesterol absorption was in the upper small intestine. The major part of the intraluminal sterol was found in the sediment; precipitation did not, however, render sterols unavailable for absorption and the micellar sterols reflected closely the pattern found in the corresponding sediment.Lathosterol was present in the lumen at all levels of the small intestine. Evidence is presented that the small intestine was not a major source of this material, which was probably derived from skin. Despite the presence of lathosterol in the intestinal lumen, it would appear that, at least in the rat, mucosal lathosterol is derived largely from local synthesis.
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title_short	Sterols in the small intestine of the rat, guinea pig, and rabbit
url	https://doi.org/10.1016/S0022-2275(20)39515-8 https://doaj.org/article/6f4195a191ca4f6b84f309d5079b3de8 http://www.sciencedirect.com/science/article/pii/S0022227520395158 https://doaj.org/toc/0022-2275
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Sterols in the small intestine of the rat, guinea pig, and rabbit

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