Whole-genome sequencing of acral melanoma reveals genomic complexity and diversity

Acral melanoma occurs on the soles of the feet, palms of the hands and in nail beds. Here, the authors reports the genomic landscape of 87 acral melanomas and find that some tumors harbor a UV signature and that the tumors are diverse at the levels of mutational signatures, structural aberrations an...
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Autor*in:	Felicity Newell [verfasserIn] James S. Wilmott [verfasserIn] Peter A. Johansson [verfasserIn] Katia Nones [verfasserIn] Venkateswar Addala [verfasserIn] Pamela Mukhopadhyay [verfasserIn] Natasa Broit [verfasserIn] Carol M. Amato [verfasserIn] Robert Van Gulick [verfasserIn] Stephen H. Kazakoff [verfasserIn] Ann-Marie Patch [verfasserIn] Lambros T. Koufariotis [verfasserIn] Vanessa Lakis [verfasserIn] Conrad Leonard [verfasserIn] Scott Wood [verfasserIn] Oliver Holmes [verfasserIn] Qinying Xu [verfasserIn] Karl Lewis [verfasserIn] Theresa Medina [verfasserIn] Rene Gonzalez [verfasserIn] Robyn P. M. Saw [verfasserIn] Andrew J. Spillane [verfasserIn] Jonathan R. Stretch [verfasserIn] Robert V. Rawson [verfasserIn] Peter M. Ferguson [verfasserIn] Tristan J. Dodds [verfasserIn] John F. Thompson [verfasserIn] Georgina V. Long [verfasserIn] Mitchell P. Levesque [verfasserIn] William A. Robinson [verfasserIn] John V. Pearson [verfasserIn] Graham J. Mann [verfasserIn] Richard A. Scolyer [verfasserIn] Nicola Waddell [verfasserIn] Nicholas K. Hayward [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Übergeordnetes Werk:	In: Nature Communications - Nature Portfolio, 2016, 11(2020), 1, Seite 14
Übergeordnetes Werk:	volume:11 ; year:2020 ; number:1 ; pages:14

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1038/s41467-020-18988-3

Katalog-ID:	DOAJ062993585

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allfields	10.1038/s41467-020-18988-3 doi (DE-627)DOAJ062993585 (DE-599)DOAJ953bcceaafac4fed9eb837e6a8612ce4 DE-627 ger DE-627 rakwb eng Felicity Newell verfasserin aut Whole-genome sequencing of acral melanoma reveals genomic complexity and diversity 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Acral melanoma occurs on the soles of the feet, palms of the hands and in nail beds. Here, the authors reports the genomic landscape of 87 acral melanomas and find that some tumors harbor a UV signature and that the tumors are diverse at the levels of mutational signatures, structural aberrations and copy number signatures. Science Q James S. Wilmott verfasserin aut Peter A. Johansson verfasserin aut Katia Nones verfasserin aut Venkateswar Addala verfasserin aut Pamela Mukhopadhyay verfasserin aut Natasa Broit verfasserin aut Carol M. Amato verfasserin aut Robert Van Gulick verfasserin aut Stephen H. Kazakoff verfasserin aut Ann-Marie Patch verfasserin aut Lambros T. Koufariotis verfasserin aut Vanessa Lakis verfasserin aut Conrad Leonard verfasserin aut Scott Wood verfasserin aut Oliver Holmes verfasserin aut Qinying Xu verfasserin aut Karl Lewis verfasserin aut Theresa Medina verfasserin aut Rene Gonzalez verfasserin aut Robyn P. M. Saw verfasserin aut Andrew J. Spillane verfasserin aut Jonathan R. Stretch verfasserin aut Robert V. Rawson verfasserin aut Peter M. Ferguson verfasserin aut Tristan J. Dodds verfasserin aut John F. Thompson verfasserin aut Georgina V. Long verfasserin aut Mitchell P. Levesque verfasserin aut William A. Robinson verfasserin aut John V. Pearson verfasserin aut Graham J. Mann verfasserin aut Richard A. Scolyer verfasserin aut Nicola Waddell verfasserin aut Nicholas K. Hayward verfasserin aut In Nature Communications Nature Portfolio, 2016 11(2020), 1, Seite 14 (DE-627)626457688 (DE-600)2553671-0 20411723 nnns volume:11 year:2020 number:1 pages:14 https://doi.org/10.1038/s41467-020-18988-3 kostenfrei https://doaj.org/article/953bcceaafac4fed9eb837e6a8612ce4 kostenfrei https://doi.org/10.1038/s41467-020-18988-3 kostenfrei https://doaj.org/toc/2041-1723 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_211 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2110 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2020 1 14
spelling	10.1038/s41467-020-18988-3 doi (DE-627)DOAJ062993585 (DE-599)DOAJ953bcceaafac4fed9eb837e6a8612ce4 DE-627 ger DE-627 rakwb eng Felicity Newell verfasserin aut Whole-genome sequencing of acral melanoma reveals genomic complexity and diversity 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Acral melanoma occurs on the soles of the feet, palms of the hands and in nail beds. Here, the authors reports the genomic landscape of 87 acral melanomas and find that some tumors harbor a UV signature and that the tumors are diverse at the levels of mutational signatures, structural aberrations and copy number signatures. Science Q James S. Wilmott verfasserin aut Peter A. Johansson verfasserin aut Katia Nones verfasserin aut Venkateswar Addala verfasserin aut Pamela Mukhopadhyay verfasserin aut Natasa Broit verfasserin aut Carol M. Amato verfasserin aut Robert Van Gulick verfasserin aut Stephen H. Kazakoff verfasserin aut Ann-Marie Patch verfasserin aut Lambros T. Koufariotis verfasserin aut Vanessa Lakis verfasserin aut Conrad Leonard verfasserin aut Scott Wood verfasserin aut Oliver Holmes verfasserin aut Qinying Xu verfasserin aut Karl Lewis verfasserin aut Theresa Medina verfasserin aut Rene Gonzalez verfasserin aut Robyn P. M. Saw verfasserin aut Andrew J. Spillane verfasserin aut Jonathan R. Stretch verfasserin aut Robert V. Rawson verfasserin aut Peter M. Ferguson verfasserin aut Tristan J. Dodds verfasserin aut John F. Thompson verfasserin aut Georgina V. Long verfasserin aut Mitchell P. Levesque verfasserin aut William A. Robinson verfasserin aut John V. Pearson verfasserin aut Graham J. Mann verfasserin aut Richard A. Scolyer verfasserin aut Nicola Waddell verfasserin aut Nicholas K. Hayward verfasserin aut In Nature Communications Nature Portfolio, 2016 11(2020), 1, Seite 14 (DE-627)626457688 (DE-600)2553671-0 20411723 nnns volume:11 year:2020 number:1 pages:14 https://doi.org/10.1038/s41467-020-18988-3 kostenfrei https://doaj.org/article/953bcceaafac4fed9eb837e6a8612ce4 kostenfrei https://doi.org/10.1038/s41467-020-18988-3 kostenfrei https://doaj.org/toc/2041-1723 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_211 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2110 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2020 1 14
allfields_unstemmed	10.1038/s41467-020-18988-3 doi (DE-627)DOAJ062993585 (DE-599)DOAJ953bcceaafac4fed9eb837e6a8612ce4 DE-627 ger DE-627 rakwb eng Felicity Newell verfasserin aut Whole-genome sequencing of acral melanoma reveals genomic complexity and diversity 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Acral melanoma occurs on the soles of the feet, palms of the hands and in nail beds. Here, the authors reports the genomic landscape of 87 acral melanomas and find that some tumors harbor a UV signature and that the tumors are diverse at the levels of mutational signatures, structural aberrations and copy number signatures. Science Q James S. Wilmott verfasserin aut Peter A. Johansson verfasserin aut Katia Nones verfasserin aut Venkateswar Addala verfasserin aut Pamela Mukhopadhyay verfasserin aut Natasa Broit verfasserin aut Carol M. Amato verfasserin aut Robert Van Gulick verfasserin aut Stephen H. Kazakoff verfasserin aut Ann-Marie Patch verfasserin aut Lambros T. Koufariotis verfasserin aut Vanessa Lakis verfasserin aut Conrad Leonard verfasserin aut Scott Wood verfasserin aut Oliver Holmes verfasserin aut Qinying Xu verfasserin aut Karl Lewis verfasserin aut Theresa Medina verfasserin aut Rene Gonzalez verfasserin aut Robyn P. M. Saw verfasserin aut Andrew J. Spillane verfasserin aut Jonathan R. Stretch verfasserin aut Robert V. Rawson verfasserin aut Peter M. Ferguson verfasserin aut Tristan J. Dodds verfasserin aut John F. Thompson verfasserin aut Georgina V. Long verfasserin aut Mitchell P. Levesque verfasserin aut William A. Robinson verfasserin aut John V. Pearson verfasserin aut Graham J. Mann verfasserin aut Richard A. Scolyer verfasserin aut Nicola Waddell verfasserin aut Nicholas K. Hayward verfasserin aut In Nature Communications Nature Portfolio, 2016 11(2020), 1, Seite 14 (DE-627)626457688 (DE-600)2553671-0 20411723 nnns volume:11 year:2020 number:1 pages:14 https://doi.org/10.1038/s41467-020-18988-3 kostenfrei https://doaj.org/article/953bcceaafac4fed9eb837e6a8612ce4 kostenfrei https://doi.org/10.1038/s41467-020-18988-3 kostenfrei https://doaj.org/toc/2041-1723 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_211 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2110 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2020 1 14
allfieldsGer	10.1038/s41467-020-18988-3 doi (DE-627)DOAJ062993585 (DE-599)DOAJ953bcceaafac4fed9eb837e6a8612ce4 DE-627 ger DE-627 rakwb eng Felicity Newell verfasserin aut Whole-genome sequencing of acral melanoma reveals genomic complexity and diversity 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Acral melanoma occurs on the soles of the feet, palms of the hands and in nail beds. Here, the authors reports the genomic landscape of 87 acral melanomas and find that some tumors harbor a UV signature and that the tumors are diverse at the levels of mutational signatures, structural aberrations and copy number signatures. Science Q James S. Wilmott verfasserin aut Peter A. Johansson verfasserin aut Katia Nones verfasserin aut Venkateswar Addala verfasserin aut Pamela Mukhopadhyay verfasserin aut Natasa Broit verfasserin aut Carol M. Amato verfasserin aut Robert Van Gulick verfasserin aut Stephen H. Kazakoff verfasserin aut Ann-Marie Patch verfasserin aut Lambros T. Koufariotis verfasserin aut Vanessa Lakis verfasserin aut Conrad Leonard verfasserin aut Scott Wood verfasserin aut Oliver Holmes verfasserin aut Qinying Xu verfasserin aut Karl Lewis verfasserin aut Theresa Medina verfasserin aut Rene Gonzalez verfasserin aut Robyn P. M. Saw verfasserin aut Andrew J. Spillane verfasserin aut Jonathan R. Stretch verfasserin aut Robert V. Rawson verfasserin aut Peter M. Ferguson verfasserin aut Tristan J. Dodds verfasserin aut John F. Thompson verfasserin aut Georgina V. Long verfasserin aut Mitchell P. Levesque verfasserin aut William A. Robinson verfasserin aut John V. Pearson verfasserin aut Graham J. Mann verfasserin aut Richard A. Scolyer verfasserin aut Nicola Waddell verfasserin aut Nicholas K. Hayward verfasserin aut In Nature Communications Nature Portfolio, 2016 11(2020), 1, Seite 14 (DE-627)626457688 (DE-600)2553671-0 20411723 nnns volume:11 year:2020 number:1 pages:14 https://doi.org/10.1038/s41467-020-18988-3 kostenfrei https://doaj.org/article/953bcceaafac4fed9eb837e6a8612ce4 kostenfrei https://doi.org/10.1038/s41467-020-18988-3 kostenfrei https://doaj.org/toc/2041-1723 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_211 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2110 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2020 1 14
allfieldsSound	10.1038/s41467-020-18988-3 doi (DE-627)DOAJ062993585 (DE-599)DOAJ953bcceaafac4fed9eb837e6a8612ce4 DE-627 ger DE-627 rakwb eng Felicity Newell verfasserin aut Whole-genome sequencing of acral melanoma reveals genomic complexity and diversity 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Acral melanoma occurs on the soles of the feet, palms of the hands and in nail beds. Here, the authors reports the genomic landscape of 87 acral melanomas and find that some tumors harbor a UV signature and that the tumors are diverse at the levels of mutational signatures, structural aberrations and copy number signatures. Science Q James S. Wilmott verfasserin aut Peter A. Johansson verfasserin aut Katia Nones verfasserin aut Venkateswar Addala verfasserin aut Pamela Mukhopadhyay verfasserin aut Natasa Broit verfasserin aut Carol M. Amato verfasserin aut Robert Van Gulick verfasserin aut Stephen H. Kazakoff verfasserin aut Ann-Marie Patch verfasserin aut Lambros T. Koufariotis verfasserin aut Vanessa Lakis verfasserin aut Conrad Leonard verfasserin aut Scott Wood verfasserin aut Oliver Holmes verfasserin aut Qinying Xu verfasserin aut Karl Lewis verfasserin aut Theresa Medina verfasserin aut Rene Gonzalez verfasserin aut Robyn P. M. Saw verfasserin aut Andrew J. Spillane verfasserin aut Jonathan R. Stretch verfasserin aut Robert V. Rawson verfasserin aut Peter M. Ferguson verfasserin aut Tristan J. Dodds verfasserin aut John F. Thompson verfasserin aut Georgina V. Long verfasserin aut Mitchell P. Levesque verfasserin aut William A. Robinson verfasserin aut John V. Pearson verfasserin aut Graham J. Mann verfasserin aut Richard A. Scolyer verfasserin aut Nicola Waddell verfasserin aut Nicholas K. Hayward verfasserin aut In Nature Communications Nature Portfolio, 2016 11(2020), 1, Seite 14 (DE-627)626457688 (DE-600)2553671-0 20411723 nnns volume:11 year:2020 number:1 pages:14 https://doi.org/10.1038/s41467-020-18988-3 kostenfrei https://doaj.org/article/953bcceaafac4fed9eb837e6a8612ce4 kostenfrei https://doi.org/10.1038/s41467-020-18988-3 kostenfrei https://doaj.org/toc/2041-1723 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_211 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2110 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2020 1 14
language	English
source	In Nature Communications 11(2020), 1, Seite 14 volume:11 year:2020 number:1 pages:14
sourceStr	In Nature Communications 11(2020), 1, Seite 14 volume:11 year:2020 number:1 pages:14
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institution	findex.gbv.de
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container_title	Nature Communications
authorswithroles_txt_mv	Felicity Newell @@aut@@ James S. Wilmott @@aut@@ Peter A. Johansson @@aut@@ Katia Nones @@aut@@ Venkateswar Addala @@aut@@ Pamela Mukhopadhyay @@aut@@ Natasa Broit @@aut@@ Carol M. Amato @@aut@@ Robert Van Gulick @@aut@@ Stephen H. Kazakoff @@aut@@ Ann-Marie Patch @@aut@@ Lambros T. Koufariotis @@aut@@ Vanessa Lakis @@aut@@ Conrad Leonard @@aut@@ Scott Wood @@aut@@ Oliver Holmes @@aut@@ Qinying Xu @@aut@@ Karl Lewis @@aut@@ Theresa Medina @@aut@@ Rene Gonzalez @@aut@@ Robyn P. M. Saw @@aut@@ Andrew J. Spillane @@aut@@ Jonathan R. Stretch @@aut@@ Robert V. Rawson @@aut@@ Peter M. Ferguson @@aut@@ Tristan J. Dodds @@aut@@ John F. Thompson @@aut@@ Georgina V. Long @@aut@@ Mitchell P. Levesque @@aut@@ William A. Robinson @@aut@@ John V. Pearson @@aut@@ Graham J. Mann @@aut@@ Richard A. Scolyer @@aut@@ Nicola Waddell @@aut@@ Nicholas K. Hayward @@aut@@
publishDateDaySort_date	2020-01-01T00:00:00Z
hierarchy_top_id	626457688
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language_de	englisch
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author	Felicity Newell
spellingShingle	Felicity Newell misc Science misc Q Whole-genome sequencing of acral melanoma reveals genomic complexity and diversity
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topic_title	Whole-genome sequencing of acral melanoma reveals genomic complexity and diversity
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title	Whole-genome sequencing of acral melanoma reveals genomic complexity and diversity
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title_full	Whole-genome sequencing of acral melanoma reveals genomic complexity and diversity
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author_browse	Felicity Newell James S. Wilmott Peter A. Johansson Katia Nones Venkateswar Addala Pamela Mukhopadhyay Natasa Broit Carol M. Amato Robert Van Gulick Stephen H. Kazakoff Ann-Marie Patch Lambros T. Koufariotis Vanessa Lakis Conrad Leonard Scott Wood Oliver Holmes Qinying Xu Karl Lewis Theresa Medina Rene Gonzalez Robyn P. M. Saw Andrew J. Spillane Jonathan R. Stretch Robert V. Rawson Peter M. Ferguson Tristan J. Dodds John F. Thompson Georgina V. Long Mitchell P. Levesque William A. Robinson John V. Pearson Graham J. Mann Richard A. Scolyer Nicola Waddell Nicholas K. Hayward
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title_sort	whole-genome sequencing of acral melanoma reveals genomic complexity and diversity
title_auth	Whole-genome sequencing of acral melanoma reveals genomic complexity and diversity
abstract	Acral melanoma occurs on the soles of the feet, palms of the hands and in nail beds. Here, the authors reports the genomic landscape of 87 acral melanomas and find that some tumors harbor a UV signature and that the tumors are diverse at the levels of mutational signatures, structural aberrations and copy number signatures.
abstractGer	Acral melanoma occurs on the soles of the feet, palms of the hands and in nail beds. Here, the authors reports the genomic landscape of 87 acral melanomas and find that some tumors harbor a UV signature and that the tumors are diverse at the levels of mutational signatures, structural aberrations and copy number signatures.
abstract_unstemmed	Acral melanoma occurs on the soles of the feet, palms of the hands and in nail beds. Here, the authors reports the genomic landscape of 87 acral melanomas and find that some tumors harbor a UV signature and that the tumors are diverse at the levels of mutational signatures, structural aberrations and copy number signatures.
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title_short	Whole-genome sequencing of acral melanoma reveals genomic complexity and diversity
url	https://doi.org/10.1038/s41467-020-18988-3 https://doaj.org/article/953bcceaafac4fed9eb837e6a8612ce4 https://doaj.org/toc/2041-1723
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author2Str	James S. Wilmott Peter A. Johansson Katia Nones Venkateswar Addala Pamela Mukhopadhyay Natasa Broit Carol M. Amato Robert Van Gulick Stephen H. Kazakoff Ann-Marie Patch Lambros T. Koufariotis Vanessa Lakis Conrad Leonard Scott Wood Oliver Holmes Qinying Xu Karl Lewis Theresa Medina Rene Gonzalez Robyn P. M. Saw Andrew J. Spillane Jonathan R. Stretch Robert V. Rawson Peter M. Ferguson Tristan J. Dodds John F. Thompson Georgina V. Long Mitchell P. Levesque William A. Robinson John V. Pearson Graham J. Mann Richard A. Scolyer Nicola Waddell Nicholas K. Hayward
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