Intradiscal quantitative chemical exchange saturation transfer MRI signal correlates with discogenic pain in human patients

Abstract Low back pain (LBP) is often a result of a degenerative process in the intervertebral disc. The precise origin of discogenic pain is diagnosed by the invasive procedure of provocative discography (PD). Previously, we developed quantitative chemical exchange saturation transfer (qCEST) magne...
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Autor*in:	Gadi Pelled [verfasserIn] Margaux M. Salas [verfasserIn] Pei Han [verfasserIn] Howard E. Gill [verfasserIn] Karl A. Lautenschlager [verfasserIn] Tristan T. Lai [verfasserIn] Cameron M. Shawver [verfasserIn] Matthew B. Hoch [verfasserIn] Brandon J. Goff [verfasserIn] Aaron M. Betts [verfasserIn] Zhengwei Zhou [verfasserIn] Cody Lynch [verfasserIn] Grant Schroeder [verfasserIn] Maxim Bez [verfasserIn] Marcel M. Maya [verfasserIn] Catherine Bresee [verfasserIn] Zulma Gazit [verfasserIn] John P. McCallin [verfasserIn] Dan Gazit [verfasserIn] Debiao Li [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Übergeordnetes Werk:	In: Scientific Reports - Nature Portfolio, 2011, 11(2021), 1, Seite 9
Übergeordnetes Werk:	volume:11 ; year:2021 ; number:1 ; pages:9

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1038/s41598-021-97672-y

Katalog-ID:	DOAJ063108844

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520			\|a Abstract Low back pain (LBP) is often a result of a degenerative process in the intervertebral disc. The precise origin of discogenic pain is diagnosed by the invasive procedure of provocative discography (PD). Previously, we developed quantitative chemical exchange saturation transfer (qCEST) magnetic resonance imaging (MRI) to detect pH as a biomarker for discogenic pain. Based on these findings we initiated a clinical study with the goal to evaluate the correlation between qCEST values and PD results in LBP patients. Twenty five volunteers with chronic low back pain were subjected to T2-weighted (T2w) and qCEST MRI scans followed by PD. A total of 72 discs were analyzed. The average qCEST signal value of painful discs was significantly higher than non-painful discs (p = 0.012). The ratio between qCEST and normalized T2w was found to be significantly higher in painful discs compared to non-painful discs (p = 0.0022). A receiver operating characteristics (ROC) analysis indicated that qCEST/T2w ratio could be used to differentiate between painful and non-painful discs with 78% sensitivity and 81% specificity. The results of the study suggest that qCEST could be used for the diagnosis of discogenic pain, in conjunction with the commonly used T2w scan.
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allfields	10.1038/s41598-021-97672-y doi (DE-627)DOAJ063108844 (DE-599)DOAJ1a3459a68fb84f2d89e23e8ca6981fe8 DE-627 ger DE-627 rakwb eng Gadi Pelled verfasserin aut Intradiscal quantitative chemical exchange saturation transfer MRI signal correlates with discogenic pain in human patients 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Low back pain (LBP) is often a result of a degenerative process in the intervertebral disc. The precise origin of discogenic pain is diagnosed by the invasive procedure of provocative discography (PD). Previously, we developed quantitative chemical exchange saturation transfer (qCEST) magnetic resonance imaging (MRI) to detect pH as a biomarker for discogenic pain. Based on these findings we initiated a clinical study with the goal to evaluate the correlation between qCEST values and PD results in LBP patients. Twenty five volunteers with chronic low back pain were subjected to T2-weighted (T2w) and qCEST MRI scans followed by PD. A total of 72 discs were analyzed. The average qCEST signal value of painful discs was significantly higher than non-painful discs (p = 0.012). The ratio between qCEST and normalized T2w was found to be significantly higher in painful discs compared to non-painful discs (p = 0.0022). A receiver operating characteristics (ROC) analysis indicated that qCEST/T2w ratio could be used to differentiate between painful and non-painful discs with 78% sensitivity and 81% specificity. The results of the study suggest that qCEST could be used for the diagnosis of discogenic pain, in conjunction with the commonly used T2w scan. Medicine R Science Q Margaux M. Salas verfasserin aut Pei Han verfasserin aut Howard E. Gill verfasserin aut Karl A. Lautenschlager verfasserin aut Tristan T. Lai verfasserin aut Cameron M. Shawver verfasserin aut Matthew B. Hoch verfasserin aut Brandon J. Goff verfasserin aut Aaron M. Betts verfasserin aut Zhengwei Zhou verfasserin aut Cody Lynch verfasserin aut Grant Schroeder verfasserin aut Maxim Bez verfasserin aut Marcel M. Maya verfasserin aut Catherine Bresee verfasserin aut Zulma Gazit verfasserin aut John P. McCallin verfasserin aut Dan Gazit verfasserin aut Debiao Li verfasserin aut In Scientific Reports Nature Portfolio, 2011 11(2021), 1, Seite 9 (DE-627)663366712 (DE-600)2615211-3 20452322 nnns volume:11 year:2021 number:1 pages:9 https://doi.org/10.1038/s41598-021-97672-y kostenfrei https://doaj.org/article/1a3459a68fb84f2d89e23e8ca6981fe8 kostenfrei https://doi.org/10.1038/s41598-021-97672-y kostenfrei https://doaj.org/toc/2045-2322 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_381 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2021 1 9
spelling	10.1038/s41598-021-97672-y doi (DE-627)DOAJ063108844 (DE-599)DOAJ1a3459a68fb84f2d89e23e8ca6981fe8 DE-627 ger DE-627 rakwb eng Gadi Pelled verfasserin aut Intradiscal quantitative chemical exchange saturation transfer MRI signal correlates with discogenic pain in human patients 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Low back pain (LBP) is often a result of a degenerative process in the intervertebral disc. The precise origin of discogenic pain is diagnosed by the invasive procedure of provocative discography (PD). Previously, we developed quantitative chemical exchange saturation transfer (qCEST) magnetic resonance imaging (MRI) to detect pH as a biomarker for discogenic pain. Based on these findings we initiated a clinical study with the goal to evaluate the correlation between qCEST values and PD results in LBP patients. Twenty five volunteers with chronic low back pain were subjected to T2-weighted (T2w) and qCEST MRI scans followed by PD. A total of 72 discs were analyzed. The average qCEST signal value of painful discs was significantly higher than non-painful discs (p = 0.012). The ratio between qCEST and normalized T2w was found to be significantly higher in painful discs compared to non-painful discs (p = 0.0022). A receiver operating characteristics (ROC) analysis indicated that qCEST/T2w ratio could be used to differentiate between painful and non-painful discs with 78% sensitivity and 81% specificity. The results of the study suggest that qCEST could be used for the diagnosis of discogenic pain, in conjunction with the commonly used T2w scan. Medicine R Science Q Margaux M. Salas verfasserin aut Pei Han verfasserin aut Howard E. Gill verfasserin aut Karl A. Lautenschlager verfasserin aut Tristan T. Lai verfasserin aut Cameron M. Shawver verfasserin aut Matthew B. Hoch verfasserin aut Brandon J. Goff verfasserin aut Aaron M. Betts verfasserin aut Zhengwei Zhou verfasserin aut Cody Lynch verfasserin aut Grant Schroeder verfasserin aut Maxim Bez verfasserin aut Marcel M. Maya verfasserin aut Catherine Bresee verfasserin aut Zulma Gazit verfasserin aut John P. McCallin verfasserin aut Dan Gazit verfasserin aut Debiao Li verfasserin aut In Scientific Reports Nature Portfolio, 2011 11(2021), 1, Seite 9 (DE-627)663366712 (DE-600)2615211-3 20452322 nnns volume:11 year:2021 number:1 pages:9 https://doi.org/10.1038/s41598-021-97672-y kostenfrei https://doaj.org/article/1a3459a68fb84f2d89e23e8ca6981fe8 kostenfrei https://doi.org/10.1038/s41598-021-97672-y kostenfrei https://doaj.org/toc/2045-2322 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_381 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2021 1 9
allfields_unstemmed	10.1038/s41598-021-97672-y doi (DE-627)DOAJ063108844 (DE-599)DOAJ1a3459a68fb84f2d89e23e8ca6981fe8 DE-627 ger DE-627 rakwb eng Gadi Pelled verfasserin aut Intradiscal quantitative chemical exchange saturation transfer MRI signal correlates with discogenic pain in human patients 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Low back pain (LBP) is often a result of a degenerative process in the intervertebral disc. The precise origin of discogenic pain is diagnosed by the invasive procedure of provocative discography (PD). Previously, we developed quantitative chemical exchange saturation transfer (qCEST) magnetic resonance imaging (MRI) to detect pH as a biomarker for discogenic pain. Based on these findings we initiated a clinical study with the goal to evaluate the correlation between qCEST values and PD results in LBP patients. Twenty five volunteers with chronic low back pain were subjected to T2-weighted (T2w) and qCEST MRI scans followed by PD. A total of 72 discs were analyzed. The average qCEST signal value of painful discs was significantly higher than non-painful discs (p = 0.012). The ratio between qCEST and normalized T2w was found to be significantly higher in painful discs compared to non-painful discs (p = 0.0022). A receiver operating characteristics (ROC) analysis indicated that qCEST/T2w ratio could be used to differentiate between painful and non-painful discs with 78% sensitivity and 81% specificity. The results of the study suggest that qCEST could be used for the diagnosis of discogenic pain, in conjunction with the commonly used T2w scan. Medicine R Science Q Margaux M. Salas verfasserin aut Pei Han verfasserin aut Howard E. Gill verfasserin aut Karl A. Lautenschlager verfasserin aut Tristan T. Lai verfasserin aut Cameron M. Shawver verfasserin aut Matthew B. Hoch verfasserin aut Brandon J. Goff verfasserin aut Aaron M. Betts verfasserin aut Zhengwei Zhou verfasserin aut Cody Lynch verfasserin aut Grant Schroeder verfasserin aut Maxim Bez verfasserin aut Marcel M. Maya verfasserin aut Catherine Bresee verfasserin aut Zulma Gazit verfasserin aut John P. McCallin verfasserin aut Dan Gazit verfasserin aut Debiao Li verfasserin aut In Scientific Reports Nature Portfolio, 2011 11(2021), 1, Seite 9 (DE-627)663366712 (DE-600)2615211-3 20452322 nnns volume:11 year:2021 number:1 pages:9 https://doi.org/10.1038/s41598-021-97672-y kostenfrei https://doaj.org/article/1a3459a68fb84f2d89e23e8ca6981fe8 kostenfrei https://doi.org/10.1038/s41598-021-97672-y kostenfrei https://doaj.org/toc/2045-2322 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_381 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2021 1 9
allfieldsGer	10.1038/s41598-021-97672-y doi (DE-627)DOAJ063108844 (DE-599)DOAJ1a3459a68fb84f2d89e23e8ca6981fe8 DE-627 ger DE-627 rakwb eng Gadi Pelled verfasserin aut Intradiscal quantitative chemical exchange saturation transfer MRI signal correlates with discogenic pain in human patients 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Low back pain (LBP) is often a result of a degenerative process in the intervertebral disc. The precise origin of discogenic pain is diagnosed by the invasive procedure of provocative discography (PD). Previously, we developed quantitative chemical exchange saturation transfer (qCEST) magnetic resonance imaging (MRI) to detect pH as a biomarker for discogenic pain. Based on these findings we initiated a clinical study with the goal to evaluate the correlation between qCEST values and PD results in LBP patients. Twenty five volunteers with chronic low back pain were subjected to T2-weighted (T2w) and qCEST MRI scans followed by PD. A total of 72 discs were analyzed. The average qCEST signal value of painful discs was significantly higher than non-painful discs (p = 0.012). The ratio between qCEST and normalized T2w was found to be significantly higher in painful discs compared to non-painful discs (p = 0.0022). A receiver operating characteristics (ROC) analysis indicated that qCEST/T2w ratio could be used to differentiate between painful and non-painful discs with 78% sensitivity and 81% specificity. The results of the study suggest that qCEST could be used for the diagnosis of discogenic pain, in conjunction with the commonly used T2w scan. Medicine R Science Q Margaux M. Salas verfasserin aut Pei Han verfasserin aut Howard E. Gill verfasserin aut Karl A. Lautenschlager verfasserin aut Tristan T. Lai verfasserin aut Cameron M. Shawver verfasserin aut Matthew B. Hoch verfasserin aut Brandon J. Goff verfasserin aut Aaron M. Betts verfasserin aut Zhengwei Zhou verfasserin aut Cody Lynch verfasserin aut Grant Schroeder verfasserin aut Maxim Bez verfasserin aut Marcel M. Maya verfasserin aut Catherine Bresee verfasserin aut Zulma Gazit verfasserin aut John P. McCallin verfasserin aut Dan Gazit verfasserin aut Debiao Li verfasserin aut In Scientific Reports Nature Portfolio, 2011 11(2021), 1, Seite 9 (DE-627)663366712 (DE-600)2615211-3 20452322 nnns volume:11 year:2021 number:1 pages:9 https://doi.org/10.1038/s41598-021-97672-y kostenfrei https://doaj.org/article/1a3459a68fb84f2d89e23e8ca6981fe8 kostenfrei https://doi.org/10.1038/s41598-021-97672-y kostenfrei https://doaj.org/toc/2045-2322 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_381 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2021 1 9
allfieldsSound	10.1038/s41598-021-97672-y doi (DE-627)DOAJ063108844 (DE-599)DOAJ1a3459a68fb84f2d89e23e8ca6981fe8 DE-627 ger DE-627 rakwb eng Gadi Pelled verfasserin aut Intradiscal quantitative chemical exchange saturation transfer MRI signal correlates with discogenic pain in human patients 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Low back pain (LBP) is often a result of a degenerative process in the intervertebral disc. The precise origin of discogenic pain is diagnosed by the invasive procedure of provocative discography (PD). Previously, we developed quantitative chemical exchange saturation transfer (qCEST) magnetic resonance imaging (MRI) to detect pH as a biomarker for discogenic pain. Based on these findings we initiated a clinical study with the goal to evaluate the correlation between qCEST values and PD results in LBP patients. Twenty five volunteers with chronic low back pain were subjected to T2-weighted (T2w) and qCEST MRI scans followed by PD. A total of 72 discs were analyzed. The average qCEST signal value of painful discs was significantly higher than non-painful discs (p = 0.012). The ratio between qCEST and normalized T2w was found to be significantly higher in painful discs compared to non-painful discs (p = 0.0022). A receiver operating characteristics (ROC) analysis indicated that qCEST/T2w ratio could be used to differentiate between painful and non-painful discs with 78% sensitivity and 81% specificity. The results of the study suggest that qCEST could be used for the diagnosis of discogenic pain, in conjunction with the commonly used T2w scan. Medicine R Science Q Margaux M. Salas verfasserin aut Pei Han verfasserin aut Howard E. Gill verfasserin aut Karl A. Lautenschlager verfasserin aut Tristan T. Lai verfasserin aut Cameron M. Shawver verfasserin aut Matthew B. Hoch verfasserin aut Brandon J. Goff verfasserin aut Aaron M. Betts verfasserin aut Zhengwei Zhou verfasserin aut Cody Lynch verfasserin aut Grant Schroeder verfasserin aut Maxim Bez verfasserin aut Marcel M. Maya verfasserin aut Catherine Bresee verfasserin aut Zulma Gazit verfasserin aut John P. McCallin verfasserin aut Dan Gazit verfasserin aut Debiao Li verfasserin aut In Scientific Reports Nature Portfolio, 2011 11(2021), 1, Seite 9 (DE-627)663366712 (DE-600)2615211-3 20452322 nnns volume:11 year:2021 number:1 pages:9 https://doi.org/10.1038/s41598-021-97672-y kostenfrei https://doaj.org/article/1a3459a68fb84f2d89e23e8ca6981fe8 kostenfrei https://doi.org/10.1038/s41598-021-97672-y kostenfrei https://doaj.org/toc/2045-2322 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_381 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2021 1 9
language	English
source	In Scientific Reports 11(2021), 1, Seite 9 volume:11 year:2021 number:1 pages:9
sourceStr	In Scientific Reports 11(2021), 1, Seite 9 volume:11 year:2021 number:1 pages:9
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Medicine R Science Q
isfreeaccess_bool	true
container_title	Scientific Reports
authorswithroles_txt_mv	Gadi Pelled @@aut@@ Margaux M. Salas @@aut@@ Pei Han @@aut@@ Howard E. Gill @@aut@@ Karl A. Lautenschlager @@aut@@ Tristan T. Lai @@aut@@ Cameron M. Shawver @@aut@@ Matthew B. Hoch @@aut@@ Brandon J. Goff @@aut@@ Aaron M. Betts @@aut@@ Zhengwei Zhou @@aut@@ Cody Lynch @@aut@@ Grant Schroeder @@aut@@ Maxim Bez @@aut@@ Marcel M. Maya @@aut@@ Catherine Bresee @@aut@@ Zulma Gazit @@aut@@ John P. McCallin @@aut@@ Dan Gazit @@aut@@ Debiao Li @@aut@@
publishDateDaySort_date	2021-01-01T00:00:00Z
hierarchy_top_id	663366712
id	DOAJ063108844
language_de	englisch
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author	Gadi Pelled
spellingShingle	Gadi Pelled misc Medicine misc R misc Science misc Q Intradiscal quantitative chemical exchange saturation transfer MRI signal correlates with discogenic pain in human patients
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topic_title	Intradiscal quantitative chemical exchange saturation transfer MRI signal correlates with discogenic pain in human patients
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title	Intradiscal quantitative chemical exchange saturation transfer MRI signal correlates with discogenic pain in human patients
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title_full	Intradiscal quantitative chemical exchange saturation transfer MRI signal correlates with discogenic pain in human patients
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author_browse	Gadi Pelled Margaux M. Salas Pei Han Howard E. Gill Karl A. Lautenschlager Tristan T. Lai Cameron M. Shawver Matthew B. Hoch Brandon J. Goff Aaron M. Betts Zhengwei Zhou Cody Lynch Grant Schroeder Maxim Bez Marcel M. Maya Catherine Bresee Zulma Gazit John P. McCallin Dan Gazit Debiao Li
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doi_str_mv	10.1038/s41598-021-97672-y
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title_sort	intradiscal quantitative chemical exchange saturation transfer mri signal correlates with discogenic pain in human patients
title_auth	Intradiscal quantitative chemical exchange saturation transfer MRI signal correlates with discogenic pain in human patients
abstract	Abstract Low back pain (LBP) is often a result of a degenerative process in the intervertebral disc. The precise origin of discogenic pain is diagnosed by the invasive procedure of provocative discography (PD). Previously, we developed quantitative chemical exchange saturation transfer (qCEST) magnetic resonance imaging (MRI) to detect pH as a biomarker for discogenic pain. Based on these findings we initiated a clinical study with the goal to evaluate the correlation between qCEST values and PD results in LBP patients. Twenty five volunteers with chronic low back pain were subjected to T2-weighted (T2w) and qCEST MRI scans followed by PD. A total of 72 discs were analyzed. The average qCEST signal value of painful discs was significantly higher than non-painful discs (p = 0.012). The ratio between qCEST and normalized T2w was found to be significantly higher in painful discs compared to non-painful discs (p = 0.0022). A receiver operating characteristics (ROC) analysis indicated that qCEST/T2w ratio could be used to differentiate between painful and non-painful discs with 78% sensitivity and 81% specificity. The results of the study suggest that qCEST could be used for the diagnosis of discogenic pain, in conjunction with the commonly used T2w scan.
abstractGer	Abstract Low back pain (LBP) is often a result of a degenerative process in the intervertebral disc. The precise origin of discogenic pain is diagnosed by the invasive procedure of provocative discography (PD). Previously, we developed quantitative chemical exchange saturation transfer (qCEST) magnetic resonance imaging (MRI) to detect pH as a biomarker for discogenic pain. Based on these findings we initiated a clinical study with the goal to evaluate the correlation between qCEST values and PD results in LBP patients. Twenty five volunteers with chronic low back pain were subjected to T2-weighted (T2w) and qCEST MRI scans followed by PD. A total of 72 discs were analyzed. The average qCEST signal value of painful discs was significantly higher than non-painful discs (p = 0.012). The ratio between qCEST and normalized T2w was found to be significantly higher in painful discs compared to non-painful discs (p = 0.0022). A receiver operating characteristics (ROC) analysis indicated that qCEST/T2w ratio could be used to differentiate between painful and non-painful discs with 78% sensitivity and 81% specificity. The results of the study suggest that qCEST could be used for the diagnosis of discogenic pain, in conjunction with the commonly used T2w scan.
abstract_unstemmed	Abstract Low back pain (LBP) is often a result of a degenerative process in the intervertebral disc. The precise origin of discogenic pain is diagnosed by the invasive procedure of provocative discography (PD). Previously, we developed quantitative chemical exchange saturation transfer (qCEST) magnetic resonance imaging (MRI) to detect pH as a biomarker for discogenic pain. Based on these findings we initiated a clinical study with the goal to evaluate the correlation between qCEST values and PD results in LBP patients. Twenty five volunteers with chronic low back pain were subjected to T2-weighted (T2w) and qCEST MRI scans followed by PD. A total of 72 discs were analyzed. The average qCEST signal value of painful discs was significantly higher than non-painful discs (p = 0.012). The ratio between qCEST and normalized T2w was found to be significantly higher in painful discs compared to non-painful discs (p = 0.0022). A receiver operating characteristics (ROC) analysis indicated that qCEST/T2w ratio could be used to differentiate between painful and non-painful discs with 78% sensitivity and 81% specificity. The results of the study suggest that qCEST could be used for the diagnosis of discogenic pain, in conjunction with the commonly used T2w scan.
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title_short	Intradiscal quantitative chemical exchange saturation transfer MRI signal correlates with discogenic pain in human patients
url	https://doi.org/10.1038/s41598-021-97672-y https://doaj.org/article/1a3459a68fb84f2d89e23e8ca6981fe8 https://doaj.org/toc/2045-2322
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author2	Margaux M. Salas Pei Han Howard E. Gill Karl A. Lautenschlager Tristan T. Lai Cameron M. Shawver Matthew B. Hoch Brandon J. Goff Aaron M. Betts Zhengwei Zhou Cody Lynch Grant Schroeder Maxim Bez Marcel M. Maya Catherine Bresee Zulma Gazit John P. McCallin Dan Gazit Debiao Li
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Intradiscal quantitative chemical exchange saturation transfer MRI signal correlates with discogenic pain in human patients

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