Essential role of TOSO/FAIM3 in intestinal IgM reverse transcytosis

Summary: Secretory immunoglobulin A (SIgA) can travel to and from the lumen and transport antigen to subepithelial cells. However, IgM can also multimerize into functional secretory component-bound immunoglobulin. While it is already known that both SIgA and SIgM undergo transcytosis to be secreted...
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Autor*in:	Nicolas Rochereau [verfasserIn] Eva Michaud [verfasserIn] Louis Waeckel [verfasserIn] Martin Killian [verfasserIn] Rémi Gayet [verfasserIn] Roman Goguyer-Deschaumes [verfasserIn] Xavier Roblin [verfasserIn] Gilles Biolley [verfasserIn] Blaise Corthésy [verfasserIn] Stéphane Paul [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	IgM TOSO/FAIM3 reverse transcytosis microfold cell

Übergeordnetes Werk:	In: Cell Reports - Elsevier, 2015, 37(2021), 7, Seite 110006-
Übergeordnetes Werk:	volume:37 ; year:2021 ; number:7 ; pages:110006-

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1016/j.celrep.2021.110006

Katalog-ID:	DOAJ06311674X

Internformat


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520			\|a Summary: Secretory immunoglobulin A (SIgA) can travel to and from the lumen and transport antigen to subepithelial cells. However, IgM can also multimerize into functional secretory component-bound immunoglobulin. While it is already known that both SIgA and SIgM undergo transcytosis to be secreted at the mucosal surface, only SIgA has been shown to perform retrotranscytosis through microfold cells (M cells) of the Peyer’s patch. Here, we investigate whether SIgM could also be taken up by M cells via retrotranscytosis. This transport involves FcμR binding at the apical membrane of M cells. We then demonstrate that SIgM can be exploited by SIgM-p24 (HIV-capsid protein) complexes during immunization in the nasal- or gut-associated lymphoid tissue (NALT or GALT), conferring efficient immune responses against p24. Our data demonstrate a mucosal function of SIgM, which could play a role in the regulation of mucosal immunity.
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publishDate	2021
allfields	10.1016/j.celrep.2021.110006 doi (DE-627)DOAJ06311674X (DE-599)DOAJ1c0d9dd7c688430d9d5f4ebbadbdf92f DE-627 ger DE-627 rakwb eng QH301-705.5 Nicolas Rochereau verfasserin aut Essential role of TOSO/FAIM3 in intestinal IgM reverse transcytosis 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: Secretory immunoglobulin A (SIgA) can travel to and from the lumen and transport antigen to subepithelial cells. However, IgM can also multimerize into functional secretory component-bound immunoglobulin. While it is already known that both SIgA and SIgM undergo transcytosis to be secreted at the mucosal surface, only SIgA has been shown to perform retrotranscytosis through microfold cells (M cells) of the Peyer’s patch. Here, we investigate whether SIgM could also be taken up by M cells via retrotranscytosis. This transport involves FcμR binding at the apical membrane of M cells. We then demonstrate that SIgM can be exploited by SIgM-p24 (HIV-capsid protein) complexes during immunization in the nasal- or gut-associated lymphoid tissue (NALT or GALT), conferring efficient immune responses against p24. Our data demonstrate a mucosal function of SIgM, which could play a role in the regulation of mucosal immunity. IgM TOSO/FAIM3 reverse transcytosis microfold cell Biology (General) Eva Michaud verfasserin aut Louis Waeckel verfasserin aut Martin Killian verfasserin aut Rémi Gayet verfasserin aut Roman Goguyer-Deschaumes verfasserin aut Xavier Roblin verfasserin aut Gilles Biolley verfasserin aut Blaise Corthésy verfasserin aut Stéphane Paul verfasserin aut In Cell Reports Elsevier, 2015 37(2021), 7, Seite 110006- (DE-627)684964562 (DE-600)2649101-1 22111247 nnns volume:37 year:2021 number:7 pages:110006- https://doi.org/10.1016/j.celrep.2021.110006 kostenfrei https://doaj.org/article/1c0d9dd7c688430d9d5f4ebbadbdf92f kostenfrei http://www.sciencedirect.com/science/article/pii/S2211124721014844 kostenfrei https://doaj.org/toc/2211-1247 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 37 2021 7 110006-
spelling	10.1016/j.celrep.2021.110006 doi (DE-627)DOAJ06311674X (DE-599)DOAJ1c0d9dd7c688430d9d5f4ebbadbdf92f DE-627 ger DE-627 rakwb eng QH301-705.5 Nicolas Rochereau verfasserin aut Essential role of TOSO/FAIM3 in intestinal IgM reverse transcytosis 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: Secretory immunoglobulin A (SIgA) can travel to and from the lumen and transport antigen to subepithelial cells. However, IgM can also multimerize into functional secretory component-bound immunoglobulin. While it is already known that both SIgA and SIgM undergo transcytosis to be secreted at the mucosal surface, only SIgA has been shown to perform retrotranscytosis through microfold cells (M cells) of the Peyer’s patch. Here, we investigate whether SIgM could also be taken up by M cells via retrotranscytosis. This transport involves FcμR binding at the apical membrane of M cells. We then demonstrate that SIgM can be exploited by SIgM-p24 (HIV-capsid protein) complexes during immunization in the nasal- or gut-associated lymphoid tissue (NALT or GALT), conferring efficient immune responses against p24. Our data demonstrate a mucosal function of SIgM, which could play a role in the regulation of mucosal immunity. IgM TOSO/FAIM3 reverse transcytosis microfold cell Biology (General) Eva Michaud verfasserin aut Louis Waeckel verfasserin aut Martin Killian verfasserin aut Rémi Gayet verfasserin aut Roman Goguyer-Deschaumes verfasserin aut Xavier Roblin verfasserin aut Gilles Biolley verfasserin aut Blaise Corthésy verfasserin aut Stéphane Paul verfasserin aut In Cell Reports Elsevier, 2015 37(2021), 7, Seite 110006- (DE-627)684964562 (DE-600)2649101-1 22111247 nnns volume:37 year:2021 number:7 pages:110006- https://doi.org/10.1016/j.celrep.2021.110006 kostenfrei https://doaj.org/article/1c0d9dd7c688430d9d5f4ebbadbdf92f kostenfrei http://www.sciencedirect.com/science/article/pii/S2211124721014844 kostenfrei https://doaj.org/toc/2211-1247 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 37 2021 7 110006-
allfields_unstemmed	10.1016/j.celrep.2021.110006 doi (DE-627)DOAJ06311674X (DE-599)DOAJ1c0d9dd7c688430d9d5f4ebbadbdf92f DE-627 ger DE-627 rakwb eng QH301-705.5 Nicolas Rochereau verfasserin aut Essential role of TOSO/FAIM3 in intestinal IgM reverse transcytosis 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: Secretory immunoglobulin A (SIgA) can travel to and from the lumen and transport antigen to subepithelial cells. However, IgM can also multimerize into functional secretory component-bound immunoglobulin. While it is already known that both SIgA and SIgM undergo transcytosis to be secreted at the mucosal surface, only SIgA has been shown to perform retrotranscytosis through microfold cells (M cells) of the Peyer’s patch. Here, we investigate whether SIgM could also be taken up by M cells via retrotranscytosis. This transport involves FcμR binding at the apical membrane of M cells. We then demonstrate that SIgM can be exploited by SIgM-p24 (HIV-capsid protein) complexes during immunization in the nasal- or gut-associated lymphoid tissue (NALT or GALT), conferring efficient immune responses against p24. Our data demonstrate a mucosal function of SIgM, which could play a role in the regulation of mucosal immunity. IgM TOSO/FAIM3 reverse transcytosis microfold cell Biology (General) Eva Michaud verfasserin aut Louis Waeckel verfasserin aut Martin Killian verfasserin aut Rémi Gayet verfasserin aut Roman Goguyer-Deschaumes verfasserin aut Xavier Roblin verfasserin aut Gilles Biolley verfasserin aut Blaise Corthésy verfasserin aut Stéphane Paul verfasserin aut In Cell Reports Elsevier, 2015 37(2021), 7, Seite 110006- (DE-627)684964562 (DE-600)2649101-1 22111247 nnns volume:37 year:2021 number:7 pages:110006- https://doi.org/10.1016/j.celrep.2021.110006 kostenfrei https://doaj.org/article/1c0d9dd7c688430d9d5f4ebbadbdf92f kostenfrei http://www.sciencedirect.com/science/article/pii/S2211124721014844 kostenfrei https://doaj.org/toc/2211-1247 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 37 2021 7 110006-
allfieldsGer	10.1016/j.celrep.2021.110006 doi (DE-627)DOAJ06311674X (DE-599)DOAJ1c0d9dd7c688430d9d5f4ebbadbdf92f DE-627 ger DE-627 rakwb eng QH301-705.5 Nicolas Rochereau verfasserin aut Essential role of TOSO/FAIM3 in intestinal IgM reverse transcytosis 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: Secretory immunoglobulin A (SIgA) can travel to and from the lumen and transport antigen to subepithelial cells. However, IgM can also multimerize into functional secretory component-bound immunoglobulin. While it is already known that both SIgA and SIgM undergo transcytosis to be secreted at the mucosal surface, only SIgA has been shown to perform retrotranscytosis through microfold cells (M cells) of the Peyer’s patch. Here, we investigate whether SIgM could also be taken up by M cells via retrotranscytosis. This transport involves FcμR binding at the apical membrane of M cells. We then demonstrate that SIgM can be exploited by SIgM-p24 (HIV-capsid protein) complexes during immunization in the nasal- or gut-associated lymphoid tissue (NALT or GALT), conferring efficient immune responses against p24. Our data demonstrate a mucosal function of SIgM, which could play a role in the regulation of mucosal immunity. IgM TOSO/FAIM3 reverse transcytosis microfold cell Biology (General) Eva Michaud verfasserin aut Louis Waeckel verfasserin aut Martin Killian verfasserin aut Rémi Gayet verfasserin aut Roman Goguyer-Deschaumes verfasserin aut Xavier Roblin verfasserin aut Gilles Biolley verfasserin aut Blaise Corthésy verfasserin aut Stéphane Paul verfasserin aut In Cell Reports Elsevier, 2015 37(2021), 7, Seite 110006- (DE-627)684964562 (DE-600)2649101-1 22111247 nnns volume:37 year:2021 number:7 pages:110006- https://doi.org/10.1016/j.celrep.2021.110006 kostenfrei https://doaj.org/article/1c0d9dd7c688430d9d5f4ebbadbdf92f kostenfrei http://www.sciencedirect.com/science/article/pii/S2211124721014844 kostenfrei https://doaj.org/toc/2211-1247 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 37 2021 7 110006-
allfieldsSound	10.1016/j.celrep.2021.110006 doi (DE-627)DOAJ06311674X (DE-599)DOAJ1c0d9dd7c688430d9d5f4ebbadbdf92f DE-627 ger DE-627 rakwb eng QH301-705.5 Nicolas Rochereau verfasserin aut Essential role of TOSO/FAIM3 in intestinal IgM reverse transcytosis 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: Secretory immunoglobulin A (SIgA) can travel to and from the lumen and transport antigen to subepithelial cells. However, IgM can also multimerize into functional secretory component-bound immunoglobulin. While it is already known that both SIgA and SIgM undergo transcytosis to be secreted at the mucosal surface, only SIgA has been shown to perform retrotranscytosis through microfold cells (M cells) of the Peyer’s patch. Here, we investigate whether SIgM could also be taken up by M cells via retrotranscytosis. This transport involves FcμR binding at the apical membrane of M cells. We then demonstrate that SIgM can be exploited by SIgM-p24 (HIV-capsid protein) complexes during immunization in the nasal- or gut-associated lymphoid tissue (NALT or GALT), conferring efficient immune responses against p24. Our data demonstrate a mucosal function of SIgM, which could play a role in the regulation of mucosal immunity. IgM TOSO/FAIM3 reverse transcytosis microfold cell Biology (General) Eva Michaud verfasserin aut Louis Waeckel verfasserin aut Martin Killian verfasserin aut Rémi Gayet verfasserin aut Roman Goguyer-Deschaumes verfasserin aut Xavier Roblin verfasserin aut Gilles Biolley verfasserin aut Blaise Corthésy verfasserin aut Stéphane Paul verfasserin aut In Cell Reports Elsevier, 2015 37(2021), 7, Seite 110006- (DE-627)684964562 (DE-600)2649101-1 22111247 nnns volume:37 year:2021 number:7 pages:110006- https://doi.org/10.1016/j.celrep.2021.110006 kostenfrei https://doaj.org/article/1c0d9dd7c688430d9d5f4ebbadbdf92f kostenfrei http://www.sciencedirect.com/science/article/pii/S2211124721014844 kostenfrei https://doaj.org/toc/2211-1247 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 37 2021 7 110006-
language	English
source	In Cell Reports 37(2021), 7, Seite 110006- volume:37 year:2021 number:7 pages:110006-
sourceStr	In Cell Reports 37(2021), 7, Seite 110006- volume:37 year:2021 number:7 pages:110006-
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	IgM TOSO/FAIM3 reverse transcytosis microfold cell Biology (General)
isfreeaccess_bool	true
container_title	Cell Reports
authorswithroles_txt_mv	Nicolas Rochereau @@aut@@ Eva Michaud @@aut@@ Louis Waeckel @@aut@@ Martin Killian @@aut@@ Rémi Gayet @@aut@@ Roman Goguyer-Deschaumes @@aut@@ Xavier Roblin @@aut@@ Gilles Biolley @@aut@@ Blaise Corthésy @@aut@@ Stéphane Paul @@aut@@
publishDateDaySort_date	2021-01-01T00:00:00Z
hierarchy_top_id	684964562
id	DOAJ06311674X
language_de	englisch
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callnumber-first	Q - Science
author	Nicolas Rochereau
spellingShingle	Nicolas Rochereau misc QH301-705.5 misc IgM misc TOSO/FAIM3 misc reverse transcytosis misc microfold cell misc Biology (General) Essential role of TOSO/FAIM3 in intestinal IgM reverse transcytosis
authorStr	Nicolas Rochereau
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topic_title	QH301-705.5 Essential role of TOSO/FAIM3 in intestinal IgM reverse transcytosis IgM TOSO/FAIM3 reverse transcytosis microfold cell
topic	misc QH301-705.5 misc IgM misc TOSO/FAIM3 misc reverse transcytosis misc microfold cell misc Biology (General)
topic_unstemmed	misc QH301-705.5 misc IgM misc TOSO/FAIM3 misc reverse transcytosis misc microfold cell misc Biology (General)
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title	Essential role of TOSO/FAIM3 in intestinal IgM reverse transcytosis
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title_full	Essential role of TOSO/FAIM3 in intestinal IgM reverse transcytosis
author_sort	Nicolas Rochereau
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author_browse	Nicolas Rochereau Eva Michaud Louis Waeckel Martin Killian Rémi Gayet Roman Goguyer-Deschaumes Xavier Roblin Gilles Biolley Blaise Corthésy Stéphane Paul
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author-letter	Nicolas Rochereau
doi_str_mv	10.1016/j.celrep.2021.110006
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title_sort	essential role of toso/faim3 in intestinal igm reverse transcytosis
callnumber	QH301-705.5
title_auth	Essential role of TOSO/FAIM3 in intestinal IgM reverse transcytosis
abstract	Summary: Secretory immunoglobulin A (SIgA) can travel to and from the lumen and transport antigen to subepithelial cells. However, IgM can also multimerize into functional secretory component-bound immunoglobulin. While it is already known that both SIgA and SIgM undergo transcytosis to be secreted at the mucosal surface, only SIgA has been shown to perform retrotranscytosis through microfold cells (M cells) of the Peyer’s patch. Here, we investigate whether SIgM could also be taken up by M cells via retrotranscytosis. This transport involves FcμR binding at the apical membrane of M cells. We then demonstrate that SIgM can be exploited by SIgM-p24 (HIV-capsid protein) complexes during immunization in the nasal- or gut-associated lymphoid tissue (NALT or GALT), conferring efficient immune responses against p24. Our data demonstrate a mucosal function of SIgM, which could play a role in the regulation of mucosal immunity.
abstractGer	Summary: Secretory immunoglobulin A (SIgA) can travel to and from the lumen and transport antigen to subepithelial cells. However, IgM can also multimerize into functional secretory component-bound immunoglobulin. While it is already known that both SIgA and SIgM undergo transcytosis to be secreted at the mucosal surface, only SIgA has been shown to perform retrotranscytosis through microfold cells (M cells) of the Peyer’s patch. Here, we investigate whether SIgM could also be taken up by M cells via retrotranscytosis. This transport involves FcμR binding at the apical membrane of M cells. We then demonstrate that SIgM can be exploited by SIgM-p24 (HIV-capsid protein) complexes during immunization in the nasal- or gut-associated lymphoid tissue (NALT or GALT), conferring efficient immune responses against p24. Our data demonstrate a mucosal function of SIgM, which could play a role in the regulation of mucosal immunity.
abstract_unstemmed	Summary: Secretory immunoglobulin A (SIgA) can travel to and from the lumen and transport antigen to subepithelial cells. However, IgM can also multimerize into functional secretory component-bound immunoglobulin. While it is already known that both SIgA and SIgM undergo transcytosis to be secreted at the mucosal surface, only SIgA has been shown to perform retrotranscytosis through microfold cells (M cells) of the Peyer’s patch. Here, we investigate whether SIgM could also be taken up by M cells via retrotranscytosis. This transport involves FcμR binding at the apical membrane of M cells. We then demonstrate that SIgM can be exploited by SIgM-p24 (HIV-capsid protein) complexes during immunization in the nasal- or gut-associated lymphoid tissue (NALT or GALT), conferring efficient immune responses against p24. Our data demonstrate a mucosal function of SIgM, which could play a role in the regulation of mucosal immunity.
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container_issue	7
title_short	Essential role of TOSO/FAIM3 in intestinal IgM reverse transcytosis
url	https://doi.org/10.1016/j.celrep.2021.110006 https://doaj.org/article/1c0d9dd7c688430d9d5f4ebbadbdf92f http://www.sciencedirect.com/science/article/pii/S2211124721014844 https://doaj.org/toc/2211-1247
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up_date	2024-07-03T15:55:55.740Z
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Essential role of TOSO/FAIM3 in intestinal IgM reverse transcytosis

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