Amphiphilic nanocarrier-induced modulation of PLK1 and miR-34a leads to improved therapeutic response in pancreatic cancer

Treatment of pancreatic ductal adenocarcinoma is still challenging and patients survival has only marginally improved in the last decade. Here the authors produce a PGA-based polymeric nanocarrier for the dual delivery of miR-34a-mimic and PLK1-targeting siRNA resulting in killing of pancreatic canc...
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Autor*in:	Hadas Gibori [verfasserIn] Shay Eliyahu [verfasserIn] Adva Krivitsky [verfasserIn] Dikla Ben-Shushan [verfasserIn] Yana Epshtein [verfasserIn] Galia Tiram [verfasserIn] Rachel Blau [verfasserIn] Paula Ofek [verfasserIn] Joo Sang Lee [verfasserIn] Eytan Ruppin [verfasserIn] Limor Landsman [verfasserIn] Iris Barshack [verfasserIn] Talia Golan [verfasserIn] Emmanuelle Merquiol [verfasserIn] Galia Blum [verfasserIn] Ronit Satchi-Fainaro [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2018

Übergeordnetes Werk:	In: Nature Communications - Nature Portfolio, 2016, 9(2018), 1, Seite 18
Übergeordnetes Werk:	volume:9 ; year:2018 ; number:1 ; pages:18

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1038/s41467-017-02283-9

Katalog-ID:	DOAJ063142937

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spelling	10.1038/s41467-017-02283-9 doi (DE-627)DOAJ063142937 (DE-599)DOAJ9f5041d02f9946eea0f19af66fa313d8 DE-627 ger DE-627 rakwb eng Hadas Gibori verfasserin aut Amphiphilic nanocarrier-induced modulation of PLK1 and miR-34a leads to improved therapeutic response in pancreatic cancer 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Treatment of pancreatic ductal adenocarcinoma is still challenging and patients survival has only marginally improved in the last decade. Here the authors produce a PGA-based polymeric nanocarrier for the dual delivery of miR-34a-mimic and PLK1-targeting siRNA resulting in killing of pancreatic cancer cells in vivo. Science Q Shay Eliyahu verfasserin aut Adva Krivitsky verfasserin aut Dikla Ben-Shushan verfasserin aut Yana Epshtein verfasserin aut Galia Tiram verfasserin aut Rachel Blau verfasserin aut Paula Ofek verfasserin aut Joo Sang Lee verfasserin aut Eytan Ruppin verfasserin aut Limor Landsman verfasserin aut Iris Barshack verfasserin aut Talia Golan verfasserin aut Emmanuelle Merquiol verfasserin aut Galia Blum verfasserin aut Ronit Satchi-Fainaro verfasserin aut In Nature Communications Nature Portfolio, 2016 9(2018), 1, Seite 18 (DE-627)626457688 (DE-600)2553671-0 20411723 nnns volume:9 year:2018 number:1 pages:18 https://doi.org/10.1038/s41467-017-02283-9 kostenfrei https://doaj.org/article/9f5041d02f9946eea0f19af66fa313d8 kostenfrei https://doi.org/10.1038/s41467-017-02283-9 kostenfrei https://doaj.org/toc/2041-1723 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_211 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2110 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2018 1 18
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allfieldsGer	10.1038/s41467-017-02283-9 doi (DE-627)DOAJ063142937 (DE-599)DOAJ9f5041d02f9946eea0f19af66fa313d8 DE-627 ger DE-627 rakwb eng Hadas Gibori verfasserin aut Amphiphilic nanocarrier-induced modulation of PLK1 and miR-34a leads to improved therapeutic response in pancreatic cancer 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Treatment of pancreatic ductal adenocarcinoma is still challenging and patients survival has only marginally improved in the last decade. Here the authors produce a PGA-based polymeric nanocarrier for the dual delivery of miR-34a-mimic and PLK1-targeting siRNA resulting in killing of pancreatic cancer cells in vivo. Science Q Shay Eliyahu verfasserin aut Adva Krivitsky verfasserin aut Dikla Ben-Shushan verfasserin aut Yana Epshtein verfasserin aut Galia Tiram verfasserin aut Rachel Blau verfasserin aut Paula Ofek verfasserin aut Joo Sang Lee verfasserin aut Eytan Ruppin verfasserin aut Limor Landsman verfasserin aut Iris Barshack verfasserin aut Talia Golan verfasserin aut Emmanuelle Merquiol verfasserin aut Galia Blum verfasserin aut Ronit Satchi-Fainaro verfasserin aut In Nature Communications Nature Portfolio, 2016 9(2018), 1, Seite 18 (DE-627)626457688 (DE-600)2553671-0 20411723 nnns volume:9 year:2018 number:1 pages:18 https://doi.org/10.1038/s41467-017-02283-9 kostenfrei https://doaj.org/article/9f5041d02f9946eea0f19af66fa313d8 kostenfrei https://doi.org/10.1038/s41467-017-02283-9 kostenfrei https://doaj.org/toc/2041-1723 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_211 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2110 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2018 1 18
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source	In Nature Communications 9(2018), 1, Seite 18 volume:9 year:2018 number:1 pages:18
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authorswithroles_txt_mv	Hadas Gibori @@aut@@ Shay Eliyahu @@aut@@ Adva Krivitsky @@aut@@ Dikla Ben-Shushan @@aut@@ Yana Epshtein @@aut@@ Galia Tiram @@aut@@ Rachel Blau @@aut@@ Paula Ofek @@aut@@ Joo Sang Lee @@aut@@ Eytan Ruppin @@aut@@ Limor Landsman @@aut@@ Iris Barshack @@aut@@ Talia Golan @@aut@@ Emmanuelle Merquiol @@aut@@ Galia Blum @@aut@@ Ronit Satchi-Fainaro @@aut@@
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author	Hadas Gibori
spellingShingle	Hadas Gibori misc Science misc Q Amphiphilic nanocarrier-induced modulation of PLK1 and miR-34a leads to improved therapeutic response in pancreatic cancer
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topic_title	Amphiphilic nanocarrier-induced modulation of PLK1 and miR-34a leads to improved therapeutic response in pancreatic cancer
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title	Amphiphilic nanocarrier-induced modulation of PLK1 and miR-34a leads to improved therapeutic response in pancreatic cancer
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title_full	Amphiphilic nanocarrier-induced modulation of PLK1 and miR-34a leads to improved therapeutic response in pancreatic cancer
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author_browse	Hadas Gibori Shay Eliyahu Adva Krivitsky Dikla Ben-Shushan Yana Epshtein Galia Tiram Rachel Blau Paula Ofek Joo Sang Lee Eytan Ruppin Limor Landsman Iris Barshack Talia Golan Emmanuelle Merquiol Galia Blum Ronit Satchi-Fainaro
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title_sort	amphiphilic nanocarrier-induced modulation of plk1 and mir-34a leads to improved therapeutic response in pancreatic cancer
title_auth	Amphiphilic nanocarrier-induced modulation of PLK1 and miR-34a leads to improved therapeutic response in pancreatic cancer
abstract	Treatment of pancreatic ductal adenocarcinoma is still challenging and patients survival has only marginally improved in the last decade. Here the authors produce a PGA-based polymeric nanocarrier for the dual delivery of miR-34a-mimic and PLK1-targeting siRNA resulting in killing of pancreatic cancer cells in vivo.
abstractGer	Treatment of pancreatic ductal adenocarcinoma is still challenging and patients survival has only marginally improved in the last decade. Here the authors produce a PGA-based polymeric nanocarrier for the dual delivery of miR-34a-mimic and PLK1-targeting siRNA resulting in killing of pancreatic cancer cells in vivo.
abstract_unstemmed	Treatment of pancreatic ductal adenocarcinoma is still challenging and patients survival has only marginally improved in the last decade. Here the authors produce a PGA-based polymeric nanocarrier for the dual delivery of miR-34a-mimic and PLK1-targeting siRNA resulting in killing of pancreatic cancer cells in vivo.
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title_short	Amphiphilic nanocarrier-induced modulation of PLK1 and miR-34a leads to improved therapeutic response in pancreatic cancer
url	https://doi.org/10.1038/s41467-017-02283-9 https://doaj.org/article/9f5041d02f9946eea0f19af66fa313d8 https://doaj.org/toc/2041-1723
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author2	Shay Eliyahu Adva Krivitsky Dikla Ben-Shushan Yana Epshtein Galia Tiram Rachel Blau Paula Ofek Joo Sang Lee Eytan Ruppin Limor Landsman Iris Barshack Talia Golan Emmanuelle Merquiol Galia Blum Ronit Satchi-Fainaro
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up_date	2024-07-03T16:04:29.570Z
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