The pandemic (H1N1) 2009 influenza virus is resistant to mannose-binding lectin

<p<Abstract</p< <p<Background</p< <p<Mannose-binding lectin (MBL) is an important component of innate immunity because it promotes bacterial clearance and neutralization of human influenza A viruses. Since a majority of humans have no neutralizing antibody against the p...
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Autor*in:	Ushirogawa Hiroshi [verfasserIn] Tokunaga Hirotoshi [verfasserIn] Ohuchi Masanobu [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2011

Übergeordnetes Werk:	In: Virology Journal - BMC, 2004, 8(2011), 1, p 50
Übergeordnetes Werk:	volume:8 ; year:2011 ; number:1, p 50

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1186/1743-422X-8-50

Katalog-ID:	DOAJ063320762

Internformat


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matchkey_str	article:1743422X:2011----::hpneihn20ifunaiuirssatoa
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allfields	10.1186/1743-422X-8-50 doi (DE-627)DOAJ063320762 (DE-599)DOAJf1fe3e73640740c2b27f3c28bb66fa6f DE-627 ger DE-627 rakwb eng RC109-216 Ushirogawa Hiroshi verfasserin aut The pandemic (H1N1) 2009 influenza virus is resistant to mannose-binding lectin 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<Mannose-binding lectin (MBL) is an important component of innate immunity because it promotes bacterial clearance and neutralization of human influenza A viruses. Since a majority of humans have no neutralizing antibody against the pandemic (H1N1) 2009 influenza (pandemic 2009) virus, innate immunity may be crucial and MBL susceptibility may therefore influence viral pathogenesis.</p< <p<Results</p< <p<We examined MBL susceptibility of influenza A viruses and observed that the pandemic 2009 virus was resistant to MBL, whereas all seasonal influenza A viruses tested were susceptible. The mortality of mice infected with a seasonal H1N1 influenza virus was evidently enhanced on transient blockage of MBL activity by simultaneous inoculation of mannan, whereas mannan inoculation had no effect on mice infected with a pandemic 2009 virus. This indicates that MBL protects mice against infection with the seasonal virus but not against that with the pandemic 2009 virus.</p< <p<Conclusions</p< <p<These results indicate that the pandemic 2009 virus is not susceptible to MBL, an important component of innate immunity.</p< Infectious and parasitic diseases Tokunaga Hirotoshi verfasserin aut Ohuchi Masanobu verfasserin aut In Virology Journal BMC, 2004 8(2011), 1, p 50 (DE-627)394165004 (DE-600)2160640-7 1743422X nnns volume:8 year:2011 number:1, p 50 https://doi.org/10.1186/1743-422X-8-50 kostenfrei https://doaj.org/article/f1fe3e73640740c2b27f3c28bb66fa6f kostenfrei http://www.virologyj.com/content/8/1/50 kostenfrei https://doaj.org/toc/1743-422X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2011 1, p 50
spelling	10.1186/1743-422X-8-50 doi (DE-627)DOAJ063320762 (DE-599)DOAJf1fe3e73640740c2b27f3c28bb66fa6f DE-627 ger DE-627 rakwb eng RC109-216 Ushirogawa Hiroshi verfasserin aut The pandemic (H1N1) 2009 influenza virus is resistant to mannose-binding lectin 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<Mannose-binding lectin (MBL) is an important component of innate immunity because it promotes bacterial clearance and neutralization of human influenza A viruses. Since a majority of humans have no neutralizing antibody against the pandemic (H1N1) 2009 influenza (pandemic 2009) virus, innate immunity may be crucial and MBL susceptibility may therefore influence viral pathogenesis.</p< <p<Results</p< <p<We examined MBL susceptibility of influenza A viruses and observed that the pandemic 2009 virus was resistant to MBL, whereas all seasonal influenza A viruses tested were susceptible. The mortality of mice infected with a seasonal H1N1 influenza virus was evidently enhanced on transient blockage of MBL activity by simultaneous inoculation of mannan, whereas mannan inoculation had no effect on mice infected with a pandemic 2009 virus. This indicates that MBL protects mice against infection with the seasonal virus but not against that with the pandemic 2009 virus.</p< <p<Conclusions</p< <p<These results indicate that the pandemic 2009 virus is not susceptible to MBL, an important component of innate immunity.</p< Infectious and parasitic diseases Tokunaga Hirotoshi verfasserin aut Ohuchi Masanobu verfasserin aut In Virology Journal BMC, 2004 8(2011), 1, p 50 (DE-627)394165004 (DE-600)2160640-7 1743422X nnns volume:8 year:2011 number:1, p 50 https://doi.org/10.1186/1743-422X-8-50 kostenfrei https://doaj.org/article/f1fe3e73640740c2b27f3c28bb66fa6f kostenfrei http://www.virologyj.com/content/8/1/50 kostenfrei https://doaj.org/toc/1743-422X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2011 1, p 50
allfields_unstemmed	10.1186/1743-422X-8-50 doi (DE-627)DOAJ063320762 (DE-599)DOAJf1fe3e73640740c2b27f3c28bb66fa6f DE-627 ger DE-627 rakwb eng RC109-216 Ushirogawa Hiroshi verfasserin aut The pandemic (H1N1) 2009 influenza virus is resistant to mannose-binding lectin 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<Mannose-binding lectin (MBL) is an important component of innate immunity because it promotes bacterial clearance and neutralization of human influenza A viruses. Since a majority of humans have no neutralizing antibody against the pandemic (H1N1) 2009 influenza (pandemic 2009) virus, innate immunity may be crucial and MBL susceptibility may therefore influence viral pathogenesis.</p< <p<Results</p< <p<We examined MBL susceptibility of influenza A viruses and observed that the pandemic 2009 virus was resistant to MBL, whereas all seasonal influenza A viruses tested were susceptible. The mortality of mice infected with a seasonal H1N1 influenza virus was evidently enhanced on transient blockage of MBL activity by simultaneous inoculation of mannan, whereas mannan inoculation had no effect on mice infected with a pandemic 2009 virus. This indicates that MBL protects mice against infection with the seasonal virus but not against that with the pandemic 2009 virus.</p< <p<Conclusions</p< <p<These results indicate that the pandemic 2009 virus is not susceptible to MBL, an important component of innate immunity.</p< Infectious and parasitic diseases Tokunaga Hirotoshi verfasserin aut Ohuchi Masanobu verfasserin aut In Virology Journal BMC, 2004 8(2011), 1, p 50 (DE-627)394165004 (DE-600)2160640-7 1743422X nnns volume:8 year:2011 number:1, p 50 https://doi.org/10.1186/1743-422X-8-50 kostenfrei https://doaj.org/article/f1fe3e73640740c2b27f3c28bb66fa6f kostenfrei http://www.virologyj.com/content/8/1/50 kostenfrei https://doaj.org/toc/1743-422X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2011 1, p 50
allfieldsGer	10.1186/1743-422X-8-50 doi (DE-627)DOAJ063320762 (DE-599)DOAJf1fe3e73640740c2b27f3c28bb66fa6f DE-627 ger DE-627 rakwb eng RC109-216 Ushirogawa Hiroshi verfasserin aut The pandemic (H1N1) 2009 influenza virus is resistant to mannose-binding lectin 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<Mannose-binding lectin (MBL) is an important component of innate immunity because it promotes bacterial clearance and neutralization of human influenza A viruses. Since a majority of humans have no neutralizing antibody against the pandemic (H1N1) 2009 influenza (pandemic 2009) virus, innate immunity may be crucial and MBL susceptibility may therefore influence viral pathogenesis.</p< <p<Results</p< <p<We examined MBL susceptibility of influenza A viruses and observed that the pandemic 2009 virus was resistant to MBL, whereas all seasonal influenza A viruses tested were susceptible. The mortality of mice infected with a seasonal H1N1 influenza virus was evidently enhanced on transient blockage of MBL activity by simultaneous inoculation of mannan, whereas mannan inoculation had no effect on mice infected with a pandemic 2009 virus. This indicates that MBL protects mice against infection with the seasonal virus but not against that with the pandemic 2009 virus.</p< <p<Conclusions</p< <p<These results indicate that the pandemic 2009 virus is not susceptible to MBL, an important component of innate immunity.</p< Infectious and parasitic diseases Tokunaga Hirotoshi verfasserin aut Ohuchi Masanobu verfasserin aut In Virology Journal BMC, 2004 8(2011), 1, p 50 (DE-627)394165004 (DE-600)2160640-7 1743422X nnns volume:8 year:2011 number:1, p 50 https://doi.org/10.1186/1743-422X-8-50 kostenfrei https://doaj.org/article/f1fe3e73640740c2b27f3c28bb66fa6f kostenfrei http://www.virologyj.com/content/8/1/50 kostenfrei https://doaj.org/toc/1743-422X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2011 1, p 50
allfieldsSound	10.1186/1743-422X-8-50 doi (DE-627)DOAJ063320762 (DE-599)DOAJf1fe3e73640740c2b27f3c28bb66fa6f DE-627 ger DE-627 rakwb eng RC109-216 Ushirogawa Hiroshi verfasserin aut The pandemic (H1N1) 2009 influenza virus is resistant to mannose-binding lectin 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<Mannose-binding lectin (MBL) is an important component of innate immunity because it promotes bacterial clearance and neutralization of human influenza A viruses. Since a majority of humans have no neutralizing antibody against the pandemic (H1N1) 2009 influenza (pandemic 2009) virus, innate immunity may be crucial and MBL susceptibility may therefore influence viral pathogenesis.</p< <p<Results</p< <p<We examined MBL susceptibility of influenza A viruses and observed that the pandemic 2009 virus was resistant to MBL, whereas all seasonal influenza A viruses tested were susceptible. The mortality of mice infected with a seasonal H1N1 influenza virus was evidently enhanced on transient blockage of MBL activity by simultaneous inoculation of mannan, whereas mannan inoculation had no effect on mice infected with a pandemic 2009 virus. This indicates that MBL protects mice against infection with the seasonal virus but not against that with the pandemic 2009 virus.</p< <p<Conclusions</p< <p<These results indicate that the pandemic 2009 virus is not susceptible to MBL, an important component of innate immunity.</p< Infectious and parasitic diseases Tokunaga Hirotoshi verfasserin aut Ohuchi Masanobu verfasserin aut In Virology Journal BMC, 2004 8(2011), 1, p 50 (DE-627)394165004 (DE-600)2160640-7 1743422X nnns volume:8 year:2011 number:1, p 50 https://doi.org/10.1186/1743-422X-8-50 kostenfrei https://doaj.org/article/f1fe3e73640740c2b27f3c28bb66fa6f kostenfrei http://www.virologyj.com/content/8/1/50 kostenfrei https://doaj.org/toc/1743-422X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2011 1, p 50
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callnumber-first	R - Medicine
author	Ushirogawa Hiroshi
spellingShingle	Ushirogawa Hiroshi misc RC109-216 misc Infectious and parasitic diseases The pandemic (H1N1) 2009 influenza virus is resistant to mannose-binding lectin
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topic_title	RC109-216 The pandemic (H1N1) 2009 influenza virus is resistant to mannose-binding lectin
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title	The pandemic (H1N1) 2009 influenza virus is resistant to mannose-binding lectin
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title_full	The pandemic (H1N1) 2009 influenza virus is resistant to mannose-binding lectin
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author_browse	Ushirogawa Hiroshi Tokunaga Hirotoshi Ohuchi Masanobu
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author-letter	Ushirogawa Hiroshi
doi_str_mv	10.1186/1743-422X-8-50
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title_sort	pandemic (h1n1) 2009 influenza virus is resistant to mannose-binding lectin
callnumber	RC109-216
title_auth	The pandemic (H1N1) 2009 influenza virus is resistant to mannose-binding lectin
abstract	<p<Abstract</p< <p<Background</p< <p<Mannose-binding lectin (MBL) is an important component of innate immunity because it promotes bacterial clearance and neutralization of human influenza A viruses. Since a majority of humans have no neutralizing antibody against the pandemic (H1N1) 2009 influenza (pandemic 2009) virus, innate immunity may be crucial and MBL susceptibility may therefore influence viral pathogenesis.</p< <p<Results</p< <p<We examined MBL susceptibility of influenza A viruses and observed that the pandemic 2009 virus was resistant to MBL, whereas all seasonal influenza A viruses tested were susceptible. The mortality of mice infected with a seasonal H1N1 influenza virus was evidently enhanced on transient blockage of MBL activity by simultaneous inoculation of mannan, whereas mannan inoculation had no effect on mice infected with a pandemic 2009 virus. This indicates that MBL protects mice against infection with the seasonal virus but not against that with the pandemic 2009 virus.</p< <p<Conclusions</p< <p<These results indicate that the pandemic 2009 virus is not susceptible to MBL, an important component of innate immunity.</p<
abstractGer	<p<Abstract</p< <p<Background</p< <p<Mannose-binding lectin (MBL) is an important component of innate immunity because it promotes bacterial clearance and neutralization of human influenza A viruses. Since a majority of humans have no neutralizing antibody against the pandemic (H1N1) 2009 influenza (pandemic 2009) virus, innate immunity may be crucial and MBL susceptibility may therefore influence viral pathogenesis.</p< <p<Results</p< <p<We examined MBL susceptibility of influenza A viruses and observed that the pandemic 2009 virus was resistant to MBL, whereas all seasonal influenza A viruses tested were susceptible. The mortality of mice infected with a seasonal H1N1 influenza virus was evidently enhanced on transient blockage of MBL activity by simultaneous inoculation of mannan, whereas mannan inoculation had no effect on mice infected with a pandemic 2009 virus. This indicates that MBL protects mice against infection with the seasonal virus but not against that with the pandemic 2009 virus.</p< <p<Conclusions</p< <p<These results indicate that the pandemic 2009 virus is not susceptible to MBL, an important component of innate immunity.</p<
abstract_unstemmed	<p<Abstract</p< <p<Background</p< <p<Mannose-binding lectin (MBL) is an important component of innate immunity because it promotes bacterial clearance and neutralization of human influenza A viruses. Since a majority of humans have no neutralizing antibody against the pandemic (H1N1) 2009 influenza (pandemic 2009) virus, innate immunity may be crucial and MBL susceptibility may therefore influence viral pathogenesis.</p< <p<Results</p< <p<We examined MBL susceptibility of influenza A viruses and observed that the pandemic 2009 virus was resistant to MBL, whereas all seasonal influenza A viruses tested were susceptible. The mortality of mice infected with a seasonal H1N1 influenza virus was evidently enhanced on transient blockage of MBL activity by simultaneous inoculation of mannan, whereas mannan inoculation had no effect on mice infected with a pandemic 2009 virus. This indicates that MBL protects mice against infection with the seasonal virus but not against that with the pandemic 2009 virus.</p< <p<Conclusions</p< <p<These results indicate that the pandemic 2009 virus is not susceptible to MBL, an important component of innate immunity.</p<
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title_short	The pandemic (H1N1) 2009 influenza virus is resistant to mannose-binding lectin
url	https://doi.org/10.1186/1743-422X-8-50 https://doaj.org/article/f1fe3e73640740c2b27f3c28bb66fa6f http://www.virologyj.com/content/8/1/50 https://doaj.org/toc/1743-422X
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up_date	2024-07-03T17:02:59.037Z
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Since a majority of humans have no neutralizing antibody against the pandemic (H1N1) 2009 influenza (pandemic 2009) virus, innate immunity may be crucial and MBL susceptibility may therefore influence viral pathogenesis.</p< <p<Results</p< <p<We examined MBL susceptibility of influenza A viruses and observed that the pandemic 2009 virus was resistant to MBL, whereas all seasonal influenza A viruses tested were susceptible. The mortality of mice infected with a seasonal H1N1 influenza virus was evidently enhanced on transient blockage of MBL activity by simultaneous inoculation of mannan, whereas mannan inoculation had no effect on mice infected with a pandemic 2009 virus. 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The pandemic (H1N1) 2009 influenza virus is resistant to mannose-binding lectin

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