Protective Effect of Mangosteen Skin Extract on Albino Mice Skin with Dimethyl-Benz(a)anthracene (DMBA) Induction: Analysis on p53 Protein Level
Introduction: Skin cancer is the most common type of malignancy in humans with a dramatic incidence increase in the past decade. One of the genes that may play a role in carcinogenesis is p53 gene. Mangosteen skin extract contains xanthone derivatives, such as α-, β-, and γ-mangostins, which are...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Dyah Pratiwi Purnaningsih [verfasserIn] Khairuddin Djawad [verfasserIn] Siswanto Wahab [verfasserIn] Nasrum Massi [verfasserIn] Gemini Alam [verfasserIn] Burhanuddin Bahar [verfasserIn] |
|---|
| Format: |
E-Artikel |
|---|---|
| Sprache: |
Englisch ; Portugiesisch |
| Erschienen: |
2019 |
|---|
| Schlagwörter: |
|---|
| Übergeordnetes Werk: |
In: International Journal of Medical Reviews and Case Reports - International Sci Ink Press Ltd, 2018, 3(2019), 5 |
|---|---|
| Übergeordnetes Werk: |
volume:3 ; year:2019 ; number:5 |
| Links: |
Link aufrufen |
|---|
| DOI / URN: |
10.5455/IJMRCR.mangosteen-skin-extract-dmba |
|---|
| Katalog-ID: |
DOAJ063362945 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | DOAJ063362945 | ||
| 003 | DE-627 | ||
| 005 | 20230502203627.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 230228s2019 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.5455/IJMRCR.mangosteen-skin-extract-dmba |2 doi | |
| 035 | |a (DE-627)DOAJ063362945 | ||
| 035 | |a (DE-599)DOAJ25ae995736dc438c9d7772788ee4a7fa | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng |a por | ||
| 100 | 0 | |a Dyah Pratiwi Purnaningsih |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Protective Effect of Mangosteen Skin Extract on Albino Mice Skin with Dimethyl-Benz(a)anthracene (DMBA) Induction: Analysis on p53 Protein Level |
| 264 | 1 | |c 2019 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 520 | |a Introduction: Skin cancer is the most common type of malignancy in humans with a dramatic incidence increase in the past decade. One of the genes that may play a role in carcinogenesis is p53 gene. Mangosteen skin extract contains xanthone derivatives, such as α-, β-, and γ-mangostins, which are known to possess anticancer property. Despite its well documented use in other types of carcinoma, its effect in skin tumor carcinogenesis is still unknown. Method: This experimental study was done in 30 mice randomly assigned into groups receiving different treatments. The positive control group received Dimethyl-Benz(a)anthracene (DMBA), a potent carcinogen, induction while the treatment groups received mangosteen skin extract with 100, 200, and 400 ppm concentrations. The protein p53 level from skin tumor in each mouse was assessed using ELISA. Result: Protein p53 level was highest in the positive control group while the lowest value was shown by the group with 100 ppm extract application. One-way ANOVA test showed a significant difference across groups (p=0.000). Least significant difference post-hoc analysis showed a significantly lower protein p53 levels of both 100 ppm and 400 ppm mangosteen skin extract compared to the DMBA control group (p=0.000). Conclusion: This study showed that topical application of mangosteen skin extract provided protective effect to skin tumor in mice, possibly through its antioxidant effects. This finding may expand potential future therapeutic options in treating skin cancers. | ||
| 650 | 4 | |a DMBA | |
| 650 | 4 | |a mangosteen skin extract | |
| 650 | 4 | |a p53 | |
| 650 | 4 | |a skin cancer | |
| 653 | 0 | |a Medicine | |
| 653 | 0 | |a R | |
| 700 | 0 | |a Khairuddin Djawad |e verfasserin |4 aut | |
| 700 | 0 | |a Siswanto Wahab |e verfasserin |4 aut | |
| 700 | 0 | |a Nasrum Massi |e verfasserin |4 aut | |
| 700 | 0 | |a Gemini Alam |e verfasserin |4 aut | |
| 700 | 0 | |a Burhanuddin Bahar |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i In |t International Journal of Medical Reviews and Case Reports |d International Sci Ink Press Ltd, 2018 |g 3(2019), 5 |w (DE-627)1760646792 |x 25349821 |7 nnns |
| 773 | 1 | 8 | |g volume:3 |g year:2019 |g number:5 |
| 856 | 4 | 0 | |u https://doi.org/10.5455/IJMRCR.mangosteen-skin-extract-dmba |z kostenfrei |
| 856 | 4 | 0 | |u https://doaj.org/article/25ae995736dc438c9d7772788ee4a7fa |z kostenfrei |
| 856 | 4 | 0 | |u http://www.ejmanager.com/fulltextpdf.php?mno=20988 |z kostenfrei |
| 856 | 4 | 2 | |u https://doaj.org/toc/2534-9821 |y Journal toc |z kostenfrei |
| 856 | 4 | 2 | |u https://doaj.org/toc/2534-9821 |y Journal toc |z kostenfrei |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a SYSFLAG_A | ||
| 912 | |a GBV_DOAJ | ||
| 912 | |a SSG-OLC-PHA | ||
| 951 | |a AR | ||
| 952 | |d 3 |j 2019 |e 5 | ||
| author_variant |
d p p dpp k d kd s w sw n m nm g a ga b b bb |
|---|---|
| matchkey_str |
article:25349821:2019----::rtciefetfagsenknxrcoabnmcsiwtdmtybnanhaeemanu |
| hierarchy_sort_str |
2019 |
| publishDate |
2019 |
| allfields |
10.5455/IJMRCR.mangosteen-skin-extract-dmba doi (DE-627)DOAJ063362945 (DE-599)DOAJ25ae995736dc438c9d7772788ee4a7fa DE-627 ger DE-627 rakwb eng por Dyah Pratiwi Purnaningsih verfasserin aut Protective Effect of Mangosteen Skin Extract on Albino Mice Skin with Dimethyl-Benz(a)anthracene (DMBA) Induction: Analysis on p53 Protein Level 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: Skin cancer is the most common type of malignancy in humans with a dramatic incidence increase in the past decade. One of the genes that may play a role in carcinogenesis is p53 gene. Mangosteen skin extract contains xanthone derivatives, such as α-, β-, and γ-mangostins, which are known to possess anticancer property. Despite its well documented use in other types of carcinoma, its effect in skin tumor carcinogenesis is still unknown. Method: This experimental study was done in 30 mice randomly assigned into groups receiving different treatments. The positive control group received Dimethyl-Benz(a)anthracene (DMBA), a potent carcinogen, induction while the treatment groups received mangosteen skin extract with 100, 200, and 400 ppm concentrations. The protein p53 level from skin tumor in each mouse was assessed using ELISA. Result: Protein p53 level was highest in the positive control group while the lowest value was shown by the group with 100 ppm extract application. One-way ANOVA test showed a significant difference across groups (p=0.000). Least significant difference post-hoc analysis showed a significantly lower protein p53 levels of both 100 ppm and 400 ppm mangosteen skin extract compared to the DMBA control group (p=0.000). Conclusion: This study showed that topical application of mangosteen skin extract provided protective effect to skin tumor in mice, possibly through its antioxidant effects. This finding may expand potential future therapeutic options in treating skin cancers. DMBA mangosteen skin extract p53 skin cancer Medicine R Khairuddin Djawad verfasserin aut Siswanto Wahab verfasserin aut Nasrum Massi verfasserin aut Gemini Alam verfasserin aut Burhanuddin Bahar verfasserin aut In International Journal of Medical Reviews and Case Reports International Sci Ink Press Ltd, 2018 3(2019), 5 (DE-627)1760646792 25349821 nnns volume:3 year:2019 number:5 https://doi.org/10.5455/IJMRCR.mangosteen-skin-extract-dmba kostenfrei https://doaj.org/article/25ae995736dc438c9d7772788ee4a7fa kostenfrei http://www.ejmanager.com/fulltextpdf.php?mno=20988 kostenfrei https://doaj.org/toc/2534-9821 Journal toc kostenfrei https://doaj.org/toc/2534-9821 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA AR 3 2019 5 |
| spelling |
10.5455/IJMRCR.mangosteen-skin-extract-dmba doi (DE-627)DOAJ063362945 (DE-599)DOAJ25ae995736dc438c9d7772788ee4a7fa DE-627 ger DE-627 rakwb eng por Dyah Pratiwi Purnaningsih verfasserin aut Protective Effect of Mangosteen Skin Extract on Albino Mice Skin with Dimethyl-Benz(a)anthracene (DMBA) Induction: Analysis on p53 Protein Level 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: Skin cancer is the most common type of malignancy in humans with a dramatic incidence increase in the past decade. One of the genes that may play a role in carcinogenesis is p53 gene. Mangosteen skin extract contains xanthone derivatives, such as α-, β-, and γ-mangostins, which are known to possess anticancer property. Despite its well documented use in other types of carcinoma, its effect in skin tumor carcinogenesis is still unknown. Method: This experimental study was done in 30 mice randomly assigned into groups receiving different treatments. The positive control group received Dimethyl-Benz(a)anthracene (DMBA), a potent carcinogen, induction while the treatment groups received mangosteen skin extract with 100, 200, and 400 ppm concentrations. The protein p53 level from skin tumor in each mouse was assessed using ELISA. Result: Protein p53 level was highest in the positive control group while the lowest value was shown by the group with 100 ppm extract application. One-way ANOVA test showed a significant difference across groups (p=0.000). Least significant difference post-hoc analysis showed a significantly lower protein p53 levels of both 100 ppm and 400 ppm mangosteen skin extract compared to the DMBA control group (p=0.000). Conclusion: This study showed that topical application of mangosteen skin extract provided protective effect to skin tumor in mice, possibly through its antioxidant effects. This finding may expand potential future therapeutic options in treating skin cancers. DMBA mangosteen skin extract p53 skin cancer Medicine R Khairuddin Djawad verfasserin aut Siswanto Wahab verfasserin aut Nasrum Massi verfasserin aut Gemini Alam verfasserin aut Burhanuddin Bahar verfasserin aut In International Journal of Medical Reviews and Case Reports International Sci Ink Press Ltd, 2018 3(2019), 5 (DE-627)1760646792 25349821 nnns volume:3 year:2019 number:5 https://doi.org/10.5455/IJMRCR.mangosteen-skin-extract-dmba kostenfrei https://doaj.org/article/25ae995736dc438c9d7772788ee4a7fa kostenfrei http://www.ejmanager.com/fulltextpdf.php?mno=20988 kostenfrei https://doaj.org/toc/2534-9821 Journal toc kostenfrei https://doaj.org/toc/2534-9821 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA AR 3 2019 5 |
| allfields_unstemmed |
10.5455/IJMRCR.mangosteen-skin-extract-dmba doi (DE-627)DOAJ063362945 (DE-599)DOAJ25ae995736dc438c9d7772788ee4a7fa DE-627 ger DE-627 rakwb eng por Dyah Pratiwi Purnaningsih verfasserin aut Protective Effect of Mangosteen Skin Extract on Albino Mice Skin with Dimethyl-Benz(a)anthracene (DMBA) Induction: Analysis on p53 Protein Level 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: Skin cancer is the most common type of malignancy in humans with a dramatic incidence increase in the past decade. One of the genes that may play a role in carcinogenesis is p53 gene. Mangosteen skin extract contains xanthone derivatives, such as α-, β-, and γ-mangostins, which are known to possess anticancer property. Despite its well documented use in other types of carcinoma, its effect in skin tumor carcinogenesis is still unknown. Method: This experimental study was done in 30 mice randomly assigned into groups receiving different treatments. The positive control group received Dimethyl-Benz(a)anthracene (DMBA), a potent carcinogen, induction while the treatment groups received mangosteen skin extract with 100, 200, and 400 ppm concentrations. The protein p53 level from skin tumor in each mouse was assessed using ELISA. Result: Protein p53 level was highest in the positive control group while the lowest value was shown by the group with 100 ppm extract application. One-way ANOVA test showed a significant difference across groups (p=0.000). Least significant difference post-hoc analysis showed a significantly lower protein p53 levels of both 100 ppm and 400 ppm mangosteen skin extract compared to the DMBA control group (p=0.000). Conclusion: This study showed that topical application of mangosteen skin extract provided protective effect to skin tumor in mice, possibly through its antioxidant effects. This finding may expand potential future therapeutic options in treating skin cancers. DMBA mangosteen skin extract p53 skin cancer Medicine R Khairuddin Djawad verfasserin aut Siswanto Wahab verfasserin aut Nasrum Massi verfasserin aut Gemini Alam verfasserin aut Burhanuddin Bahar verfasserin aut In International Journal of Medical Reviews and Case Reports International Sci Ink Press Ltd, 2018 3(2019), 5 (DE-627)1760646792 25349821 nnns volume:3 year:2019 number:5 https://doi.org/10.5455/IJMRCR.mangosteen-skin-extract-dmba kostenfrei https://doaj.org/article/25ae995736dc438c9d7772788ee4a7fa kostenfrei http://www.ejmanager.com/fulltextpdf.php?mno=20988 kostenfrei https://doaj.org/toc/2534-9821 Journal toc kostenfrei https://doaj.org/toc/2534-9821 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA AR 3 2019 5 |
| allfieldsGer |
10.5455/IJMRCR.mangosteen-skin-extract-dmba doi (DE-627)DOAJ063362945 (DE-599)DOAJ25ae995736dc438c9d7772788ee4a7fa DE-627 ger DE-627 rakwb eng por Dyah Pratiwi Purnaningsih verfasserin aut Protective Effect of Mangosteen Skin Extract on Albino Mice Skin with Dimethyl-Benz(a)anthracene (DMBA) Induction: Analysis on p53 Protein Level 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: Skin cancer is the most common type of malignancy in humans with a dramatic incidence increase in the past decade. One of the genes that may play a role in carcinogenesis is p53 gene. Mangosteen skin extract contains xanthone derivatives, such as α-, β-, and γ-mangostins, which are known to possess anticancer property. Despite its well documented use in other types of carcinoma, its effect in skin tumor carcinogenesis is still unknown. Method: This experimental study was done in 30 mice randomly assigned into groups receiving different treatments. The positive control group received Dimethyl-Benz(a)anthracene (DMBA), a potent carcinogen, induction while the treatment groups received mangosteen skin extract with 100, 200, and 400 ppm concentrations. The protein p53 level from skin tumor in each mouse was assessed using ELISA. Result: Protein p53 level was highest in the positive control group while the lowest value was shown by the group with 100 ppm extract application. One-way ANOVA test showed a significant difference across groups (p=0.000). Least significant difference post-hoc analysis showed a significantly lower protein p53 levels of both 100 ppm and 400 ppm mangosteen skin extract compared to the DMBA control group (p=0.000). Conclusion: This study showed that topical application of mangosteen skin extract provided protective effect to skin tumor in mice, possibly through its antioxidant effects. This finding may expand potential future therapeutic options in treating skin cancers. DMBA mangosteen skin extract p53 skin cancer Medicine R Khairuddin Djawad verfasserin aut Siswanto Wahab verfasserin aut Nasrum Massi verfasserin aut Gemini Alam verfasserin aut Burhanuddin Bahar verfasserin aut In International Journal of Medical Reviews and Case Reports International Sci Ink Press Ltd, 2018 3(2019), 5 (DE-627)1760646792 25349821 nnns volume:3 year:2019 number:5 https://doi.org/10.5455/IJMRCR.mangosteen-skin-extract-dmba kostenfrei https://doaj.org/article/25ae995736dc438c9d7772788ee4a7fa kostenfrei http://www.ejmanager.com/fulltextpdf.php?mno=20988 kostenfrei https://doaj.org/toc/2534-9821 Journal toc kostenfrei https://doaj.org/toc/2534-9821 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA AR 3 2019 5 |
| allfieldsSound |
10.5455/IJMRCR.mangosteen-skin-extract-dmba doi (DE-627)DOAJ063362945 (DE-599)DOAJ25ae995736dc438c9d7772788ee4a7fa DE-627 ger DE-627 rakwb eng por Dyah Pratiwi Purnaningsih verfasserin aut Protective Effect of Mangosteen Skin Extract on Albino Mice Skin with Dimethyl-Benz(a)anthracene (DMBA) Induction: Analysis on p53 Protein Level 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: Skin cancer is the most common type of malignancy in humans with a dramatic incidence increase in the past decade. One of the genes that may play a role in carcinogenesis is p53 gene. Mangosteen skin extract contains xanthone derivatives, such as α-, β-, and γ-mangostins, which are known to possess anticancer property. Despite its well documented use in other types of carcinoma, its effect in skin tumor carcinogenesis is still unknown. Method: This experimental study was done in 30 mice randomly assigned into groups receiving different treatments. The positive control group received Dimethyl-Benz(a)anthracene (DMBA), a potent carcinogen, induction while the treatment groups received mangosteen skin extract with 100, 200, and 400 ppm concentrations. The protein p53 level from skin tumor in each mouse was assessed using ELISA. Result: Protein p53 level was highest in the positive control group while the lowest value was shown by the group with 100 ppm extract application. One-way ANOVA test showed a significant difference across groups (p=0.000). Least significant difference post-hoc analysis showed a significantly lower protein p53 levels of both 100 ppm and 400 ppm mangosteen skin extract compared to the DMBA control group (p=0.000). Conclusion: This study showed that topical application of mangosteen skin extract provided protective effect to skin tumor in mice, possibly through its antioxidant effects. This finding may expand potential future therapeutic options in treating skin cancers. DMBA mangosteen skin extract p53 skin cancer Medicine R Khairuddin Djawad verfasserin aut Siswanto Wahab verfasserin aut Nasrum Massi verfasserin aut Gemini Alam verfasserin aut Burhanuddin Bahar verfasserin aut In International Journal of Medical Reviews and Case Reports International Sci Ink Press Ltd, 2018 3(2019), 5 (DE-627)1760646792 25349821 nnns volume:3 year:2019 number:5 https://doi.org/10.5455/IJMRCR.mangosteen-skin-extract-dmba kostenfrei https://doaj.org/article/25ae995736dc438c9d7772788ee4a7fa kostenfrei http://www.ejmanager.com/fulltextpdf.php?mno=20988 kostenfrei https://doaj.org/toc/2534-9821 Journal toc kostenfrei https://doaj.org/toc/2534-9821 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA AR 3 2019 5 |
| language |
English Portuguese |
| source |
In International Journal of Medical Reviews and Case Reports 3(2019), 5 volume:3 year:2019 number:5 |
| sourceStr |
In International Journal of Medical Reviews and Case Reports 3(2019), 5 volume:3 year:2019 number:5 |
| format_phy_str_mv |
Article |
| institution |
findex.gbv.de |
| topic_facet |
DMBA mangosteen skin extract p53 skin cancer Medicine R |
| isfreeaccess_bool |
true |
| container_title |
International Journal of Medical Reviews and Case Reports |
| authorswithroles_txt_mv |
Dyah Pratiwi Purnaningsih @@aut@@ Khairuddin Djawad @@aut@@ Siswanto Wahab @@aut@@ Nasrum Massi @@aut@@ Gemini Alam @@aut@@ Burhanuddin Bahar @@aut@@ |
| publishDateDaySort_date |
2019-01-01T00:00:00Z |
| hierarchy_top_id |
1760646792 |
| id |
DOAJ063362945 |
| language_de |
englisch portugiesisch |
| fullrecord |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">DOAJ063362945</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230502203627.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230228s2019 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.5455/IJMRCR.mangosteen-skin-extract-dmba</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)DOAJ063362945</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DOAJ25ae995736dc438c9d7772788ee4a7fa</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield><subfield code="a">por</subfield></datafield><datafield tag="100" ind1="0" ind2=" "><subfield code="a">Dyah Pratiwi Purnaningsih</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Protective Effect of Mangosteen Skin Extract on Albino Mice Skin with Dimethyl-Benz(a)anthracene (DMBA) Induction: Analysis on p53 Protein Level</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2019</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Introduction: Skin cancer is the most common type of malignancy in humans with a dramatic incidence increase in the past decade. One of the genes that may play a role in carcinogenesis is p53 gene. Mangosteen skin extract contains xanthone derivatives, such as α-, β-, and γ-mangostins, which are known to possess anticancer property. Despite its well documented use in other types of carcinoma, its effect in skin tumor carcinogenesis is still unknown. Method: This experimental study was done in 30 mice randomly assigned into groups receiving different treatments. The positive control group received Dimethyl-Benz(a)anthracene (DMBA), a potent carcinogen, induction while the treatment groups received mangosteen skin extract with 100, 200, and 400 ppm concentrations. The protein p53 level from skin tumor in each mouse was assessed using ELISA. Result: Protein p53 level was highest in the positive control group while the lowest value was shown by the group with 100 ppm extract application. One-way ANOVA test showed a significant difference across groups (p=0.000). Least significant difference post-hoc analysis showed a significantly lower protein p53 levels of both 100 ppm and 400 ppm mangosteen skin extract compared to the DMBA control group (p=0.000). Conclusion: This study showed that topical application of mangosteen skin extract provided protective effect to skin tumor in mice, possibly through its antioxidant effects. This finding may expand potential future therapeutic options in treating skin cancers.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">DMBA</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">mangosteen skin extract</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">p53</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">skin cancer</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Medicine</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">R</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Khairuddin Djawad</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Siswanto Wahab</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Nasrum Massi</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Gemini Alam</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Burhanuddin Bahar</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">In</subfield><subfield code="t">International Journal of Medical Reviews and Case Reports</subfield><subfield code="d">International Sci Ink Press Ltd, 2018</subfield><subfield code="g">3(2019), 5</subfield><subfield code="w">(DE-627)1760646792</subfield><subfield code="x">25349821</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:3</subfield><subfield code="g">year:2019</subfield><subfield code="g">number:5</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doi.org/10.5455/IJMRCR.mangosteen-skin-extract-dmba</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doaj.org/article/25ae995736dc438c9d7772788ee4a7fa</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">http://www.ejmanager.com/fulltextpdf.php?mno=20988</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="u">https://doaj.org/toc/2534-9821</subfield><subfield code="y">Journal toc</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="u">https://doaj.org/toc/2534-9821</subfield><subfield code="y">Journal toc</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_DOAJ</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-PHA</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">3</subfield><subfield code="j">2019</subfield><subfield code="e">5</subfield></datafield></record></collection>
|
| author |
Dyah Pratiwi Purnaningsih |
| spellingShingle |
Dyah Pratiwi Purnaningsih misc DMBA misc mangosteen skin extract misc p53 misc skin cancer misc Medicine misc R Protective Effect of Mangosteen Skin Extract on Albino Mice Skin with Dimethyl-Benz(a)anthracene (DMBA) Induction: Analysis on p53 Protein Level |
| authorStr |
Dyah Pratiwi Purnaningsih |
| ppnlink_with_tag_str_mv |
@@773@@(DE-627)1760646792 |
| format |
electronic Article |
| delete_txt_mv |
keep |
| author_role |
aut aut aut aut aut aut |
| collection |
DOAJ |
| remote_str |
true |
| illustrated |
Not Illustrated |
| issn |
25349821 |
| topic_title |
Protective Effect of Mangosteen Skin Extract on Albino Mice Skin with Dimethyl-Benz(a)anthracene (DMBA) Induction: Analysis on p53 Protein Level DMBA mangosteen skin extract p53 skin cancer |
| topic |
misc DMBA misc mangosteen skin extract misc p53 misc skin cancer misc Medicine misc R |
| topic_unstemmed |
misc DMBA misc mangosteen skin extract misc p53 misc skin cancer misc Medicine misc R |
| topic_browse |
misc DMBA misc mangosteen skin extract misc p53 misc skin cancer misc Medicine misc R |
| format_facet |
Elektronische Aufsätze Aufsätze Elektronische Ressource |
| format_main_str_mv |
Text Zeitschrift/Artikel |
| carriertype_str_mv |
cr |
| hierarchy_parent_title |
International Journal of Medical Reviews and Case Reports |
| hierarchy_parent_id |
1760646792 |
| hierarchy_top_title |
International Journal of Medical Reviews and Case Reports |
| isfreeaccess_txt |
true |
| familylinks_str_mv |
(DE-627)1760646792 |
| title |
Protective Effect of Mangosteen Skin Extract on Albino Mice Skin with Dimethyl-Benz(a)anthracene (DMBA) Induction: Analysis on p53 Protein Level |
| ctrlnum |
(DE-627)DOAJ063362945 (DE-599)DOAJ25ae995736dc438c9d7772788ee4a7fa |
| title_full |
Protective Effect of Mangosteen Skin Extract on Albino Mice Skin with Dimethyl-Benz(a)anthracene (DMBA) Induction: Analysis on p53 Protein Level |
| author_sort |
Dyah Pratiwi Purnaningsih |
| journal |
International Journal of Medical Reviews and Case Reports |
| journalStr |
International Journal of Medical Reviews and Case Reports |
| lang_code |
eng por |
| isOA_bool |
true |
| recordtype |
marc |
| publishDateSort |
2019 |
| contenttype_str_mv |
txt |
| author_browse |
Dyah Pratiwi Purnaningsih Khairuddin Djawad Siswanto Wahab Nasrum Massi Gemini Alam Burhanuddin Bahar |
| container_volume |
3 |
| format_se |
Elektronische Aufsätze |
| author-letter |
Dyah Pratiwi Purnaningsih |
| doi_str_mv |
10.5455/IJMRCR.mangosteen-skin-extract-dmba |
| author2-role |
verfasserin |
| title_sort |
protective effect of mangosteen skin extract on albino mice skin with dimethyl-benz(a)anthracene (dmba) induction: analysis on p53 protein level |
| title_auth |
Protective Effect of Mangosteen Skin Extract on Albino Mice Skin with Dimethyl-Benz(a)anthracene (DMBA) Induction: Analysis on p53 Protein Level |
| abstract |
Introduction: Skin cancer is the most common type of malignancy in humans with a dramatic incidence increase in the past decade. One of the genes that may play a role in carcinogenesis is p53 gene. Mangosteen skin extract contains xanthone derivatives, such as α-, β-, and γ-mangostins, which are known to possess anticancer property. Despite its well documented use in other types of carcinoma, its effect in skin tumor carcinogenesis is still unknown. Method: This experimental study was done in 30 mice randomly assigned into groups receiving different treatments. The positive control group received Dimethyl-Benz(a)anthracene (DMBA), a potent carcinogen, induction while the treatment groups received mangosteen skin extract with 100, 200, and 400 ppm concentrations. The protein p53 level from skin tumor in each mouse was assessed using ELISA. Result: Protein p53 level was highest in the positive control group while the lowest value was shown by the group with 100 ppm extract application. One-way ANOVA test showed a significant difference across groups (p=0.000). Least significant difference post-hoc analysis showed a significantly lower protein p53 levels of both 100 ppm and 400 ppm mangosteen skin extract compared to the DMBA control group (p=0.000). Conclusion: This study showed that topical application of mangosteen skin extract provided protective effect to skin tumor in mice, possibly through its antioxidant effects. This finding may expand potential future therapeutic options in treating skin cancers. |
| abstractGer |
Introduction: Skin cancer is the most common type of malignancy in humans with a dramatic incidence increase in the past decade. One of the genes that may play a role in carcinogenesis is p53 gene. Mangosteen skin extract contains xanthone derivatives, such as α-, β-, and γ-mangostins, which are known to possess anticancer property. Despite its well documented use in other types of carcinoma, its effect in skin tumor carcinogenesis is still unknown. Method: This experimental study was done in 30 mice randomly assigned into groups receiving different treatments. The positive control group received Dimethyl-Benz(a)anthracene (DMBA), a potent carcinogen, induction while the treatment groups received mangosteen skin extract with 100, 200, and 400 ppm concentrations. The protein p53 level from skin tumor in each mouse was assessed using ELISA. Result: Protein p53 level was highest in the positive control group while the lowest value was shown by the group with 100 ppm extract application. One-way ANOVA test showed a significant difference across groups (p=0.000). Least significant difference post-hoc analysis showed a significantly lower protein p53 levels of both 100 ppm and 400 ppm mangosteen skin extract compared to the DMBA control group (p=0.000). Conclusion: This study showed that topical application of mangosteen skin extract provided protective effect to skin tumor in mice, possibly through its antioxidant effects. This finding may expand potential future therapeutic options in treating skin cancers. |
| abstract_unstemmed |
Introduction: Skin cancer is the most common type of malignancy in humans with a dramatic incidence increase in the past decade. One of the genes that may play a role in carcinogenesis is p53 gene. Mangosteen skin extract contains xanthone derivatives, such as α-, β-, and γ-mangostins, which are known to possess anticancer property. Despite its well documented use in other types of carcinoma, its effect in skin tumor carcinogenesis is still unknown. Method: This experimental study was done in 30 mice randomly assigned into groups receiving different treatments. The positive control group received Dimethyl-Benz(a)anthracene (DMBA), a potent carcinogen, induction while the treatment groups received mangosteen skin extract with 100, 200, and 400 ppm concentrations. The protein p53 level from skin tumor in each mouse was assessed using ELISA. Result: Protein p53 level was highest in the positive control group while the lowest value was shown by the group with 100 ppm extract application. One-way ANOVA test showed a significant difference across groups (p=0.000). Least significant difference post-hoc analysis showed a significantly lower protein p53 levels of both 100 ppm and 400 ppm mangosteen skin extract compared to the DMBA control group (p=0.000). Conclusion: This study showed that topical application of mangosteen skin extract provided protective effect to skin tumor in mice, possibly through its antioxidant effects. This finding may expand potential future therapeutic options in treating skin cancers. |
| collection_details |
GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA |
| container_issue |
5 |
| title_short |
Protective Effect of Mangosteen Skin Extract on Albino Mice Skin with Dimethyl-Benz(a)anthracene (DMBA) Induction: Analysis on p53 Protein Level |
| url |
https://doi.org/10.5455/IJMRCR.mangosteen-skin-extract-dmba https://doaj.org/article/25ae995736dc438c9d7772788ee4a7fa http://www.ejmanager.com/fulltextpdf.php?mno=20988 https://doaj.org/toc/2534-9821 |
| remote_bool |
true |
| author2 |
Khairuddin Djawad Siswanto Wahab Nasrum Massi Gemini Alam Burhanuddin Bahar |
| author2Str |
Khairuddin Djawad Siswanto Wahab Nasrum Massi Gemini Alam Burhanuddin Bahar |
| ppnlink |
1760646792 |
| mediatype_str_mv |
c |
| isOA_txt |
true |
| hochschulschrift_bool |
false |
| doi_str |
10.5455/IJMRCR.mangosteen-skin-extract-dmba |
| up_date |
2024-07-03T17:17:36.299Z |
| _version_ |
1803579090585780224 |
| fullrecord_marcxml |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">DOAJ063362945</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230502203627.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230228s2019 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.5455/IJMRCR.mangosteen-skin-extract-dmba</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)DOAJ063362945</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DOAJ25ae995736dc438c9d7772788ee4a7fa</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield><subfield code="a">por</subfield></datafield><datafield tag="100" ind1="0" ind2=" "><subfield code="a">Dyah Pratiwi Purnaningsih</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Protective Effect of Mangosteen Skin Extract on Albino Mice Skin with Dimethyl-Benz(a)anthracene (DMBA) Induction: Analysis on p53 Protein Level</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2019</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Introduction: Skin cancer is the most common type of malignancy in humans with a dramatic incidence increase in the past decade. One of the genes that may play a role in carcinogenesis is p53 gene. Mangosteen skin extract contains xanthone derivatives, such as α-, β-, and γ-mangostins, which are known to possess anticancer property. Despite its well documented use in other types of carcinoma, its effect in skin tumor carcinogenesis is still unknown. Method: This experimental study was done in 30 mice randomly assigned into groups receiving different treatments. The positive control group received Dimethyl-Benz(a)anthracene (DMBA), a potent carcinogen, induction while the treatment groups received mangosteen skin extract with 100, 200, and 400 ppm concentrations. The protein p53 level from skin tumor in each mouse was assessed using ELISA. Result: Protein p53 level was highest in the positive control group while the lowest value was shown by the group with 100 ppm extract application. One-way ANOVA test showed a significant difference across groups (p=0.000). Least significant difference post-hoc analysis showed a significantly lower protein p53 levels of both 100 ppm and 400 ppm mangosteen skin extract compared to the DMBA control group (p=0.000). Conclusion: This study showed that topical application of mangosteen skin extract provided protective effect to skin tumor in mice, possibly through its antioxidant effects. This finding may expand potential future therapeutic options in treating skin cancers.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">DMBA</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">mangosteen skin extract</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">p53</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">skin cancer</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Medicine</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">R</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Khairuddin Djawad</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Siswanto Wahab</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Nasrum Massi</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Gemini Alam</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Burhanuddin Bahar</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">In</subfield><subfield code="t">International Journal of Medical Reviews and Case Reports</subfield><subfield code="d">International Sci Ink Press Ltd, 2018</subfield><subfield code="g">3(2019), 5</subfield><subfield code="w">(DE-627)1760646792</subfield><subfield code="x">25349821</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:3</subfield><subfield code="g">year:2019</subfield><subfield code="g">number:5</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doi.org/10.5455/IJMRCR.mangosteen-skin-extract-dmba</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doaj.org/article/25ae995736dc438c9d7772788ee4a7fa</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">http://www.ejmanager.com/fulltextpdf.php?mno=20988</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="u">https://doaj.org/toc/2534-9821</subfield><subfield code="y">Journal toc</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="u">https://doaj.org/toc/2534-9821</subfield><subfield code="y">Journal toc</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_DOAJ</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-PHA</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">3</subfield><subfield code="j">2019</subfield><subfield code="e">5</subfield></datafield></record></collection>
|
| score |
7.398386 |